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The map label for this gene is guaB [H]

Identifier: 119357429

GI number: 119357429

Start: 1850897

End: 1852390

Strand: Direct

Name: guaB [H]

Synonym: Cpha266_1628

Alternate gene names: 119357429

Gene position: 1850897-1852390 (Clockwise)

Preceding gene: 119357423

Following gene: 119357434

Centisome position: 59.06

GC content: 49.4

Gene sequence:

>1494_bases
ATGAACAAAATTCTTTACGAAGCGCTGACGTTTGATGACGTTCTCCTTATACCAGCATACTCATGTGTCCTGCCGAAGGA
GACCTCTGTTGCAAGCCGTCTGACAAAGAACATAACATTGAATATCCCGATGGTAAGCGCTGCCATGGATACCGTTACTG
AATCACGACTTGCTATTGCGCTTGCCCGTGCCGGAGGTATTGGCATCATCCATAAAAATCTGACCATTGAGGATCAGGCT
CGGGAAGTCGCAAGGGTAAAACGGTATGAAAGCGGTATTATCCGCAACCCCTTTACTCTTTTTGAAGATGCTACGATGCA
GGACGCGCTTGATCTTATGTATAAACACTCCATCTCGGGCATTCCCGTCGTTGAGCATCCAAAAGCTGAAGGTGATGCCT
GCATGAAGCTCAAGGGAATTGTTACCAACAGGGATCTTCGCATTAAACCGGCACTTGATGCGAAAATTTCGACGATCATG
ACCAGCAAAAACCTGATCACTGCCCGTGAGGATATCAGCCTGGAAAAAGCCGAACAGATTCTTCTGAAAAACAAGATTGA
AAAACTGCTGATTACCGATGATGAAGGCAATCTGCTCGGACTCATCACCTTCAAGGACATCCAGAAACGCAAGCAGTTTC
CCAATGCGAGCAAGGACAGTCAGGGACATCTGAGAGTCGGCGCTGCTGTCGGAATTCGTGATAACACCATGGAAAGAGTC
AAGGCGCTCGTTGATGCCGGGGTTGATATCGTTGCCGTCGATACGGCCCATGGTCACAGTCAGGCGGTAATAACGATGGT
TGAAACCATCAAAAAAGTCTATCCTGATCTGCAGGTTATTGCCGGTAACGTTGCTACGCCGGATGCGGTTAGAGATCTTG
TTGCGGCTGGCGCAGACTGCGTGAAAATCGGTATCGGACCGGGTAGCATCTGCACCACCAGAATTGTAGCCGGTGTCGGC
ATGCCCCAGTTTACCGCAATTCTGAACTGCGCAGAAGAGGCGGCAAAAACCGATACCCCGATTATTGCAGACGGCGGCAT
CAAGTACAGCGGCGATATAGCAAAAGCGCTTGCCGCCGGCGCCGATACGGTGATGATGGGAAGTATTTTCGCCGGTACTG
ACGAAAGTCCCGGTGAAACCATTCTTCTTGAAGGGAGAAAATTCAAAACCTATCGCGGTATGGGCTCTCTGGGGGCAATG
TCCGAACCGGAAGGCAGCAGCGATCGGTACTTTCAGGATGCTTCAAGCGAATCTAAAAAGTATGTTCCTGAGGGAATTGA
AGGCAGGATCCCATCCAAGGGCAATCTTGACGAAGTTGTCTACCAATTGATCGGCGGCCTGAAATCTGCGATGGGCTACT
GCGGGGTAAACAACATTGAAGAACTGAAAAAGAATACCCGTTTTGTGAGGATTACCTCTGCTGGTCTCAGAGAGAGCCAC
CCTCACGACGTCAAAATCACAAAGGAAGCGCCAAACTACTCAACATCGATGTAA

Upstream 100 bases:

>100_bases
TTTTACCGCTCAACTCCATGATTAACATTGCCATACTATGATCGGTTTTTGTAAATTGGCGAAACATATTTAAAGCAATC
ATTTTATTATCGGCTTCACC

Downstream 100 bases:

>100_bases
ACTCTTCCTGTTTTTCATACCTCCCATCATGCAAAAAGTCCCATAAGTCATTTGACCTATGGGACTTTTTAGCATTTCAT
CCTCTTACAAAGCCTACGCC

Product: inosine-5'-monophosphate dehydrogenase

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH [H]

Number of amino acids: Translated: 497; Mature: 497

Protein sequence:

>497_residues
MNKILYEALTFDDVLLIPAYSCVLPKETSVASRLTKNITLNIPMVSAAMDTVTESRLAIALARAGGIGIIHKNLTIEDQA
REVARVKRYESGIIRNPFTLFEDATMQDALDLMYKHSISGIPVVEHPKAEGDACMKLKGIVTNRDLRIKPALDAKISTIM
TSKNLITAREDISLEKAEQILLKNKIEKLLITDDEGNLLGLITFKDIQKRKQFPNASKDSQGHLRVGAAVGIRDNTMERV
KALVDAGVDIVAVDTAHGHSQAVITMVETIKKVYPDLQVIAGNVATPDAVRDLVAAGADCVKIGIGPGSICTTRIVAGVG
MPQFTAILNCAEEAAKTDTPIIADGGIKYSGDIAKALAAGADTVMMGSIFAGTDESPGETILLEGRKFKTYRGMGSLGAM
SEPEGSSDRYFQDASSESKKYVPEGIEGRIPSKGNLDEVVYQLIGGLKSAMGYCGVNNIEELKKNTRFVRITSAGLRESH
PHDVKITKEAPNYSTSM

Sequences:

>Translated_497_residues
MNKILYEALTFDDVLLIPAYSCVLPKETSVASRLTKNITLNIPMVSAAMDTVTESRLAIALARAGGIGIIHKNLTIEDQA
REVARVKRYESGIIRNPFTLFEDATMQDALDLMYKHSISGIPVVEHPKAEGDACMKLKGIVTNRDLRIKPALDAKISTIM
TSKNLITAREDISLEKAEQILLKNKIEKLLITDDEGNLLGLITFKDIQKRKQFPNASKDSQGHLRVGAAVGIRDNTMERV
KALVDAGVDIVAVDTAHGHSQAVITMVETIKKVYPDLQVIAGNVATPDAVRDLVAAGADCVKIGIGPGSICTTRIVAGVG
MPQFTAILNCAEEAAKTDTPIIADGGIKYSGDIAKALAAGADTVMMGSIFAGTDESPGETILLEGRKFKTYRGMGSLGAM
SEPEGSSDRYFQDASSESKKYVPEGIEGRIPSKGNLDEVVYQLIGGLKSAMGYCGVNNIEELKKNTRFVRITSAGLRESH
PHDVKITKEAPNYSTSM
>Mature_497_residues
MNKILYEALTFDDVLLIPAYSCVLPKETSVASRLTKNITLNIPMVSAAMDTVTESRLAIALARAGGIGIIHKNLTIEDQA
REVARVKRYESGIIRNPFTLFEDATMQDALDLMYKHSISGIPVVEHPKAEGDACMKLKGIVTNRDLRIKPALDAKISTIM
TSKNLITAREDISLEKAEQILLKNKIEKLLITDDEGNLLGLITFKDIQKRKQFPNASKDSQGHLRVGAAVGIRDNTMERV
KALVDAGVDIVAVDTAHGHSQAVITMVETIKKVYPDLQVIAGNVATPDAVRDLVAAGADCVKIGIGPGSICTTRIVAGVG
MPQFTAILNCAEEAAKTDTPIIADGGIKYSGDIAKALAAGADTVMMGSIFAGTDESPGETILLEGRKFKTYRGMGSLGAM
SEPEGSSDRYFQDASSESKKYVPEGIEGRIPSKGNLDEVVYQLIGGLKSAMGYCGVNNIEELKKNTRFVRITSAGLRESH
PHDVKITKEAPNYSTSM

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI217035146, Length=460, Percent_Identity=42.1739130434783, Blast_Score=346, Evalue=3e-95,
Organism=Homo sapiens, GI34328930, Length=460, Percent_Identity=42.1739130434783, Blast_Score=345, Evalue=4e-95,
Organism=Homo sapiens, GI34328928, Length=460, Percent_Identity=42.1739130434783, Blast_Score=345, Evalue=4e-95,
Organism=Homo sapiens, GI156616279, Length=460, Percent_Identity=42.1739130434783, Blast_Score=345, Evalue=5e-95,
Organism=Homo sapiens, GI217035152, Length=454, Percent_Identity=42.2907488986784, Blast_Score=340, Evalue=3e-93,
Organism=Homo sapiens, GI66933016, Length=486, Percent_Identity=39.0946502057613, Blast_Score=337, Evalue=2e-92,
Organism=Homo sapiens, GI217035148, Length=460, Percent_Identity=41.5217391304348, Blast_Score=334, Evalue=1e-91,
Organism=Homo sapiens, GI217035150, Length=460, Percent_Identity=38.9130434782609, Blast_Score=305, Evalue=5e-83,
Organism=Homo sapiens, GI50541954, Length=266, Percent_Identity=36.0902255639098, Blast_Score=183, Evalue=4e-46,
Organism=Homo sapiens, GI50541952, Length=266, Percent_Identity=36.0902255639098, Blast_Score=183, Evalue=4e-46,
Organism=Homo sapiens, GI50541948, Length=266, Percent_Identity=36.0902255639098, Blast_Score=183, Evalue=4e-46,
Organism=Homo sapiens, GI50541956, Length=266, Percent_Identity=36.0902255639098, Blast_Score=183, Evalue=4e-46,
Organism=Homo sapiens, GI156104880, Length=249, Percent_Identity=36.144578313253, Blast_Score=179, Evalue=5e-45,
Organism=Escherichia coli, GI1788855, Length=494, Percent_Identity=54.251012145749, Blast_Score=489, Evalue=1e-139,
Organism=Escherichia coli, GI1786293, Length=259, Percent_Identity=36.2934362934363, Blast_Score=176, Evalue=3e-45,
Organism=Caenorhabditis elegans, GI71994385, Length=477, Percent_Identity=37.3165618448637, Blast_Score=287, Evalue=7e-78,
Organism=Caenorhabditis elegans, GI71994389, Length=424, Percent_Identity=39.3867924528302, Blast_Score=273, Evalue=2e-73,
Organism=Caenorhabditis elegans, GI17560440, Length=345, Percent_Identity=33.0434782608696, Blast_Score=191, Evalue=7e-49,
Organism=Saccharomyces cerevisiae, GI6322012, Length=494, Percent_Identity=39.0688259109312, Blast_Score=341, Evalue=1e-94,
Organism=Saccharomyces cerevisiae, GI6323464, Length=487, Percent_Identity=41.4784394250513, Blast_Score=340, Evalue=3e-94,
Organism=Saccharomyces cerevisiae, GI6323585, Length=487, Percent_Identity=39.4250513347023, Blast_Score=337, Evalue=3e-93,
Organism=Saccharomyces cerevisiae, GI6319352, Length=342, Percent_Identity=40.9356725146199, Blast_Score=261, Evalue=1e-70,
Organism=Saccharomyces cerevisiae, GI6319353, Length=119, Percent_Identity=38.655462184874, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24641071, Length=485, Percent_Identity=40.8247422680412, Blast_Score=342, Evalue=4e-94,
Organism=Drosophila melanogaster, GI24641073, Length=485, Percent_Identity=40.8247422680412, Blast_Score=342, Evalue=4e-94,
Organism=Drosophila melanogaster, GI28571163, Length=443, Percent_Identity=40.8577878103837, Blast_Score=306, Evalue=2e-83,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 53510; Mature: 53510

Theoretical pI: Translated: 6.72; Mature: 6.72

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKILYEALTFDDVLLIPAYSCVLPKETSVASRLTKNITLNIPMVSAAMDTVTESRLAIA
CCCHHHHHHCCCCEEEECCHHEECCCCHHHHHHHHCCEEEECCHHHHHHHHHHHHHHEEE
LARAGGIGIIHKNLTIEDQAREVARVKRYESGIIRNPFTLFEDATMQDALDLMYKHSISG
EECCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCHHHHCCCHHHHHHHHHHHHCCCC
IPVVEHPKAEGDACMKLKGIVTNRDLRIKPALDAKISTIMTSKNLITAREDISLEKAEQI
CCEECCCCCCCCCEEEEEEEEECCCEEEECCCCCHHHHHEECCCCEEEHHCCCHHHHHHH
LLKNKIEKLLITDDEGNLLGLITFKDIQKRKQFPNASKDSQGHLRVGAAVGIRDNTMERV
HHHHHCCEEEEECCCCCEEEEEEHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCCHHHHH
KALVDAGVDIVAVDTAHGHSQAVITMVETIKKVYPDLQVIAGNVATPDAVRDLVAAGADC
HHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHCCCCE
VKIGIGPGSICTTRIVAGVGMPQFTAILNCAEEAAKTDTPIIADGGIKYSGDIAKALAAG
EEEECCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCEEECCCEEECCHHHHHHHCC
ADTVMMGSIFAGTDESPGETILLEGRKFKTYRGMGSLGAMSEPEGSSDRYFQDASSESKK
CCCEEECEEEECCCCCCCCEEEEECCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCC
YVPEGIEGRIPSKGNLDEVVYQLIGGLKSAMGYCGVNNIEELKKNTRFVRITSAGLRESH
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCEEEEECCCCCCCC
PHDVKITKEAPNYSTSM
CCCEEEEECCCCCCCCC
>Mature Secondary Structure
MNKILYEALTFDDVLLIPAYSCVLPKETSVASRLTKNITLNIPMVSAAMDTVTESRLAIA
CCCHHHHHHCCCCEEEECCHHEECCCCHHHHHHHHCCEEEECCHHHHHHHHHHHHHHEEE
LARAGGIGIIHKNLTIEDQAREVARVKRYESGIIRNPFTLFEDATMQDALDLMYKHSISG
EECCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCHHHHCCCHHHHHHHHHHHHCCCC
IPVVEHPKAEGDACMKLKGIVTNRDLRIKPALDAKISTIMTSKNLITAREDISLEKAEQI
CCEECCCCCCCCCEEEEEEEEECCCEEEECCCCCHHHHHEECCCCEEEHHCCCHHHHHHH
LLKNKIEKLLITDDEGNLLGLITFKDIQKRKQFPNASKDSQGHLRVGAAVGIRDNTMERV
HHHHHCCEEEEECCCCCEEEEEEHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCCHHHHH
KALVDAGVDIVAVDTAHGHSQAVITMVETIKKVYPDLQVIAGNVATPDAVRDLVAAGADC
HHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHCCCCE
VKIGIGPGSICTTRIVAGVGMPQFTAILNCAEEAAKTDTPIIADGGIKYSGDIAKALAAG
EEEECCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCEEECCCEEECCHHHHHHHCC
ADTVMMGSIFAGTDESPGETILLEGRKFKTYRGMGSLGAMSEPEGSSDRYFQDASSESKK
CCCEEECEEEECCCCCCCCEEEEECCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCC
YVPEGIEGRIPSKGNLDEVVYQLIGGLKSAMGYCGVNNIEELKKNTRFVRITSAGLRESH
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCEEEEECCCCCCCC
PHDVKITKEAPNYSTSM
CCCEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA