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The map label for this gene is hmgA [H]

Identifier: 119386258

GI number: 119386258

Start: 694964

End: 696325

Strand: Direct

Name: hmgA [H]

Synonym: Pden_3547

Alternate gene names: 119386258

Gene position: 694964-696325 (Clockwise)

Preceding gene: 119386256

Following gene: 119386259

Centisome position: 40.17

GC content: 66.45

Gene sequence:

>1362_bases
ATGACCCAGCACGACCTGCCCCCCGGCATGACCCGCGCCGCCGTCGCCACCGGCACGCATCCGGGCTACATGCCCGGCTT
CGGCAACGATTTCGAGACCGAGGCGCTGCCCGGCGCCCTGCCGCAGGGCCAGAACAGCCCGCAGAAATGCGAATACGGGC
TTTATGCCGAGCAGCTGTCGGGCACCGCCTTCACCGCGCCGCGCGGCCAGAACGAGCGGACCTGGTGCTATCGCATCCGG
CCCTCGGTCCGCCATACCGGCGATTTCGCGGCGATCGATCTGCCGCATTGGAAGACGGCGCCGAACCTGCGCGACGACAT
CGTCAGCCTGGGCCAGTATCGCTGGGACCCGATCCCGGTCCCGGAGGAGGAGCTGACCTGGATCACCGGCATGCGCAGCA
TGACCACGGCCGGCGACGTGAACATCCAGGTCGGCATGGCGTCGCATGTCTACCTGGTCACCCGCTCGATGCAGGACGAA
TATTTCTTCTCGGCCGACAGCGAGTTGCTGGTGGTCCCGCAAGAGGGCCGGCTGCGCTTCTGCACCGAGCTGGGGGTGAT
CGACCTGGAGCCGCGGGAAATCGCCATCCTGCCGCGCGGCCTGGTCTACCGCGTCGAGGTGCTGGAGGGCCCGGCCCGCG
GCTTCGTCTGCGAGAATTACGGCCAGAAGTTCGACCTGCCGGGCCGCGGCCCGATCGGCGCCAATTGCCTGGCCAATCCG
CGCGACTTCAAATGCCCGGTCGCCGCCTTCGAGGACCGCGAGGCGCGCTCGCGCGTGGTGATCAAGTGGTGCGGCCGGTT
CCACGAGACCTGGATCGACCACAGCCCGCTGGACGTGGTGGCCTGGCACGGGAATTACTGCCCCTACAAATACGACCTGC
GCACCTATTCGCCGGTGGGCGCGATCCTGTTCGACCATCCCGACCCGTCGATCTTCACCGTGCTGACCGCGCCCTCGGGC
CAGGAGGGCACGGCGAATATCGACTTCGTGCTGTTCCGCGAGCGCTGGATGGTGGCCGAGCACAGCTTCCGCCCGCCCTG
GTATCACAAGAACATCATGTCCGAGCTGATGGGCAACATCTACGGCATCTACGACGCCAAGCCGCAGGGCTTTGCGCCGG
GCGGCATCAGCCTGCACAATTGCATGCTGCCGCACGGCCCGGACCGCGACGCCTTCGAGGGCGCCAGCAACGCCGATCTG
AAGCCCGAGAAGCTGGAGGAGACCATGAGCTTCATGTTCGAGACCCGCTTTCCCCAGCACCTCACCGAATTCGCTGCGCG
CGAGGCCCCGATGCAGAAGGACTATATCGAAGTCTGGAACCGGCTCGAGAAGAAGTTCGACGGAACGCCAGGCGTCAAGT
GA

Upstream 100 bases:

>100_bases
CTGCAATAAAGATCGGCCCGGATGCAGATCCGCATTGACATCGTTGCCATCGCAATGACATAATCGTTGCAACTGCAATG
ACACCGCAGGGAGGAGCCCC

Downstream 100 bases:

>100_bases
GGCCCCAAGGTCGAAGGCCGAGGGCCGAGGGCCGAGAGCCGGGGATATTTGCACAAGAAAGAAGGAGGCCGGATGTGGCT
CTATTGCGGTCCTGGCTCGA

Product: homogentisate 1,2-dioxygenase

Products: NA

Alternate protein names: Homogentisate oxygenase; Homogentisic acid oxidase; Homogentisicase [H]

Number of amino acids: Translated: 453; Mature: 452

Protein sequence:

>453_residues
MTQHDLPPGMTRAAVATGTHPGYMPGFGNDFETEALPGALPQGQNSPQKCEYGLYAEQLSGTAFTAPRGQNERTWCYRIR
PSVRHTGDFAAIDLPHWKTAPNLRDDIVSLGQYRWDPIPVPEEELTWITGMRSMTTAGDVNIQVGMASHVYLVTRSMQDE
YFFSADSELLVVPQEGRLRFCTELGVIDLEPREIAILPRGLVYRVEVLEGPARGFVCENYGQKFDLPGRGPIGANCLANP
RDFKCPVAAFEDREARSRVVIKWCGRFHETWIDHSPLDVVAWHGNYCPYKYDLRTYSPVGAILFDHPDPSIFTVLTAPSG
QEGTANIDFVLFRERWMVAEHSFRPPWYHKNIMSELMGNIYGIYDAKPQGFAPGGISLHNCMLPHGPDRDAFEGASNADL
KPEKLEETMSFMFETRFPQHLTEFAAREAPMQKDYIEVWNRLEKKFDGTPGVK

Sequences:

>Translated_453_residues
MTQHDLPPGMTRAAVATGTHPGYMPGFGNDFETEALPGALPQGQNSPQKCEYGLYAEQLSGTAFTAPRGQNERTWCYRIR
PSVRHTGDFAAIDLPHWKTAPNLRDDIVSLGQYRWDPIPVPEEELTWITGMRSMTTAGDVNIQVGMASHVYLVTRSMQDE
YFFSADSELLVVPQEGRLRFCTELGVIDLEPREIAILPRGLVYRVEVLEGPARGFVCENYGQKFDLPGRGPIGANCLANP
RDFKCPVAAFEDREARSRVVIKWCGRFHETWIDHSPLDVVAWHGNYCPYKYDLRTYSPVGAILFDHPDPSIFTVLTAPSG
QEGTANIDFVLFRERWMVAEHSFRPPWYHKNIMSELMGNIYGIYDAKPQGFAPGGISLHNCMLPHGPDRDAFEGASNADL
KPEKLEETMSFMFETRFPQHLTEFAAREAPMQKDYIEVWNRLEKKFDGTPGVK
>Mature_452_residues
TQHDLPPGMTRAAVATGTHPGYMPGFGNDFETEALPGALPQGQNSPQKCEYGLYAEQLSGTAFTAPRGQNERTWCYRIRP
SVRHTGDFAAIDLPHWKTAPNLRDDIVSLGQYRWDPIPVPEEELTWITGMRSMTTAGDVNIQVGMASHVYLVTRSMQDEY
FFSADSELLVVPQEGRLRFCTELGVIDLEPREIAILPRGLVYRVEVLEGPARGFVCENYGQKFDLPGRGPIGANCLANPR
DFKCPVAAFEDREARSRVVIKWCGRFHETWIDHSPLDVVAWHGNYCPYKYDLRTYSPVGAILFDHPDPSIFTVLTAPSGQ
EGTANIDFVLFRERWMVAEHSFRPPWYHKNIMSELMGNIYGIYDAKPQGFAPGGISLHNCMLPHGPDRDAFEGASNADLK
PEKLEETMSFMFETRFPQHLTEFAAREAPMQKDYIEVWNRLEKKFDGTPGVK

Specific function: Unknown

COG id: COG3508

COG function: function code Q; Homogentisate 1,2-dioxygenase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the homogentisate dioxygenase family [H]

Homologues:

Organism=Homo sapiens, GI115527117, Length=433, Percent_Identity=45.2655889145497, Blast_Score=384, Evalue=1e-106,
Organism=Caenorhabditis elegans, GI17507969, Length=430, Percent_Identity=50.4651162790698, Blast_Score=420, Evalue=1e-117,
Organism=Drosophila melanogaster, GI24583650, Length=435, Percent_Identity=46.2068965517241, Blast_Score=379, Evalue=1e-105,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011051
- InterPro:   IPR005708
- InterPro:   IPR022950 [H]

Pfam domain/function: PF04209 HgmA [H]

EC number: =1.13.11.5 [H]

Molecular weight: Translated: 51157; Mature: 51026

Theoretical pI: Translated: 5.45; Mature: 5.45

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQHDLPPGMTRAAVATGTHPGYMPGFGNDFETEALPGALPQGQNSPQKCEYGLYAEQLS
CCCCCCCCCCCHHEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHC
GTAFTAPRGQNERTWCYRIRPSVRHTGDFAAIDLPHWKTAPNLRDDIVSLGQYRWDPIPV
CCEEECCCCCCCCEEEEEECCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHCCCCCCCC
PEEELTWITGMRSMTTAGDVNIQVGMASHVYLVTRSMQDEYFFSADSELLVVPQEGRLRF
CHHHHHHHHCCCHHCCCCCCEEEEECCCEEEEEEECCCCCEEECCCCCEEEECCCCCEEE
CTELGVIDLEPREIAILPRGLVYRVEVLEGPARGFVCENYGQKFDLPGRGPIGANCLANP
EEECCEEECCCCEEEEECCCEEEEEEEECCCCCCCEECCCCCEECCCCCCCCCCCCCCCC
RDFKCPVAAFEDREARSRVVIKWCGRFHETWIDHSPLDVVAWHGNYCPYKYDLRTYSPVG
CCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCEEECCCCCCCCE
AILFDHPDPSIFTVLTAPSGQEGTANIDFVLFRERWMVAEHSFRPPWYHKNIMSELMGNI
EEEEECCCCCEEEEEECCCCCCCCCCEEEEEEECHHHHHHCCCCCCHHHHHHHHHHHHHE
YGIYDAKPQGFAPGGISLHNCMLPHGPDRDAFEGASNADLKPEKLEETMSFMFETRFPQH
EEEECCCCCCCCCCCCCCEEECCCCCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHCCHHH
LTEFAAREAPMQKDYIEVWNRLEKKFDGTPGVK
HHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
TQHDLPPGMTRAAVATGTHPGYMPGFGNDFETEALPGALPQGQNSPQKCEYGLYAEQLS
CCCCCCCCCCHHEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHC
GTAFTAPRGQNERTWCYRIRPSVRHTGDFAAIDLPHWKTAPNLRDDIVSLGQYRWDPIPV
CCEEECCCCCCCCEEEEEECCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHCCCCCCCC
PEEELTWITGMRSMTTAGDVNIQVGMASHVYLVTRSMQDEYFFSADSELLVVPQEGRLRF
CHHHHHHHHCCCHHCCCCCCEEEEECCCEEEEEEECCCCCEEECCCCCEEEECCCCCEEE
CTELGVIDLEPREIAILPRGLVYRVEVLEGPARGFVCENYGQKFDLPGRGPIGANCLANP
EEECCEEECCCCEEEEECCCEEEEEEEECCCCCCCEECCCCCEECCCCCCCCCCCCCCCC
RDFKCPVAAFEDREARSRVVIKWCGRFHETWIDHSPLDVVAWHGNYCPYKYDLRTYSPVG
CCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCEEECCCCCCCCE
AILFDHPDPSIFTVLTAPSGQEGTANIDFVLFRERWMVAEHSFRPPWYHKNIMSELMGNI
EEEEECCCCCEEEEEECCCCCCCCCCEEEEEEECHHHHHHCCCCCCHHHHHHHHHHHHHE
YGIYDAKPQGFAPGGISLHNCMLPHGPDRDAFEGASNADLKPEKLEETMSFMFETRFPQH
EEEECCCCCCCCCCCCCCEEECCCCCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHCCHHH
LTEFAAREAPMQKDYIEVWNRLEKKFDGTPGVK
HHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10220173; 11481430 [H]