Click here to switch to the map view.

The map label for this gene is gph [C]

Identifier: 119356961

GI number: 119356961

Start: 1293161

End: 1293802

Strand: Direct

Name: gph [C]

Synonym: Cpha266_1144

Alternate gene names: 119356961

Gene position: 1293161-1293802 (Clockwise)

Preceding gene: 119356960

Following gene: 119356962

Centisome position: 41.26

GC content: 52.49

Gene sequence:

>642_bases
GTGAAATACAAACTTCTGGTTTTTGATTTTGACGGGACCTTGGCTGATAGCGAAGCGAGCATTATGGAGTCTCTGCAGCT
TGTCGCCCAGGATCTGGGGATTCCGGCTTTTGACAGGGACGGAGCCCGGCGAAGTATCGGTTTGCCGTTGCGGCGTACAA
TTGAAATGGGGCTTGGTCTCGCTCCTGAAGAAGCTCCTGAGGCAGTTGACCTCTACAGAAAGCGTTACAACGAGGTTGCT
TTAGACTTGACGCATCTGTTTCCGGGAGTGAACGAGACCCTGGACCGATTGCGGCACGATTACCTGCTGGCCGTCGCTTC
AAGCAAGAGCACCCAGGGGCTGTTGTTGATGATGCGGCATCTCGGGATTTATGAGATATTCTCCCTTATTTCCGGGGCTC
AGGATGTGCAACAGCCAAAGCCAGCACCCGATATGGTGCTGCTTGCACTGGAGTCCATGAATATTCCGGCTCAAGAGTGC
CTGGTTGTGGGCGACACTGTTTACGATATCGAAATGGGTCAACGCGCATTCACCGATACCTGTGCCGTCACCTACGGCAA
CCATTCAGCCGATGAACTCCGCTGCTTCAATCCCACCTTTATTATTAACGCATTCCCGCATCTCATGCATTGTTTGGAGT
GA

Upstream 100 bases:

>100_bases
AATAGTGCCTCTACTCCATTGGTTAAAACACTTCAGATGGTGAGCTTTCAGAAAGCAATATCTTCAGTGGCGAGCATTGC
ACGAAGTACGATGAAAAAGA

Downstream 100 bases:

>100_bases
TTTTTCCCTTTACCTCACCGAAGATAAGCGCATAGCTCCGGGAGATTGTTCGATAGCAGCAACACTGGGCGGAAGAGAGC
TTTTGTTCATAACAAATCGG

Product: HAD family hydrolase

Products: NA

Alternate protein names: PGP; PGPase [H]

Number of amino acids: Translated: 213; Mature: 213

Protein sequence:

>213_residues
MKYKLLVFDFDGTLADSEASIMESLQLVAQDLGIPAFDRDGARRSIGLPLRRTIEMGLGLAPEEAPEAVDLYRKRYNEVA
LDLTHLFPGVNETLDRLRHDYLLAVASSKSTQGLLLMMRHLGIYEIFSLISGAQDVQQPKPAPDMVLLALESMNIPAQEC
LVVGDTVYDIEMGQRAFTDTCAVTYGNHSADELRCFNPTFIINAFPHLMHCLE

Sequences:

>Translated_213_residues
MKYKLLVFDFDGTLADSEASIMESLQLVAQDLGIPAFDRDGARRSIGLPLRRTIEMGLGLAPEEAPEAVDLYRKRYNEVA
LDLTHLFPGVNETLDRLRHDYLLAVASSKSTQGLLLMMRHLGIYEIFSLISGAQDVQQPKPAPDMVLLALESMNIPAQEC
LVVGDTVYDIEMGQRAFTDTCAVTYGNHSADELRCFNPTFIINAFPHLMHCLE
>Mature_213_residues
MKYKLLVFDFDGTLADSEASIMESLQLVAQDLGIPAFDRDGARRSIGLPLRRTIEMGLGLAPEEAPEAVDLYRKRYNEVA
LDLTHLFPGVNETLDRLRHDYLLAVASSKSTQGLLLMMRHLGIYEIFSLISGAQDVQQPKPAPDMVLLALESMNIPAQEC
LVVGDTVYDIEMGQRAFTDTCAVTYGNHSADELRCFNPTFIINAFPHLMHCLE

Specific function: Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stres

COG id: COG0546

COG function: function code R; Predicted phosphatases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family [H]

Homologues:

Organism=Escherichia coli, GI1789787, Length=230, Percent_Identity=30, Blast_Score=86, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005834
- InterPro:   IPR023214
- InterPro:   IPR006439
- InterPro:   IPR006402
- InterPro:   IPR005833
- InterPro:   IPR006346
- InterPro:   IPR023198 [H]

Pfam domain/function: PF00702 Hydrolase [H]

EC number: =3.1.3.18 [H]

Molecular weight: Translated: 23734; Mature: 23734

Theoretical pI: Translated: 4.52; Mature: 4.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKYKLLVFDFDGTLADSEASIMESLQLVAQDLGIPAFDRDGARRSIGLPLRRTIEMGLGL
CCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHCCCC
APEEAPEAVDLYRKRYNEVALDLTHLFPGVNETLDRLRHDYLLAVASSKSTQGLLLMMRH
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHEEEEECCCCCHHHHHHHHH
LGIYEIFSLISGAQDVQQPKPAPDMVLLALESMNIPAQECLVVGDTVYDIEMGQRAFTDT
CCHHHHHHHHHCHHHHHCCCCCCHHEEEEHHHCCCCHHHHEEECCEEEEECCCCHHHHHH
CAVTYGNHSADELRCFNPTFIINAFPHLMHCLE
EEEEECCCCCCCEEECCCCCEEHHHHHHHHHCC
>Mature Secondary Structure
MKYKLLVFDFDGTLADSEASIMESLQLVAQDLGIPAFDRDGARRSIGLPLRRTIEMGLGL
CCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHCCCC
APEEAPEAVDLYRKRYNEVALDLTHLFPGVNETLDRLRHDYLLAVASSKSTQGLLLMMRH
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHEEEEECCCCCHHHHHHHHH
LGIYEIFSLISGAQDVQQPKPAPDMVLLALESMNIPAQECLVVGDTVYDIEMGQRAFTDT
CCHHHHHHHHHCHHHHHCCCCCCHHEEEEHHHCCCCHHHHEEECCEEEEECCCCHHHHHH
CAVTYGNHSADELRCFNPTFIINAFPHLMHCLE
EEEEECCCCCCCEEECCCCCEEHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA