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The map label for this gene is ndoA [H]

Identifier: 119357189

GI number: 119357189

Start: 1574889

End: 1575233

Strand: Direct

Name: ndoA [H]

Synonym: Cpha266_1380

Alternate gene names: 119357189

Gene position: 1574889-1575233 (Clockwise)

Preceding gene: 119357188

Following gene: 119357190

Centisome position: 50.25

GC content: 50.14

Gene sequence:

>345_bases
ATGGCCGGAATACTGAGGGGTGATATCCGATGGGCCGACCTCAACTCGACGCGGGGAAATGAGCAATCCGGCCTCCGACC
TGTTCTGGTGGTAAGCCATGATGTGTTTAATGACCGATCAGGAACTGTTATTGCAATAGCATTGACAAGCCAGCCGCAAA
AAGCGGGTTTTCCGCTTACCATGCCGATTGAATCAGCCGCTCTTCCGAAAAAATCGTGGGTTAAAATCAGCCAGATCAGA
ACACTGTCAACAGAACGGATCGGAAGCAGAATCGGAAGGCTTTCAGCCGAAGAGCTGATTCGGGTTATCGAAGGCCTCAA
TGAGATTATCGGAAAAGGCTGTTGA

Upstream 100 bases:

>100_bases
AGCGCATCGAGCACAACAGACTGGCCGAAGAATGCGCAAAACTTGATGCTGTCGAAGAGCGCCAACTCGCGGAAGAAGGG
ATGAACAGAGAGATTGACGC

Downstream 100 bases:

>100_bases
AAGTATGATGTAGCTTCACTCCGGAATCTCCATTCCTTCCCGTCGGGACAGCACATTGCTTCGCAGGCTCAACATCAGCT
TTTCGGGCAACGGATCAACC

Product: transcriptional modulator of MazE/toxin, MazF

Products: NA

Alternate protein names: Endoribonuclease EndoA; Toxin EndoA [H]

Number of amino acids: Translated: 114; Mature: 113

Protein sequence:

>114_residues
MAGILRGDIRWADLNSTRGNEQSGLRPVLVVSHDVFNDRSGTVIAIALTSQPQKAGFPLTMPIESAALPKKSWVKISQIR
TLSTERIGSRIGRLSAEELIRVIEGLNEIIGKGC

Sequences:

>Translated_114_residues
MAGILRGDIRWADLNSTRGNEQSGLRPVLVVSHDVFNDRSGTVIAIALTSQPQKAGFPLTMPIESAALPKKSWVKISQIR
TLSTERIGSRIGRLSAEELIRVIEGLNEIIGKGC
>Mature_113_residues
AGILRGDIRWADLNSTRGNEQSGLRPVLVVSHDVFNDRSGTVIAIALTSQPQKAGFPLTMPIESAALPKKSWVKISQIRT
LSTERIGSRIGRLSAEELIRVIEGLNEIIGKGC

Specific function: Part of a toxin-antitoxin (TA) module. Has specificity for UAC sequences, yielding cleavage products with 3' phosphate and 5' hydroxyl groups. Overexpression is toxic for cell growth, probably by inhibiting protein synthesis through the cleavage of single

COG id: COG2337

COG function: function code T; Growth inhibitor

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PemK/MazF family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003477
- InterPro:   IPR011067 [H]

Pfam domain/function: PF02452 PemK [H]

EC number: NA

Molecular weight: Translated: 12380; Mature: 12248

Theoretical pI: Translated: 10.59; Mature: 10.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAGILRGDIRWADLNSTRGNEQSGLRPVLVVSHDVFNDRSGTVIAIALTSQPQKAGFPLT
CCCCCCCCEEEEECCCCCCCCCCCCCEEEEEECCCCCCCCCCEEEEEECCCCCCCCCCEE
MPIESAALPKKSWVKISQIRTLSTERIGSRIGRLSAEELIRVIEGLNEIIGKGC
CCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
AGILRGDIRWADLNSTRGNEQSGLRPVLVVSHDVFNDRSGTVIAIALTSQPQKAGFPLT
CCCCCCCEEEEECCCCCCCCCCCCCEEEEEECCCCCCCCCCEEEEEECCCCCCCCCCEE
MPIESAALPKKSWVKISQIRTLSTERIGSRIGRLSAEELIRVIEGLNEIIGKGC
CCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]