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The map label for this gene is gltT [H]

Identifier: 118578985

GI number: 118578985

Start: 581618

End: 582853

Strand: Direct

Name: gltT [H]

Synonym: Ppro_0546

Alternate gene names: 118578985

Gene position: 581618-582853 (Clockwise)

Preceding gene: 118578983

Following gene: 118578986

Centisome position: 14.51

GC content: 62.06

Gene sequence:

>1236_bases
ATGAAAACCAGAGTGCCGTTGTTCCTGAAATCCCATGGATTCTCCCTGCTGCTGATCCTCTCCCTCATCGCCGGCGTCGG
CCTGGGCGTGGTCTATAAAAAGGACGCCGTCCTCTTCAAGCCGCTGGGCGACATATTCCTGAACCTGCTCTTCACGGTGA
TCGTTCCGCTGGTCTTCTTCTCCATCTCGTCTGCCGTCGCTTCCATGACCGACCTCAGGCGTCTGGGCAGGATTCTGTCG
GTCATGTTCCTGGTCTTCGTCCTAACCGGATTCATCGCCTCCGGCGTCATGCTCCTTGGCGTCATCCTCTACCCGCCCGC
CTTTGGTGTCGCCATACCCCTTGCCGCGGCTGGCGAAATCCGGCACCTCAGGGCAGTGGACCAGATCGTCGGGGCCTTCA
CCGTCTCCGATTTTCCGCTGCTCCTGTCCAAGAACAACATGCTGGCCCTGATCCTGTTCTCCATCCTGACCGGCCTGGCC
ACCTCCGCCGTGGGGGAGAGGGGAAAACCGTTCGCCGCGTTTCTGGTTTCGGCCAACGAGGTGATGATGAAACTGGTCTC
CTTCATCATGTACTATGCGCCGGTCGGCCTGTGTGCCTACTTCGCCTACCTGGTGGGAACCTTCGGGCCGGAGCTTTTGG
GCTCCTACGGCCGGGCCATGGCACTGTACTATCCCCTGGCCGTCGCCTACTATCTGCTCGCCTTCAGCCTGTATGCCTTT
CTCGCCGGCGGCGTCTCCTGTGTCGGCAGGTTCTGGCGCAACATCATACCGCCATCGGTCACGGCCCTGGCCACCGGCAG
CTCCATGGCGGCCATTCCCTCCAACCTGCAGGCGGCTGACAGGATCGGCGTGCCCCGGGATATCAGCGAGGTGGTCATTC
CCATCGGAGCCACGCTGCACATGGAAGGGTCGTGCCTGGCCGCGGTGCTGAAGATAGCTTTTCTCTTTGGTATCTTCCGC
ATCCCCTTTTCCGGCATCGAGCCGATCGCAACCGCCCTGGGCATTGCCCTCCTGACCGGCGTGGTGGTCAGCGGCATTCC
GGGCGGCGGCACCATCGGGGAACTGTTGATCCTCTCCCTGTACGGTTTTCCGCCGGAAGCCTTTGCCCTGGTCACCATGA
TCGGCACCCTGGTGGATGCGCCGGCCACCATGCTCAACGCCGTGGGGGACAACGTCTCCAGTATGCTGGTGGCCCGGGTG
CTGGGGGGGAGGGGATGGATGGAAAACCAGGGATGA

Upstream 100 bases:

>100_bases
AAAACGGCTTTCACCTCAAGCCGGCGGAGTGGTAGCATGACGTCCTTGAAATCCGAGCCGACTATTCACACTCCCCGGCC
CATCGCCATGGCGTGATAAC

Downstream 100 bases:

>100_bases
GCGGGCGCGGGGAGAGGTAATGAAAAAGAGGAAACTGGGCGGGTATGTTCTTTCAGCCGTTTTACTCTGCATTCTGTCAA
TCGGATCGGTGTCGGCCGCA

Product: sodium:dicarboxylate symporter

Products: L-aspartate [Cytoplasm]; Proton [Cytoplasm]; L-glutamate [Cytoplasm] [C]

Alternate protein names: Glutamate-aspartate carrier protein [H]

Number of amino acids: Translated: 411; Mature: 411

Protein sequence:

>411_residues
MKTRVPLFLKSHGFSLLLILSLIAGVGLGVVYKKDAVLFKPLGDIFLNLLFTVIVPLVFFSISSAVASMTDLRRLGRILS
VMFLVFVLTGFIASGVMLLGVILYPPAFGVAIPLAAAGEIRHLRAVDQIVGAFTVSDFPLLLSKNNMLALILFSILTGLA
TSAVGERGKPFAAFLVSANEVMMKLVSFIMYYAPVGLCAYFAYLVGTFGPELLGSYGRAMALYYPLAVAYYLLAFSLYAF
LAGGVSCVGRFWRNIIPPSVTALATGSSMAAIPSNLQAADRIGVPRDISEVVIPIGATLHMEGSCLAAVLKIAFLFGIFR
IPFSGIEPIATALGIALLTGVVVSGIPGGGTIGELLILSLYGFPPEAFALVTMIGTLVDAPATMLNAVGDNVSSMLVARV
LGGRGWMENQG

Sequences:

>Translated_411_residues
MKTRVPLFLKSHGFSLLLILSLIAGVGLGVVYKKDAVLFKPLGDIFLNLLFTVIVPLVFFSISSAVASMTDLRRLGRILS
VMFLVFVLTGFIASGVMLLGVILYPPAFGVAIPLAAAGEIRHLRAVDQIVGAFTVSDFPLLLSKNNMLALILFSILTGLA
TSAVGERGKPFAAFLVSANEVMMKLVSFIMYYAPVGLCAYFAYLVGTFGPELLGSYGRAMALYYPLAVAYYLLAFSLYAF
LAGGVSCVGRFWRNIIPPSVTALATGSSMAAIPSNLQAADRIGVPRDISEVVIPIGATLHMEGSCLAAVLKIAFLFGIFR
IPFSGIEPIATALGIALLTGVVVSGIPGGGTIGELLILSLYGFPPEAFALVTMIGTLVDAPATMLNAVGDNVSSMLVARV
LGGRGWMENQG
>Mature_411_residues
MKTRVPLFLKSHGFSLLLILSLIAGVGLGVVYKKDAVLFKPLGDIFLNLLFTVIVPLVFFSISSAVASMTDLRRLGRILS
VMFLVFVLTGFIASGVMLLGVILYPPAFGVAIPLAAAGEIRHLRAVDQIVGAFTVSDFPLLLSKNNMLALILFSILTGLA
TSAVGERGKPFAAFLVSANEVMMKLVSFIMYYAPVGLCAYFAYLVGTFGPELLGSYGRAMALYYPLAVAYYLLAFSLYAF
LAGGVSCVGRFWRNIIPPSVTALATGSSMAAIPSNLQAADRIGVPRDISEVVIPIGATLHMEGSCLAAVLKIAFLFGIFR
IPFSGIEPIATALGIALLTGVVVSGIPGGGTIGELLILSLYGFPPEAFALVTMIGTLVDAPATMLNAVGDNVSSMLVARV
LGGRGWMENQG

Specific function: This carrier protein is part of the Na(+)-dependent, binding-protein-independent glutamate-aspartate transport system [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI21314632, Length=401, Percent_Identity=26.1845386533666, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI223468564, Length=262, Percent_Identity=31.6793893129771, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI223468566, Length=262, Percent_Identity=31.6793893129771, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI5032093, Length=262, Percent_Identity=31.6793893129771, Blast_Score=91, Evalue=3e-18,
Organism=Homo sapiens, GI40254478, Length=253, Percent_Identity=28.8537549407115, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI169790839, Length=277, Percent_Identity=27.0758122743682, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI4827012, Length=270, Percent_Identity=25.9259259259259, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI66773030, Length=247, Percent_Identity=27.5303643724696, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI194239697, Length=275, Percent_Identity=25.0909090909091, Blast_Score=77, Evalue=4e-14,
Organism=Homo sapiens, GI262359914, Length=200, Percent_Identity=29.5, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI1790514, Length=423, Percent_Identity=26.241134751773, Blast_Score=112, Evalue=4e-26,
Organism=Escherichia coli, GI1789947, Length=408, Percent_Identity=26.2254901960784, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI1788024, Length=417, Percent_Identity=28.0575539568345, Blast_Score=77, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI71983106, Length=401, Percent_Identity=23.1920199501247, Blast_Score=95, Evalue=6e-20,
Organism=Caenorhabditis elegans, GI71983099, Length=401, Percent_Identity=23.1920199501247, Blast_Score=95, Evalue=8e-20,
Organism=Caenorhabditis elegans, GI193206505, Length=408, Percent_Identity=25.4901960784314, Blast_Score=94, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI71996953, Length=464, Percent_Identity=24.1379310344828, Blast_Score=91, Evalue=8e-19,
Organism=Caenorhabditis elegans, GI17537407, Length=394, Percent_Identity=22.8426395939086, Blast_Score=85, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI193206654, Length=414, Percent_Identity=23.4299516908213, Blast_Score=76, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17541374, Length=402, Percent_Identity=22.8855721393035, Blast_Score=66, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24583025, Length=397, Percent_Identity=23.6775818639798, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI17137668, Length=397, Percent_Identity=23.6775818639798, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24583023, Length=397, Percent_Identity=23.6775818639798, Blast_Score=88, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 43320; Mature: 43320

Theoretical pI: Translated: 9.21; Mature: 9.21

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure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HCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-aspartate [Periplasm]; Proton [Periplasm]; L-glutamate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-aspartate [Periplasm] = Proton [Cytoplasm] + L-aspartate [Cytoplasm] Proton [Periplasm] + L-glutamate [Periplasm] = Proton [Cytoplasm] + L-glutamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377 [H]