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The map label for this gene is pyrC [H]

Identifier: 119357147

GI number: 119357147

Start: 1531191

End: 1532531

Strand: Direct

Name: pyrC [H]

Synonym: Cpha266_1336

Alternate gene names: 119357147

Gene position: 1531191-1532531 (Clockwise)

Preceding gene: 119357146

Following gene: 119357148

Centisome position: 48.86

GC content: 49.89

Gene sequence:

>1341_bases
ATGAGCACCATTTTTCAAAACGCCCATATCATCAACCCACAAAGCAACCTTGATTATACCGGATCAATAAGGGTGTCCGT
TGATGGTTTCATTGAAGAGATTATTCAAGGCGAATGCGATAAAAGCCCCGACGACAGAATAATCGATCTTCAGGGAAAAC
TGCTGGTGCCGGGTCTTTTCGACATGCACTGCCATTTCCGTGAACCGGGGCAGGAGTATAAGGAAACCCTTGAAAGCGGC
TCGAAAGCTGCCGTAGCCGGCGGATTTACCGGGGTAGCCCTCATGCCTAACACAAAACCGGTGATCGACAGCCCGCTCGG
AGTAGCATACATACGTCACAACGCACAGCAGTTGCCGGTTGATCTTGAGGTTATCGGCGCAATGAGCGAAGGAAGCAAGG
GAGAACAGCTTGCACCATACGGAAAATTCCGTTCGTATGGGGTAAAAGCTGTTTCCGATGACGGAACGGCGATTCAGAAC
AGCCAGAATATGCGACTGGTGTTCCAGTACGCATCAAATTTCGATCTTCTTGTCATTCAGCATTGCGAAGACAAATCCAT
GACCGCCGAAGCCGTCATGAACGAAGGGGTATTTTCAACAAAACTTGGCCTTAAAGGAATACCTGATGTATCCGAAGCGG
TCATGCTGTGCCGTGATCTTCACCTGATCCGCTATATCGTGGAGCACGAATTGCACGATCCGGCCAACAAACCGAGATAC
CATGTGGCACACATCAGCACCAAAGCCTCCCTCGACCTTGTCCGGCAGGCTAAAGCCGAAGGCTTGCAGGTAACGTGCGA
GGTTACGCCTCACCATTTCACCCTTACCGACGAAGATCTTTTCAATGCGCCCTCAAAAGGCAATTTCATCATGAAGCCCC
CGCTCCCCTCAAAGAAGAACAGGGCAGCTATCCTTGAAGCAATTGCAGACGGAACGATTGATGCCATTGCTACCGATCAC
GCCCCTCATGCTCCACATGAAAAAGAGTGCCCTCCCGATCAGGCGTCATTCGGCATTATCGGTCTGGAAACCGCTGTAGG
ACTCACAATAACCGAACTGGTCGAACCGGGAATCATAACGCTTTCAAGAGCGATTGAGCTGATGTCAGTCAATCCCCGTA
AAATTCTTCAGCTTGATCCCCTGCTGTTCGCGCAGGGAGAAAGGGCTAATTTTACCATTATTGATCCAGAGGAGGAGTGG
GCGCTTACCGCGAATGCCGTTAAATCAAAGTCAACGAATACGCCCTTTCTTGGCCGTAAACTCAAGGGCAGGGCGATTGC
TGTTTACCACAAAGGGATGTTTCATGAAAGCGTAACTTCACAAGAGCATTTTAGCGTGTAA

Upstream 100 bases:

>100_bases
ACAGAGAGATTTTGTCTGATACCGATGCCGCAATGCTCGCCCTTAAAGCGTGCGTCATATAAAAAAGCATGCTTTAACTC
CATAACTATTCCATTTTATC

Downstream 100 bases:

>100_bases
AAGTTGTTAATCGATAGTTTATTTCTTACATTCTTTATCTTTTTCAAGGCACTGCGTATCGGAGAAAAATGTATATAATT
ACAGATTTTCCGGTTACGAC

Product: dihydroorotase

Products: NA

Alternate protein names: DHOase [H]

Number of amino acids: Translated: 446; Mature: 445

Protein sequence:

>446_residues
MSTIFQNAHIINPQSNLDYTGSIRVSVDGFIEEIIQGECDKSPDDRIIDLQGKLLVPGLFDMHCHFREPGQEYKETLESG
SKAAVAGGFTGVALMPNTKPVIDSPLGVAYIRHNAQQLPVDLEVIGAMSEGSKGEQLAPYGKFRSYGVKAVSDDGTAIQN
SQNMRLVFQYASNFDLLVIQHCEDKSMTAEAVMNEGVFSTKLGLKGIPDVSEAVMLCRDLHLIRYIVEHELHDPANKPRY
HVAHISTKASLDLVRQAKAEGLQVTCEVTPHHFTLTDEDLFNAPSKGNFIMKPPLPSKKNRAAILEAIADGTIDAIATDH
APHAPHEKECPPDQASFGIIGLETAVGLTITELVEPGIITLSRAIELMSVNPRKILQLDPLLFAQGERANFTIIDPEEEW
ALTANAVKSKSTNTPFLGRKLKGRAIAVYHKGMFHESVTSQEHFSV

Sequences:

>Translated_446_residues
MSTIFQNAHIINPQSNLDYTGSIRVSVDGFIEEIIQGECDKSPDDRIIDLQGKLLVPGLFDMHCHFREPGQEYKETLESG
SKAAVAGGFTGVALMPNTKPVIDSPLGVAYIRHNAQQLPVDLEVIGAMSEGSKGEQLAPYGKFRSYGVKAVSDDGTAIQN
SQNMRLVFQYASNFDLLVIQHCEDKSMTAEAVMNEGVFSTKLGLKGIPDVSEAVMLCRDLHLIRYIVEHELHDPANKPRY
HVAHISTKASLDLVRQAKAEGLQVTCEVTPHHFTLTDEDLFNAPSKGNFIMKPPLPSKKNRAAILEAIADGTIDAIATDH
APHAPHEKECPPDQASFGIIGLETAVGLTITELVEPGIITLSRAIELMSVNPRKILQLDPLLFAQGERANFTIIDPEEEW
ALTANAVKSKSTNTPFLGRKLKGRAIAVYHKGMFHESVTSQEHFSV
>Mature_445_residues
STIFQNAHIINPQSNLDYTGSIRVSVDGFIEEIIQGECDKSPDDRIIDLQGKLLVPGLFDMHCHFREPGQEYKETLESGS
KAAVAGGFTGVALMPNTKPVIDSPLGVAYIRHNAQQLPVDLEVIGAMSEGSKGEQLAPYGKFRSYGVKAVSDDGTAIQNS
QNMRLVFQYASNFDLLVIQHCEDKSMTAEAVMNEGVFSTKLGLKGIPDVSEAVMLCRDLHLIRYIVEHELHDPANKPRYH
VAHISTKASLDLVRQAKAEGLQVTCEVTPHHFTLTDEDLFNAPSKGNFIMKPPLPSKKNRAAILEAIADGTIDAIATDHA
PHAPHEKECPPDQASFGIIGLETAVGLTITELVEPGIITLSRAIELMSVNPRKILQLDPLLFAQGERANFTIIDPEEEWA
LTANAVKSKSTNTPFLGRKLKGRAIAVYHKGMFHESVTSQEHFSV

Specific function: Involved In The Anaerobic Utilization Of Allantoin. [C]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI18105007, Length=397, Percent_Identity=31.4861460957179, Blast_Score=147, Evalue=2e-35,
Organism=Escherichia coli, GI1786722, Length=404, Percent_Identity=26.2376237623762, Blast_Score=123, Evalue=2e-29,
Organism=Escherichia coli, GI87082175, Length=424, Percent_Identity=24.0566037735849, Blast_Score=83, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI193204318, Length=399, Percent_Identity=30.5764411027569, Blast_Score=145, Evalue=5e-35,
Organism=Saccharomyces cerevisiae, GI6322218, Length=407, Percent_Identity=22.8501228501229, Blast_Score=86, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24642586, Length=382, Percent_Identity=31.9371727748691, Blast_Score=138, Evalue=9e-33,
Organism=Drosophila melanogaster, GI18859883, Length=458, Percent_Identity=24.8908296943231, Blast_Score=82, Evalue=7e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR004722
- InterPro:   IPR002195
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.2.3 [H]

Molecular weight: Translated: 48851; Mature: 48720

Theoretical pI: Translated: 5.79; Mature: 5.79

Prosite motif: PS00483 DIHYDROOROTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTIFQNAHIINPQSNLDYTGSIRVSVDGFIEEIIQGECDKSPDDRIIDLQGKLLVPGLF
CCCCCCCCEEECCCCCCCCCEEEEEEHHHHHHHHHCCCCCCCCCCCEEEECCCEECCCCE
DMHCHFREPGQEYKETLESGSKAAVAGGFTGVALMPNTKPVIDSPLGVAYIRHNAQQLPV
ECCCCCCCCCHHHHHHHHCCCCEEEECCCEEEEECCCCCCCCCCCCCEEEECCCHHHCCE
DLEVIGAMSEGSKGEQLAPYGKFRSYGVKAVSDDGTAIQNSQNMRLVFQYASNFDLLVIQ
EEEEEEECCCCCCCCCCCCCHHHHHCCCEEECCCCCEEECCCCEEEEEEECCCCCEEEEE
HCEDKSMTAEAVMNEGVFSTKLGLKGIPDVSEAVMLCRDLHLIRYIVEHELHDPANKPRY
ECCCCCHHHHHHHCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCE
HVAHISTKASLDLVRQAKAEGLQVTCEVTPHHFTLTDEDLFNAPSKGNFIMKPPLPSKKN
EEEEECCHHHHHHHHHHCCCCEEEEEEECCCEEEECCHHHHCCCCCCCEEECCCCCCCCC
RAAILEAIADGTIDAIATDHAPHAPHEKECPPDQASFGIIGLETAVGLTITELVEPGIIT
HHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCCCCCCEEEECHHHCEEHHHHHCCCCEE
LSRAIELMSVNPRKILQLDPLLFAQGERANFTIIDPEEEWALTANAVKSKSTNTPFLGRK
HHHHHHHCCCCCHHEEEECCEEEECCCCCCEEEECCCHHHEEEHHHHHCCCCCCCCCCCC
LKGRAIAVYHKGMFHESVTSQEHFSV
CCCCEEEEEECCCHHHHCCCCHHCCC
>Mature Secondary Structure 
STIFQNAHIINPQSNLDYTGSIRVSVDGFIEEIIQGECDKSPDDRIIDLQGKLLVPGLF
CCCCCCCEEECCCCCCCCCEEEEEEHHHHHHHHHCCCCCCCCCCCEEEECCCEECCCCE
DMHCHFREPGQEYKETLESGSKAAVAGGFTGVALMPNTKPVIDSPLGVAYIRHNAQQLPV
ECCCCCCCCCHHHHHHHHCCCCEEEECCCEEEEECCCCCCCCCCCCCEEEECCCHHHCCE
DLEVIGAMSEGSKGEQLAPYGKFRSYGVKAVSDDGTAIQNSQNMRLVFQYASNFDLLVIQ
EEEEEEECCCCCCCCCCCCCHHHHHCCCEEECCCCCEEECCCCEEEEEEECCCCCEEEEE
HCEDKSMTAEAVMNEGVFSTKLGLKGIPDVSEAVMLCRDLHLIRYIVEHELHDPANKPRY
ECCCCCHHHHHHHCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCE
HVAHISTKASLDLVRQAKAEGLQVTCEVTPHHFTLTDEDLFNAPSKGNFIMKPPLPSKKN
EEEEECCHHHHHHHHHHCCCCEEEEEEECCCEEEECCHHHHCCCCCCCEEECCCCCCCCC
RAAILEAIADGTIDAIATDHAPHAPHEKECPPDQASFGIIGLETAVGLTITELVEPGIIT
HHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCCCCCCEEEECHHHCEEHHHHHCCCCEE
LSRAIELMSVNPRKILQLDPLLFAQGERANFTIIDPEEEWALTANAVKSKSTNTPFLGRK
HHHHHHHCCCCCHHEEEECCEEEECCCCCCEEEECCCHHHEEEHHHHHCCCCCCCCCCCC
LKGRAIAVYHKGMFHESVTSQEHFSV
CCCCEEEEEECCCHHHHCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12093901 [H]