Click here to switch to the map view.

The map label for this gene is resE [H]

Identifier: 118480120

GI number: 118480120

Start: 4805811

End: 4807253

Strand: Direct

Name: resE [H]

Synonym: BALH_4571

Alternate gene names: 118480120

Gene position: 4805811-4807253 (Clockwise)

Preceding gene: 118480119

Following gene: 118480121

Centisome position: 91.42

GC content: 32.36

Gene sequence:

>1443_bases
TTGGCTACAAAATCGAATCGTAGCAAAGACAACATCACCAAAAATATTTTCATCAAAACCTTATTATTTTGTATTCTTTT
ATCACTTTGTCTTTATCAAATTATTTACTTCTTAGCTTCAGACTACGATAAAGAACGTTTTGCGAAAGAAAATGGACCGC
CTACTACAGAACAAGCGGATTCAGATAAACAAAACGCCCAAAGTAAAACGAATCAAAATAAAGCTGTAACACAGGGAGAC
ATGTTTAATTTTCAATCTTCTATTATAGATTATAACGCTCTCTCTACAGCTATCAATCATCTTTTGCAGCCTAGCCAAAC
TGCAAAAGCAAAAGAACATACTCAAAATATTTCGGGGAAAAATAGCGCTTCTGCTCCATCTACAGAAACGGAAAAGCAAG
TCGCTACTAATGATGCCTTACATAAACAAAATATAGCAAGTAAAGCAAATAGTGCACAAGATGATCCAAAATTAACAGAC
GCACTGCAGCAGTTAGCTCCACATATTGGCGCGACAATGCTTGCATTATCTTTGCTCGGATCTTTAATTTATGCAAAACT
AATTGCTAAACCTTTTCAATATATGAGTGATGCTTTAAAAGATATTATGAATCTTGATTTCTCAGATAAAAAGCTACTTA
ACAAAAATACTGATCAAACAGATTTTGATTTACAAGTAGCTGCTTCACAAGTACCAAATATAGTGAAAAATTTACATGCA
AGCAATCAAGATTTAAGAAATGAACTCAAAAAGGAGCAACAATTAGAACAATCTCGTAAAGAATTTATGTCTATGGTTTC
CCATGAATTAAAAACACCAATCGCAGCCGTTATGGGACAACTAGATGGTATGATTCACGGAATTGGAGCTTATAAAGATC
GAGATAAATATTTAAAACGTTCTTATGAAATGATGCAAGACATTAACATATTAACGGAAAAAATGTCGGAATTATCCAAA
ATACAAAACCCTCAATTTAAACCTGATTTAAAAGTTATCTCATTAACTAATATTATTGAGGATGTTATGAAGAAAGTAGA
TTATTTCGTATCAGTCAAGCAGTTAAATGTTCAATCTAACATTAAACAAGATGTACAAGTTTTAGCTGATCCTAAATTTA
TTCAAACTGCTATTTTTAACATTATTTCAAATGCAATTCATTATACAATTGACCATCAGCATGTATATATAAAGCTTTAT
GAAAAGCCAAACGGTTACGCATTAGAAGTTTTAAATACAGGTTCACAAATAGATGAAGATAAACTTGCCCATTTATTTGA
GCCATTCTATCGCGCAAACCCTGACAAACACGGCTTAGTACAAGGCAGTGGTCTTGGGTTATACATTGTAAAACAAATAC
TAGATAAACATCAATTTCCTTATGGGATACAAAACACGCCTCAAGGTGTAAAATGTTCTATCGTATTCCCAAAAGCAATG
TAA

Upstream 100 bases:

>100_bases
TGGGGCTATGAACATTATGGTGATGTAAGAGTTATAGATACACATATTAAAAACTTACGAAAAAAATTAGGAATTCCTTA
TATTAAAACGGTGAAAGGCA

Downstream 100 bases:

>100_bases
AAACCTACTACAATCTCATACCCCAAATTCATACTTCGTATGAGTGGCGGAATTTTGTAGAGTATATGACTCTGTTTCGT
TCGCCCGTTATCCTTATTTG

Product: sensor histidine kinase

Products: NA

Alternate protein names: Vancomycin B-type resistance protein vanSB; Vancomycin histidine protein kinase [H]

Number of amino acids: Translated: 480; Mature: 479

Protein sequence:

>480_residues
MATKSNRSKDNITKNIFIKTLLFCILLSLCLYQIIYFLASDYDKERFAKENGPPTTEQADSDKQNAQSKTNQNKAVTQGD
MFNFQSSIIDYNALSTAINHLLQPSQTAKAKEHTQNISGKNSASAPSTETEKQVATNDALHKQNIASKANSAQDDPKLTD
ALQQLAPHIGATMLALSLLGSLIYAKLIAKPFQYMSDALKDIMNLDFSDKKLLNKNTDQTDFDLQVAASQVPNIVKNLHA
SNQDLRNELKKEQQLEQSRKEFMSMVSHELKTPIAAVMGQLDGMIHGIGAYKDRDKYLKRSYEMMQDINILTEKMSELSK
IQNPQFKPDLKVISLTNIIEDVMKKVDYFVSVKQLNVQSNIKQDVQVLADPKFIQTAIFNIISNAIHYTIDHQHVYIKLY
EKPNGYALEVLNTGSQIDEDKLAHLFEPFYRANPDKHGLVQGSGLGLYIVKQILDKHQFPYGIQNTPQGVKCSIVFPKAM

Sequences:

>Translated_480_residues
MATKSNRSKDNITKNIFIKTLLFCILLSLCLYQIIYFLASDYDKERFAKENGPPTTEQADSDKQNAQSKTNQNKAVTQGD
MFNFQSSIIDYNALSTAINHLLQPSQTAKAKEHTQNISGKNSASAPSTETEKQVATNDALHKQNIASKANSAQDDPKLTD
ALQQLAPHIGATMLALSLLGSLIYAKLIAKPFQYMSDALKDIMNLDFSDKKLLNKNTDQTDFDLQVAASQVPNIVKNLHA
SNQDLRNELKKEQQLEQSRKEFMSMVSHELKTPIAAVMGQLDGMIHGIGAYKDRDKYLKRSYEMMQDINILTEKMSELSK
IQNPQFKPDLKVISLTNIIEDVMKKVDYFVSVKQLNVQSNIKQDVQVLADPKFIQTAIFNIISNAIHYTIDHQHVYIKLY
EKPNGYALEVLNTGSQIDEDKLAHLFEPFYRANPDKHGLVQGSGLGLYIVKQILDKHQFPYGIQNTPQGVKCSIVFPKAM
>Mature_479_residues
ATKSNRSKDNITKNIFIKTLLFCILLSLCLYQIIYFLASDYDKERFAKENGPPTTEQADSDKQNAQSKTNQNKAVTQGDM
FNFQSSIIDYNALSTAINHLLQPSQTAKAKEHTQNISGKNSASAPSTETEKQVATNDALHKQNIASKANSAQDDPKLTDA
LQQLAPHIGATMLALSLLGSLIYAKLIAKPFQYMSDALKDIMNLDFSDKKLLNKNTDQTDFDLQVAASQVPNIVKNLHAS
NQDLRNELKKEQQLEQSRKEFMSMVSHELKTPIAAVMGQLDGMIHGIGAYKDRDKYLKRSYEMMQDINILTEKMSELSKI
QNPQFKPDLKVISLTNIIEDVMKKVDYFVSVKQLNVQSNIKQDVQVLADPKFIQTAIFNIISNAIHYTIDHQHVYIKLYE
KPNGYALEVLNTGSQIDEDKLAHLFEPFYRANPDKHGLVQGSGLGLYIVKQILDKHQFPYGIQNTPQGVKCSIVFPKAM

Specific function: Member of the two-component regulatory system vanS/vanR. Activates the transcription of vanH, vanA and vanX in response to vancomycin which results in vancomycin resistance. VanS activates vanR by phosphorylation [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1786600, Length=230, Percent_Identity=28.695652173913, Blast_Score=90, Evalue=4e-19,
Organism=Escherichia coli, GI1786783, Length=265, Percent_Identity=24.5283018867925, Blast_Score=89, Evalue=6e-19,
Organism=Escherichia coli, GI1788279, Length=234, Percent_Identity=26.9230769230769, Blast_Score=82, Evalue=7e-17,
Organism=Escherichia coli, GI145693157, Length=218, Percent_Identity=27.9816513761468, Blast_Score=82, Evalue=7e-17,
Organism=Escherichia coli, GI87082128, Length=238, Percent_Identity=25.2100840336134, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1788393, Length=265, Percent_Identity=24.5283018867925, Blast_Score=75, Evalue=6e-15,
Organism=Escherichia coli, GI87081816, Length=288, Percent_Identity=24.3055555555556, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1788713, Length=256, Percent_Identity=22.265625, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1786912, Length=246, Percent_Identity=20.7317073170732, Blast_Score=66, Evalue=6e-12,
Organism=Escherichia coli, GI48994928, Length=224, Percent_Identity=22.7678571428571, Blast_Score=63, Evalue=5e-11,
Organism=Escherichia coli, GI1790861, Length=241, Percent_Identity=24.0663900414938, Blast_Score=62, Evalue=1e-10,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 54024; Mature: 53893

Theoretical pI: Translated: 8.38; Mature: 8.38

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATKSNRSKDNITKNIFIKTLLFCILLSLCLYQIIYFLASDYDKERFAKENGPPTTEQAD
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCCCCC
SDKQNAQSKTNQNKAVTQGDMFNFQSSIIDYNALSTAINHLLQPSQTAKAKEHTQNISGK
CHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCC
NSASAPSTETEKQVATNDALHKQNIASKANSAQDDPKLTDALQQLAPHIGATMLALSLLG
CCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
SLIYAKLIAKPFQYMSDALKDIMNLDFSDKKLLNKNTDQTDFDLQVAASQVPNIVKNLHA
HHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCC
SNQDLRNELKKEQQLEQSRKEFMSMVSHELKTPIAAVMGQLDGMIHGIGAYKDRDKYLKR
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCCHHHHHHHH
SYEMMQDINILTEKMSELSKIQNPQFKPDLKVISLTNIIEDVMKKVDYFVSVKQLNVQSN
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IKQDVQVLADPKFIQTAIFNIISNAIHYTIDHQHVYIKLYEKPNGYALEVLNTGSQIDED
HHHHHHHHCCCHHHHHHHHHHHHHHHHEEECCCEEEEEEEECCCCCEEEEECCCCCCCHH
KLAHLFEPFYRANPDKHGLVQGSGLGLYIVKQILDKHQFPYGIQNTPQGVKCSIVFPKAM
HHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCC
>Mature Secondary Structure 
ATKSNRSKDNITKNIFIKTLLFCILLSLCLYQIIYFLASDYDKERFAKENGPPTTEQAD
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCCCCC
SDKQNAQSKTNQNKAVTQGDMFNFQSSIIDYNALSTAINHLLQPSQTAKAKEHTQNISGK
CHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCC
NSASAPSTETEKQVATNDALHKQNIASKANSAQDDPKLTDALQQLAPHIGATMLALSLLG
CCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
SLIYAKLIAKPFQYMSDALKDIMNLDFSDKKLLNKNTDQTDFDLQVAASQVPNIVKNLHA
HHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCC
SNQDLRNELKKEQQLEQSRKEFMSMVSHELKTPIAAVMGQLDGMIHGIGAYKDRDKYLKR
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCCHHHHHHHH
SYEMMQDINILTEKMSELSKIQNPQFKPDLKVISLTNIIEDVMKKVDYFVSVKQLNVQSN
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IKQDVQVLADPKFIQTAIFNIISNAIHYTIDHQHVYIKLYEKPNGYALEVLNTGSQIDED
HHHHHHHHCCCHHHHHHHHHHHHHHHHEEECCCEEEEEEEECCCCCEEEEECCCCCCCHH
KLAHLFEPFYRANPDKHGLVQGSGLGLYIVKQILDKHQFPYGIQNTPQGVKCSIVFPKAM
HHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8631706; 12663927 [H]