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The map label for this gene is argE [H]

Identifier: 119386170

GI number: 119386170

Start: 601117

End: 602274

Strand: Direct

Name: argE [H]

Synonym: Pden_3458

Alternate gene names: 119386170

Gene position: 601117-602274 (Clockwise)

Preceding gene: 119386165

Following gene: 119386171

Centisome position: 34.74

GC content: 70.55

Gene sequence:

>1158_bases
ATGACCGAACCCCGCCCCGAGACGCTGGCGCTGCTGGCGCGCCTGGTCGCCTTTCCCACCGTCAGCGCCGAAAGCAACCT
GGCGCTGATCGATTTCGCCGAACACCATCTGCGGCACGCCGGCTTTGTCACGCACCGCCTGCCGTCCCGCGACGGAACCA
AGGCCGGACTGATGGCCCGACTGGGCGAGGGGCGGGGCGGCGTCATGCTTTCGGCCCATAGCGACGTCGTGCCGGCCGAA
GGGCAGGGCTGGAGCCGGCCGCCCTTTGCCCTGTCGCGCCGGGGGGACAGGCTTTACGGGCGCGGCACGACCGACATGAA
GGGCTTTCTTGCGGCGATGCTTTCGCGGGCGGCGCGGGCGGGAAAGGCTACGCCGGCCCGGCCGCTGATGCTGGCGATCT
CTTACGACGAAGAGGTCGGCTGCACCGGCATCCGCGAGATGCTGCCCGGGATCGAGGCACTGGGCTGGCGGCCCGAACTC
TGCATCGTGGGCGAGCCGACCGGGATGCGACCGGCCATCGGGCACAAGGGCAAGGCCGCGCTGGTCGCGACCTGCCACGG
CACGGCCGGGCATTCCTCGCTGGCGCCGCGCCATGTCAATGCGCTGCATCTCGCGGCCGAGTTCATCGCCGCCCTGCGCC
GCATCCAGGGCGATTACGCCGCGTCCGCCTGCACCGATCCCGCCTACGACATTCCGTTTTCCACCGTCCATGCCGGCAGG
ATGCAGGGCGGGGCGGCGCTGAACATCGTCCCCGACCGGGCCGCGGTCGAATTCGAGCTGCGCCACCTGCCCGGTGATGC
GCTGTCGGATTTCCAGGACCGCCTGCGATGCGAGATCGCCCGCATCCTCGCGCCGTTTCGTGCGCAGGACGAGGCGGCGG
ACATCCGCATCGCCCTGACCAACACCTATCCCGGGCACGACATCGCCCCGGATCATCCGGCGGTGCAGGATGTCGTGCGC
CATTGCGGCGACCCGCGGCGGATCAAGGTCGCCTATGGCACCGAAGCGGGCTATTTCGCGCGGCTGGGCATCCCGACCGT
GGTCTGCGGCCCCGGCGACATGGAGGGGCAGGGGCACAAGCCGGACGAATTCCTGGCCCTGCCGCAGCTAGCCCTGTGCG
AGCGGATGCTGGACCGGCTGCTGGCCGGCTTGCGGTGA

Upstream 100 bases:

>100_bases
GGATTAGGCCCGGCCGCAGCAATGGCTCGGGAAATGCTCATTTCGCCGTGCCGGGATCGGCGATAGCCATCCTTGTCCGC
AGCCCGGACAGGAGATGAGC

Downstream 100 bases:

>100_bases
CGGGCTGAAACGGCCGGCCGGATGCGCGGCTTAGGATTCGCCGAAGTACCGTTGCGGAAAACATTAATTTACGCGCCGCC
GCCATTCCCGATGATGGGCG

Product: acetylornithine deacetylase

Products: NA

Alternate protein names: AO; Acetylornithinase; N-acetylornithinase; NAO [H]

Number of amino acids: Translated: 385; Mature: 384

Protein sequence:

>385_residues
MTEPRPETLALLARLVAFPTVSAESNLALIDFAEHHLRHAGFVTHRLPSRDGTKAGLMARLGEGRGGVMLSAHSDVVPAE
GQGWSRPPFALSRRGDRLYGRGTTDMKGFLAAMLSRAARAGKATPARPLMLAISYDEEVGCTGIREMLPGIEALGWRPEL
CIVGEPTGMRPAIGHKGKAALVATCHGTAGHSSLAPRHVNALHLAAEFIAALRRIQGDYAASACTDPAYDIPFSTVHAGR
MQGGAALNIVPDRAAVEFELRHLPGDALSDFQDRLRCEIARILAPFRAQDEAADIRIALTNTYPGHDIAPDHPAVQDVVR
HCGDPRRIKVAYGTEAGYFARLGIPTVVCGPGDMEGQGHKPDEFLALPQLALCERMLDRLLAGLR

Sequences:

>Translated_385_residues
MTEPRPETLALLARLVAFPTVSAESNLALIDFAEHHLRHAGFVTHRLPSRDGTKAGLMARLGEGRGGVMLSAHSDVVPAE
GQGWSRPPFALSRRGDRLYGRGTTDMKGFLAAMLSRAARAGKATPARPLMLAISYDEEVGCTGIREMLPGIEALGWRPEL
CIVGEPTGMRPAIGHKGKAALVATCHGTAGHSSLAPRHVNALHLAAEFIAALRRIQGDYAASACTDPAYDIPFSTVHAGR
MQGGAALNIVPDRAAVEFELRHLPGDALSDFQDRLRCEIARILAPFRAQDEAADIRIALTNTYPGHDIAPDHPAVQDVVR
HCGDPRRIKVAYGTEAGYFARLGIPTVVCGPGDMEGQGHKPDEFLALPQLALCERMLDRLLAGLR
>Mature_384_residues
TEPRPETLALLARLVAFPTVSAESNLALIDFAEHHLRHAGFVTHRLPSRDGTKAGLMARLGEGRGGVMLSAHSDVVPAEG
QGWSRPPFALSRRGDRLYGRGTTDMKGFLAAMLSRAARAGKATPARPLMLAISYDEEVGCTGIREMLPGIEALGWRPELC
IVGEPTGMRPAIGHKGKAALVATCHGTAGHSSLAPRHVNALHLAAEFIAALRRIQGDYAASACTDPAYDIPFSTVHAGRM
QGGAALNIVPDRAAVEFELRHLPGDALSDFQDRLRCEIARILAPFRAQDEAADIRIALTNTYPGHDIAPDHPAVQDVVRH
CGDPRRIKVAYGTEAGYFARLGIPTVVCGPGDMEGQGHKPDEFLALPQLALCERMLDRLLAGLR

Specific function: Displays A Broad Specificity And Can Also Deacylate Substrates Such As Acetylarginine, Acetylhistidine Or Acetylglutamate Semialdehyde. [C]

COG id: COG0624

COG function: function code E; Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M20A family. ArgE subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790395, Length=374, Percent_Identity=30.2139037433155, Blast_Score=166, Evalue=3e-42,
Organism=Escherichia coli, GI1788816, Length=363, Percent_Identity=27.2727272727273, Blast_Score=97, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17551016, Length=363, Percent_Identity=25.3443526170799, Blast_Score=72, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010169
- InterPro:   IPR001261
- InterPro:   IPR002933
- InterPro:   IPR011650 [H]

Pfam domain/function: PF07687 M20_dimer; PF01546 Peptidase_M20 [H]

EC number: =3.5.1.16 [H]

Molecular weight: Translated: 41320; Mature: 41189

Theoretical pI: Translated: 7.64; Mature: 7.64

Prosite motif: PS00758 ARGE_DAPE_CPG2_1 ; PS00759 ARGE_DAPE_CPG2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEPRPETLALLARLVAFPTVSAESNLALIDFAEHHLRHAGFVTHRLPSRDGTKAGLMAR
CCCCCHHHHHHHHHHHHCCCCCCCCCEEEEEHHHHHHHHHCHHHHCCCCCCCCHHHHHHH
LGEGRGGVMLSAHSDVVPAEGQGWSRPPFALSRRGDRLYGRGTTDMKGFLAAMLSRAARA
HCCCCCCEEEEECCCCCCCCCCCCCCCCHHHHCCCCEEECCCCCHHHHHHHHHHHHHHHC
GKATPARPLMLAISYDEEVGCTGIREMLPGIEALGWRPELCIVGEPTGMRPAIGHKGKAA
CCCCCCCCEEEEEECCCCCCCHHHHHHCCCHHHCCCCCCEEEEECCCCCCCCCCCCCCEE
LVATCHGTAGHSSLAPRHVNALHLAAEFIAALRRIQGDYAASACTDPAYDIPFSTVHAGR
EEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCCCHHHHHCC
MQGGAALNIVPDRAAVEFELRHLPGDALSDFQDRLRCEIARILAPFRAQDEAADIRIALT
CCCCEEEEEECCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEE
NTYPGHDIAPDHPAVQDVVRHCGDPRRIKVAYGTEAGYFARLGIPTVVCGPGDMEGQGHK
CCCCCCCCCCCCHHHHHHHHHCCCCCEEEEEECCCCCEEEECCCCEEEECCCCCCCCCCC
PDEFLALPQLALCERMLDRLLAGLR
CHHHHHCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TEPRPETLALLARLVAFPTVSAESNLALIDFAEHHLRHAGFVTHRLPSRDGTKAGLMAR
CCCCHHHHHHHHHHHHCCCCCCCCCEEEEEHHHHHHHHHCHHHHCCCCCCCCHHHHHHH
LGEGRGGVMLSAHSDVVPAEGQGWSRPPFALSRRGDRLYGRGTTDMKGFLAAMLSRAARA
HCCCCCCEEEEECCCCCCCCCCCCCCCCHHHHCCCCEEECCCCCHHHHHHHHHHHHHHHC
GKATPARPLMLAISYDEEVGCTGIREMLPGIEALGWRPELCIVGEPTGMRPAIGHKGKAA
CCCCCCCCEEEEEECCCCCCCHHHHHHCCCHHHCCCCCCEEEEECCCCCCCCCCCCCCEE
LVATCHGTAGHSSLAPRHVNALHLAAEFIAALRRIQGDYAASACTDPAYDIPFSTVHAGR
EEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCCCHHHHHCC
MQGGAALNIVPDRAAVEFELRHLPGDALSDFQDRLRCEIARILAPFRAQDEAADIRIALT
CCCCEEEEEECCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEE
NTYPGHDIAPDHPAVQDVVRHCGDPRRIKVAYGTEAGYFARLGIPTVVCGPGDMEGQGHK
CCCCCCCCCCCCHHHHHHHHHCCCCCEEEEEECCCCCEEEECCCCEEEECCCCCCCCCCC
PDEFLALPQLALCERMLDRLLAGLR
CHHHHHCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11248100 [H]