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The map label for this gene is icd [H]

Identifier: 118578892

GI number: 118578892

Start: 475085

End: 476497

Strand: Direct

Name: icd [H]

Synonym: Ppro_0452

Alternate gene names: 118578892

Gene position: 475085-476497 (Clockwise)

Preceding gene: 118578891

Following gene: 118578895

Centisome position: 11.85

GC content: 63.27

Gene sequence:

>1413_bases
ATGAACTACACCTACCTCACGGTCCCGCAGGGAGAGAAGATCAGCATGGGGAGCGACGGCAAGCTTCGGGTCCCCGCCAA
CCCCATCATCCCGTTCATCGAGGGAGACGGCACCGGCCCCGACATCTGGCGGGCGGCGAAGAGGGTGTTGGACGCCGCCG
TTGCCAGGGCCTATGGCGGAGCACGGAAGATCAGCTGGATGGAGGTCTTTGCCGGCGAGAAGTCCTTCAACATGTTCAGG
GAGAGCATGGGAGACCGGGCCTGGCTGCCGGACGAGACCGTGGATGCCTACCGCGAGTTCCTGGTGGGCATCAAGGGGCC
CCTGACCACCCCCATCGGCGGCGGCATCCGCTCGCTGAACGTGGCTTTGCGCCAGCTTTTGGACCTGTACGTCTGCCTGC
GGCCGGTGCGCTACTTCCAGGGGGTGCCGTCGCCGGTGAAGAAACCCCAGGACGTGGACATGGTTATTTTCCGGGAGAAC
ACGGAGGACATCTACGCCGGTATCGAGTGGATGCAGGGCACAACCGAGTGCGAAAAACTCAAGAGATTCCTGCTGGAGGA
GATGAAGGTCACCAATATCCGCTTCCCGGGCAGCGTCTCCCTGGGGGTCAAGCCGATTTCAAAGGAGGGGTCCCAGCGCC
TGGTCAGGGCCGCCATCGATTATGCCCTGGAGCAGGGACGGCGCTCGGTCACCCTGGTGCACAAGGGGAACATCATGAAG
TACACCGAGGGGGCCTTCAAGGAGTGGGGCTACCAGGTGGCTACCGAACAGTTCCGCGACCGGGTGGTCACCGAACGGGA
GAGCTGGATCATCGCCAACCAGGACAAGAACCCCACCATGGCGCCGGAGGAGAACGCCCGGCTGATCGAACCGGGCTATG
ACCTGATGACGCCCAACCAGCGCCAAAGGATCGTTGACGAGGTGCAGGCCGCCCTGGGGCTGATGGCGACCCACGGCAAC
GGCCAGTGGAAGAAACTCCTGCTTATCAAAGACTCCATCGCCGATATCGCCCTGCAGCAGGTACTGACCCGCGCCAAAGA
GTTCGACGTCATCGCCACCATGAATCTGGAGGGGGACTTCCTCTCCGACGCCCTGGCAGCCCAGGTGGGCGGCATCGGCA
TCGCTCCGGGTGCCAACATCAACTACCTGACCGGCCACGCCATCTTCGAGGCCACCCACGGCACGGCGCCCAAGTACGCC
AACCAGGACAAGGTCAACCCCGGTTCGGTGATCCTCTCCGGCGTGATGATGCTGGAGTACCTGGGATGGCGGGAGGCTGC
CGACCTGGTCATCGCCGCCATCGACAGGACCATCTCCCAGAAGAAGGTCACCTACGACTTCGAGCGTCTGATGGAGGGGG
CCACCCTGGTGAGCTGCTCCGGCTTCGCCGACGCTCTGATCGGGAATATGTGA

Upstream 100 bases:

>100_bases
CGCCCAATTCACTGTATGAAGAGGCCATTTTTGAGGCGCTCCAGGCTGTTCGCTGCACGGCTTGGTAAACCCGATTCAGA
TCCAACAGAAAGGATGTGGC

Downstream 100 bases:

>100_bases
CCGTATTTCCAAGGCAGGTGAGAATACACACAAACAGGCCGGGACTGCCCCGGCCTGTTTGTGTGTGCTGCGCGTACGGC
GTCTCAGGTCACCAGCCCCC

Product: isocitrate dehydrogenase, NADP-dependent

Products: NA

Alternate protein names: IDH; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase [H]

Number of amino acids: Translated: 470; Mature: 470

Protein sequence:

>470_residues
MNYTYLTVPQGEKISMGSDGKLRVPANPIIPFIEGDGTGPDIWRAAKRVLDAAVARAYGGARKISWMEVFAGEKSFNMFR
ESMGDRAWLPDETVDAYREFLVGIKGPLTTPIGGGIRSLNVALRQLLDLYVCLRPVRYFQGVPSPVKKPQDVDMVIFREN
TEDIYAGIEWMQGTTECEKLKRFLLEEMKVTNIRFPGSVSLGVKPISKEGSQRLVRAAIDYALEQGRRSVTLVHKGNIMK
YTEGAFKEWGYQVATEQFRDRVVTERESWIIANQDKNPTMAPEENARLIEPGYDLMTPNQRQRIVDEVQAALGLMATHGN
GQWKKLLLIKDSIADIALQQVLTRAKEFDVIATMNLEGDFLSDALAAQVGGIGIAPGANINYLTGHAIFEATHGTAPKYA
NQDKVNPGSVILSGVMMLEYLGWREAADLVIAAIDRTISQKKVTYDFERLMEGATLVSCSGFADALIGNM

Sequences:

>Translated_470_residues
MNYTYLTVPQGEKISMGSDGKLRVPANPIIPFIEGDGTGPDIWRAAKRVLDAAVARAYGGARKISWMEVFAGEKSFNMFR
ESMGDRAWLPDETVDAYREFLVGIKGPLTTPIGGGIRSLNVALRQLLDLYVCLRPVRYFQGVPSPVKKPQDVDMVIFREN
TEDIYAGIEWMQGTTECEKLKRFLLEEMKVTNIRFPGSVSLGVKPISKEGSQRLVRAAIDYALEQGRRSVTLVHKGNIMK
YTEGAFKEWGYQVATEQFRDRVVTERESWIIANQDKNPTMAPEENARLIEPGYDLMTPNQRQRIVDEVQAALGLMATHGN
GQWKKLLLIKDSIADIALQQVLTRAKEFDVIATMNLEGDFLSDALAAQVGGIGIAPGANINYLTGHAIFEATHGTAPKYA
NQDKVNPGSVILSGVMMLEYLGWREAADLVIAAIDRTISQKKVTYDFERLMEGATLVSCSGFADALIGNM
>Mature_470_residues
MNYTYLTVPQGEKISMGSDGKLRVPANPIIPFIEGDGTGPDIWRAAKRVLDAAVARAYGGARKISWMEVFAGEKSFNMFR
ESMGDRAWLPDETVDAYREFLVGIKGPLTTPIGGGIRSLNVALRQLLDLYVCLRPVRYFQGVPSPVKKPQDVDMVIFREN
TEDIYAGIEWMQGTTECEKLKRFLLEEMKVTNIRFPGSVSLGVKPISKEGSQRLVRAAIDYALEQGRRSVTLVHKGNIMK
YTEGAFKEWGYQVATEQFRDRVVTERESWIIANQDKNPTMAPEENARLIEPGYDLMTPNQRQRIVDEVQAALGLMATHGN
GQWKKLLLIKDSIADIALQQVLTRAKEFDVIATMNLEGDFLSDALAAQVGGIGIAPGANINYLTGHAIFEATHGTAPKYA
NQDKVNPGSVILSGVMMLEYLGWREAADLVIAAIDRTISQKKVTYDFERLMEGATLVSCSGFADALIGNM

Specific function: Unknown

COG id: COG0538

COG function: function code C; Isocitrate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate and isopropylmalate dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI5031777, Length=231, Percent_Identity=30.7359307359307, Blast_Score=103, Evalue=4e-22,
Organism=Homo sapiens, GI28178821, Length=296, Percent_Identity=27.027027027027, Blast_Score=90, Evalue=3e-18,
Organism=Homo sapiens, GI28178816, Length=296, Percent_Identity=27.027027027027, Blast_Score=90, Evalue=4e-18,
Organism=Homo sapiens, GI4758582, Length=294, Percent_Identity=27.891156462585, Blast_Score=74, Evalue=4e-13,
Organism=Homo sapiens, GI28178838, Length=294, Percent_Identity=27.891156462585, Blast_Score=73, Evalue=5e-13,
Organism=Escherichia coli, GI1787381, Length=466, Percent_Identity=56.6523605150215, Blast_Score=508, Evalue=1e-145,
Organism=Escherichia coli, GI1788101, Length=120, Percent_Identity=37.5, Blast_Score=79, Evalue=9e-16,
Organism=Escherichia coli, GI87081683, Length=131, Percent_Identity=35.1145038167939, Blast_Score=66, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI71986051, Length=219, Percent_Identity=33.3333333333333, Blast_Score=103, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI25144293, Length=417, Percent_Identity=23.2613908872902, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17505779, Length=345, Percent_Identity=24.6376811594203, Blast_Score=72, Evalue=6e-13,
Organism=Saccharomyces cerevisiae, GI6324709, Length=442, Percent_Identity=27.8280542986425, Blast_Score=139, Evalue=8e-34,
Organism=Saccharomyces cerevisiae, GI6324291, Length=293, Percent_Identity=26.6211604095563, Blast_Score=87, Evalue=5e-18,
Organism=Saccharomyces cerevisiae, GI6322097, Length=231, Percent_Identity=31.1688311688312, Blast_Score=86, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24643270, Length=217, Percent_Identity=33.1797235023041, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24643268, Length=217, Percent_Identity=33.1797235023041, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24661184, Length=131, Percent_Identity=38.9312977099237, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI281362242, Length=287, Percent_Identity=28.5714285714286, Blast_Score=81, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24648872, Length=287, Percent_Identity=28.5714285714286, Blast_Score=81, Evalue=2e-15,
Organism=Drosophila melanogaster, GI161078637, Length=167, Percent_Identity=31.1377245508982, Blast_Score=75, Evalue=9e-14,
Organism=Drosophila melanogaster, GI161078639, Length=167, Percent_Identity=31.1377245508982, Blast_Score=75, Evalue=9e-14,
Organism=Drosophila melanogaster, GI161078635, Length=167, Percent_Identity=31.1377245508982, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI161078633, Length=167, Percent_Identity=31.1377245508982, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24650122, Length=167, Percent_Identity=31.1377245508982, Blast_Score=75, Evalue=1e-13,

Paralogues:

None

Copy number: 8180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019818
- InterPro:   IPR001804
- InterPro:   IPR004439 [H]

Pfam domain/function: PF00180 Iso_dh [H]

EC number: =1.1.1.42 [H]

Molecular weight: Translated: 52096; Mature: 52096

Theoretical pI: Translated: 5.88; Mature: 5.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNYTYLTVPQGEKISMGSDGKLRVPANPIIPFIEGDGTGPDIWRAAKRVLDAAVARAYGG
CCCEEEECCCCCEECCCCCCEEECCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHCC
ARKISWMEVFAGEKSFNMFRESMGDRAWLPDETVDAYREFLVGIKGPLTTPIGGGIRSLN
CCCCHHHHHHCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHH
VALRQLLDLYVCLRPVRYFQGVPSPVKKPQDVDMVIFRENTEDIYAGIEWMQGTTECEKL
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHCCCHHHHHH
KRFLLEEMKVTNIRFPGSVSLGVKPISKEGSQRLVRAAIDYALEQGRRSVTLVHKGNIMK
HHHHHHHHHHHEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCEEE
YTEGAFKEWGYQVATEQFRDRVVTERESWIIANQDKNPTMAPEENARLIEPGYDLMTPNQ
ECCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCEEECCCCCCCCCCH
RQRIVDEVQAALGLMATHGNGQWKKLLLIKDSIADIALQQVLTRAKEFDVIATMNLEGDF
HHHHHHHHHHHHHHEEECCCCCEEEEEEEHHHHHHHHHHHHHHHHHHCCEEEEEECCCCH
LSDALAAQVGGIGIAPGANINYLTGHAIFEATHGTAPKYANQDKVNPGSVILSGVMMLEY
HHHHHHHHHCCEEECCCCCCEEEECCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHH
LGWREAADLVIAAIDRTISQKKVTYDFERLMEGATLVSCSGFADALIGNM
HCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHCCC
>Mature Secondary Structure
MNYTYLTVPQGEKISMGSDGKLRVPANPIIPFIEGDGTGPDIWRAAKRVLDAAVARAYGG
CCCEEEECCCCCEECCCCCCEEECCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHCC
ARKISWMEVFAGEKSFNMFRESMGDRAWLPDETVDAYREFLVGIKGPLTTPIGGGIRSLN
CCCCHHHHHHCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHH
VALRQLLDLYVCLRPVRYFQGVPSPVKKPQDVDMVIFRENTEDIYAGIEWMQGTTECEKL
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHCCCHHHHHH
KRFLLEEMKVTNIRFPGSVSLGVKPISKEGSQRLVRAAIDYALEQGRRSVTLVHKGNIMK
HHHHHHHHHHHEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCEEE
YTEGAFKEWGYQVATEQFRDRVVTERESWIIANQDKNPTMAPEENARLIEPGYDLMTPNQ
ECCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCEEECCCCCCCCCCH
RQRIVDEVQAALGLMATHGNGQWKKLLLIKDSIADIALQQVLTRAKEFDVIATMNLEGDF
HHHHHHHHHHHHHHEEECCCCCEEEEEEEHHHHHHHHHHHHHHHHHHCCEEEEEECCCCH
LSDALAAQVGGIGIAPGANINYLTGHAIFEATHGTAPKYANQDKVNPGSVILSGVMMLEY
HHHHHHHHHCCEEECCCCCCEEEECCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHH
LGWREAADLVIAAIDRTISQKKVTYDFERLMEGATLVSCSGFADALIGNM
HCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8045898; 9387221; 9384377; 11751849; 11290745 [H]