Click here to switch to the map view.

The map label for this gene is nuoH

Identifier: 119356793

GI number: 119356793

Start: 1105508

End: 1106626

Strand: Direct

Name: nuoH

Synonym: Cpha266_0965

Alternate gene names: 119356793

Gene position: 1105508-1106626 (Clockwise)

Preceding gene: 119356792

Following gene: 119356794

Centisome position: 35.28

GC content: 47.99

Gene sequence:

>1119_bases
ATGAGTGTAATGGCTTTATCGCAAATCCGTATTCCTCTGCTTATGGGTAACAGTCTCAATGCCTGGTCGGAAGCCCTTAC
CGGTTTTTCGATCTGGGGATTTCCTCTTGGTCTTGTCATTCTTGCCGCCATTCCGTTAGTTTTTATTGCGCTTTACGCTC
TGACATACGGAGTCTACGGCGAACGGAAAATTTCCGCATTCATGCAGGACAGGCTTGGTCCGATGGAGGTTGGCAAATGG
GGTATTCTGCAGACCCTTGCCGATATTCTCAAGCTTTTGCAGAAAGAGGATATTGTTCCTGCCGCTGCTGACAAATTTCT
TTTTGTCGTTGGCCCCGGAATTCTGTTTGTCGGCTCCTTTCTTGCATTTGCCGTGCTTCCGTTCAGTTCTGCTTTTATTG
GTGCCAATTTAAATGTAGGCCTCTTTTATGCAATCGGCATCGTATCCATTGAAGTGGTCGGTATTCTTGCTGCCGGCTGG
GGATCAAACAACAAGTGGTCGCTCTATGGAGCGGTTCGGAGTGTCGCCCAGATAGTCAGCTATGAAATTCCTGCCGGAAT
TGCCCTTTTGTGCGGAGCCATGATGGCAGGAACGCTTGATATGCAGCAGATAACAATGCTCCAGTCCGGTCATCTCGGGT
TTGCCCATTTCAATCTTTTTCAGTCGCCGATTGCCTGGCTTCCTTTTCTGATCTATTTCATCGCTTCGCTTGCAGAGGTT
AATCGGGCCCCTTTTGATATTCCCGAAGCCGAATCCGAGCTTGTTGCCGGTTATTTTACCGAGTATAGCGGGATGAAATT
TGCGGTTATTTTTCTTGCCGAATATGGTAGTATGTTTATGGTTTCAGCCGTTCTCTCCATTGTTTTTCTTGGAGGCTGGA
ACTCGCCTCTTCCCGATCTTGGCCCTGTATCGCTCAATGCCATGACAAGTGGCCCTGTGTGGGGGGTCTTCTGGATTATT
TCGAAGGGATTTTTCTTTATTTTTGTGCAGATGTGGCTGCGCTGGACCCTGCCTCGTTTGAGGGTTGATCAGTTGATGTA
CCTCTGCTGGAAAGTTCTGACACCGTTCGCTTTTATCGGATTTGTTCTGACGGCGATCTGGGAAATTTATGTGCCATAG

Upstream 100 bases:

>100_bases
TTAATCTTTCGGCAATGAAAGATCTTTCCAAAGGTCAGTTGATCCCTGATCTCGTTGCAATAATCGGCAGTATCGATATT
GTACTCGGGGAGGTTGACCG

Downstream 100 bases:

>100_bases
AAAGGGAAATTGCCGCAGTACGGCAACCAATGAAGCAAGACTATGAGTGAATATTTCAGAAACATAAAGACAGGTGCCTC
GACCATTGCTACCGGTATGG

Product: respiratory-chain NADH dehydrogenase, subunit 1

Products: NA

Alternate protein names: NADH dehydrogenase I subunit H; NDH-1 subunit H

Number of amino acids: Translated: 372; Mature: 371

Protein sequence:

>372_residues
MSVMALSQIRIPLLMGNSLNAWSEALTGFSIWGFPLGLVILAAIPLVFIALYALTYGVYGERKISAFMQDRLGPMEVGKW
GILQTLADILKLLQKEDIVPAAADKFLFVVGPGILFVGSFLAFAVLPFSSAFIGANLNVGLFYAIGIVSIEVVGILAAGW
GSNNKWSLYGAVRSVAQIVSYEIPAGIALLCGAMMAGTLDMQQITMLQSGHLGFAHFNLFQSPIAWLPFLIYFIASLAEV
NRAPFDIPEAESELVAGYFTEYSGMKFAVIFLAEYGSMFMVSAVLSIVFLGGWNSPLPDLGPVSLNAMTSGPVWGVFWII
SKGFFFIFVQMWLRWTLPRLRVDQLMYLCWKVLTPFAFIGFVLTAIWEIYVP

Sequences:

>Translated_372_residues
MSVMALSQIRIPLLMGNSLNAWSEALTGFSIWGFPLGLVILAAIPLVFIALYALTYGVYGERKISAFMQDRLGPMEVGKW
GILQTLADILKLLQKEDIVPAAADKFLFVVGPGILFVGSFLAFAVLPFSSAFIGANLNVGLFYAIGIVSIEVVGILAAGW
GSNNKWSLYGAVRSVAQIVSYEIPAGIALLCGAMMAGTLDMQQITMLQSGHLGFAHFNLFQSPIAWLPFLIYFIASLAEV
NRAPFDIPEAESELVAGYFTEYSGMKFAVIFLAEYGSMFMVSAVLSIVFLGGWNSPLPDLGPVSLNAMTSGPVWGVFWII
SKGFFFIFVQMWLRWTLPRLRVDQLMYLCWKVLTPFAFIGFVLTAIWEIYVP
>Mature_371_residues
SVMALSQIRIPLLMGNSLNAWSEALTGFSIWGFPLGLVILAAIPLVFIALYALTYGVYGERKISAFMQDRLGPMEVGKWG
ILQTLADILKLLQKEDIVPAAADKFLFVVGPGILFVGSFLAFAVLPFSSAFIGANLNVGLFYAIGIVSIEVVGILAAGWG
SNNKWSLYGAVRSVAQIVSYEIPAGIALLCGAMMAGTLDMQQITMLQSGHLGFAHFNLFQSPIAWLPFLIYFIASLAEVN
RAPFDIPEAESELVAGYFTEYSGMKFAVIFLAEYGSMFMVSAVLSIVFLGGWNSPLPDLGPVSLNAMTSGPVWGVFWIIS
KGFFFIFVQMWLRWTLPRLRVDQLMYLCWKVLTPFAFIGFVLTAIWEIYVP

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1005

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 1 (chain H)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 1 family

Homologues:

Organism=Homo sapiens, GI251831107, Length=306, Percent_Identity=33.9869281045752, Blast_Score=182, Evalue=5e-46,
Organism=Escherichia coli, GI1788618, Length=328, Percent_Identity=35.9756097560976, Blast_Score=206, Evalue=3e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NUOH_CHLPD (A1BF36)

Other databases:

- EMBL:   CP000492
- RefSeq:   YP_911437.1
- STRING:   A1BF36
- GeneID:   4570734
- GenomeReviews:   CP000492_GR
- KEGG:   cph:Cpha266_0965
- NMPDR:   fig|290317.7.peg.1027
- eggNOG:   COG1005
- HOGENOM:   HBG727670
- OMA:   GNSLNAW
- ProtClustDB:   CLSK637462
- HAMAP:   MF_01350
- InterPro:   IPR023020
- InterPro:   IPR001694
- InterPro:   IPR018086
- PANTHER:   PTHR11432

Pfam domain/function: PF00146 NADHdh

EC number: =1.6.99.5

Molecular weight: Translated: 40848; Mature: 40717

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: PS00667 COMPLEX1_ND1_1; PS00668 COMPLEX1_ND1_2

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xff7d544)-; HASH(0xff7d35c)-; HASH(0xd3e94b4)-; HASH(0xfcd4c84)-; HASH(0x101f07e4)-; HASH(0xfb0ac00)-; HASH(0xcef021c)-; HASH(0x101424d8)-;

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVMALSQIRIPLLMGNSLNAWSEALTGFSIWGFPLGLVILAAIPLVFIALYALTYGVYG
CCCHHHHHCCEEEEECCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
ERKISAFMQDRLGPMEVGKWGILQTLADILKLLQKEDIVPAAADKFLFVVGPGILFVGSF
HHHHHHHHHHCCCCHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCHHHHHHHH
LAFAVLPFSSAFIGANLNVGLFYAIGIVSIEVVGILAAGWGSNNKWSLYGAVRSVAQIVS
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHEECCCCCCCEEHHHHHHHHHHHHH
YEIPAGIALLCGAMMAGTLDMQQITMLQSGHLGFAHFNLFQSPIAWLPFLIYFIASLAEV
HCCCCCHHHHHHHHHHCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
NRAPFDIPEAESELVAGYFTEYSGMKFAVIFLAEYGSMFMVSAVLSIVFLGGWNSPLPDL
CCCCCCCCCCHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
GPVSLNAMTSGPVWGVFWIISKGFFFIFVQMWLRWTLPRLRVDQLMYLCWKVLTPFAFIG
CCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
FVLTAIWEIYVP
HHHHHHHHHCCH
>Mature Secondary Structure 
SVMALSQIRIPLLMGNSLNAWSEALTGFSIWGFPLGLVILAAIPLVFIALYALTYGVYG
CCHHHHHCCEEEEECCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
ERKISAFMQDRLGPMEVGKWGILQTLADILKLLQKEDIVPAAADKFLFVVGPGILFVGSF
HHHHHHHHHHCCCCHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCHHHHHHHH
LAFAVLPFSSAFIGANLNVGLFYAIGIVSIEVVGILAAGWGSNNKWSLYGAVRSVAQIVS
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHEECCCCCCCEEHHHHHHHHHHHHH
YEIPAGIALLCGAMMAGTLDMQQITMLQSGHLGFAHFNLFQSPIAWLPFLIYFIASLAEV
HCCCCCHHHHHHHHHHCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
NRAPFDIPEAESELVAGYFTEYSGMKFAVIFLAEYGSMFMVSAVLSIVFLGGWNSPLPDL
CCCCCCCCCCHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
GPVSLNAMTSGPVWGVFWIISKGFFFIFVQMWLRWTLPRLRVDQLMYLCWKVLTPFAFIG
CCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
FVLTAIWEIYVP
HHHHHHHHHCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA