Click here to switch to the map view.

The map label for this gene is yvcT [H]

Identifier: 118479997

GI number: 118479997

Start: 4680232

End: 4681224

Strand: Direct

Name: yvcT [H]

Synonym: BALH_4444

Alternate gene names: 118479997

Gene position: 4680232-4681224 (Clockwise)

Preceding gene: 118479991

Following gene: 118479998

Centisome position: 89.03

GC content: 38.47

Gene sequence:

>993_bases
ATGCGTGATAAAGCGAAAGGGGATGGAACCGTGAAACCAAAAGTTTATATTGCTGAACCAGTTCCAACATTTGTAGAAAA
CTATTTATCAGAACACTGTGATTATGAAAAATGGGAGCAAAATGAGAAGGTACCTCGTGATGTTCTACTAGAGAAAATAC
AAGATAAAGATGGTTTATTAAATTTTGGATCTGCTATTAATGAAGAATTATTGGAGGCGGCTCCTAACTTAAAAGTAGTA
AGCAACATTTCTGTCGGTTACGATAATTTTGATTTACAAGCGATGGCAAAGCACAATGTTATCGGAACAAATACACCATA
CGTACTAGATGATACAGTAGCTGACCTCGTTTTCGCTCTTATGTTATCTGCTGGTCGTCGTGTTTGTGAACTCGACTCCT
ACGTAAAAAATGGTGAATGGAATGCCGAAATTGGAAAAGAACACTTTGGTCTAGATGTACATCATAGTACAATCGGCATT
ATCGGTATGGGCCGAATTGGAGAAGCTGTTGCAAAACGAGCGAAATTCGGATTTGATATGGATGTTCTTTATTATAACCG
TCGCCGAAAAGAAGAAGCTGAACAAAAATTCGACGCTACATATTGTGATTTACAGACACTACTCAAACAGTCTGACTTTA
TCGTTCTTCTTACTCCATTAACAGATGAAACGTATCACCTTATCGGAGAAAAGGAATTTTCATTCATGAAAGAAACAGCT
ATCTTCATTAATGCTTCTCGCGGGAAAACAGTCGATGAAGAAGCGTTAATCGATGCGTTAACTGAAAAGAAAATCTTTGC
AGCAGGCATCGATACGTTTACACAAGAGCCGATTCAAAAAGACAATCCGCTCTTATCATTACAAAACGTTGTGACTTTAC
CACACATCGGATCTGCAACATTAAAAACTAGGCAGCAAATGGCTATGACCGCCGCTGAAAATTTAGTTGCAGCGTTACAA
GGAAAAACACCACCGAATATTGTTCGCGGGTAA

Upstream 100 bases:

>100_bases
AGTTGCTCTCCCGCCTAACCTCTTCGCTTGAGCTTCTTTTTGAGGCGAGAGGCTTACTGTCCGTTAAAGCGGGGTAAAGT
GAAACTTAATCAGCGGAAAA

Downstream 100 bases:

>100_bases
TATGGAATAAACGAAAGGCAAGATGACATCGTCATCTTGCCTTTTTTTGTTAACATATTTTCTTTTCTCTTGGAGATGAT
ATGAACAAAAATCAATGGAG

Product: D-isomer specific 2-hydroxyacid dehydrogenase family protein

Products: NA

Alternate protein names: 2KR [H]

Number of amino acids: Translated: 330; Mature: 330

Protein sequence:

>330_residues
MRDKAKGDGTVKPKVYIAEPVPTFVENYLSEHCDYEKWEQNEKVPRDVLLEKIQDKDGLLNFGSAINEELLEAAPNLKVV
SNISVGYDNFDLQAMAKHNVIGTNTPYVLDDTVADLVFALMLSAGRRVCELDSYVKNGEWNAEIGKEHFGLDVHHSTIGI
IGMGRIGEAVAKRAKFGFDMDVLYYNRRRKEEAEQKFDATYCDLQTLLKQSDFIVLLTPLTDETYHLIGEKEFSFMKETA
IFINASRGKTVDEEALIDALTEKKIFAAGIDTFTQEPIQKDNPLLSLQNVVTLPHIGSATLKTRQQMAMTAAENLVAALQ
GKTPPNIVRG

Sequences:

>Translated_330_residues
MRDKAKGDGTVKPKVYIAEPVPTFVENYLSEHCDYEKWEQNEKVPRDVLLEKIQDKDGLLNFGSAINEELLEAAPNLKVV
SNISVGYDNFDLQAMAKHNVIGTNTPYVLDDTVADLVFALMLSAGRRVCELDSYVKNGEWNAEIGKEHFGLDVHHSTIGI
IGMGRIGEAVAKRAKFGFDMDVLYYNRRRKEEAEQKFDATYCDLQTLLKQSDFIVLLTPLTDETYHLIGEKEFSFMKETA
IFINASRGKTVDEEALIDALTEKKIFAAGIDTFTQEPIQKDNPLLSLQNVVTLPHIGSATLKTRQQMAMTAAENLVAALQ
GKTPPNIVRG
>Mature_330_residues
MRDKAKGDGTVKPKVYIAEPVPTFVENYLSEHCDYEKWEQNEKVPRDVLLEKIQDKDGLLNFGSAINEELLEAAPNLKVV
SNISVGYDNFDLQAMAKHNVIGTNTPYVLDDTVADLVFALMLSAGRRVCELDSYVKNGEWNAEIGKEHFGLDVHHSTIGI
IGMGRIGEAVAKRAKFGFDMDVLYYNRRRKEEAEQKFDATYCDLQTLLKQSDFIVLLTPLTDETYHLIGEKEFSFMKETA
IFINASRGKTVDEEALIDALTEKKIFAAGIDTFTQEPIQKDNPLLSLQNVVTLPHIGSATLKTRQQMAMTAAENLVAALQ
GKTPPNIVRG

Specific function: Unknown

COG id: COG1052

COG function: function code CHR; Lactate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI6912396, Length=318, Percent_Identity=40.5660377358491, Blast_Score=219, Evalue=4e-57,
Organism=Homo sapiens, GI23308577, Length=290, Percent_Identity=28.6206896551724, Blast_Score=145, Evalue=7e-35,
Organism=Homo sapiens, GI145580578, Length=266, Percent_Identity=30.8270676691729, Blast_Score=116, Evalue=3e-26,
Organism=Homo sapiens, GI4557499, Length=266, Percent_Identity=30.8270676691729, Blast_Score=116, Evalue=3e-26,
Organism=Homo sapiens, GI4557497, Length=266, Percent_Identity=29.6992481203008, Blast_Score=115, Evalue=7e-26,
Organism=Homo sapiens, GI61743967, Length=266, Percent_Identity=29.6992481203008, Blast_Score=115, Evalue=8e-26,
Organism=Homo sapiens, GI145580575, Length=266, Percent_Identity=30.8270676691729, Blast_Score=114, Evalue=1e-25,
Organism=Escherichia coli, GI87082289, Length=326, Percent_Identity=49.6932515337423, Blast_Score=320, Evalue=9e-89,
Organism=Escherichia coli, GI1789279, Length=273, Percent_Identity=31.5018315018315, Blast_Score=117, Evalue=8e-28,
Organism=Escherichia coli, GI1787645, Length=263, Percent_Identity=29.277566539924, Blast_Score=104, Evalue=7e-24,
Organism=Escherichia coli, GI87081824, Length=236, Percent_Identity=25.8474576271186, Blast_Score=75, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI17532191, Length=281, Percent_Identity=31.3167259786477, Blast_Score=122, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI25147481, Length=270, Percent_Identity=27.037037037037, Blast_Score=87, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6324055, Length=254, Percent_Identity=35.0393700787402, Blast_Score=145, Evalue=1e-35,
Organism=Saccharomyces cerevisiae, GI6322116, Length=294, Percent_Identity=28.9115646258503, Blast_Score=123, Evalue=4e-29,
Organism=Saccharomyces cerevisiae, GI6320925, Length=286, Percent_Identity=28.6713286713287, Blast_Score=119, Evalue=9e-28,
Organism=Saccharomyces cerevisiae, GI6324964, Length=253, Percent_Identity=27.6679841897233, Blast_Score=87, Evalue=5e-18,
Organism=Saccharomyces cerevisiae, GI6325144, Length=160, Percent_Identity=30, Blast_Score=84, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6321253, Length=284, Percent_Identity=27.112676056338, Blast_Score=80, Evalue=4e-16,
Organism=Drosophila melanogaster, GI45551003, Length=314, Percent_Identity=40.7643312101911, Blast_Score=213, Evalue=1e-55,
Organism=Drosophila melanogaster, GI28574284, Length=314, Percent_Identity=40.7643312101911, Blast_Score=213, Evalue=2e-55,
Organism=Drosophila melanogaster, GI45552429, Length=314, Percent_Identity=40.7643312101911, Blast_Score=213, Evalue=2e-55,
Organism=Drosophila melanogaster, GI24585514, Length=314, Percent_Identity=40.7643312101911, Blast_Score=213, Evalue=2e-55,
Organism=Drosophila melanogaster, GI28574282, Length=314, Percent_Identity=40.7643312101911, Blast_Score=213, Evalue=2e-55,
Organism=Drosophila melanogaster, GI28574286, Length=319, Percent_Identity=38.2445141065831, Blast_Score=201, Evalue=6e-52,
Organism=Drosophila melanogaster, GI28571528, Length=311, Percent_Identity=37.9421221864952, Blast_Score=197, Evalue=9e-51,
Organism=Drosophila melanogaster, GI24585516, Length=312, Percent_Identity=34.9358974358974, Blast_Score=182, Evalue=2e-46,
Organism=Drosophila melanogaster, GI19921140, Length=286, Percent_Identity=28.6713286713287, Blast_Score=126, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24646446, Length=271, Percent_Identity=31.3653136531365, Blast_Score=111, Evalue=9e-25,
Organism=Drosophila melanogaster, GI24646448, Length=271, Percent_Identity=31.3653136531365, Blast_Score=111, Evalue=9e-25,
Organism=Drosophila melanogaster, GI24646452, Length=271, Percent_Identity=31.3653136531365, Blast_Score=111, Evalue=9e-25,
Organism=Drosophila melanogaster, GI24646450, Length=271, Percent_Identity=31.3653136531365, Blast_Score=111, Evalue=9e-25,
Organism=Drosophila melanogaster, GI62472511, Length=271, Percent_Identity=31.3653136531365, Blast_Score=110, Evalue=1e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.215 [H]

Molecular weight: Translated: 36876; Mature: 36876

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRDKAKGDGTVKPKVYIAEPVPTFVENYLSEHCDYEKWEQNEKVPRDVLLEKIQDKDGLL
CCCCCCCCCCCCCEEEEECCCHHHHHHHHHHCCCCHHHHHCCCCCHHHHHHHHCCCCCCC
NFGSAINEELLEAAPNLKVVSNISVGYDNFDLQAMAKHNVIGTNTPYVLDDTVADLVFAL
HHHHHHHHHHHHHCCCCEEEEEEEECCCCCCHHHHHHCCCCCCCCCEEEHHHHHHHHHHH
MLSAGRRVCELDSYVKNGEWNAEIGKEHFGLDVHHSTIGIIGMGRIGEAVAKRAKFGFDM
HHHCCCHHHHHHHHHHCCCCCCCCCHHHCCCEEECCEEEEEECCHHHHHHHHHHHCCCCC
DVLYYNRRRKEEAEQKFDATYCDLQTLLKQSDFIVLLTPLTDETYHLIGEKEFSFMKETA
HHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCEEEEEECCCCCHHHHHCCHHHHHHHHEE
IFINASRGKTVDEEALIDALTEKKIFAAGIDTFTQEPIQKDNPLLSLQNVVTLPHIGSAT
EEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEHHHEEECCCCCCHH
LKTRQQMAMTAAENLVAALQGKTPPNIVRG
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MRDKAKGDGTVKPKVYIAEPVPTFVENYLSEHCDYEKWEQNEKVPRDVLLEKIQDKDGLL
CCCCCCCCCCCCCEEEEECCCHHHHHHHHHHCCCCHHHHHCCCCCHHHHHHHHCCCCCCC
NFGSAINEELLEAAPNLKVVSNISVGYDNFDLQAMAKHNVIGTNTPYVLDDTVADLVFAL
HHHHHHHHHHHHHCCCCEEEEEEEECCCCCCHHHHHHCCCCCCCCCEEEHHHHHHHHHHH
MLSAGRRVCELDSYVKNGEWNAEIGKEHFGLDVHHSTIGIIGMGRIGEAVAKRAKFGFDM
HHHCCCHHHHHHHHHHCCCCCCCCCHHHCCCEEECCEEEEEECCHHHHHHHHHHHCCCCC
DVLYYNRRRKEEAEQKFDATYCDLQTLLKQSDFIVLLTPLTDETYHLIGEKEFSFMKETA
HHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCEEEEEECCCCCHHHHHCCHHHHHHHHEE
IFINASRGKTVDEEALIDALTEKKIFAAGIDTFTQEPIQKDNPLLSLQNVVTLPHIGSAT
EEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEHHHEEECCCCCCHH
LKTRQQMAMTAAENLVAALQGKTPPNIVRG
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]