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The map label for this gene is hslU [H]

Identifier: 119357347

GI number: 119357347

Start: 1754357

End: 1755844

Strand: Reverse

Name: hslU [H]

Synonym: Cpha266_1545

Alternate gene names: 119357347

Gene position: 1755844-1754357 (Counterclockwise)

Preceding gene: 119357348

Following gene: 119357346

Centisome position: 56.03

GC content: 47.04

Gene sequence:

>1488_bases
ATGCTCATGACAATTCATAATAACGAAAATATTGCCGAGGGTCTCGTGGTCGCCGCTGAAACAAAAAGTTCGATTTCCGC
AAGCCATCTTACTCCAAACCAGATTGTCGCTTTGCTTGATAAATATATTATTGGTCAGAGTGAGGCCAAGAAATCAGTTG
CCATAGCTTTGCGCAACAGACTGCGCAGGCAAAATGTGGGCGATGAGCTTCGGGATGAGATCATGCCGAACAATATTATC
ATGATCGGGCCTACCGGTGTAGGAAAGACCGAAATTGCCCGCAGGCTTGCAAAAATGGCAAAAGCTCCCTTTGTAAAGGT
TGAGGCATCCAAGTTTACCGAGGTTGGCTATGTCGGCAGGGATGTAGAGTCGATGATTCGTGACCTTGTCGATCAGTCGG
TCGCCATGGTGAGAACCGAAAAGTCCGAAGAGGTTCGCGAAAAAGCAGCTGTACTGGTTGAAGAGCGATTGCTCGATATT
TTACTTCCTCCGGTTTCTCATTCACATGAAGAGCAGGAAGACCGGGATGCAGAGAACGAAGAGATGCAGGTATTCGATGC
TTCGCAAGAGGTGGATAAGGCAAAGGAAAATAACAGGAAAAGTCGTAAAAAGATGCTTGAACGGCTTCGGCAGGGCAAGC
TCGAGGATCGTCAGATCGAGATGGAAATTACTGGTGATGCTCCGGGGGGAATGATGCAGATTTTCGGGCCTATGGGGCAG
ATGGAGGAGATTGGCGGTATCATGCAGGACCTGATGAGCGGCTTGCCGAGAAAACGTAAAAAACGACGGGTATCAATAGC
CGAAGCAAGGAAAATTCTTGAGCAGGAAGAGGTGCAGAAGCTTATTGACATGGATGCAGTCATTAAAGAGGCGATCAACA
AGGTTGAGCAGTCAGGCATTGTGTTTATTGATGAAATCGATAAAATTGCAGCTCCGTCCTCAGGATCGGGGGGCAAGGGT
CCTGACGTTAGCAGGGAAGGGGTACAGCGTGATCTTCTGCCTATTGTTGAAGGGTCGAATGTTGCGACGAAATATGGTAT
GGTGAAAACTGATCATGTGCTCTTTATCGCATCGGGAGCGTTTCATGTGGCAAAACCATCCGATCTTATTCCTGAGCTTC
AAGGTCGATTTCCTATCAGGGTCGAATTGAAAAGCCTGACTGAAGAGGATTTTTACAAGATACTGACACAACCTAAAAAC
GCCTTGATCAAACAGTATAAGGCTCTGCTGAAAACAGAGGGAGTGGAACTCTCTTTTACCGACGGCGCAATTCTTGAGAT
TGCAAAAACGGCCGCCAAGGTTAATGAAAGCGTTGAAAATATCGGGGCCCGAAGGCTGCACACCATTATGACCAATTTGC
TTGAGGAACTCATGTTCAATATTCCGGAGAATGTTACCGATGAGGAAATCGAGATTGATGAGACCATGGTGAAAGAGAAA
TTAAACCATGTTGCCGCCGACAGGGACCTGAGCCAGTACATTCTGTGA

Upstream 100 bases:

>100_bases
TATCTGTATTTATACTAACGACCATATTGTGATCGAAGAGGTCTGATCGCGTTTTTTTTGCCGCGGACGCTCCTGGAGAG
ATTTATTGTAACCATAATTT

Downstream 100 bases:

>100_bases
GGTCATTTTTTCCGTTAATAGAGCAGGATGAAAAGAAAGCATCCAGCCAAAGATCATAATCGCATGACGAAACACTCTTT
TCTTGTACTGAACGGGCCTA

Product: ATP-dependent protease ATP-binding subunit HslU

Products: NA

Alternate protein names: Unfoldase HslU [H]

Number of amino acids: Translated: 495; Mature: 495

Protein sequence:

>495_residues
MLMTIHNNENIAEGLVVAAETKSSISASHLTPNQIVALLDKYIIGQSEAKKSVAIALRNRLRRQNVGDELRDEIMPNNII
MIGPTGVGKTEIARRLAKMAKAPFVKVEASKFTEVGYVGRDVESMIRDLVDQSVAMVRTEKSEEVREKAAVLVEERLLDI
LLPPVSHSHEEQEDRDAENEEMQVFDASQEVDKAKENNRKSRKKMLERLRQGKLEDRQIEMEITGDAPGGMMQIFGPMGQ
MEEIGGIMQDLMSGLPRKRKKRRVSIAEARKILEQEEVQKLIDMDAVIKEAINKVEQSGIVFIDEIDKIAAPSSGSGGKG
PDVSREGVQRDLLPIVEGSNVATKYGMVKTDHVLFIASGAFHVAKPSDLIPELQGRFPIRVELKSLTEEDFYKILTQPKN
ALIKQYKALLKTEGVELSFTDGAILEIAKTAAKVNESVENIGARRLHTIMTNLLEELMFNIPENVTDEEIEIDETMVKEK
LNHVAADRDLSQYIL

Sequences:

>Translated_495_residues
MLMTIHNNENIAEGLVVAAETKSSISASHLTPNQIVALLDKYIIGQSEAKKSVAIALRNRLRRQNVGDELRDEIMPNNII
MIGPTGVGKTEIARRLAKMAKAPFVKVEASKFTEVGYVGRDVESMIRDLVDQSVAMVRTEKSEEVREKAAVLVEERLLDI
LLPPVSHSHEEQEDRDAENEEMQVFDASQEVDKAKENNRKSRKKMLERLRQGKLEDRQIEMEITGDAPGGMMQIFGPMGQ
MEEIGGIMQDLMSGLPRKRKKRRVSIAEARKILEQEEVQKLIDMDAVIKEAINKVEQSGIVFIDEIDKIAAPSSGSGGKG
PDVSREGVQRDLLPIVEGSNVATKYGMVKTDHVLFIASGAFHVAKPSDLIPELQGRFPIRVELKSLTEEDFYKILTQPKN
ALIKQYKALLKTEGVELSFTDGAILEIAKTAAKVNESVENIGARRLHTIMTNLLEELMFNIPENVTDEEIEIDETMVKEK
LNHVAADRDLSQYIL
>Mature_495_residues
MLMTIHNNENIAEGLVVAAETKSSISASHLTPNQIVALLDKYIIGQSEAKKSVAIALRNRLRRQNVGDELRDEIMPNNII
MIGPTGVGKTEIARRLAKMAKAPFVKVEASKFTEVGYVGRDVESMIRDLVDQSVAMVRTEKSEEVREKAAVLVEERLLDI
LLPPVSHSHEEQEDRDAENEEMQVFDASQEVDKAKENNRKSRKKMLERLRQGKLEDRQIEMEITGDAPGGMMQIFGPMGQ
MEEIGGIMQDLMSGLPRKRKKRRVSIAEARKILEQEEVQKLIDMDAVIKEAINKVEQSGIVFIDEIDKIAAPSSGSGGKG
PDVSREGVQRDLLPIVEGSNVATKYGMVKTDHVLFIASGAFHVAKPSDLIPELQGRFPIRVELKSLTEEDFYKILTQPKN
ALIKQYKALLKTEGVELSFTDGAILEIAKTAAKVNESVENIGARRLHTIMTNLLEELMFNIPENVTDEEIEIDETMVKEK
LNHVAADRDLSQYIL

Specific function: ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N

COG id: COG1220

COG function: function code O; ATP-dependent protease HslVU (ClpYQ), ATPase subunit

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ClpX chaperone family. HslU subfamily [H]

Homologues:

Organism=Homo sapiens, GI7242140, Length=112, Percent_Identity=41.0714285714286, Blast_Score=77, Evalue=3e-14,
Organism=Escherichia coli, GI1790366, Length=469, Percent_Identity=53.3049040511727, Blast_Score=472, Evalue=1e-134,
Organism=Escherichia coli, GI1786642, Length=253, Percent_Identity=33.201581027668, Blast_Score=105, Evalue=6e-24,
Organism=Saccharomyces cerevisiae, GI6319704, Length=143, Percent_Identity=36.3636363636364, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24648291, Length=254, Percent_Identity=31.496062992126, Blast_Score=96, Evalue=5e-20,
Organism=Drosophila melanogaster, GI24648289, Length=254, Percent_Identity=31.496062992126, Blast_Score=96, Evalue=6e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR019489
- InterPro:   IPR004491 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF10431 ClpB_D2-small [H]

EC number: NA

Molecular weight: Translated: 55316; Mature: 55316

Theoretical pI: Translated: 5.07; Mature: 5.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLMTIHNNENIAEGLVVAAETKSSISASHLTPNQIVALLDKYIIGQSEAKKSVAIALRNR
CEEEEECCCCHHHCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
LRRQNVGDELRDEIMPNNIIMIGPTGVGKTEIARRLAKMAKAPFVKVEASKFTEVGYVGR
HHHCCCCHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHCCCEEEEHHHHHHHCCCCC
DVESMIRDLVDQSVAMVRTEKSEEVREKAAVLVEERLLDILLPPVSHSHEEQEDRDAENE
CHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHCCCCCC
EMQVFDASQEVDKAKENNRKSRKKMLERLRQGKLEDRQIEMEITGDAPGGMMQIFGPMGQ
HHHHCCCHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCHHHHHCCCCH
MEEIGGIMQDLMSGLPRKRKKRRVSIAEARKILEQEEVQKLIDMDAVIKEAINKVEQSGI
HHHHHHHHHHHHHCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
VFIDEIDKIAAPSSGSGGKGPDVSREGVQRDLLPIVEGSNVATKYGMVKTDHVLFIASGA
EEEECHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHCCCEEECCEEEEECCC
FHVAKPSDLIPELQGRFPIRVELKSLTEEDFYKILTQPKNALIKQYKALLKTEGVELSFT
EECCCCHHHHHHHCCCCCEEEEHHHCCHHHHHHHHHCCHHHHHHHHHHHHHHCCCEEEEC
DGAILEIAKTAAKVNESVENIGARRLHTIMTNLLEELMFNIPENVTDEEIEIDETMVKEK
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHH
LNHVAADRDLSQYIL
HHHHHHCCCHHHHCC
>Mature Secondary Structure
MLMTIHNNENIAEGLVVAAETKSSISASHLTPNQIVALLDKYIIGQSEAKKSVAIALRNR
CEEEEECCCCHHHCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
LRRQNVGDELRDEIMPNNIIMIGPTGVGKTEIARRLAKMAKAPFVKVEASKFTEVGYVGR
HHHCCCCHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHCCCEEEEHHHHHHHCCCCC
DVESMIRDLVDQSVAMVRTEKSEEVREKAAVLVEERLLDILLPPVSHSHEEQEDRDAENE
CHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHCCCCCC
EMQVFDASQEVDKAKENNRKSRKKMLERLRQGKLEDRQIEMEITGDAPGGMMQIFGPMGQ
HHHHCCCHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCHHHHHCCCCH
MEEIGGIMQDLMSGLPRKRKKRRVSIAEARKILEQEEVQKLIDMDAVIKEAINKVEQSGI
HHHHHHHHHHHHHCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
VFIDEIDKIAAPSSGSGGKGPDVSREGVQRDLLPIVEGSNVATKYGMVKTDHVLFIASGA
EEEECHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHCCCEEECCEEEEECCC
FHVAKPSDLIPELQGRFPIRVELKSLTEEDFYKILTQPKNALIKQYKALLKTEGVELSFT
EECCCCHHHHHHHCCCCCEEEEHHHCCHHHHHHHHHCCHHHHHHHHHHHHHHCCCEEEEC
DGAILEIAKTAAKVNESVENIGARRLHTIMTNLLEELMFNIPENVTDEEIEIDETMVKEK
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHH
LNHVAADRDLSQYIL
HHHHHHCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12093901 [H]