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The map label for this gene is tlpA [C]

Identifier: 118480125

GI number: 118480125

Start: 4813560

End: 4815251

Strand: Direct

Name: tlpA [C]

Synonym: BALH_4576

Alternate gene names: 118480125

Gene position: 4813560-4815251 (Clockwise)

Preceding gene: 118480124

Following gene: 118480126

Centisome position: 91.56

GC content: 36.58

Gene sequence:

>1692_bases
ATGAGTTTTATTAGCATTCGAAAAAAACTAATGTTCATGATGGGAACGATTTGCGCTTTATTTGGCATCGCCTTAGCTTT
TATTTTATTTTTTGCCATTGATCAATCTCGTCAAGCTGAAGCATTACAAAAAGAGATTTCTCCCCTTGCAACACAATTAA
AAGAGCGCGGGGATGCTTATCAAGTACAGCTCTCTGCCTTAAGAGGGTACTTATTACAACATGATCAAGTTGAATTTGAC
AAGTTTAATTCGATGAGTAAAGAGCTTGAAGATGCAAAAGATAAGCTTCTTTCTAATCCAAATGTTTCTGAGTCCATGAA
AAATACAATGGAATCAGGATCAACTTGGAGAAAATATATTGAAGAAAAAGTTTTCCCTCTTGCAAAAGAACAAAAGTGGG
ACGAGGCCCTGCAAGTAGCTTATGCAGAAAATGGTACTGTTTATAAAGTAATTGGTGACTTTACAAATTACAGTAATGAA
CAAGCTAAGTTACGTGATCAATCTATTAAAAAAATTGATCAATCTTCACTACAAATTGAATATGTTGTTTTCTTATCACT
TGTTATTTGTATTATTGTAGCTATGATTCTTGCATGGTGGTTCTCTGGTAAACTTGTAAAACCAATTCAACAAATTGATA
GTAAACTAAAAGAATTATCATCTCAAGAAGGTGACTTAACAGCCCGCCTACAAGTAAACAGTAATGATGAAATTGGTACG
ATCGCAACATCATTTAATAAAATGTTAGAAAACCTACAACATATCATTAACCGTGTTCAAAAAACATCTGTAGAAGTACA
AAACGCTTCAGAAAATATGCTAGAAAAGACGAATATATCACGCGAGGCAACGATAAAAGTTCAAAGCTCGATGTCCAATT
TAAATGAAAGTATTCAATCGCAAGCCTCTAGCATGGAAGAAAGCTCAACTGCAATGGACGATATGGCAGTAAGTGTTCAG
CGCATTGCTGAATCTGCTTCATCTGTAACTGAACTTGCTGTAGCTACATCTGAACAAGCTAACGATGGAAGTTCGGTTAT
TCAAAAATCCGTTTCACAAATGACAACGATACACGACGCTGTAAATGCTACGTCAGAAGTGGTCGAACGTCTAATCACTC
ACACGAAATACATTGATACAGCTGTACAATCTATTTCTAATATCGCGGAACAAACAAACTTACTTGCTTTAAATGCATCT
ATCGAAGCAGCTCGTGCTGGCGAACAAGGAAAAGGCTTCGCTGTCGTAGCTGACGAAGTTAGAAAACTTGCTGAACAATC
TAAAACTGCTGCAACAGATATTAACCAATTACTACATCAAATTCAACAAGACACTGAAACTGCGAGCTCTATGATGTCAC
AAGGGCGTTCTGAAGCATTTGAAGGCATTCATGTCATTCGTGAAGCTGGCAATTCTTTCACAACAATTGTGGAGCAAGTA
AATAAAGTATCTACTCAAATGCAAGACATCTCAGCAACTGCTGAAGAAATGGCTGCAAGTGCTGAAGAAATGAACGCTTC
ACTGAATAACATCGCTTCTATTTCGACTGAAGTATCTAGTGAAACAGCGGCAACAGCACAATCTGCTGAGCAAAAAGTCA
TTACGATGAATGAGATGACACAAACAGCTAAACAAATGAAACAAACAGTTGAAGAATTAGATCAACTCGTATCACACTTC
AAAACTGAATAG

Upstream 100 bases:

>100_bases
GAAAGAAGAAAGCTTTATTCCAAATGGAGTAAAGCTTTCTTTCAATTTTTTACATTAATTAATTCTAATACTATGATTTC
ATAAAGGAGGCTTTTATCAT

Downstream 100 bases:

>100_bases
CCTTTAAAAAATATCCCTCTTCCAAAAGGGATATTTTTTTGAGCTCATTCCCTGCATATTATACACATTTCCGTTATAAT
GAGAATCGATATCATTAAAA

Product: methyl-accepting chemotaxis protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 563; Mature: 562

Protein sequence:

>563_residues
MSFISIRKKLMFMMGTICALFGIALAFILFFAIDQSRQAEALQKEISPLATQLKERGDAYQVQLSALRGYLLQHDQVEFD
KFNSMSKELEDAKDKLLSNPNVSESMKNTMESGSTWRKYIEEKVFPLAKEQKWDEALQVAYAENGTVYKVIGDFTNYSNE
QAKLRDQSIKKIDQSSLQIEYVVFLSLVICIIVAMILAWWFSGKLVKPIQQIDSKLKELSSQEGDLTARLQVNSNDEIGT
IATSFNKMLENLQHIINRVQKTSVEVQNASENMLEKTNISREATIKVQSSMSNLNESIQSQASSMEESSTAMDDMAVSVQ
RIAESASSVTELAVATSEQANDGSSVIQKSVSQMTTIHDAVNATSEVVERLITHTKYIDTAVQSISNIAEQTNLLALNAS
IEAARAGEQGKGFAVVADEVRKLAEQSKTAATDINQLLHQIQQDTETASSMMSQGRSEAFEGIHVIREAGNSFTTIVEQV
NKVSTQMQDISATAEEMAASAEEMNASLNNIASISTEVSSETAATAQSAEQKVITMNEMTQTAKQMKQTVEELDQLVSHF
KTE

Sequences:

>Translated_563_residues
MSFISIRKKLMFMMGTICALFGIALAFILFFAIDQSRQAEALQKEISPLATQLKERGDAYQVQLSALRGYLLQHDQVEFD
KFNSMSKELEDAKDKLLSNPNVSESMKNTMESGSTWRKYIEEKVFPLAKEQKWDEALQVAYAENGTVYKVIGDFTNYSNE
QAKLRDQSIKKIDQSSLQIEYVVFLSLVICIIVAMILAWWFSGKLVKPIQQIDSKLKELSSQEGDLTARLQVNSNDEIGT
IATSFNKMLENLQHIINRVQKTSVEVQNASENMLEKTNISREATIKVQSSMSNLNESIQSQASSMEESSTAMDDMAVSVQ
RIAESASSVTELAVATSEQANDGSSVIQKSVSQMTTIHDAVNATSEVVERLITHTKYIDTAVQSISNIAEQTNLLALNAS
IEAARAGEQGKGFAVVADEVRKLAEQSKTAATDINQLLHQIQQDTETASSMMSQGRSEAFEGIHVIREAGNSFTTIVEQV
NKVSTQMQDISATAEEMAASAEEMNASLNNIASISTEVSSETAATAQSAEQKVITMNEMTQTAKQMKQTVEELDQLVSHF
KTE
>Mature_562_residues
SFISIRKKLMFMMGTICALFGIALAFILFFAIDQSRQAEALQKEISPLATQLKERGDAYQVQLSALRGYLLQHDQVEFDK
FNSMSKELEDAKDKLLSNPNVSESMKNTMESGSTWRKYIEEKVFPLAKEQKWDEALQVAYAENGTVYKVIGDFTNYSNEQ
AKLRDQSIKKIDQSSLQIEYVVFLSLVICIIVAMILAWWFSGKLVKPIQQIDSKLKELSSQEGDLTARLQVNSNDEIGTI
ATSFNKMLENLQHIINRVQKTSVEVQNASENMLEKTNISREATIKVQSSMSNLNESIQSQASSMEESSTAMDDMAVSVQR
IAESASSVTELAVATSEQANDGSSVIQKSVSQMTTIHDAVNATSEVVERLITHTKYIDTAVQSISNIAEQTNLLALNASI
EAARAGEQGKGFAVVADEVRKLAEQSKTAATDINQLLHQIQQDTETASSMMSQGRSEAFEGIHVIREAGNSFTTIVEQVN
KVSTQMQDISATAEEMAASAEEMNASLNNIASISTEVSSETAATAQSAEQKVITMNEMTQTAKQMKQTVEELDQLVSHFK
TE

Specific function: Chemotactic-signal transducers respond to changes in the concentration of attractants and repellents in the environment, transduce a signal from the outside to the inside of the cell, and facilitate sensory adaptation through the variation of the level of

COG id: COG0840

COG function: function code NT; Methyl-accepting chemotaxis protein

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 methyl-accepting transducer domain [H]

Homologues:

Organism=Escherichia coli, GI2367378, Length=345, Percent_Identity=28.9855072463768, Blast_Score=135, Evalue=8e-33,
Organism=Escherichia coli, GI1787690, Length=432, Percent_Identity=25.9259259259259, Blast_Score=123, Evalue=4e-29,
Organism=Escherichia coli, GI1789453, Length=314, Percent_Identity=28.9808917197452, Blast_Score=118, Evalue=9e-28,
Organism=Escherichia coli, GI1788195, Length=299, Percent_Identity=28.7625418060201, Blast_Score=117, Evalue=2e-27,
Organism=Escherichia coli, GI1788194, Length=360, Percent_Identity=29.4444444444444, Blast_Score=114, Evalue=1e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004010
- InterPro:   IPR003122
- InterPro:   IPR004089
- InterPro:   IPR003660
- InterPro:   IPR022094 [H]

Pfam domain/function: PF02743 Cache_1; PF00672 HAMP; PF12332 McpA_N; PF00015 MCPsignal; PF02203 TarH [H]

EC number: NA

Molecular weight: Translated: 62203; Mature: 62072

Theoretical pI: Translated: 4.55; Mature: 4.55

Prosite motif: PS50885 HAMP ; PS50111 CHEMOTAXIS_TRANSDUC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFISIRKKLMFMMGTICALFGIALAFILFFAIDQSRQAEALQKEISPLATQLKERGDAY
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCHH
QVQLSALRGYLLQHDQVEFDKFNSMSKELEDAKDKLLSNPNVSESMKNTMESGSTWRKYI
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCHHHHHHH
EEKVFPLAKEQKWDEALQVAYAENGTVYKVIGDFTNYSNEQAKLRDQSIKKIDQSSLQIE
HHHHCCCHHHHHHHHHHHHHHCCCCCEEEEECCHHCCCCHHHHHHHHHHHHHHHHHHHHH
YVVFLSLVICIIVAMILAWWFSGKLVKPIQQIDSKLKELSSQEGDLTARLQVNSNDEIGT
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCHHH
IATSFNKMLENLQHIINRVQKTSVEVQNASENMLEKTNISREATIKVQSSMSNLNESIQS
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
QASSMEESSTAMDDMAVSVQRIAESASSVTELAVATSEQANDGSSVIQKSVSQMTTIHDA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
VNATSEVVERLITHTKYIDTAVQSISNIAEQTNLLALNASIEAARAGEQGKGFAVVADEV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEECCCHHHHHCCCCCCCEEHHHHHH
RKLAEQSKTAATDINQLLHQIQQDTETASSMMSQGRSEAFEGIHVIREAGNSFTTIVEQV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCHHHHHHHHH
NKVSTQMQDISATAEEMAASAEEMNASLNNIASISTEVSSETAATAQSAEQKVITMNEMT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QTAKQMKQTVEELDQLVSHFKTE
HHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SFISIRKKLMFMMGTICALFGIALAFILFFAIDQSRQAEALQKEISPLATQLKERGDAY
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCHH
QVQLSALRGYLLQHDQVEFDKFNSMSKELEDAKDKLLSNPNVSESMKNTMESGSTWRKYI
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCHHHHHHH
EEKVFPLAKEQKWDEALQVAYAENGTVYKVIGDFTNYSNEQAKLRDQSIKKIDQSSLQIE
HHHHCCCHHHHHHHHHHHHHHCCCCCEEEEECCHHCCCCHHHHHHHHHHHHHHHHHHHHH
YVVFLSLVICIIVAMILAWWFSGKLVKPIQQIDSKLKELSSQEGDLTARLQVNSNDEIGT
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCHHH
IATSFNKMLENLQHIINRVQKTSVEVQNASENMLEKTNISREATIKVQSSMSNLNESIQS
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
QASSMEESSTAMDDMAVSVQRIAESASSVTELAVATSEQANDGSSVIQKSVSQMTTIHDA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
VNATSEVVERLITHTKYIDTAVQSISNIAEQTNLLALNASIEAARAGEQGKGFAVVADEV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEECCCHHHHHCCCCCCCEEHHHHHH
RKLAEQSKTAATDINQLLHQIQQDTETASSMMSQGRSEAFEGIHVIREAGNSFTTIVEQV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCHHHHHHHHH
NKVSTQMQDISATAEEMAASAEEMNASLNNIASISTEVSSETAATAQSAEQKVITMNEMT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QTAKQMKQTVEELDQLVSHFKTE
HHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA