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The map label for this gene is glcD [H]

Identifier: 118581654

GI number: 118581654

Start: 3574786

End: 3576165

Strand: Direct

Name: glcD [H]

Synonym: Ppro_3253

Alternate gene names: 118581654

Gene position: 3574786-3576165 (Clockwise)

Preceding gene: 118581651

Following gene: 118581655

Centisome position: 89.19

GC content: 63.7

Gene sequence:

>1380_bases
ATGTTGAAACAGGAAGTACTCCAAGAGCTTGCCACCATTGTGGGCAGGGACAACATCGCCACCGAGCGCCAGGACCTGCT
CTGCTACTCCTATGACGCAACCCAGATGGAGTTCCTCCCGGACGCGGTCGTCCATCCCGCCAACACCGAAGAGGTGGCCG
CAATCATGCGCCTGGCCAACAGCGCCGGCTTTCCGGTCTTTCCACGGGGCGCGGGGAGCGGATTCAGCGGCGGCGCCCTG
CCCAAGACCGGAGGCATCGTGCTGGTCACCACCCGCATGAACCGCATCCTGCGCATCGACACCGAAAACCTGATCGCCGA
GGTGGAGCCGGGCGTGGTCACGGAGCAGTTCCAGCAGGAGGTGGAGAAGCTGGGGCTCTTCTACCCGCCTGATCCGGCCT
CGCTGAAGTTTTCCACCCTGGGGGGGAACGTGGCCGAGAACGCCGGCGGCCCCCGTGCGGTGAAGTACGGCTGCACCAAG
GATTTCGTCATGGGACTGGAGGTGGTGCTCCCCACCGGCGCCATCATCCGCACCGGCGGCGAGACCTACAAGGGGGTGGT
GGGGTACGACATGACCAAGCTGCTCTGCGGCAGCGAGGGGACCCTGGGCATCATCACCAAGATCGTCTTCAAACTGCTCC
CCTACCCGGACGCCAAGAAAACCATGCTGACCATCTTCGACTCCATCGACGGGGCAGCCAAGGCGGTTTCGTCCATCATC
GGCGGGAAGATCATCCCCACCACCCTGGAGTTCATGGATTACGCCACCCTGCAGTGCGTGGACCGACGCTTCAACCTGGG
CATACCGTCGGAAGGGAGGGCGGTGCTGCTGATCGAGGTGGACGGCGACCGGGACCTGATCGAGAAGCAGGCCAGCCAGA
TCCACGACATCATCAGGCCCCTGGGACTGGTGCAGTTCCGGGCGGCGAAGGACAAGGCCGAATCGGAGCAGCTCTGGCAG
GTCCGGCGGCTGGTCTCACCGTCGCTTCGGGACGTGAACCCGGACAAGTTCAACGAGGACATCGTGGTGCCGCGCAGCAG
GGTGCCAGACGTTATCCGCCGCATCGAGGCGATCAGACAGCGCCACGACATCCCCATCGTCAACTTCGGCCATGCCGGTG
ACGGCAACATCCACGTCAACATCATGGTGGACAAGAAGATTGCCGGCATGGAGGAGAAGGCCCACCAGGCGATTCGCGAG
GTATTCCAGGCCGCCCTGGAGCTGGGCGGCACCATGTCGGGCGAGCACGGCGTCGGCCTCTCCAAGGCGCCTTTCATCGA
ACTGGAACTGACCCCGGACCAGATCGCGGCCATGAAGGCGATCAAGCAGGCCCTGGACCCCAACAACATCCTCAACCCCG
GCAAGATGTTTCCCTGGTAA

Upstream 100 bases:

>100_bases
CCGCTTTGTTGGCCAGTTAGCCCAAAACGGCCTTGCGCGTGGCAGCCACTATCATGTATCGTAGCAGGTCCGAATGCAAT
CGTCACAGGAGAGAGAGAGT

Downstream 100 bases:

>100_bases
TTCCGAACAGGGCGCGTTCCCACGGAGGCCCGCCATGGATACCAACAAACAGCATCAGGAAGCCTCGCTGATCGGCATGT
TGCTCTCCCTGGAAGTTCTG

Product: FAD linked oxidase domain-containing protein

Products: 2-oxo acid; H2O2

Alternate protein names: NA

Number of amino acids: Translated: 459; Mature: 459

Protein sequence:

>459_residues
MLKQEVLQELATIVGRDNIATERQDLLCYSYDATQMEFLPDAVVHPANTEEVAAIMRLANSAGFPVFPRGAGSGFSGGAL
PKTGGIVLVTTRMNRILRIDTENLIAEVEPGVVTEQFQQEVEKLGLFYPPDPASLKFSTLGGNVAENAGGPRAVKYGCTK
DFVMGLEVVLPTGAIIRTGGETYKGVVGYDMTKLLCGSEGTLGIITKIVFKLLPYPDAKKTMLTIFDSIDGAAKAVSSII
GGKIIPTTLEFMDYATLQCVDRRFNLGIPSEGRAVLLIEVDGDRDLIEKQASQIHDIIRPLGLVQFRAAKDKAESEQLWQ
VRRLVSPSLRDVNPDKFNEDIVVPRSRVPDVIRRIEAIRQRHDIPIVNFGHAGDGNIHVNIMVDKKIAGMEEKAHQAIRE
VFQAALELGGTMSGEHGVGLSKAPFIELELTPDQIAAMKAIKQALDPNNILNPGKMFPW

Sequences:

>Translated_459_residues
MLKQEVLQELATIVGRDNIATERQDLLCYSYDATQMEFLPDAVVHPANTEEVAAIMRLANSAGFPVFPRGAGSGFSGGAL
PKTGGIVLVTTRMNRILRIDTENLIAEVEPGVVTEQFQQEVEKLGLFYPPDPASLKFSTLGGNVAENAGGPRAVKYGCTK
DFVMGLEVVLPTGAIIRTGGETYKGVVGYDMTKLLCGSEGTLGIITKIVFKLLPYPDAKKTMLTIFDSIDGAAKAVSSII
GGKIIPTTLEFMDYATLQCVDRRFNLGIPSEGRAVLLIEVDGDRDLIEKQASQIHDIIRPLGLVQFRAAKDKAESEQLWQ
VRRLVSPSLRDVNPDKFNEDIVVPRSRVPDVIRRIEAIRQRHDIPIVNFGHAGDGNIHVNIMVDKKIAGMEEKAHQAIRE
VFQAALELGGTMSGEHGVGLSKAPFIELELTPDQIAAMKAIKQALDPNNILNPGKMFPW
>Mature_459_residues
MLKQEVLQELATIVGRDNIATERQDLLCYSYDATQMEFLPDAVVHPANTEEVAAIMRLANSAGFPVFPRGAGSGFSGGAL
PKTGGIVLVTTRMNRILRIDTENLIAEVEPGVVTEQFQQEVEKLGLFYPPDPASLKFSTLGGNVAENAGGPRAVKYGCTK
DFVMGLEVVLPTGAIIRTGGETYKGVVGYDMTKLLCGSEGTLGIITKIVFKLLPYPDAKKTMLTIFDSIDGAAKAVSSII
GGKIIPTTLEFMDYATLQCVDRRFNLGIPSEGRAVLLIEVDGDRDLIEKQASQIHDIIRPLGLVQFRAAKDKAESEQLWQ
VRRLVSPSLRDVNPDKFNEDIVVPRSRVPDVIRRIEAIRQRHDIPIVNFGHAGDGNIHVNIMVDKKIAGMEEKAHQAIRE
VFQAALELGGTMSGEHGVGLSKAPFIELELTPDQIAAMKAIKQALDPNNILNPGKMFPW

Specific function: Unknown

COG id: COG0277

COG function: function code C; FAD/FMN-containing dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain [H]

Homologues:

Organism=Homo sapiens, GI37595756, Length=423, Percent_Identity=31.6784869976359, Blast_Score=233, Evalue=2e-61,
Organism=Homo sapiens, GI37595754, Length=446, Percent_Identity=30.0448430493274, Blast_Score=224, Evalue=1e-58,
Organism=Homo sapiens, GI119964728, Length=428, Percent_Identity=31.7757009345794, Blast_Score=191, Evalue=9e-49,
Organism=Homo sapiens, GI4501993, Length=460, Percent_Identity=25.6521739130435, Blast_Score=136, Evalue=4e-32,
Organism=Escherichia coli, GI1789351, Length=419, Percent_Identity=36.7541766109785, Blast_Score=283, Evalue=1e-77,
Organism=Escherichia coli, GI1787977, Length=527, Percent_Identity=27.3244781783681, Blast_Score=163, Evalue=2e-41,
Organism=Escherichia coli, GI48994907, Length=499, Percent_Identity=22.8456913827655, Blast_Score=100, Evalue=3e-22,
Organism=Escherichia coli, GI48994914, Length=144, Percent_Identity=34.7222222222222, Blast_Score=80, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI71992373, Length=465, Percent_Identity=31.3978494623656, Blast_Score=224, Evalue=5e-59,
Organism=Caenorhabditis elegans, GI71992381, Length=465, Percent_Identity=30.3225806451613, Blast_Score=203, Evalue=1e-52,
Organism=Caenorhabditis elegans, GI71992392, Length=384, Percent_Identity=31.25, Blast_Score=182, Evalue=3e-46,
Organism=Caenorhabditis elegans, GI17534361, Length=470, Percent_Identity=27.8723404255319, Blast_Score=181, Evalue=9e-46,
Organism=Caenorhabditis elegans, GI17556096, Length=455, Percent_Identity=24.6153846153846, Blast_Score=124, Evalue=9e-29,
Organism=Saccharomyces cerevisiae, GI6320027, Length=471, Percent_Identity=27.6008492569002, Blast_Score=189, Evalue=7e-49,
Organism=Saccharomyces cerevisiae, GI6320023, Length=477, Percent_Identity=29.1404612159329, Blast_Score=182, Evalue=1e-46,
Organism=Saccharomyces cerevisiae, GI6320764, Length=476, Percent_Identity=28.1512605042017, Blast_Score=166, Evalue=8e-42,
Organism=Drosophila melanogaster, GI18921117, Length=426, Percent_Identity=30.2816901408451, Blast_Score=187, Evalue=1e-47,
Organism=Drosophila melanogaster, GI24639277, Length=426, Percent_Identity=30.2816901408451, Blast_Score=187, Evalue=1e-47,
Organism=Drosophila melanogaster, GI24639275, Length=426, Percent_Identity=30.2816901408451, Blast_Score=187, Evalue=1e-47,
Organism=Drosophila melanogaster, GI24653753, Length=229, Percent_Identity=31.4410480349345, Blast_Score=114, Evalue=1e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016166
- InterPro:   IPR016167
- InterPro:   IPR016164
- InterPro:   IPR016168
- InterPro:   IPR004113
- InterPro:   IPR004490
- InterPro:   IPR006094
- InterPro:   IPR016171 [H]

Pfam domain/function: PF02913 FAD-oxidase_C; PF01565 FAD_binding_4 [H]

EC number: 1.1.3.15

Molecular weight: Translated: 50070; Mature: 50070

Theoretical pI: Translated: 5.54; Mature: 5.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKQEVLQELATIVGRDNIATERQDLLCYSYDATQMEFLPDAVVHPANTEEVAAIMRLAN
CCHHHHHHHHHHHHCCCCCCCCHHHCEEEECCCCHHHHCCHHHCCCCCHHHHHHHHHHHH
SAGFPVFPRGAGSGFSGGALPKTGGIVLVTTRMNRILRIDTENLIAEVEPGVVTEQFQQE
CCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCEEEECHHHHHHHCCCCCHHHHHHHH
VEKLGLFYPPDPASLKFSTLGGNVAENAGGPRAVKYGCTKDFVMGLEVVLPTGAIIRTGG
HHHCCCCCCCCCCCEEEEECCCCHHHCCCCCCEEECCCCHHHHHHHHHEECCCEEEECCC
ETYKGVVGYDMTKLLCGSEGTLGIITKIVFKLLPYPDAKKTMLTIFDSIDGAAKAVSSII
CHHCCCCCCCHHHHHCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHCCHHHHHHHHHH
GGKIIPTTLEFMDYATLQCVDRRFNLGIPSEGRAVLLIEVDGDRDLIEKQASQIHDIIRP
CCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHH
LGLVQFRAAKDKAESEQLWQVRRLVSPSLRDVNPDKFNEDIVVPRSRVPDVIRRIEAIRQ
HHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCEECCCHHHHHHHHHHHHHHH
RHDIPIVNFGHAGDGNIHVNIMVDKKIAGMEEKAHQAIREVFQAALELGGTMSGEHGVGL
HCCCCEEECCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
SKAPFIELELTPDQIAAMKAIKQALDPNNILNPGKMFPW
CCCCEEEEEECHHHHHHHHHHHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure
MLKQEVLQELATIVGRDNIATERQDLLCYSYDATQMEFLPDAVVHPANTEEVAAIMRLAN
CCHHHHHHHHHHHHCCCCCCCCHHHCEEEECCCCHHHHCCHHHCCCCCHHHHHHHHHHHH
SAGFPVFPRGAGSGFSGGALPKTGGIVLVTTRMNRILRIDTENLIAEVEPGVVTEQFQQE
CCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCEEEECHHHHHHHCCCCCHHHHHHHH
VEKLGLFYPPDPASLKFSTLGGNVAENAGGPRAVKYGCTKDFVMGLEVVLPTGAIIRTGG
HHHCCCCCCCCCCCEEEEECCCCHHHCCCCCCEEECCCCHHHHHHHHHEECCCEEEECCC
ETYKGVVGYDMTKLLCGSEGTLGIITKIVFKLLPYPDAKKTMLTIFDSIDGAAKAVSSII
CHHCCCCCCCHHHHHCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHCCHHHHHHHHHH
GGKIIPTTLEFMDYATLQCVDRRFNLGIPSEGRAVLLIEVDGDRDLIEKQASQIHDIIRP
CCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHH
LGLVQFRAAKDKAESEQLWQVRRLVSPSLRDVNPDKFNEDIVVPRSRVPDVIRRIEAIRQ
HHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCEECCCHHHHHHHHHHHHHHH
RHDIPIVNFGHAGDGNIHVNIMVDKKIAGMEEKAHQAIREVFQAALELGGTMSGEHGVGL
HCCCCEEECCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
SKAPFIELELTPDQIAAMKAIKQALDPNNILNPGKMFPW
CCCCEEEEEECHHHHHHHHHHHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (S)-2-hydroxy acid; O2

Specific reaction: (S)-2-hydroxy acid + O2 = 2-oxo acid + H2O2

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969504; 9384377 [H]