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The map label for this gene is ung [H]

Identifier: 118578668

GI number: 118578668

Start: 218706

End: 219341

Strand: Direct

Name: ung [H]

Synonym: Ppro_0224

Alternate gene names: 118578668

Gene position: 218706-219341 (Clockwise)

Preceding gene: 118578667

Following gene: 118578669

Centisome position: 5.46

GC content: 49.21

Gene sequence:

>636_bases
ATGAAGAGATGGTTACAGGAAGTCCCAGAACTTGCATCTCATCCGGTACTTGCAAAGGTGTATTCGGCACGTAAGAAAAG
CGTCATCTATCCAGCACCTGAAAAAGTTTATTGTGCGTTGCAACTTACTGACTTTGATCGAGTGAGGGTGGTACTCTTCG
GACAGGACCCATACCATGGAGCAGGGCAAGCACAAGGACTTGCTTTCTCGGTTCCCGATGGGCTGAAGGTGCCTCCTTCG
CTGCGTAACATCCACAAAGAACTCGACAGGGATCTTGGTGTGACTTGCAACAGATCAAGCGATTTGTCCCACTGGGCAAA
GCAAGGGGTGTTATTATTGAATACTGTTCTGACGGTGGAGGCAGGCAAGGCCAGAAGCCATCAAGGATGGGGTTGGGAAG
AAGTTACTGATGCAATTATTCGTTCCTTGAATGTCCGCCGGGAGCATTTGGTCTTTCTCCTCTGGGGGAATGATGCGAAG
AAGAAAATTTCCCTCATCGATATTGGGCGACACACCGTACTTTCTACTTCACATCCCTCCGGTTTTTCTGCTTACCGAGG
ATTCTTCGGCTGCGGACATTTCTCTCAAGTGAATAAGACACTCGTCGGTTTGGGGCAAGAGCCGATTTGCTGGTAG

Upstream 100 bases:

>100_bases
CGTTTGTACCTGCTGTTCAAAATCTTATTGGAAAGATAATTGAACAGTTACCAGTACTTAACGCTAACAAGCCAAATTCA
TAAGATAATCAGGAAATATT

Downstream 100 bases:

>100_bases
CATAAACTCAAAAATTTGATGGTGAAAACAGCATCGAATTACGTGTTGACCTTATCGTGCGGTAAGGGTTGTCGTCCACC
GACTTGACCTTGCAGGTAAT

Product: uracil-DNA glycosylase

Products: NA

Alternate protein names: UDG [H]

Number of amino acids: Translated: 211; Mature: 211

Protein sequence:

>211_residues
MKRWLQEVPELASHPVLAKVYSARKKSVIYPAPEKVYCALQLTDFDRVRVVLFGQDPYHGAGQAQGLAFSVPDGLKVPPS
LRNIHKELDRDLGVTCNRSSDLSHWAKQGVLLLNTVLTVEAGKARSHQGWGWEEVTDAIIRSLNVRREHLVFLLWGNDAK
KKISLIDIGRHTVLSTSHPSGFSAYRGFFGCGHFSQVNKTLVGLGQEPICW

Sequences:

>Translated_211_residues
MKRWLQEVPELASHPVLAKVYSARKKSVIYPAPEKVYCALQLTDFDRVRVVLFGQDPYHGAGQAQGLAFSVPDGLKVPPS
LRNIHKELDRDLGVTCNRSSDLSHWAKQGVLLLNTVLTVEAGKARSHQGWGWEEVTDAIIRSLNVRREHLVFLLWGNDAK
KKISLIDIGRHTVLSTSHPSGFSAYRGFFGCGHFSQVNKTLVGLGQEPICW
>Mature_211_residues
MKRWLQEVPELASHPVLAKVYSARKKSVIYPAPEKVYCALQLTDFDRVRVVLFGQDPYHGAGQAQGLAFSVPDGLKVPPS
LRNIHKELDRDLGVTCNRSSDLSHWAKQGVLLLNTVLTVEAGKARSHQGWGWEEVTDAIIRSLNVRREHLVFLLWGNDAK
KKISLIDIGRHTVLSTSHPSGFSAYRGFFGCGHFSQVNKTLVGLGQEPICW

Specific function: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine [H]

COG id: COG0692

COG function: function code L; Uracil DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uracil-DNA glycosylase family [H]

Homologues:

Organism=Homo sapiens, GI19718751, Length=197, Percent_Identity=52.2842639593909, Blast_Score=199, Evalue=2e-51,
Organism=Homo sapiens, GI6224979, Length=197, Percent_Identity=52.2842639593909, Blast_Score=197, Evalue=5e-51,
Organism=Escherichia coli, GI1788934, Length=198, Percent_Identity=52.5252525252525, Blast_Score=200, Evalue=7e-53,
Organism=Caenorhabditis elegans, GI17556304, Length=185, Percent_Identity=45.945945945946, Blast_Score=168, Evalue=2e-42,
Organism=Saccharomyces cerevisiae, GI6323620, Length=201, Percent_Identity=44.2786069651741, Blast_Score=158, Evalue=7e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002043
- InterPro:   IPR018085
- InterPro:   IPR005122 [H]

Pfam domain/function: PF03167 UDG [H]

EC number: =3.2.2.27 [H]

Molecular weight: Translated: 23553; Mature: 23553

Theoretical pI: Translated: 9.68; Mature: 9.68

Prosite motif: PS00130 U_DNA_GLYCOSYLASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRWLQEVPELASHPVLAKVYSARKKSVIYPAPEKVYCALQLTDFDRVRVVLFGQDPYHG
CCHHHHHHHHHHCCCHHHHHHHHHHCCEECCCCCCEEEEEEECCCCCEEEEEEECCCCCC
AGQAQGLAFSVPDGLKVPPSLRNIHKELDRDLGVTCNRSSDLSHWAKQGVLLLNTVLTVE
CCCCCCEEEECCCCCCCCHHHHHHHHHHHHHCCCEECCCCCHHHHHHCCEEEEEEEEEEE
AGKARSHQGWGWEEVTDAIIRSLNVRREHLVFLLWGNDAKKKISLIDIGRHTVLSTSHPS
CCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEEEECCCCCCEEEEEECCCCEEEECCCCC
GFSAYRGFFGCGHFSQVNKTLVGLGQEPICW
CHHHHHHHHCCCCHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MKRWLQEVPELASHPVLAKVYSARKKSVIYPAPEKVYCALQLTDFDRVRVVLFGQDPYHG
CCHHHHHHHHHHCCCHHHHHHHHHHCCEECCCCCCEEEEEEECCCCCEEEEEEECCCCCC
AGQAQGLAFSVPDGLKVPPSLRNIHKELDRDLGVTCNRSSDLSHWAKQGVLLLNTVLTVE
CCCCCCEEEECCCCCCCCHHHHHHHHHHHHHCCCEECCCCCHHHHHHCCEEEEEEEEEEE
AGKARSHQGWGWEEVTDAIIRSLNVRREHLVFLLWGNDAKKKISLIDIGRHTVLSTSHPS
CCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEEEECCCCCCEEEEEECCCCEEEECCCCC
GFSAYRGFFGCGHFSQVNKTLVGLGQEPICW
CHHHHHHHHCCCCHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA