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The map label for this gene is macA [H]

Identifier: 119357467

GI number: 119357467

Start: 1893833

End: 1895089

Strand: Direct

Name: macA [H]

Synonym: Cpha266_1666

Alternate gene names: 119357467

Gene position: 1893833-1895089 (Clockwise)

Preceding gene: 119357466

Following gene: 119357468

Centisome position: 60.43

GC content: 47.89

Gene sequence:

>1257_bases
ATGTCAAAAAAGAAACCTTCACAGAAACGCAACACGATAATCTTTGCTCTAACCGGAATTCTTGTTGCTGGCGGAATCCT
CTTCACCTGGATGATGTTACGGGAAAAACCGCTCGAAGTGACAACTGAGAAGGCATTCAGAAAAGATGTCATCCACCTTG
TAACGGCTACAGGAAAAATCGAGCCTGAAATCGAAGTTGCCATGTCACCCGATGTTTCAGGAGAGATTATCGAGCTTCCC
GTCAAGGAAGGCGACCAGGTTCTGATGGGAGCCCTTCTCTTCAAGATCCAGCCTGATGTCTATATCAACCAGGTTGAGCA
GAGTCAGGCACAACTCAACCAGGCAAAATCGCAAAGTCTCGAGGCGGGATCGAGAAAATTAAAAGCAGAAGATGATTTTC
GAAAGGCAAACCTGCTTTTCAGGGAAAAACTGATTTCTGAAACAGATTACATGACAGCCAAAACCAACGTTCAGGCAGCC
AGAGCATCCTATGAATCCTCGCTGTATGCTATTCAACAGAACAAAAGCCTGCTCGACCTGAACAATGACAGAATGAAAAA
AACTGTTGTCAGCGCACCGATCAGCGGCAGCATTGTTGCCTTGAACAGCAAATCCGGCGAACGCGTTGTCGGAACCGGTC
AGTTTCCCGGAACCGAAGTACTGCGTCTTGCAAACCTCGACAGCATGCAGGTTAGCGTTGAGGTCAATGAAAACGACATT
GTAAATGTAAAAAAAGGCGACCCGGTCTCCGTTACCGTTGATGCCTACGGTGATCGTATCTTCAAAGGCGTGGTTCACGA
AATTTCCAACTCGGCCCTTGCCCAGGCTGTCGGAAGCCAGGAAGAGGTGACAAATTTTTCGGTTAAAATCCGCATCCTGA
ACCACAACAGACTTCTGAAACCCGGTATGAGCGCAACGGCCGATATCGAAACAGATCGAGTGGCAAACGCTCTTGTTGTG
CCGATTCAAAGCGTGACCATCAGAAACCCTCATGAAGCGAAGGATGCAAAAAAACCGGAACAACCGACAGCGGTAAAAAC
CGCGCGGCCTCTTAAGGAAAACAATACGGTACAGGGGGTATTTATCGTCAGCGGGTCTAAAGCATGGTTCAGAAAGGTTA
CCACCGGGACTACCGACAATTCACATATCATCGTCACCTCCGGTATTAAAGAGGGCGATGAGATTGTCTCGGGCAGCTAT
AACGCAATCTCTTCCGGACTTCTCGACGGAAGTCCGGTAAAGACCCAAAAAAAATAG

Upstream 100 bases:

>100_bases
GCCAGGCCACCTACACCCTTGCTCTTCAGAAAAACACACTTGATTTTGCTACAGGAAACGTACCTATTTATTGAACAACG
CAAATTTTTTGCAAGAACCA

Downstream 100 bases:

>100_bases
ACGATGCAGCCAGTCATCATCAATATGAAGTCTCTCTCCAAGTTTTATCAGATGGGAGAACAGACTGTCAAAGCACTCGA
CTCGATTGATCTTCAGTTCA

Product: RND family efflux transporter MFP subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 418; Mature: 417

Protein sequence:

>418_residues
MSKKKPSQKRNTIIFALTGILVAGGILFTWMMLREKPLEVTTEKAFRKDVIHLVTATGKIEPEIEVAMSPDVSGEIIELP
VKEGDQVLMGALLFKIQPDVYINQVEQSQAQLNQAKSQSLEAGSRKLKAEDDFRKANLLFREKLISETDYMTAKTNVQAA
RASYESSLYAIQQNKSLLDLNNDRMKKTVVSAPISGSIVALNSKSGERVVGTGQFPGTEVLRLANLDSMQVSVEVNENDI
VNVKKGDPVSVTVDAYGDRIFKGVVHEISNSALAQAVGSQEEVTNFSVKIRILNHNRLLKPGMSATADIETDRVANALVV
PIQSVTIRNPHEAKDAKKPEQPTAVKTARPLKENNTVQGVFIVSGSKAWFRKVTTGTTDNSHIIVTSGIKEGDEIVSGSY
NAISSGLLDGSPVKTQKK

Sequences:

>Translated_418_residues
MSKKKPSQKRNTIIFALTGILVAGGILFTWMMLREKPLEVTTEKAFRKDVIHLVTATGKIEPEIEVAMSPDVSGEIIELP
VKEGDQVLMGALLFKIQPDVYINQVEQSQAQLNQAKSQSLEAGSRKLKAEDDFRKANLLFREKLISETDYMTAKTNVQAA
RASYESSLYAIQQNKSLLDLNNDRMKKTVVSAPISGSIVALNSKSGERVVGTGQFPGTEVLRLANLDSMQVSVEVNENDI
VNVKKGDPVSVTVDAYGDRIFKGVVHEISNSALAQAVGSQEEVTNFSVKIRILNHNRLLKPGMSATADIETDRVANALVV
PIQSVTIRNPHEAKDAKKPEQPTAVKTARPLKENNTVQGVFIVSGSKAWFRKVTTGTTDNSHIIVTSGIKEGDEIVSGSY
NAISSGLLDGSPVKTQKK
>Mature_417_residues
SKKKPSQKRNTIIFALTGILVAGGILFTWMMLREKPLEVTTEKAFRKDVIHLVTATGKIEPEIEVAMSPDVSGEIIELPV
KEGDQVLMGALLFKIQPDVYINQVEQSQAQLNQAKSQSLEAGSRKLKAEDDFRKANLLFREKLISETDYMTAKTNVQAAR
ASYESSLYAIQQNKSLLDLNNDRMKKTVVSAPISGSIVALNSKSGERVVGTGQFPGTEVLRLANLDSMQVSVEVNENDIV
NVKKGDPVSVTVDAYGDRIFKGVVHEISNSALAQAVGSQEEVTNFSVKIRILNHNRLLKPGMSATADIETDRVANALVVP
IQSVTIRNPHEAKDAKKPEQPTAVKTARPLKENNTVQGVFIVSGSKAWFRKVTTGTTDNSHIIVTSGIKEGDEIVSGSYN
AISSGLLDGSPVKTQKK

Specific function: Efflux transporter for macrolide antibiotics [H]

COG id: COG0845

COG function: function code M; Membrane-fusion protein

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI87081796, Length=403, Percent_Identity=24.317617866005, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI87081951, Length=270, Percent_Identity=27.4074074074074, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1789929, Length=354, Percent_Identity=25.7062146892655, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 45543; Mature: 45411

Theoretical pI: Translated: 9.66; Mature: 9.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKKKPSQKRNTIIFALTGILVAGGILFTWMMLREKPLEVTTEKAFRKDVIHLVTATGKI
CCCCCCCCHHCEEEEEEHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHEEEEECCCC
EPEIEVAMSPDVSGEIIELPVKEGDQVLMGALLFKIQPDVYINQVEQSQAQLNQAKSQSL
CCCEEEEECCCCCCCEEEEECCCCCHHHHHHHHHEECCCHHHHHHHHHHHHHHHHHHHHH
EAGSRKLKAEDDFRKANLLFREKLISETDYMTAKTNVQAARASYESSLYAIQQNKSLLDL
HHCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEECCCHHHHHHHHHHCEEEEECCCCEEEC
NNDRMKKTVVSAPISGSIVALNSKSGERVVGTGQFPGTEVLRLANLDSMQVSVEVNENDI
CCCHHHHHHEECCCCCCEEEEECCCCCEEEECCCCCCHHEEEEECCCCEEEEEEECCCCE
VNVKKGDPVSVTVDAYGDRIFKGVVHEISNSALAQAVGSQEEVTNFSVKIRILNHNRLLK
EEEECCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHCCCHHHCEEEEEEEEEECCCCEEC
PGMSATADIETDRVANALVVPIQSVTIRNPHEAKDAKKPEQPTAVKTARPLKENNTVQGV
CCCCCCCCCCHHHHCCEEEEEEEEEEECCCHHHHCCCCCCCCCCHHHCCCCCCCCCEEEE
FIVSGSKAWFRKVTTGTTDNSHIIVTSGIKEGDEIVSGSYNAISSGLLDGSPVKTQKK
EEEECCHHHHHEEECCCCCCCEEEEECCCCCCCHHHCCCCHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
SKKKPSQKRNTIIFALTGILVAGGILFTWMMLREKPLEVTTEKAFRKDVIHLVTATGKI
CCCCCCCHHCEEEEEEHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHEEEEECCCC
EPEIEVAMSPDVSGEIIELPVKEGDQVLMGALLFKIQPDVYINQVEQSQAQLNQAKSQSL
CCCEEEEECCCCCCCEEEEECCCCCHHHHHHHHHEECCCHHHHHHHHHHHHHHHHHHHHH
EAGSRKLKAEDDFRKANLLFREKLISETDYMTAKTNVQAARASYESSLYAIQQNKSLLDL
HHCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEECCCHHHHHHHHHHCEEEEECCCCEEEC
NNDRMKKTVVSAPISGSIVALNSKSGERVVGTGQFPGTEVLRLANLDSMQVSVEVNENDI
CCCHHHHHHEECCCCCCEEEEECCCCCEEEECCCCCCHHEEEEECCCCEEEEEEECCCCE
VNVKKGDPVSVTVDAYGDRIFKGVVHEISNSALAQAVGSQEEVTNFSVKIRILNHNRLLK
EEEECCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHCCCHHHCEEEEEEEEEECCCCEEC
PGMSATADIETDRVANALVVPIQSVTIRNPHEAKDAKKPEQPTAVKTARPLKENNTVQGV
CCCCCCCCCCHHHHCCEEEEEEEEEEECCCHHHHCCCCCCCCCCHHHCCCCCCCCCEEEE
FIVSGSKAWFRKVTTGTTDNSHIIVTSGIKEGDEIVSGSYNAISSGLLDGSPVKTQKK
EEEECCHHHHHEEECCCCCCCEEEEECCCCCCCHHHCCCCHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]