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The map label for this gene is ddl

Identifier: 119357463

GI number: 119357463

Start: 1889285

End: 1890376

Strand: Direct

Name: ddl

Synonym: Cpha266_1662

Alternate gene names: 119357463

Gene position: 1889285-1890376 (Clockwise)

Preceding gene: 119357445

Following gene: 119357464

Centisome position: 60.29

GC content: 47.53

Gene sequence:

>1092_bases
ATGCCACTAAGCACCGTTGCCCTGATCTTTGGAGGCAAATCAACTGAACATGAAATTTCCATCATATCGGCAAAATCCAT
TGCTGCTGTTATAGATCCGTTTCGTTTTCAGGTTCTTCCCCTCTACATCACTCATGAAGGGAAATGGTTTACAGGAGAAT
TTGCCGAAAACATCCTGCAGCTTGATCTTGCCGAAATGCTGCGATCAACATCCCTTGATGCGACAGGAAACACCTTGAGA
CAGATGGCAATGCACACCGGTCAACAGGGATTTGACTTCGATTTCTTCAAAGCAGGTATTGACCTTGCATTTATTGCGCT
CCACGGCAGTTATGGAGAAGACGGGAGAATACAGGGGCTGCTCGATACATTCGGGATTCCCTATACCGGTTGCGGAGTGC
TTGCTTCGGCTGTTGCCATGGATAAAGCACTCACCAAACTATGTGTGACCGAAGCTGGTATTGCAACCGCTCCGGGCATA
ACGATTCTGAGCAGCGAATACTTCGCTGATCCAAAGAGTACGCAAAAGTCAATTGAAGAGCAATTCACCTGGCCAGTCTT
TGTCAAACCGGCAAGTCTCGGCTCATCAGTCGGCATTTCAAAAGTCCATCATATCGGTGAATTAATCGCAGCACTCGAAA
CAGCATGCCGTTATGACAGCAAAATTCTTGTAGAAAAAGCAATGCAAGGCAGGGAGGTTGAAGTTGCCGTACTTGGAAAC
AATGCACCGGAAGTGTCGATCACGGGAGAGATAGAACCGGGAAGCGAGTTCTACGACTATGCAGACAAATATATTCACAA
CGCGGCGAAAATGTATATTCCCGCTCGCATCTCCCCTGAGTTGCAGGAACAGGTAAGAAAAGATGCTCTCCGCGCATACA
AGGCTCTCGGCTGCCGGGGAATGTCGAGAATCGATTTTTTTGTCGATGAAACATCCGGTACGATTGTGCTTAATGAAGTA
AACACCATTCCCGGTTTTACCGATATCAGCATGTATCCACGGCTTTTTGCCGCATCAGGTCTTCCATTCAACGAGCTGGT
CGAGAAACTGCTTCAGTTTGCCCTTGAAACACCTTCGGGAGCAAGGAGCTAA

Upstream 100 bases:

>100_bases
AATCTGCCCCTGTACAAGAACATGCCGTTTTCGAAAACTTCTGCTTTACTGAAGAATACCATAATCTCTTCACAGCCAAA
CCATTTATACTAAAAGAGCT

Downstream 100 bases:

>100_bases
CCCAATGATGAGCAGTGATCCCTCGCTTTTTTACGCTGACGTATCCCTTGATCTCGCAAAAGGCGAATACCAGTCGGCAC
AGAACAAAATCGTCCCCTTT

Product: D-alanyl-alanine synthetase A

Products: NA

Alternate protein names: D-Ala-D-Ala ligase; D-alanylalanine synthetase

Number of amino acids: Translated: 363; Mature: 362

Protein sequence:

>363_residues
MPLSTVALIFGGKSTEHEISIISAKSIAAVIDPFRFQVLPLYITHEGKWFTGEFAENILQLDLAEMLRSTSLDATGNTLR
QMAMHTGQQGFDFDFFKAGIDLAFIALHGSYGEDGRIQGLLDTFGIPYTGCGVLASAVAMDKALTKLCVTEAGIATAPGI
TILSSEYFADPKSTQKSIEEQFTWPVFVKPASLGSSVGISKVHHIGELIAALETACRYDSKILVEKAMQGREVEVAVLGN
NAPEVSITGEIEPGSEFYDYADKYIHNAAKMYIPARISPELQEQVRKDALRAYKALGCRGMSRIDFFVDETSGTIVLNEV
NTIPGFTDISMYPRLFAASGLPFNELVEKLLQFALETPSGARS

Sequences:

>Translated_363_residues
MPLSTVALIFGGKSTEHEISIISAKSIAAVIDPFRFQVLPLYITHEGKWFTGEFAENILQLDLAEMLRSTSLDATGNTLR
QMAMHTGQQGFDFDFFKAGIDLAFIALHGSYGEDGRIQGLLDTFGIPYTGCGVLASAVAMDKALTKLCVTEAGIATAPGI
TILSSEYFADPKSTQKSIEEQFTWPVFVKPASLGSSVGISKVHHIGELIAALETACRYDSKILVEKAMQGREVEVAVLGN
NAPEVSITGEIEPGSEFYDYADKYIHNAAKMYIPARISPELQEQVRKDALRAYKALGCRGMSRIDFFVDETSGTIVLNEV
NTIPGFTDISMYPRLFAASGLPFNELVEKLLQFALETPSGARS
>Mature_362_residues
PLSTVALIFGGKSTEHEISIISAKSIAAVIDPFRFQVLPLYITHEGKWFTGEFAENILQLDLAEMLRSTSLDATGNTLRQ
MAMHTGQQGFDFDFFKAGIDLAFIALHGSYGEDGRIQGLLDTFGIPYTGCGVLASAVAMDKALTKLCVTEAGIATAPGIT
ILSSEYFADPKSTQKSIEEQFTWPVFVKPASLGSSVGISKVHHIGELIAALETACRYDSKILVEKAMQGREVEVAVLGNN
APEVSITGEIEPGSEFYDYADKYIHNAAKMYIPARISPELQEQVRKDALRAYKALGCRGMSRIDFFVDETSGTIVLNEVN
TIPGFTDISMYPRLFAASGLPFNELVEKLLQFALETPSGARS

Specific function: Cell wall formation

COG id: COG1181

COG function: function code M; D-alanine-D-alanine ligase and related ATP-grasp enzymes

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-grasp domain

Homologues:

Organism=Escherichia coli, GI1786579, Length=354, Percent_Identity=40.6779661016949, Blast_Score=271, Evalue=6e-74,
Organism=Escherichia coli, GI1786280, Length=256, Percent_Identity=38.671875, Blast_Score=179, Evalue=2e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DDL_CHLPD (A1BH06)

Other databases:

- EMBL:   CP000492
- RefSeq:   YP_912107.1
- ProteinModelPortal:   A1BH06
- SMR:   A1BH06
- STRING:   A1BH06
- GeneID:   4571042
- GenomeReviews:   CP000492_GR
- KEGG:   cph:Cpha266_1662
- NMPDR:   fig|290317.7.peg.1743
- eggNOG:   COG1181
- HOGENOM:   HBG427092
- OMA:   FTDISMY
- ProtClustDB:   PRK01966
- GO:   GO:0005737
- HAMAP:   MF_00047
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR000291
- InterPro:   IPR005905
- InterPro:   IPR011095
- InterPro:   IPR011127
- InterPro:   IPR013817
- InterPro:   IPR016185
- Gene3D:   G3DSA:3.30.1490.20
- Gene3D:   G3DSA:3.30.470.20
- Gene3D:   G3DSA:3.40.50.20
- TIGRFAMs:   TIGR01205

Pfam domain/function: PF07478 Dala_Dala_lig_C; PF01820 Dala_Dala_lig_N; SSF52440 PreATP-grasp-like

EC number: =6.3.2.4

Molecular weight: Translated: 39503; Mature: 39371

Theoretical pI: Translated: 4.75; Mature: 4.75

Prosite motif: PS50975 ATP_GRASP; PS00843 DALA_DALA_LIGASE_1; PS00844 DALA_DALA_LIGASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLSTVALIFGGKSTEHEISIISAKSIAAVIDPFRFQVLPLYITHEGKWFTGEFAENILQ
CCCCEEEEEECCCCCCCEEEEEEHHHHHHHHCCCEEEEEEEEEEECCCEEEHHHHHHHHH
LDLAEMLRSTSLDATGNTLRQMAMHTGQQGFDFDFFKAGIDLAFIALHGSYGEDGRIQGL
HHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCHHHHHHCCCEEEEEEECCCCCCCCEEHH
LDTFGIPYTGCGVLASAVAMDKALTKLCVTEAGIATAPGITILSSEYFADPKSTQKSIEE
HHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEHHHCCCCHHHHHHHHH
QFTWPVFVKPASLGSSVGISKVHHIGELIAALETACRYDSKILVEKAMQGREVEVAVLGN
HCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCEEEEEEECC
NAPEVSITGEIEPGSEFYDYADKYIHNAAKMYIPARISPELQEQVRKDALRAYKALGCRG
CCCCEEEEECCCCCHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHHHHHHCCCC
MSRIDFFVDETSGTIVLNEVNTIPGFTDISMYPRLFAASGLPFNELVEKLLQFALETPSG
CCCEEEEEECCCCEEEEEECCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCC
ARS
CCC
>Mature Secondary Structure 
PLSTVALIFGGKSTEHEISIISAKSIAAVIDPFRFQVLPLYITHEGKWFTGEFAENILQ
CCCEEEEEECCCCCCCEEEEEEHHHHHHHHCCCEEEEEEEEEEECCCEEEHHHHHHHHH
LDLAEMLRSTSLDATGNTLRQMAMHTGQQGFDFDFFKAGIDLAFIALHGSYGEDGRIQGL
HHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCHHHHHHCCCEEEEEEECCCCCCCCEEHH
LDTFGIPYTGCGVLASAVAMDKALTKLCVTEAGIATAPGITILSSEYFADPKSTQKSIEE
HHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEHHHCCCCHHHHHHHHH
QFTWPVFVKPASLGSSVGISKVHHIGELIAALETACRYDSKILVEKAMQGREVEVAVLGN
HCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCEEEEEEECC
NAPEVSITGEIEPGSEFYDYADKYIHNAAKMYIPARISPELQEQVRKDALRAYKALGCRG
CCCCEEEEECCCCCHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHHHHHHCCCC
MSRIDFFVDETSGTIVLNEVNTIPGFTDISMYPRLFAASGLPFNELVEKLLQFALETPSG
CCCEEEEEECCCCEEEEEECCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCC
ARS
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA