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The map label for this gene is pth

Identifier: 119357218

GI number: 119357218

Start: 1605868

End: 1606440

Strand: Direct

Name: pth

Synonym: Cpha266_1409

Alternate gene names: 119357218

Gene position: 1605868-1606440 (Clockwise)

Preceding gene: 119357216

Following gene: 119357222

Centisome position: 51.24

GC content: 47.29

Gene sequence:

>573_bases
ATGAAACTTGTTGTCGGTCTTGGAAATCCGGAACCCCGGTATGCAGGAACAAGGCACAATGTCGGTTTCGATGTTCTCGA
CACCCTTGCCGCAACGTTCCAGACAAGGTTCGGCAAAGGAAAAGGAAACTACCTCTCGACAAAAATCTCCCACAGAAACC
GGTCGGTTATCCTTTTAAAACCGATGACCTATATGAACCTTTCGGGTCATGCCGTTGTTGCCGCAATGAATTTTTACAAG
GTATCCGAAAGTGGCCTTTTGATCGTATGCGATGATCTGAATCTCCCCGCAGGATCGATCAGGCTGCGTGCAAAGGGCTC
CGCAGGCGGCCAGAACGGATTGAAGCACATTATAGAGTGCCTCGGATCTGAAGGATTTGCCAGACTCAGGGTGGGAATTC
GTCCTCTTGACCGTCCGTTGCACTCATTTTCATCATTTGTGCTCGGAAAATTCACTGAAGAAGAACGAATAGTGATGGAA
AAAGTAATTCCCGTATGCAGAGAAGCAGCGCTTGATGTCGTCGTTAACGGGATTGAACATGCCATGAACAATTACAACAA
ACCGATCATTTAA

Upstream 100 bases:

>100_bases
TTGTTTTCAGTAGCGGAAGCGGAAACGCCCGTTACCGATTATCCCTTTCCCCTGCTATATTCCAAACTGGAATAACCCAT
TTATAAAAAAACGCTTGCCA

Downstream 100 bases:

>100_bases
ACAACGGCATAAGCGGCATACTCTTCCATCTCGAAAGTTCTCTGCTGCACAGACGACATTTTCTTGAGAAATGCAATGGC
ACGCTCGTTGAACTCCTTTG

Product: peptidyl-tRNA hydrolase

Products: NA

Alternate protein names: PTH

Number of amino acids: Translated: 190; Mature: 190

Protein sequence:

>190_residues
MKLVVGLGNPEPRYAGTRHNVGFDVLDTLAATFQTRFGKGKGNYLSTKISHRNRSVILLKPMTYMNLSGHAVVAAMNFYK
VSESGLLIVCDDLNLPAGSIRLRAKGSAGGQNGLKHIIECLGSEGFARLRVGIRPLDRPLHSFSSFVLGKFTEEERIVME
KVIPVCREAALDVVVNGIEHAMNNYNKPII

Sequences:

>Translated_190_residues
MKLVVGLGNPEPRYAGTRHNVGFDVLDTLAATFQTRFGKGKGNYLSTKISHRNRSVILLKPMTYMNLSGHAVVAAMNFYK
VSESGLLIVCDDLNLPAGSIRLRAKGSAGGQNGLKHIIECLGSEGFARLRVGIRPLDRPLHSFSSFVLGKFTEEERIVME
KVIPVCREAALDVVVNGIEHAMNNYNKPII
>Mature_190_residues
MKLVVGLGNPEPRYAGTRHNVGFDVLDTLAATFQTRFGKGKGNYLSTKISHRNRSVILLKPMTYMNLSGHAVVAAMNFYK
VSESGLLIVCDDLNLPAGSIRLRAKGSAGGQNGLKHIIECLGSEGFARLRVGIRPLDRPLHSFSSFVLGKFTEEERIVME
KVIPVCREAALDVVVNGIEHAMNNYNKPII

Specific function: The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis

COG id: COG0193

COG function: function code J; Peptidyl-tRNA hydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PTH family

Homologues:

Organism=Homo sapiens, GI50897284, Length=181, Percent_Identity=32.0441988950276, Blast_Score=88, Evalue=5e-18,
Organism=Escherichia coli, GI1787455, Length=186, Percent_Identity=35.4838709677419, Blast_Score=92, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6321983, Length=171, Percent_Identity=33.9181286549708, Blast_Score=80, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PTH_CHLPD (A1BGB1)

Other databases:

- EMBL:   CP000492
- RefSeq:   YP_911862.1
- ProteinModelPortal:   A1BGB1
- SMR:   A1BGB1
- STRING:   A1BGB1
- GeneID:   4568494
- GenomeReviews:   CP000492_GR
- KEGG:   cph:Cpha266_1409
- NMPDR:   fig|290317.7.peg.1488
- eggNOG:   COG0193
- HOGENOM:   HBG610927
- OMA:   FSPKHNA
- ProtClustDB:   PRK05426
- GO:   GO:0005737
- GO:   GO:0006412
- HAMAP:   MF_00083
- InterPro:   IPR001328
- InterPro:   IPR018171
- Gene3D:   G3DSA:3.40.50.1470
- PANTHER:   PTHR17224
- TIGRFAMs:   TIGR00447

Pfam domain/function: PF01195 Pept_tRNA_hydro; SSF53178 Pept_tRNA_hydro

EC number: =3.1.1.29

Molecular weight: Translated: 20823; Mature: 20823

Theoretical pI: Translated: 10.06; Mature: 10.06

Prosite motif: PS01195 PEPT_TRNA_HYDROL_1; PS01196 PEPT_TRNA_HYDROL_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLVVGLGNPEPRYAGTRHNVGFDVLDTLAATFQTRFGKGKGNYLSTKISHRNRSVILLK
CEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCEEEEEC
PMTYMNLSGHAVVAAMNFYKVSESGLLIVCDDLNLPAGSIRLRAKGSAGGQNGLKHIIEC
CCCEECCCCCEEEEEEEEEEECCCCEEEEECCCCCCCCCEEEEECCCCCCHHHHHHHHHH
LGSEGFARLRVGIRPLDRPLHSFSSFVLGKFTEEERIVMEKVIPVCREAALDVVVNGIEH
HCCCCCEEEEECCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
AMNNYNKPII
HHHCCCCCCC
>Mature Secondary Structure
MKLVVGLGNPEPRYAGTRHNVGFDVLDTLAATFQTRFGKGKGNYLSTKISHRNRSVILLK
CEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCEEEEEC
PMTYMNLSGHAVVAAMNFYKVSESGLLIVCDDLNLPAGSIRLRAKGSAGGQNGLKHIIEC
CCCEECCCCCEEEEEEEEEEECCCCEEEEECCCCCCCCCEEEEECCCCCCHHHHHHHHHH
LGSEGFARLRVGIRPLDRPLHSFSSFVLGKFTEEERIVMEKVIPVCREAALDVVVNGIEH
HCCCCCEEEEECCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
AMNNYNKPII
HHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA