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The map label for this gene is mscL [H]

Identifier: 119715032

GI number: 119715032

Start: 828989

End: 829378

Strand: Reverse

Name: mscL [H]

Synonym: Noca_0785

Alternate gene names: 119715032

Gene position: 829378-828989 (Counterclockwise)

Preceding gene: 119715033

Following gene: 119715029

Centisome position: 16.63

GC content: 65.38

Gene sequence:

>390_bases
ATGACCGGATTCAAGAACTTCATCCTGCGCGGGAACCTCGTCGAGCTCGCGGTCGCCTTCGTCATGGCCGCCGCGTTCGC
AACCGTGGTCACCGCCACCGTCGGCCTGATCATGGACCTGATCGGCAAGGCCGGCGGCACTCCGGACTTCTCGGACTACG
TCTGGAACGGCATCTCGATCGGCGCCTGGCTCACCGCGCTGATCTCGTTCCTCATCATCGCGGCGGTGGTGTACTTCTTC
ATCGTGGTGCCCTACACGAAGGCGAAGGAGCGCTACTTCCCGAGCCCGGAGCCCGGCACCCCCGAGGACGTCAAGCTGCT
CGAGGAGATCCGCGACCTGCTGGCCACCCAGCAGGGACGATCGACCTCAGGTCCGACCGACCTCGGCTAG

Upstream 100 bases:

>100_bases
GCTGGTCGTCGTCGGCGCCGAGCCCGCCGACGTGGCCCGGATCGCGGATGCCTCGGTGCGCACCTTCCTCACGATCGCCT
TTCCCGGCTAGCGTGCCGAC

Downstream 100 bases:

>100_bases
CTCAGCGGAACCGACGCGCCGATCACAACCACACCGTCGGACGACCCACCCAGGAACGATCCCGCGGCCCGCGCGGCGAC
GAAGTCGACGCGCGAGCCGC

Product: large-conductance mechanosensitive channel

Products: non-specific ion/solute [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 129; Mature: 128

Protein sequence:

>129_residues
MTGFKNFILRGNLVELAVAFVMAAAFATVVTATVGLIMDLIGKAGGTPDFSDYVWNGISIGAWLTALISFLIIAAVVYFF
IVVPYTKAKERYFPSPEPGTPEDVKLLEEIRDLLATQQGRSTSGPTDLG

Sequences:

>Translated_129_residues
MTGFKNFILRGNLVELAVAFVMAAAFATVVTATVGLIMDLIGKAGGTPDFSDYVWNGISIGAWLTALISFLIIAAVVYFF
IVVPYTKAKERYFPSPEPGTPEDVKLLEEIRDLLATQQGRSTSGPTDLG
>Mature_128_residues
TGFKNFILRGNLVELAVAFVMAAAFATVVTATVGLIMDLIGKAGGTPDFSDYVWNGISIGAWLTALISFLIIAAVVYFFI
VVPYTKAKERYFPSPEPGTPEDVKLLEEIRDLLATQQGRSTSGPTDLG

Specific function: Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell [H]

COG id: COG1970

COG function: function code M; Large-conductance mechanosensitive channel

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mscL family [H]

Homologues:

Organism=Escherichia coli, GI1789686, Length=130, Percent_Identity=30, Blast_Score=59, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019823
- InterPro:   IPR001185
- InterPro:   IPR015089 [H]

Pfam domain/function: PF01741 MscL [H]

EC number: NA

Molecular weight: Translated: 13877; Mature: 13746

Theoretical pI: Translated: 4.50; Mature: 4.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGFKNFILRGNLVELAVAFVMAAAFATVVTATVGLIMDLIGKAGGTPDFSDYVWNGISI
CCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCH
GAWLTALISFLIIAAVVYFFIVVPYTKAKERYFPSPEPGTPEDVKLLEEIRDLLATQQGR
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCC
STSGPTDLG
CCCCCCCCC
>Mature Secondary Structure 
TGFKNFILRGNLVELAVAFVMAAAFATVVTATVGLIMDLIGKAGGTPDFSDYVWNGISI
CCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCH
GAWLTALISFLIIAAVVYFFIVVPYTKAKERYFPSPEPGTPEDVKLLEEIRDLLATQQGR
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCC
STSGPTDLG
CCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: non-specific ion/solute [Cytoplasm] [C]

Specific reaction: non-specific ion/solute [Cytoplasm] = non-specific ion/solute [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA