Click here to switch to the map view.

The map label for this gene is ndk

Identifier: 118581645

GI number: 118581645

Start: 3563927

End: 3564340

Strand: Direct

Name: ndk

Synonym: Ppro_3244

Alternate gene names: 118581645

Gene position: 3563927-3564340 (Clockwise)

Preceding gene: 118581639

Following gene: 118581648

Centisome position: 88.92

GC content: 62.08

Gene sequence:

>414_bases
ATGGAACGGACATTCGCCATCATCAAGCCGGATGCGGTGGAACGCAGGCTGGCCGGCACGGTCATCGACCGCATCGAGGC
CAACGGCTTCACCATCGTCGGCATGAAGAAGATCAAACTAAGCAAGGAGCAGGCCGGAGGTTTCTACTGCGTCCACCGGG
AACGACCCTTCTTCGGTGAACTGTGCGACTTCATGTCCCGCAGCCCGGTGATCGTGCTCTGCCTGGAGAAGGAAAACGCC
ATCGCCGACTGGCGAAAGCTGATGGGGGCCACCAATCCGGCCAACGCCGAACCGGGCACCATCCGCAGGGATTTCGCCCT
CAGCCTGAGCGAGAACTCGGCCCACGGCTCCGACGCCCCGGAAACCGCCGCCTTCGAGATCGCCTACTTCTTCAACGCCC
TGGAGTTGGTCTGA

Upstream 100 bases:

>100_bases
GATAGGACCCGGCTGCTCCGCGGGGAGGCAAAACCCTTGACAGTTGCGGAAGCGGGGTGGTATCCGGTGACTCTGCCATT
ACAGAATCAGGGGAGGAACC

Downstream 100 bases:

>100_bases
TCTTTCTGCTTTACGCAGCAATGCACTAAACCCAAAATTCGGCAGATGAGGCGGTCCTTCGTTCGCTCCAGATCCCTGAT
CCTGTGGTTCCACGGCTCAT

Product: nucleoside diphosphate kinase

Products: NA

Alternate protein names: NDK; NDP kinase; Nucleoside-2-P kinase

Number of amino acids: Translated: 137; Mature: 137

Protein sequence:

>137_residues
MERTFAIIKPDAVERRLAGTVIDRIEANGFTIVGMKKIKLSKEQAGGFYCVHRERPFFGELCDFMSRSPVIVLCLEKENA
IADWRKLMGATNPANAEPGTIRRDFALSLSENSAHGSDAPETAAFEIAYFFNALELV

Sequences:

>Translated_137_residues
MERTFAIIKPDAVERRLAGTVIDRIEANGFTIVGMKKIKLSKEQAGGFYCVHRERPFFGELCDFMSRSPVIVLCLEKENA
IADWRKLMGATNPANAEPGTIRRDFALSLSENSAHGSDAPETAAFEIAYFFNALELV
>Mature_137_residues
MERTFAIIKPDAVERRLAGTVIDRIEANGFTIVGMKKIKLSKEQAGGFYCVHRERPFFGELCDFMSRSPVIVLCLEKENA
IADWRKLMGATNPANAEPGTIRRDFALSLSENSAHGSDAPETAAFEIAYFFNALELV

Specific function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate

COG id: COG0105

COG function: function code F; Nucleoside diphosphate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NDK family

Homologues:

Organism=Homo sapiens, GI37693993, Length=136, Percent_Identity=44.8529411764706, Blast_Score=126, Evalue=6e-30,
Organism=Homo sapiens, GI66392227, Length=137, Percent_Identity=42.3357664233577, Blast_Score=120, Evalue=3e-28,
Organism=Homo sapiens, GI66392205, Length=137, Percent_Identity=42.3357664233577, Blast_Score=120, Evalue=3e-28,
Organism=Homo sapiens, GI4505409, Length=137, Percent_Identity=42.3357664233577, Blast_Score=120, Evalue=3e-28,
Organism=Homo sapiens, GI66392192, Length=137, Percent_Identity=42.3357664233577, Blast_Score=120, Evalue=3e-28,
Organism=Homo sapiens, GI66392203, Length=137, Percent_Identity=42.3357664233577, Blast_Score=120, Evalue=3e-28,
Organism=Homo sapiens, GI4557797, Length=136, Percent_Identity=42.6470588235294, Blast_Score=120, Evalue=5e-28,
Organism=Homo sapiens, GI38045913, Length=136, Percent_Identity=42.6470588235294, Blast_Score=120, Evalue=5e-28,
Organism=Homo sapiens, GI4826862, Length=136, Percent_Identity=42.6470588235294, Blast_Score=115, Evalue=9e-27,
Organism=Homo sapiens, GI37574614, Length=133, Percent_Identity=38.3458646616541, Blast_Score=97, Evalue=3e-21,
Organism=Homo sapiens, GI7019465, Length=133, Percent_Identity=38.3458646616541, Blast_Score=97, Evalue=3e-21,
Organism=Homo sapiens, GI5031951, Length=135, Percent_Identity=39.2592592592593, Blast_Score=87, Evalue=3e-18,
Organism=Homo sapiens, GI4505413, Length=134, Percent_Identity=35.0746268656716, Blast_Score=80, Evalue=6e-16,
Organism=Homo sapiens, GI148839372, Length=120, Percent_Identity=32.5, Blast_Score=72, Evalue=2e-13,
Organism=Escherichia coli, GI1788866, Length=136, Percent_Identity=54.4117647058823, Blast_Score=151, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI17506807, Length=135, Percent_Identity=40, Blast_Score=112, Evalue=4e-26,
Organism=Saccharomyces cerevisiae, GI6322783, Length=136, Percent_Identity=37.5, Blast_Score=110, Evalue=1e-25,
Organism=Drosophila melanogaster, GI45549037, Length=136, Percent_Identity=45.5882352941176, Blast_Score=124, Evalue=2e-29,
Organism=Drosophila melanogaster, GI18860097, Length=134, Percent_Identity=34.3283582089552, Blast_Score=84, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NDK_PELPD (A1AU17)

Other databases:

- EMBL:   CP000482
- RefSeq:   YP_902895.1
- ProteinModelPortal:   A1AU17
- SMR:   A1AU17
- STRING:   A1AU17
- GeneID:   4572480
- GenomeReviews:   CP000482_GR
- KEGG:   ppd:Ppro_3244
- eggNOG:   COG0105
- HOGENOM:   HBG445152
- OMA:   IRAEFAE
- PhylomeDB:   A1AU17
- ProtClustDB:   PRK00668
- GO:   GO:0005737
- HAMAP:   MF_00451
- InterPro:   IPR001564
- InterPro:   IPR023005
- Gene3D:   G3DSA:3.30.70.141
- PANTHER:   PTHR11349
- PRINTS:   PR01243
- SMART:   SM00562

Pfam domain/function: PF00334 NDK; SSF54919 NDK

EC number: =2.7.4.6

Molecular weight: Translated: 15230; Mature: 15230

Theoretical pI: Translated: 5.80; Mature: 5.80

Prosite motif: PS00469 NDP_KINASES

Important sites: ACT_SITE 115-115 BINDING 9-9 BINDING 57-57 BINDING 85-85 BINDING 91-91 BINDING 102-102 BINDING 112-112

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MERTFAIIKPDAVERRLAGTVIDRIEANGFTIVGMKKIKLSKEQAGGFYCVHRERPFFGE
CCCEEEEECCHHHHHHHHHHHHHHHCCCCEEEEEEEEEEECCCCCCCEEEEECCCCCHHH
LCDFMSRSPVIVLCLEKENAIADWRKLMGATNPANAEPGTIRRDFALSLSENSAHGSDAP
HHHHHCCCCEEEEEECCCCCHHHHHHHHCCCCCCCCCCCCEEEEEEEEECCCCCCCCCCC
ETAAFEIAYFFNALELV
CCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MERTFAIIKPDAVERRLAGTVIDRIEANGFTIVGMKKIKLSKEQAGGFYCVHRERPFFGE
CCCEEEEECCHHHHHHHHHHHHHHHCCCCEEEEEEEEEEECCCCCCCEEEEECCCCCHHH
LCDFMSRSPVIVLCLEKENAIADWRKLMGATNPANAEPGTIRRDFALSLSENSAHGSDAP
HHHHHCCCCEEEEEECCCCCHHHHHHHHCCCCCCCCCCCCEEEEEEEEECCCCCCCCCCC
ETAAFEIAYFFNALELV
CCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA