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The map label for this gene is argH [H]

Identifier: 118479772

GI number: 118479772

Start: 4432904

End: 4434292

Strand: Reverse

Name: argH [H]

Synonym: BALH_4209

Alternate gene names: 118479772

Gene position: 4434292-4432904 (Counterclockwise)

Preceding gene: 118479773

Following gene: 118479770

Centisome position: 84.35

GC content: 38.52

Gene sequence:

>1389_bases
GTGAGCAAACTTTGGGGCGGACGTTTTACAGAAGAAGCGGAAGCGTGGGTTGAAGAGTTCGGGGCATCCATCTCCTTCGA
TCAACAATTAGTAAATCAAGATATAAACGGGAGTATTGCGCACGTAACGATGCTAGCAAAGCAAGGCATCGTTACGAAAG
AAGAAGCAGAGAAAATAAAGATAGGTCTTCAATATTTATTAGAAGAAGCGAAACAAAATAAATTGCATTTTTCCGTTGAA
GCGGAAGACATTCATTTAAATATCGAAAAGATGTTAATTGAAAAAATCGGTGAAGTAGGAGGGAAACTTCATACTGGCCG
AAGTCGTAATGATCAAGTAGCGACAGATATGCACTTATATTTAAAAGAAAAAGTAGAGCGTATTATTAAAGCTACAAAAC
AATTGCAAACGGTTCTTGTTCATCAAGCAGAAAATAATATTGAGACAATTATGCCTGGCTATACACACTTACAGCGTGCT
CAGCCAATTTCATTTGCACATCATATTCTCGCTTACTTTTGGATGTTAGAGCGCGATGTGAATCGTTATGAAGATTCGTT
AAAGCGTATTAACATTTCGCCATTAGGAGCAGGAGCGTTAGCTGGGACAACATTCCCGATTGATCGAGAATATAGTGCGG
AGCTTCTTGGATTGAATGGAATCTATGAAAATAGTTTAGATGCAGTAAGCGATCGTGATTTCATATTGGAGTTCCTCAGT
AACTCATCTATCCTTATGATGCATTTATCACGCTTTTGCGAAGAACTTATTTTATGGAGTAGCCAAGAGTTTCAATTTAT
TGAAATGAGCGATCAATACGCAACGGGAAGCAGCATTATGCCGCAAAAGAAAAATCCAGATATGGCGGAACTTATTCGTG
GTAAAACAGGCAGAGTGTACGGTAATTTATTTAGTTTACTTACAGTTATGAAAGGATTGCCGCTCGCATACAATAAAGAC
TTGCAAGAAGATAAAGAAGGAATGTTTGATACAGTAAAAACAGTAGAAGGATGCCTTCATATTATGGCAGGCATGTTAGA
GACGATGACTGTCAACAAAGAAAAAATGGGGCAAGCTGTAACGAAAGATTTCTCTAACGCAACAGAAATTGCTGACTACT
TAGCAAGTAAAGGACTACCATTCCGTCAAGCTCATGAAATTGTTGGAAAGCTAGTGCTACACTGCACACAAAAAGGAATT
TATTTAGTAGATGTACCACTTGAAACGTATAAAGAAATGAGCTTGTTATTTGAAGAAGATTTGTATGAAGTTCTTTCACC
GTATGCCGCTGTAAAGCGCCGTAATAGTGCTGGCGGGACAGGATTTGAGCAAATTAAAAAAGCTTTGGAGAAGGCGAAGG
GATTAGTTGGAGAGTTTGTGGGAAGTTGA

Upstream 100 bases:

>100_bases
CTCAGGATGAATTCAATCATGATGCAGCAGTTGGGTTCATTTCATTATTCGGTTTACCGACGAAAGTATATAGCCAAGTG
AATCAAAAGAAGGTGGAAGC

Downstream 100 bases:

>100_bases
TTGATAAGAAAGAAGGTACGCTAACCTTAGTAGAGGGAAGTGTACCTTCTTTTGTAATTTCTATGAAAACTAAATTATTG
TTGATTTGTTTTCCTTAATT

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL; Arginosuccinase [H]

Number of amino acids: Translated: 462; Mature: 461

Protein sequence:

>462_residues
MSKLWGGRFTEEAEAWVEEFGASISFDQQLVNQDINGSIAHVTMLAKQGIVTKEEAEKIKIGLQYLLEEAKQNKLHFSVE
AEDIHLNIEKMLIEKIGEVGGKLHTGRSRNDQVATDMHLYLKEKVERIIKATKQLQTVLVHQAENNIETIMPGYTHLQRA
QPISFAHHILAYFWMLERDVNRYEDSLKRINISPLGAGALAGTTFPIDREYSAELLGLNGIYENSLDAVSDRDFILEFLS
NSSILMMHLSRFCEELILWSSQEFQFIEMSDQYATGSSIMPQKKNPDMAELIRGKTGRVYGNLFSLLTVMKGLPLAYNKD
LQEDKEGMFDTVKTVEGCLHIMAGMLETMTVNKEKMGQAVTKDFSNATEIADYLASKGLPFRQAHEIVGKLVLHCTQKGI
YLVDVPLETYKEMSLLFEEDLYEVLSPYAAVKRRNSAGGTGFEQIKKALEKAKGLVGEFVGS

Sequences:

>Translated_462_residues
MSKLWGGRFTEEAEAWVEEFGASISFDQQLVNQDINGSIAHVTMLAKQGIVTKEEAEKIKIGLQYLLEEAKQNKLHFSVE
AEDIHLNIEKMLIEKIGEVGGKLHTGRSRNDQVATDMHLYLKEKVERIIKATKQLQTVLVHQAENNIETIMPGYTHLQRA
QPISFAHHILAYFWMLERDVNRYEDSLKRINISPLGAGALAGTTFPIDREYSAELLGLNGIYENSLDAVSDRDFILEFLS
NSSILMMHLSRFCEELILWSSQEFQFIEMSDQYATGSSIMPQKKNPDMAELIRGKTGRVYGNLFSLLTVMKGLPLAYNKD
LQEDKEGMFDTVKTVEGCLHIMAGMLETMTVNKEKMGQAVTKDFSNATEIADYLASKGLPFRQAHEIVGKLVLHCTQKGI
YLVDVPLETYKEMSLLFEEDLYEVLSPYAAVKRRNSAGGTGFEQIKKALEKAKGLVGEFVGS
>Mature_461_residues
SKLWGGRFTEEAEAWVEEFGASISFDQQLVNQDINGSIAHVTMLAKQGIVTKEEAEKIKIGLQYLLEEAKQNKLHFSVEA
EDIHLNIEKMLIEKIGEVGGKLHTGRSRNDQVATDMHLYLKEKVERIIKATKQLQTVLVHQAENNIETIMPGYTHLQRAQ
PISFAHHILAYFWMLERDVNRYEDSLKRINISPLGAGALAGTTFPIDREYSAELLGLNGIYENSLDAVSDRDFILEFLSN
SSILMMHLSRFCEELILWSSQEFQFIEMSDQYATGSSIMPQKKNPDMAELIRGKTGRVYGNLFSLLTVMKGLPLAYNKDL
QEDKEGMFDTVKTVEGCLHIMAGMLETMTVNKEKMGQAVTKDFSNATEIADYLASKGLPFRQAHEIVGKLVLHCTQKGIY
LVDVPLETYKEMSLLFEEDLYEVLSPYAAVKRRNSAGGTGFEQIKKALEKAKGLVGEFVGS

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily [H]

Homologues:

Organism=Homo sapiens, GI31541964, Length=454, Percent_Identity=44.0528634361233, Blast_Score=390, Evalue=1e-109,
Organism=Homo sapiens, GI68303542, Length=454, Percent_Identity=44.0528634361233, Blast_Score=390, Evalue=1e-109,
Organism=Homo sapiens, GI68303549, Length=454, Percent_Identity=41.6299559471366, Blast_Score=358, Evalue=9e-99,
Organism=Homo sapiens, GI68303547, Length=454, Percent_Identity=41.4096916299559, Blast_Score=355, Evalue=4e-98,
Organism=Escherichia coli, GI1790398, Length=455, Percent_Identity=49.010989010989, Blast_Score=465, Evalue=1e-132,
Organism=Caenorhabditis elegans, GI17553882, Length=226, Percent_Identity=28.7610619469027, Blast_Score=72, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI32565146, Length=208, Percent_Identity=29.3269230769231, Blast_Score=71, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6321806, Length=454, Percent_Identity=45.8149779735683, Blast_Score=397, Evalue=1e-111,
Organism=Drosophila melanogaster, GI221473854, Length=451, Percent_Identity=39.689578713969, Blast_Score=354, Evalue=6e-98,
Organism=Drosophila melanogaster, GI78706858, Length=451, Percent_Identity=39.689578713969, Blast_Score=354, Evalue=6e-98,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF00206 Lyase_1 [H]

EC number: =4.3.2.1 [H]

Molecular weight: Translated: 52051; Mature: 51920

Theoretical pI: Translated: 5.38; Mature: 5.38

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKLWGGRFTEEAEAWVEEFGASISFDQQLVNQDINGSIAHVTMLAKQGIVTKEEAEKIK
CCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHCCCCCCCHHHHHHHHHCCCCCHHHHHHHH
IGLQYLLEEAKQNKLHFSVEAEDIHLNIEKMLIEKIGEVGGKLHTGRSRNDQVATDMHLY
HHHHHHHHHHHCCCEEEEEECCHHEEHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHH
LKEKVERIIKATKQLQTVLVHQAENNIETIMPGYTHLQRAQPISFAHHILAYFWMLERDV
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCHHHHHHCCCHHHHHHHHHHHHHHHHHH
NRYEDSLKRINISPLGAGALAGTTFPIDREYSAELLGLNGIYENSLDAVSDRDFILEFLS
HHHHHHHHEECCCCCCCCHHCCCCCCCCCCCCHHHCCCCCCHHCCCHHHCHHHHHHHHHC
NSSILMMHLSRFCEELILWSSQEFQFIEMSDQYATGSSIMPQKKNPDMAELIRGKTGRVY
CCCHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCCCCCCHHHHHCCCCCHHH
GNLFSLLTVMKGLPLAYNKDLQEDKEGMFDTVKTVEGCLHIMAGMLETMTVNKEKMGQAV
HHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
TKDFSNATEIADYLASKGLPFRQAHEIVGKLVLHCTQKGIYLVDVPLETYKEMSLLFEED
HHHHCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHH
LYEVLSPYAAVKRRNSAGGTGFEQIKKALEKAKGLVGEFVGS
HHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SKLWGGRFTEEAEAWVEEFGASISFDQQLVNQDINGSIAHVTMLAKQGIVTKEEAEKIK
CCCCCCCCCHHHHHHHHHHCCCCCHHHHHHCCCCCCCHHHHHHHHHCCCCCHHHHHHHH
IGLQYLLEEAKQNKLHFSVEAEDIHLNIEKMLIEKIGEVGGKLHTGRSRNDQVATDMHLY
HHHHHHHHHHHCCCEEEEEECCHHEEHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHH
LKEKVERIIKATKQLQTVLVHQAENNIETIMPGYTHLQRAQPISFAHHILAYFWMLERDV
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCHHHHHHCCCHHHHHHHHHHHHHHHHHH
NRYEDSLKRINISPLGAGALAGTTFPIDREYSAELLGLNGIYENSLDAVSDRDFILEFLS
HHHHHHHHEECCCCCCCCHHCCCCCCCCCCCCHHHCCCCCCHHCCCHHHCHHHHHHHHHC
NSSILMMHLSRFCEELILWSSQEFQFIEMSDQYATGSSIMPQKKNPDMAELIRGKTGRVY
CCCHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCCCCCCHHHHHCCCCCHHH
GNLFSLLTVMKGLPLAYNKDLQEDKEGMFDTVKTVEGCLHIMAGMLETMTVNKEKMGQAV
HHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
TKDFSNATEIADYLASKGLPFRQAHEIVGKLVLHCTQKGIYLVDVPLETYKEMSLLFEED
HHHHCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHH
LYEVLSPYAAVKRRNSAGGTGFEQIKKALEKAKGLVGEFVGS
HHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA