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The map label for this gene is leuS

Identifier: 118479871

GI number: 118479871

Start: 4531481

End: 4533889

Strand: Reverse

Name: leuS

Synonym: BALH_4313

Alternate gene names: 118479871

Gene position: 4533889-4531481 (Counterclockwise)

Preceding gene: 118479872

Following gene: 118479870

Centisome position: 86.24

GC content: 40.93

Gene sequence:

>2409_bases
ATGAGCTTTAATCATCAAGAAATTGAGAAGAAGTGGCAAGGGTACTGGGAAGAGAATAAAACATTCCGTACGCCAGATGA
GACAGAAAAACCAAAATTTTATGCACTAGATATGTTCCCATATCCATCAGGTGCAGGCCTACACGTAGGACATCCAGAAG
GTTATACAGCAACGGATATTTTATCTCGTATGAAGCGTATGCAAGGGTATAACGTTCTTCATCCAATGGGATGGGATGCA
TTCGGTCTTCCAGCAGAGCAATATGCACTTGATACTGGAAACAGCCCGGCTGAATTTACAGAGCATAATATTAATACGTT
CCGTAACCAAATTAAATCATTAGGTTTCTCTTATGATTGGGACCGTGAAGTAAATACAACAGATCCAAACTACTACAAGT
GGACACAATGGATCTTCCTGAAACTATTTGAAAAAGGCTTAGCTTATGTTGATGAAGTACCTGTAAACTGGTGCCCAGCA
CTTGGTACAGTACTTGCAAACGAAGAAATCATCGATGGTAAGAGTGAGCGCGGTGGACATCCAGTTGAGCGTCGTCCGAT
GAGACAGTGGATGTTAAAAATTACAGCATACGGAGATCGTCTATTGGAAGATCTAGATGAGCTTGATTGGCCAGAAAGTT
TAAAAGATATGCAACGTAACTGGATCGGTCGTTCTGAAGGTGCAGAAGTACACTTCAACATCGATGGTACAGACGAGAAG
TTCACAGTTTTCACAACGCGTCCTGATACACTATTTGGTGCAAGCTACTGTGTACTTGCTCCGGAACATGCGCTTGTTGC
TGACATTACAACTGCTGATCAAAAAGAAGCTGTAGAAGCTTACATTAATTCTGTAAAAATGAAGAGTGATCTAGAGCGTA
CAGAACTTGCGAAAGAGAAAACTGGTGTATTCACTGGTGCTTACGCAGTTAATCCAGTAAATGGTGAGAAATTACCAATC
TGGATCGCTGATTACGTTCTTGCAACTTACGGAACAGGTGCTGTAATGGCGGTTCCAGCTCACGATGAGCGTGACTATGA
ATTTGCATCAACGTTCAATCTTCCAATGAAGGAAGTTGTAAAAGGTGGAGATATTACGAAAGAAGCATACACAGGTGATG
GTGCTCACGTAAACTCAGCATTCCTTGATGGTTTAAATAAAGAAGAAGCAATCGCAAAAATGATTGAATGGCTTGAAGTA
ACGAGCGCAGGAAATCAAAAAGTAACATACCGTCTACGTGACTGGTTATTCAGCCGTCAACGTTACTGGGGTGAGCCAAT
TCCAGTAATTCACTGGGAAGATGGCACAATGACAGCTGTGAAAGAAGAAGAATTACCATTAGTTCTTCCGAAAACAGAAA
ACATCCGTCCTTCAGGTACAGGTGAATCACCACTTGCTAACATTGACGAGTGGGTAAATGTTGTTGATCCTGAGACTGGT
AAAAAAGGTCGTCGTGAAACAAATACAATGCCGCAATGGGCTGGTAGTTGCTGGTATTACCTACGTTACATCGATCCAAA
CAATAGCGAAGCACTTGTAGATCCTGAAAAAGTAAAACAATGGCTTCCAGTTGATATTTATATCGGTGGTGCAGAACACG
CTGTACTTCACTTACTGTATGCTCGTTTCTGGCATAAAGTATTATATGATATCGGTGTAGTTCCAACGAAAGAGCCGTTC
CAACAATTATTCAACCAAGGTATGATTCTAGGTGAAAACAACGAGAAAATGAGTAAATCAAAAGGTAACGTTGTAAACCC
TGATGATATCGTAGCGAGCCACGGTGCAGATACACTTCGTCTATACGAAATGTTCATGGGACCATTAGATGCTTCAATCG
CTTGGTCTGAAAATGGTCTTGACGGAGCTCGTCGTTTCCTAGACCGCGTATGGCGCCTATTCGTTCAAGATAACGGTGAA
TTAAGTGAGAAAATTACTGATGCACCAAATAAAGATCTTGAAAAAGCTTACCACCAAACAGTGAAGAAAGTAACAGAAGA
CTATGCAGAGCTTCGCTTCAACACAGCGATTTCTCAAATGATGGTATTCATCAACGATGCATACAAAGCTGAAACACTTC
CGAAAGAATATGTAGAAGGTTTCGTAAAAATGATTGCACCAGTTGCACCTCACATCGGGGAAGAACTATGGAGCAAACTT
GGATACAATGAAACAATCACATATGCAAGCTGGCCAACATTCGATGAGTCTAAACTTGTAGAAGATGAAGTTGAAATCGT
TGTTCAAGTTATGGGTAAAGTTCGCGCAAAACTAACAATGAGTAAAGACGCATCAAAAGACGAAATGGAAAAACTTGCAC
TTGAAGCAATTCAAGACCAAATCGAAGGGAAAACAGTTCGTAAAGTAATTGTTGTTCCTGGAAAACTTGTTAACGTTGTT
GCAAACTAA

Upstream 100 bases:

>100_bases
GGTACCGCGGGAATCTATAACCTCTCGTCCCTTTCTAGGGATGAGAGGTTTTTTGTATTTTGGGCGGTGAAAATAAATAG
AATTTTAAGGAGGGTATCTC

Downstream 100 bases:

>100_bases
TGCATTTCAAATAAAAGCTCAGAGTATTTATGCTCTGAGCTTTTTTGTGTAGAAAATAATTTCTGGATCACCTTCATCTA
AATTTTCAACTATTCCACTA

Product: leucyl-tRNA synthetase

Products: NA

Alternate protein names: Leucine--tRNA ligase; LeuRS

Number of amino acids: Translated: 802; Mature: 801

Protein sequence:

>802_residues
MSFNHQEIEKKWQGYWEENKTFRTPDETEKPKFYALDMFPYPSGAGLHVGHPEGYTATDILSRMKRMQGYNVLHPMGWDA
FGLPAEQYALDTGNSPAEFTEHNINTFRNQIKSLGFSYDWDREVNTTDPNYYKWTQWIFLKLFEKGLAYVDEVPVNWCPA
LGTVLANEEIIDGKSERGGHPVERRPMRQWMLKITAYGDRLLEDLDELDWPESLKDMQRNWIGRSEGAEVHFNIDGTDEK
FTVFTTRPDTLFGASYCVLAPEHALVADITTADQKEAVEAYINSVKMKSDLERTELAKEKTGVFTGAYAVNPVNGEKLPI
WIADYVLATYGTGAVMAVPAHDERDYEFASTFNLPMKEVVKGGDITKEAYTGDGAHVNSAFLDGLNKEEAIAKMIEWLEV
TSAGNQKVTYRLRDWLFSRQRYWGEPIPVIHWEDGTMTAVKEEELPLVLPKTENIRPSGTGESPLANIDEWVNVVDPETG
KKGRRETNTMPQWAGSCWYYLRYIDPNNSEALVDPEKVKQWLPVDIYIGGAEHAVLHLLYARFWHKVLYDIGVVPTKEPF
QQLFNQGMILGENNEKMSKSKGNVVNPDDIVASHGADTLRLYEMFMGPLDASIAWSENGLDGARRFLDRVWRLFVQDNGE
LSEKITDAPNKDLEKAYHQTVKKVTEDYAELRFNTAISQMMVFINDAYKAETLPKEYVEGFVKMIAPVAPHIGEELWSKL
GYNETITYASWPTFDESKLVEDEVEIVVQVMGKVRAKLTMSKDASKDEMEKLALEAIQDQIEGKTVRKVIVVPGKLVNVV
AN

Sequences:

>Translated_802_residues
MSFNHQEIEKKWQGYWEENKTFRTPDETEKPKFYALDMFPYPSGAGLHVGHPEGYTATDILSRMKRMQGYNVLHPMGWDA
FGLPAEQYALDTGNSPAEFTEHNINTFRNQIKSLGFSYDWDREVNTTDPNYYKWTQWIFLKLFEKGLAYVDEVPVNWCPA
LGTVLANEEIIDGKSERGGHPVERRPMRQWMLKITAYGDRLLEDLDELDWPESLKDMQRNWIGRSEGAEVHFNIDGTDEK
FTVFTTRPDTLFGASYCVLAPEHALVADITTADQKEAVEAYINSVKMKSDLERTELAKEKTGVFTGAYAVNPVNGEKLPI
WIADYVLATYGTGAVMAVPAHDERDYEFASTFNLPMKEVVKGGDITKEAYTGDGAHVNSAFLDGLNKEEAIAKMIEWLEV
TSAGNQKVTYRLRDWLFSRQRYWGEPIPVIHWEDGTMTAVKEEELPLVLPKTENIRPSGTGESPLANIDEWVNVVDPETG
KKGRRETNTMPQWAGSCWYYLRYIDPNNSEALVDPEKVKQWLPVDIYIGGAEHAVLHLLYARFWHKVLYDIGVVPTKEPF
QQLFNQGMILGENNEKMSKSKGNVVNPDDIVASHGADTLRLYEMFMGPLDASIAWSENGLDGARRFLDRVWRLFVQDNGE
LSEKITDAPNKDLEKAYHQTVKKVTEDYAELRFNTAISQMMVFINDAYKAETLPKEYVEGFVKMIAPVAPHIGEELWSKL
GYNETITYASWPTFDESKLVEDEVEIVVQVMGKVRAKLTMSKDASKDEMEKLALEAIQDQIEGKTVRKVIVVPGKLVNVV
AN
>Mature_801_residues
SFNHQEIEKKWQGYWEENKTFRTPDETEKPKFYALDMFPYPSGAGLHVGHPEGYTATDILSRMKRMQGYNVLHPMGWDAF
GLPAEQYALDTGNSPAEFTEHNINTFRNQIKSLGFSYDWDREVNTTDPNYYKWTQWIFLKLFEKGLAYVDEVPVNWCPAL
GTVLANEEIIDGKSERGGHPVERRPMRQWMLKITAYGDRLLEDLDELDWPESLKDMQRNWIGRSEGAEVHFNIDGTDEKF
TVFTTRPDTLFGASYCVLAPEHALVADITTADQKEAVEAYINSVKMKSDLERTELAKEKTGVFTGAYAVNPVNGEKLPIW
IADYVLATYGTGAVMAVPAHDERDYEFASTFNLPMKEVVKGGDITKEAYTGDGAHVNSAFLDGLNKEEAIAKMIEWLEVT
SAGNQKVTYRLRDWLFSRQRYWGEPIPVIHWEDGTMTAVKEEELPLVLPKTENIRPSGTGESPLANIDEWVNVVDPETGK
KGRRETNTMPQWAGSCWYYLRYIDPNNSEALVDPEKVKQWLPVDIYIGGAEHAVLHLLYARFWHKVLYDIGVVPTKEPFQ
QLFNQGMILGENNEKMSKSKGNVVNPDDIVASHGADTLRLYEMFMGPLDASIAWSENGLDGARRFLDRVWRLFVQDNGEL
SEKITDAPNKDLEKAYHQTVKKVTEDYAELRFNTAISQMMVFINDAYKAETLPKEYVEGFVKMIAPVAPHIGEELWSKLG
YNETITYASWPTFDESKLVEDEVEIVVQVMGKVRAKLTMSKDASKDEMEKLALEAIQDQIEGKTVRKVIVVPGKLVNVVA
N

Specific function: Unknown

COG id: COG0495

COG function: function code J; Leucyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family

Homologues:

Organism=Homo sapiens, GI7661872, Length=875, Percent_Identity=32.1142857142857, Blast_Score=460, Evalue=1e-129,
Organism=Homo sapiens, GI94721239, Length=688, Percent_Identity=23.1104651162791, Blast_Score=94, Evalue=6e-19,
Organism=Homo sapiens, GI94721241, Length=688, Percent_Identity=23.1104651162791, Blast_Score=94, Evalue=6e-19,
Organism=Escherichia coli, GI1786861, Length=863, Percent_Identity=43.3371958285052, Blast_Score=687, Evalue=0.0,
Organism=Escherichia coli, GI1790708, Length=391, Percent_Identity=24.5524296675192, Blast_Score=99, Evalue=7e-22,
Organism=Caenorhabditis elegans, GI71997510, Length=806, Percent_Identity=29.5285359801489, Blast_Score=311, Evalue=9e-85,
Organism=Caenorhabditis elegans, GI71997517, Length=774, Percent_Identity=30.1033591731266, Blast_Score=310, Evalue=1e-84,
Organism=Caenorhabditis elegans, GI212645227, Length=366, Percent_Identity=28.6885245901639, Blast_Score=130, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI17510661, Length=378, Percent_Identity=25.3968253968254, Blast_Score=97, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI71980946, Length=150, Percent_Identity=30.6666666666667, Blast_Score=67, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6323414, Length=837, Percent_Identity=36.3201911589008, Blast_Score=468, Evalue=1e-132,
Organism=Saccharomyces cerevisiae, GI6321531, Length=378, Percent_Identity=25.1322751322751, Blast_Score=95, Evalue=4e-20,
Organism=Saccharomyces cerevisiae, GI6319395, Length=373, Percent_Identity=23.8605898123324, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI21355409, Length=819, Percent_Identity=31.990231990232, Blast_Score=383, Evalue=1e-106,
Organism=Drosophila melanogaster, GI281366294, Length=364, Percent_Identity=26.0989010989011, Blast_Score=84, Evalue=4e-16,

Paralogues:

None

Copy number: 800 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): SYL_BACAA (C3PBK0)

Other databases:

- EMBL:   CP001598
- RefSeq:   YP_002869016.1
- ProteinModelPortal:   C3PBK0
- SMR:   C3PBK0
- EnsemblBacteria:   EBBACT00000128599
- GeneID:   7848367
- GenomeReviews:   CP001598_GR
- KEGG:   bai:BAA_5004
- GeneTree:   EBGT00070000031891
- ProtClustDB:   PRK00390
- GO:   GO:0005737
- HAMAP:   MF_00049_B
- InterPro:   IPR001412
- InterPro:   IPR002300
- InterPro:   IPR002302
- InterPro:   IPR014729
- InterPro:   IPR009080
- InterPro:   IPR013155
- InterPro:   IPR009008
- Gene3D:   G3DSA:3.40.50.620
- PANTHER:   PTHR11946:SF7
- PRINTS:   PR00985
- TIGRFAMs:   TIGR00396

Pfam domain/function: PF08264 Anticodon_1; PF00133 tRNA-synt_1; SSF47323 tRNAsyn_1a_bind; SSF50677 ValRS_IleRS_edit

EC number: =6.1.1.4

Molecular weight: Translated: 91274; Mature: 91143

Theoretical pI: Translated: 4.70; Mature: 4.70

Prosite motif: PS00178 AA_TRNA_LIGASE_I

Important sites: BINDING 579-579

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFNHQEIEKKWQGYWEENKTFRTPDETEKPKFYALDMFPYPSGAGLHVGHPEGYTATDI
CCCCHHHHHHHHCCHHHCCCCCCCCCCCCCCCEEEEEECCCCCCCCEECCCCCCCCHHHH
LSRMKRMQGYNVLHPMGWDAFGLPAEQYALDTGNSPAEFTEHNINTFRNQIKSLGFSYDW
HHHHHHHCCCCCCCCCCCCCCCCCHHHHEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCC
DREVNTTDPNYYKWTQWIFLKLFEKGLAYVDEVPVNWCPALGTVLANEEIIDGKSERGGH
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCHHCCCCCCCCCC
PVERRPMRQWMLKITAYGDRLLEDLDELDWPESLKDMQRNWIGRSEGAEVHFNIDGTDEK
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCEEEEEECCCCCE
FTVFTTRPDTLFGASYCVLAPEHALVADITTADQKEAVEAYINSVKMKSDLERTELAKEK
EEEEECCCCCHHCCEEEEECCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
TGVFTGAYAVNPVNGEKLPIWIADYVLATYGTGAVMAVPAHDERDYEFASTFNLPMKEVV
CCEEECCEEECCCCCCCCEEEHHHHHHHHCCCCEEEEECCCCCCCCCHHHHCCCCHHHHH
KGGDITKEAYTGDGAHVNSAFLDGLNKEEAIAKMIEWLEVTSAGNQKVTYRLRDWLFSRQ
CCCCCCHHHCCCCCCEECHHHHCCCCHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHH
RYWGEPIPVIHWEDGTMTAVKEEELPLVLPKTENIRPSGTGESPLANIDEWVNVVDPETG
HHCCCCCCEEEECCCCEEEEECCCCCEECCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCC
KKGRRETNTMPQWAGSCWYYLRYIDPNNSEALVDPEKVKQWLPVDIYIGGAEHAVLHLLY
CCCCCCCCCCCHHCCCEEEEEEEECCCCCCCCCCHHHHHHCCCEEEEECCHHHHHHHHHH
ARFWHKVLYDIGVVPTKEPFQQLFNQGMILGENNEKMSKSKGNVVNPDDIVASHGADTLR
HHHHHHHHHHCCCCCCHHHHHHHHHCCEEEECCCCHHHHCCCCCCCHHHHHHCCCCHHHH
LYEMFMGPLDASIAWSENGLDGARRFLDRVWRLFVQDNGELSEKITDAPNKDLEKAYHQT
HHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCHHHHHHHHHH
VKKVTEDYAELRFNTAISQMMVFINDAYKAETLPKEYVEGFVKMIAPVAPHIGEELWSKL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHC
GYNETITYASWPTFDESKLVEDEVEIVVQVMGKVRAKLTMSKDASKDEMEKLALEAIQDQ
CCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHHH
IEGKTVRKVIVVPGKLVNVVAN
HCCCEEEEEEECCCHHHHHHCC
>Mature Secondary Structure 
SFNHQEIEKKWQGYWEENKTFRTPDETEKPKFYALDMFPYPSGAGLHVGHPEGYTATDI
CCCHHHHHHHHCCHHHCCCCCCCCCCCCCCCEEEEEECCCCCCCCEECCCCCCCCHHHH
LSRMKRMQGYNVLHPMGWDAFGLPAEQYALDTGNSPAEFTEHNINTFRNQIKSLGFSYDW
HHHHHHHCCCCCCCCCCCCCCCCCHHHHEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCC
DREVNTTDPNYYKWTQWIFLKLFEKGLAYVDEVPVNWCPALGTVLANEEIIDGKSERGGH
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCHHCCCCCCCCCC
PVERRPMRQWMLKITAYGDRLLEDLDELDWPESLKDMQRNWIGRSEGAEVHFNIDGTDEK
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCEEEEEECCCCCE
FTVFTTRPDTLFGASYCVLAPEHALVADITTADQKEAVEAYINSVKMKSDLERTELAKEK
EEEEECCCCCHHCCEEEEECCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
TGVFTGAYAVNPVNGEKLPIWIADYVLATYGTGAVMAVPAHDERDYEFASTFNLPMKEVV
CCEEECCEEECCCCCCCCEEEHHHHHHHHCCCCEEEEECCCCCCCCCHHHHCCCCHHHHH
KGGDITKEAYTGDGAHVNSAFLDGLNKEEAIAKMIEWLEVTSAGNQKVTYRLRDWLFSRQ
CCCCCCHHHCCCCCCEECHHHHCCCCHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHH
RYWGEPIPVIHWEDGTMTAVKEEELPLVLPKTENIRPSGTGESPLANIDEWVNVVDPETG
HHCCCCCCEEEECCCCEEEEECCCCCEECCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCC
KKGRRETNTMPQWAGSCWYYLRYIDPNNSEALVDPEKVKQWLPVDIYIGGAEHAVLHLLY
CCCCCCCCCCCHHCCCEEEEEEEECCCCCCCCCCHHHHHHCCCEEEEECCHHHHHHHHHH
ARFWHKVLYDIGVVPTKEPFQQLFNQGMILGENNEKMSKSKGNVVNPDDIVASHGADTLR
HHHHHHHHHHCCCCCCHHHHHHHHHCCEEEECCCCHHHHCCCCCCCHHHHHHCCCCHHHH
LYEMFMGPLDASIAWSENGLDGARRFLDRVWRLFVQDNGELSEKITDAPNKDLEKAYHQT
HHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCHHHHHHHHHH
VKKVTEDYAELRFNTAISQMMVFINDAYKAETLPKEYVEGFVKMIAPVAPHIGEELWSKL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHC
GYNETITYASWPTFDESKLVEDEVEIVVQVMGKVRAKLTMSKDASKDEMEKLALEAIQDQ
CCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHHH
IEGKTVRKVIVVPGKLVNVVAN
HCCCEEEEEEECCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA