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The map label for this gene is adk

Identifier: 119357343

GI number: 119357343

Start: 1750051

End: 1750707

Strand: Direct

Name: adk

Synonym: Cpha266_1541

Alternate gene names: 119357343

Gene position: 1750051-1750707 (Clockwise)

Preceding gene: 119357342

Following gene: 119357344

Centisome position: 55.84

GC content: 46.73

Gene sequence:

>657_bases
ATGAGAATTATTCTACTGGGAGCTCCGGGAGCCGGAAAAGGGACACAAGCTTCATATATCTGCAAAACGTTGAATATCCC
CCAGATTTCAACGGGCGATATGCTTCGGGCAGCAGTGCAAGCACAAACGCCTGTAGGTATAGAGGCAAAAAAAGTAATGG
ATGCAGGCAAACTCGTTTCTGACGAGATTATTCTCGCACTTGTAAAAGAACGGCTTGCAAGCCAGGATTGTATAAACGGA
TGCCTCTTTGATGGCTTTCCCCGAACGATCGCCCAGGCGGAATCACTGAAAAATGACTCGATTTTGCTTGACTATGTTAT
GGAAATACATGTTGACGACAAGGAAATCATTGAAAGAATGAGCGGACGTCGGGTACACCTTTCATCGGGAAGGACCTACC
ATGTCCGTTTCAATCCACCAAAAAAAGAGGGGCTCGATGATCTGACCGGAGAACCTCTTGTCCAAAGAGAAGATGATCAG
GAAGAAACCGTAAAAAAACGATTGCAAATTTACCATGACCAGACAGCACCGCTTCTTCAGTACTACCATGACTGGTCTCT
TACCGGTTCGCCCGATGCTCCGCGTTACAGCAGCATCAAGGGAACGGGAAGTGTTGAAGAGATCCGCCAGAGAATACTTG
ATGCACTCAATTCCTGA

Upstream 100 bases:

>100_bases
CCTGTTTCAGTCACGGTTCCCGTTCCCGAAGAAATTCGACTTTCCAAACCAAAAGTCACCATTATCACTACCAAAAAACC
CATTTAATTTATCAAGTTTA

Downstream 100 bases:

>100_bases
AACCGGAAAATCGGCAGAATATCAAAAAAAAGTCAGTGTTTGCCACTGGCTTTTTTTCTTTTAAACCTATGCAGGCTGAA
ATCGTTATCGACAAGCTTTA

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase

Number of amino acids: Translated: 218; Mature: 218

Protein sequence:

>218_residues
MRIILLGAPGAGKGTQASYICKTLNIPQISTGDMLRAAVQAQTPVGIEAKKVMDAGKLVSDEIILALVKERLASQDCING
CLFDGFPRTIAQAESLKNDSILLDYVMEIHVDDKEIIERMSGRRVHLSSGRTYHVRFNPPKKEGLDDLTGEPLVQREDDQ
EETVKKRLQIYHDQTAPLLQYYHDWSLTGSPDAPRYSSIKGTGSVEEIRQRILDALNS

Sequences:

>Translated_218_residues
MRIILLGAPGAGKGTQASYICKTLNIPQISTGDMLRAAVQAQTPVGIEAKKVMDAGKLVSDEIILALVKERLASQDCING
CLFDGFPRTIAQAESLKNDSILLDYVMEIHVDDKEIIERMSGRRVHLSSGRTYHVRFNPPKKEGLDDLTGEPLVQREDDQ
EETVKKRLQIYHDQTAPLLQYYHDWSLTGSPDAPRYSSIKGTGSVEEIRQRILDALNS
>Mature_218_residues
MRIILLGAPGAGKGTQASYICKTLNIPQISTGDMLRAAVQAQTPVGIEAKKVMDAGKLVSDEIILALVKERLASQDCING
CLFDGFPRTIAQAESLKNDSILLDYVMEIHVDDKEIIERMSGRRVHLSSGRTYHVRFNPPKKEGLDDLTGEPLVQREDDQ
EETVKKRLQIYHDQTAPLLQYYHDWSLTGSPDAPRYSSIKGTGSVEEIRQRILDALNS

Specific function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family

Homologues:

Organism=Homo sapiens, GI7524346, Length=199, Percent_Identity=47.7386934673367, Blast_Score=192, Evalue=1e-49,
Organism=Homo sapiens, GI4502013, Length=199, Percent_Identity=47.7386934673367, Blast_Score=192, Evalue=2e-49,
Organism=Homo sapiens, GI19923437, Length=187, Percent_Identity=44.9197860962567, Blast_Score=168, Evalue=4e-42,
Organism=Homo sapiens, GI310110345, Length=183, Percent_Identity=40.4371584699454, Blast_Score=140, Evalue=9e-34,
Organism=Homo sapiens, GI53832003, Length=183, Percent_Identity=40.4371584699454, Blast_Score=140, Evalue=9e-34,
Organism=Homo sapiens, GI8051579, Length=183, Percent_Identity=40.4371584699454, Blast_Score=140, Evalue=9e-34,
Organism=Homo sapiens, GI53832001, Length=183, Percent_Identity=40.4371584699454, Blast_Score=140, Evalue=9e-34,
Organism=Homo sapiens, GI22749187, Length=182, Percent_Identity=29.1208791208791, Blast_Score=89, Evalue=4e-18,
Organism=Homo sapiens, GI4502011, Length=219, Percent_Identity=26.4840182648402, Blast_Score=85, Evalue=5e-17,
Organism=Homo sapiens, GI28144897, Length=195, Percent_Identity=25.6410256410256, Blast_Score=71, Evalue=7e-13,
Organism=Homo sapiens, GI28144899, Length=195, Percent_Identity=25.6410256410256, Blast_Score=71, Evalue=8e-13,
Organism=Homo sapiens, GI237858799, Length=139, Percent_Identity=27.3381294964029, Blast_Score=68, Evalue=8e-12,
Organism=Homo sapiens, GI21450759, Length=139, Percent_Identity=27.3381294964029, Blast_Score=67, Evalue=9e-12,
Organism=Escherichia coli, GI1786680, Length=209, Percent_Identity=59.8086124401914, Blast_Score=259, Evalue=1e-70,
Organism=Caenorhabditis elegans, GI17552384, Length=201, Percent_Identity=45.771144278607, Blast_Score=182, Evalue=9e-47,
Organism=Caenorhabditis elegans, GI17537943, Length=185, Percent_Identity=35.1351351351351, Blast_Score=117, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI17567503, Length=217, Percent_Identity=28.110599078341, Blast_Score=92, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17533833, Length=190, Percent_Identity=27.3684210526316, Blast_Score=70, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6320432, Length=198, Percent_Identity=45.959595959596, Blast_Score=187, Evalue=1e-48,
Organism=Saccharomyces cerevisiae, GI6321018, Length=194, Percent_Identity=43.8144329896907, Blast_Score=152, Evalue=3e-38,
Organism=Saccharomyces cerevisiae, GI6322828, Length=217, Percent_Identity=27.1889400921659, Blast_Score=80, Evalue=2e-16,
Organism=Drosophila melanogaster, GI22026816, Length=201, Percent_Identity=49.2537313432836, Blast_Score=197, Evalue=5e-51,
Organism=Drosophila melanogaster, GI17737899, Length=190, Percent_Identity=40.5263157894737, Blast_Score=145, Evalue=2e-35,
Organism=Drosophila melanogaster, GI24645822, Length=190, Percent_Identity=40.5263157894737, Blast_Score=145, Evalue=2e-35,
Organism=Drosophila melanogaster, GI24663208, Length=187, Percent_Identity=26.2032085561497, Blast_Score=76, Evalue=1e-14,
Organism=Drosophila melanogaster, GI17647141, Length=187, Percent_Identity=26.2032085561497, Blast_Score=76, Evalue=1e-14,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): KAD_CHLPD (A1BGN6)

Other databases:

- EMBL:   CP000492
- RefSeq:   YP_911987.1
- ProteinModelPortal:   A1BGN6
- SMR:   A1BGN6
- STRING:   A1BGN6
- GeneID:   4569126
- GenomeReviews:   CP000492_GR
- KEGG:   cph:Cpha266_1541
- NMPDR:   fig|290317.7.peg.1623
- eggNOG:   COG0563
- HOGENOM:   HBG630208
- OMA:   RTYHVKY
- ProtClustDB:   PRK00279
- GO:   GO:0005737
- HAMAP:   MF_00235
- InterPro:   IPR006259
- InterPro:   IPR000850
- InterPro:   IPR007862
- PANTHER:   PTHR23359
- PRINTS:   PR00094
- TIGRFAMs:   TIGR01351

Pfam domain/function: PF00406 ADK; PF05191 ADK_lid

EC number: =2.7.4.3

Molecular weight: Translated: 24249; Mature: 24249

Theoretical pI: Translated: 6.03; Mature: 6.03

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIILLGAPGAGKGTQASYICKTLNIPQISTGDMLRAAVQAQTPVGIEAKKVMDAGKLVS
CEEEEEECCCCCCCCCHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
DEIILALVKERLASQDCINGCLFDGFPRTIAQAESLKNDSILLDYVMEIHVDDKEIIERM
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCEEEHHHHCCCHHHHHHHH
SGRRVHLSSGRTYHVRFNPPKKEGLDDLTGEPLVQREDDQEETVKKRLQIYHDQTAPLLQ
CCCEEEECCCCEEEEEECCCHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHH
YYHDWSLTGSPDAPRYSSIKGTGSVEEIRQRILDALNS
HHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MRIILLGAPGAGKGTQASYICKTLNIPQISTGDMLRAAVQAQTPVGIEAKKVMDAGKLVS
CEEEEEECCCCCCCCCHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
DEIILALVKERLASQDCINGCLFDGFPRTIAQAESLKNDSILLDYVMEIHVDDKEIIERM
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCEEEHHHHCCCHHHHHHHH
SGRRVHLSSGRTYHVRFNPPKKEGLDDLTGEPLVQREDDQEETVKKRLQIYHDQTAPLLQ
CCCEEEECCCCEEEEEECCCHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHH
YYHDWSLTGSPDAPRYSSIKGTGSVEEIRQRILDALNS
HHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA