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The map label for this gene is hbd [H]

Identifier: 119386286

GI number: 119386286

Start: 729392

End: 730327

Strand: Direct

Name: hbd [H]

Synonym: Pden_3577

Alternate gene names: 119386286

Gene position: 729392-730327 (Clockwise)

Preceding gene: 119386285

Following gene: 119386287

Centisome position: 42.16

GC content: 71.47

Gene sequence:

>936_bases
ATGTCTCATATCGCCATTGTCGGAGCGGGGCTGATCGGCCGCGCATGGGCCTTTGTCTTTGCGCGCGCCGGGTTCGACGT
GCGGGTCTGGGACCTCGACCCGCAGGTGCTGGAACGGCTGGACGGCGACATCGCCGCGATGGTCGCGCAGACCGCGCCCT
TCGGGCAGGCGGGCGCGGATCCCGACGCCACCGCCGCGCGCATCCGCGCCGTGCCGGACCTGGCCGGGGCGCTGGACGGC
GCCGAGCTGGTGCAGGAAAGCGGCCCCGAGGTGCTGGCGATCAAGCGCGAGCTTTTCGCCCGGTTGGACGGGCTGGCGGC
GGCGGGGGTGATCCTTGCCTCCAGCTCATCGGCGCTGATGGCCTCGGCCTTCGCCGAGGGCCTGCCGGGGGCGTCGCGCT
GCCTTGTCGGCCATCCGGTCAACCCCCCGCATCTGGTGCCGGTGGTCGAGATCGCCCCCGCGCCCTTTACCGATCCGGTG
ATCACCGCCCGCGCCCGCGACATCTATGCCCGCGCCGGTCAGGTGCCGGTCATGCTGAAGCGCGAGATCGACGGCTTTAT
CCTCAACCGCCTGCAAGCGGTGGTCCTGGCCGAAAGCCTGCGCCTGATCGAGCAGGGCTATGTCGATCCGCAGGGGCTTG
ACGACACCATCCGGCATGGGCTTGGCCGCCGCTGGGCCTTCATGGGCCCGATGGAGACGATCAACCTCAACGCGCCCGGC
GGTGCGGGGGATTACCTCGCCCGCTATGGCCGGATGATGGCCGGTCTGGCGAAGACCTCGGCGCGCGACGAGGCCTTTAC
GGCGCAGGCCGCCGCCATCGTCGGCTCGGCCTTTCCCGATACCGCGACCCCGCAGGCCATCCGCGCCCGGCAGGACTGGC
GCGACGGGCGCCTTGCCGCGCTGGCCCGCCATCTGGCCGACCAGCCGCAACATTAG

Upstream 100 bases:

>100_bases
TCGTGCTGGAGCGCGGTCGCGTGCTGCATGAAATCGAATCCCGCCGCATCGCCGAAGATATCGAGCTGCGGCGCGAAATG
CTGTGGATGTAGGGGGGCGC

Downstream 100 bases:

>100_bases
ATTTTCAGGAGCAAACCCATGAGCCTCAACGGAAAAGTCATCATCACCTGCGCCGTGACAGGTGCGATCCACACGCCGTC
CATGTCGCCCTATCTGCCGG

Product: 3-hydroxyacyl-CoA dehydrogenase, NAD-binding

Products: NA

Alternate protein names: Beta-hydroxybutyryl-CoA dehydrogenase; BHBD [H]

Number of amino acids: Translated: 311; Mature: 310

Protein sequence:

>311_residues
MSHIAIVGAGLIGRAWAFVFARAGFDVRVWDLDPQVLERLDGDIAAMVAQTAPFGQAGADPDATAARIRAVPDLAGALDG
AELVQESGPEVLAIKRELFARLDGLAAAGVILASSSSALMASAFAEGLPGASRCLVGHPVNPPHLVPVVEIAPAPFTDPV
ITARARDIYARAGQVPVMLKREIDGFILNRLQAVVLAESLRLIEQGYVDPQGLDDTIRHGLGRRWAFMGPMETINLNAPG
GAGDYLARYGRMMAGLAKTSARDEAFTAQAAAIVGSAFPDTATPQAIRARQDWRDGRLAALARHLADQPQH

Sequences:

>Translated_311_residues
MSHIAIVGAGLIGRAWAFVFARAGFDVRVWDLDPQVLERLDGDIAAMVAQTAPFGQAGADPDATAARIRAVPDLAGALDG
AELVQESGPEVLAIKRELFARLDGLAAAGVILASSSSALMASAFAEGLPGASRCLVGHPVNPPHLVPVVEIAPAPFTDPV
ITARARDIYARAGQVPVMLKREIDGFILNRLQAVVLAESLRLIEQGYVDPQGLDDTIRHGLGRRWAFMGPMETINLNAPG
GAGDYLARYGRMMAGLAKTSARDEAFTAQAAAIVGSAFPDTATPQAIRARQDWRDGRLAALARHLADQPQH
>Mature_310_residues
SHIAIVGAGLIGRAWAFVFARAGFDVRVWDLDPQVLERLDGDIAAMVAQTAPFGQAGADPDATAARIRAVPDLAGALDGA
ELVQESGPEVLAIKRELFARLDGLAAAGVILASSSSALMASAFAEGLPGASRCLVGHPVNPPHLVPVVEIAPAPFTDPVI
TARARDIYARAGQVPVMLKREIDGFILNRLQAVVLAESLRLIEQGYVDPQGLDDTIRHGLGRRWAFMGPMETINLNAPGG
AGDYLARYGRMMAGLAKTSARDEAFTAQAAAIVGSAFPDTATPQAIRARQDWRDGRLAALARHLADQPQH

Specific function: Butyrate/butanol-producing pathway. Phenylacetic acid aerobic catabolism. [C]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI115430219, Length=317, Percent_Identity=36.5930599369085, Blast_Score=214, Evalue=7e-56,
Organism=Homo sapiens, GI296179429, Length=242, Percent_Identity=29.7520661157025, Blast_Score=93, Evalue=3e-19,
Organism=Homo sapiens, GI296179427, Length=250, Percent_Identity=30, Blast_Score=85, Evalue=9e-17,
Organism=Escherichia coli, GI1787661, Length=235, Percent_Identity=28.0851063829787, Blast_Score=78, Evalue=9e-16,
Organism=Caenorhabditis elegans, GI115533614, Length=250, Percent_Identity=35.2, Blast_Score=147, Evalue=9e-36,
Organism=Caenorhabditis elegans, GI193203623, Length=250, Percent_Identity=35.6, Blast_Score=145, Evalue=3e-35,
Organism=Caenorhabditis elegans, GI17553560, Length=236, Percent_Identity=27.5423728813559, Blast_Score=85, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI71985930, Length=240, Percent_Identity=26.25, Blast_Score=81, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI17549919, Length=238, Percent_Identity=28.5714285714286, Blast_Score=80, Evalue=9e-16,
Organism=Caenorhabditis elegans, GI71985923, Length=242, Percent_Identity=23.5537190082645, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI20129993, Length=260, Percent_Identity=42.3076923076923, Blast_Score=204, Evalue=6e-53,
Organism=Drosophila melanogaster, GI45549573, Length=305, Percent_Identity=36.0655737704918, Blast_Score=199, Evalue=3e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022694
- InterPro:   IPR006180
- InterPro:   IPR006176
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N [H]

EC number: =1.1.1.157 [H]

Molecular weight: Translated: 32847; Mature: 32716

Theoretical pI: Translated: 5.96; Mature: 5.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSHIAIVGAGLIGRAWAFVFARAGFDVRVWDLDPQVLERLDGDIAAMVAQTAPFGQAGAD
CCCEEEECCCHHHHHHHHHHHHCCCEEEEEECCHHHHHHCCCHHHHHHHHCCCCCCCCCC
PDATAARIRAVPDLAGALDGAELVQESGPEVLAIKRELFARLDGLAAAGVILASSSSALM
CCHHHHHHHHCHHHHHHCCHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHEEEECCCHHHH
ASAFAEGLPGASRCLVGHPVNPPHLVPVVEIAPAPFTDPVITARARDIYARAGQVPVMLK
HHHHHHCCCCCCCEEECCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHCCCCCEEHH
REIDGFILNRLQAVVLAESLRLIEQGYVDPQGLDDTIRHGLGRRWAFMGPMETINLNAPG
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCCEEECCCCCEEEECCCC
GAGDYLARYGRMMAGLAKTSARDEAFTAQAAAIVGSAFPDTATPQAIRARQDWRDGRLAA
CCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCHHHH
LARHLADQPQH
HHHHHHCCCCC
>Mature Secondary Structure 
SHIAIVGAGLIGRAWAFVFARAGFDVRVWDLDPQVLERLDGDIAAMVAQTAPFGQAGAD
CCEEEECCCHHHHHHHHHHHHCCCEEEEEECCHHHHHHCCCHHHHHHHHCCCCCCCCCC
PDATAARIRAVPDLAGALDGAELVQESGPEVLAIKRELFARLDGLAAAGVILASSSSALM
CCHHHHHHHHCHHHHHHCCHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHEEEECCCHHHH
ASAFAEGLPGASRCLVGHPVNPPHLVPVVEIAPAPFTDPVITARARDIYARAGQVPVMLK
HHHHHHCCCCCCCEEECCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHCCCCCEEHH
REIDGFILNRLQAVVLAESLRLIEQGYVDPQGLDDTIRHGLGRRWAFMGPMETINLNAPG
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCCEEECCCCCEEEECCCC
GAGDYLARYGRMMAGLAKTSARDEAFTAQAAAIVGSAFPDTATPQAIRARQDWRDGRLAA
CCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCHHHH
LARHLADQPQH
HHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA