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The map label for this gene is kinA [H]

Identifier: 118578878

GI number: 118578878

Start: 457770

End: 459008

Strand: Direct

Name: kinA [H]

Synonym: Ppro_0437

Alternate gene names: 118578878

Gene position: 457770-459008 (Clockwise)

Preceding gene: 118578877

Following gene: 118578879

Centisome position: 11.42

GC content: 60.29

Gene sequence:

>1239_bases
ATGCGCCGTACTGAGCGGCCATGGCTCCCCATGGACCAGATCATGTCTCCCGAAACCAAAGCAGCCATCGTTGTCATTGA
TGGCGATGGCACTGCTGGCGAGAGGATTGCAGCGATCCTCTCGCGCCAGCGCTATCGCGTGTACGTCGCCGGATCCGTCA
CTGAGGGGATCGGGCTGATCGGCGATAGCAGGGCTGAGCTTGCCCTGATCGATTGCCAGGCCGTCGACGCCGAGTTGTGC
ACGGTTCTGGGGGAGATCGGATCTCGTTTCCCCTCCACCTACCTGATCGTTTCCTCCCCCCGATGCCAGCTGAAGAGAGC
GGCCCAGCTGGCAGGGGAGTTGAGCGTGGAGTGGTTCTCCAAGCCGATCACCAGCGCTGATCTTATTGGGCGCCTGGACT
CATTACTGCGTATCCGTGAGCTGGAATTGGGCAACAGGAGGCTCCAACTCGAACAGGAGCTGCTGCTGCTCCAGCTGGAA
ACCTGCCAGCAGGACTTCCACCAGCTGATCAGGGAAAAGACCGAGTCGCTGCAGAAGGCTCATTCCGAGATTGCCCAGAC
TGAAAAGCTGGCCGCCATGGGGTACCTGGCCGCCGGTATGGCCCACGATATCCGCAACCCGCTCAATTCCATATCGCTCT
TCACCCAGCTCATGCGCCAGAACAGCATCGACCCGGATCAGGAAGAATACTTGGGCAAGATCATCAAGGAGATTGAGAGA
ATCGATGCCATCATCCGCAAGCTGCTGAATATGTCCTCGCGTTCGCGTAACGTTACGTCGGATGTGCGCATCGATCGGGT
CATCGATACCGCCCTGGAGGTCTTCGCCCCGCAGATCGAGACCGGAAAAATCCGTCTGGAGCGACGCTATGAGCTGACTC
CACCCCCCATCAAGGCGGATGCGGCCGAACTGGAGCAAGTATTCACCAACCTGTTCCTGAACGCCCTGGACGAGATGCCC
GGTGGCGGGCGCCTGGGAGTTGGCATCGCCGTGGAAGAGGATATGGTTGTGGTCAGGGTTGAGGATAGCGGCAAGGGCAT
ACCTGAGCATGCCCTGCCCAGGATCTTCGACCCGTTTTTTACCACCAAGCCCCGCGGTACCGGCGTTGGACTGCCGGTGG
TCAAGCGCATCGCCCGCCTGTGCGGCGGGAGCGTCAGGGTTGAGCGCTCCAGTCGGGAGGGGACCGTTGTCCGGCTGGAA
TTTCCGGTATGCAGGGAGGAGGCGCTTCGTTCAAGCTGA

Upstream 100 bases:

>100_bases
GACCGTATCATTTTCGGCAGTACCGCAGCACGTGTCGTACGCAGTTCTCCCCATCCTGTGCTCAGTATCCGCCTGCCGGC
GGAATCCAGCTAGCCCGACC

Downstream 100 bases:

>100_bases
TTCCCCTTTCCCGTGGTTTTCCTCATCTGGCCGCTTTCCCACCCTTCCGCGTATCCCTGCCCTCGGTGCTCTCCGTTGTC
CCTGATGGCGGTTTTGCGCC

Product: response regulator receiver sensor signal transduction histidine kinase

Products: NA

Alternate protein names: Stage II sporulation protein F; Stage II sporulation protein J [H]

Number of amino acids: Translated: 412; Mature: 412

Protein sequence:

>412_residues
MRRTERPWLPMDQIMSPETKAAIVVIDGDGTAGERIAAILSRQRYRVYVAGSVTEGIGLIGDSRAELALIDCQAVDAELC
TVLGEIGSRFPSTYLIVSSPRCQLKRAAQLAGELSVEWFSKPITSADLIGRLDSLLRIRELELGNRRLQLEQELLLLQLE
TCQQDFHQLIREKTESLQKAHSEIAQTEKLAAMGYLAAGMAHDIRNPLNSISLFTQLMRQNSIDPDQEEYLGKIIKEIER
IDAIIRKLLNMSSRSRNVTSDVRIDRVIDTALEVFAPQIETGKIRLERRYELTPPPIKADAAELEQVFTNLFLNALDEMP
GGGRLGVGIAVEEDMVVVRVEDSGKGIPEHALPRIFDPFFTTKPRGTGVGLPVVKRIARLCGGSVRVERSSREGTVVRLE
FPVCREEALRSS

Sequences:

>Translated_412_residues
MRRTERPWLPMDQIMSPETKAAIVVIDGDGTAGERIAAILSRQRYRVYVAGSVTEGIGLIGDSRAELALIDCQAVDAELC
TVLGEIGSRFPSTYLIVSSPRCQLKRAAQLAGELSVEWFSKPITSADLIGRLDSLLRIRELELGNRRLQLEQELLLLQLE
TCQQDFHQLIREKTESLQKAHSEIAQTEKLAAMGYLAAGMAHDIRNPLNSISLFTQLMRQNSIDPDQEEYLGKIIKEIER
IDAIIRKLLNMSSRSRNVTSDVRIDRVIDTALEVFAPQIETGKIRLERRYELTPPPIKADAAELEQVFTNLFLNALDEMP
GGGRLGVGIAVEEDMVVVRVEDSGKGIPEHALPRIFDPFFTTKPRGTGVGLPVVKRIARLCGGSVRVERSSREGTVVRLE
FPVCREEALRSS
>Mature_412_residues
MRRTERPWLPMDQIMSPETKAAIVVIDGDGTAGERIAAILSRQRYRVYVAGSVTEGIGLIGDSRAELALIDCQAVDAELC
TVLGEIGSRFPSTYLIVSSPRCQLKRAAQLAGELSVEWFSKPITSADLIGRLDSLLRIRELELGNRRLQLEQELLLLQLE
TCQQDFHQLIREKTESLQKAHSEIAQTEKLAAMGYLAAGMAHDIRNPLNSISLFTQLMRQNSIDPDQEEYLGKIIKEIER
IDAIIRKLLNMSSRSRNVTSDVRIDRVIDTALEVFAPQIETGKIRLERRYELTPPPIKADAAELEQVFTNLFLNALDEMP
GGGRLGVGIAVEEDMVVVRVEDSGKGIPEHALPRIFDPFFTTKPRGTGVGLPVVKRIARLCGGSVRVERSSREGTVVRLE
FPVCREEALRSS

Specific function: Phosphorylates the sporulation-regulatory proteins spo0A and spo0F. It also autophosphorylates in the presence of ATP [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 3 PAS (PER-ARNT-SIM) domains [H]

Homologues:

Organism=Escherichia coli, GI1790436, Length=234, Percent_Identity=33.7606837606838, Blast_Score=131, Evalue=8e-32,
Organism=Escherichia coli, GI1788549, Length=221, Percent_Identity=33.0316742081448, Blast_Score=130, Evalue=2e-31,
Organism=Escherichia coli, GI1790861, Length=208, Percent_Identity=28.3653846153846, Blast_Score=82, Evalue=9e-17,
Organism=Escherichia coli, GI1790346, Length=219, Percent_Identity=27.3972602739726, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1790300, Length=237, Percent_Identity=27.4261603375527, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI48994928, Length=221, Percent_Identity=27.6018099547511, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI87081816, Length=286, Percent_Identity=29.020979020979, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1789808, Length=218, Percent_Identity=29.3577981651376, Blast_Score=68, Evalue=8e-13,
Organism=Escherichia coli, GI1789149, Length=218, Percent_Identity=24.7706422018349, Blast_Score=65, Evalue=7e-12,
Organism=Escherichia coli, GI1786783, Length=217, Percent_Identity=27.6497695852535, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI145693157, Length=254, Percent_Identity=24.4094488188976, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR001610
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR013655
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS; PF08447 PAS_3 [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 45898; Mature: 45898

Theoretical pI: Translated: 5.63; Mature: 5.63

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRTERPWLPMDQIMSPETKAAIVVIDGDGTAGERIAAILSRQRYRVYVAGSVTEGIGLI
CCCCCCCCCCHHHHCCCCCCEEEEEEECCCCCHHHHHHHHCCCCEEEEEEECHHCCCCCC
GDSRAELALIDCQAVDAELCTVLGEIGSRFPSTYLIVSSPRCQLKRAAQLAGELSVEWFS
CCCCCCEEEEEHHHHHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHHCCHHHHH
KPITSADLIGRLDSLLRIRELELGNRRLQLEQELLLLQLETCQQDFHQLIREKTESLQKA
CCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HSEIAQTEKLAAMGYLAAGMAHDIRNPLNSISLFTQLMRQNSIDPDQEEYLGKIIKEIER
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
IDAIIRKLLNMSSRSRNVTSDVRIDRVIDTALEVFAPQIETGKIRLERRYELTPPPIKAD
HHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCCCC
AAELEQVFTNLFLNALDEMPGGGRLGVGIAVEEDMVVVRVEDSGKGIPEHALPRIFDPFF
HHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEECCEEEEEECCCCCCCCHHHHHHHHCHHH
TTKPRGTGVGLPVVKRIARLCGGSVRVERSSREGTVVRLEFPVCREEALRSS
CCCCCCCCCCCHHHHHHHHHCCCCEEEEECCCCCCEEEEECCHHHHHHHCCC
>Mature Secondary Structure
MRRTERPWLPMDQIMSPETKAAIVVIDGDGTAGERIAAILSRQRYRVYVAGSVTEGIGLI
CCCCCCCCCCHHHHCCCCCCEEEEEEECCCCCHHHHHHHHCCCCEEEEEEECHHCCCCCC
GDSRAELALIDCQAVDAELCTVLGEIGSRFPSTYLIVSSPRCQLKRAAQLAGELSVEWFS
CCCCCCEEEEEHHHHHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHHCCHHHHH
KPITSADLIGRLDSLLRIRELELGNRRLQLEQELLLLQLETCQQDFHQLIREKTESLQKA
CCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HSEIAQTEKLAAMGYLAAGMAHDIRNPLNSISLFTQLMRQNSIDPDQEEYLGKIIKEIER
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
IDAIIRKLLNMSSRSRNVTSDVRIDRVIDTALEVFAPQIETGKIRLERRYELTPPPIKAD
HHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCCCC
AAELEQVFTNLFLNALDEMPGGGRLGVGIAVEEDMVVVRVEDSGKGIPEHALPRIFDPFF
HHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEECCEEEEEECCCCCCCCHHHHHHHHCHHH
TTKPRGTGVGLPVVKRIARLCGGSVRVERSSREGTVVRLEFPVCREEALRSS
CCCCCCCCCCCHHHHHHHHHCCCCEEEEECCCCCCEEEEECCHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2104615; 2509430; 9384377 [H]