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The map label for this gene is hemD [H]

Identifier: 118479629

GI number: 118479629

Start: 4277363

End: 4278115

Strand: Reverse

Name: hemD [H]

Synonym: BALH_4056

Alternate gene names: 118479629

Gene position: 4278115-4277363 (Counterclockwise)

Preceding gene: 118479630

Following gene: 118479628

Centisome position: 81.38

GC content: 38.38

Gene sequence:

>753_bases
ATGAACGCTCTCGCTGGCAAAACGGTATTGATTACACGTGCCCAGCACCAAGCAAAACAAATGAGTGTAGCGGTGAAAGA
AAAGAGCGGAATTCCATTGGAAATTCCGCTTTTGCGTATGGAGGGTATGTCTCATAGGCAAATTCAACATATAGCAGGGC
AGTTACATTCGTATGACTGGGTTATTTTTACGAGTAAAAATGGGGTAGCTTTTTTTCTAGATTCTTTGAGAAAGAAGCTC
CCCGTAACGACTAAAATTGCTGCAGTAGGCGTGAAAACAAAGTTAGAGTTAGAAAAGCGAGGCTATCATGTAGACTTTGT
TCCAACTTCATTTGTTGCAGAAGTATTTGCAGAAGAGTTTGTAAAAAGATTAAGTGGAAACGAACGTATTTTATTTCCGA
AAGGGAATTTAGCAAGAGAGGTAATTCCGGTTGCACTTCGGGAAATTGGTGTTTCTCTAGATGAGCTAATCGTATACGGT
ACGAAAGTGAATATAGAAAAAAAGCAAGAGCTTATAGCAGCATTGAAGTTAGGGAAAGTAGACATTATTACATTTACGAG
CCCTTCAACTGTTACTAGTTTTGTTCGTTTACTTGATGGTACAAACTGGAGAGAATGGACAAAAAAATGTACAATTGCTT
GTATAGGGCCTATTACGGAAAAAGAGGCGAGCCTTTATTTTCCGCATGTTATTATGCCGAAAGAGTACACTGTAGAAGCA
TTACTACAATGCGTTTGTGAATCTATAAAATAA

Upstream 100 bases:

>100_bases
GAACTGATCCAGAGAAAGTAGGATTAGAGGCTGCGGACCGTTTAATTAAGCAAGGCGCAAAAGAACTCATTCTTGCTGCA
AATAAGGGGCAACAATAAAT

Downstream 100 bases:

>100_bases
AAGAATGGGGATAGAAATCTATGAACTCTTTACAATTTAATCGTCATCGTCGCTTAAGACAAAGCGGGGGCATGCGTGCG
CTTGTGCGTGAAACGTTTTT

Product: uroporphyrinogen-III synthase

Products: NA

Alternate protein names: UROS; Hydroxymethylbilane hydrolyase [cyclizing]; Uroporphyrinogen-III cosynthase [H]

Number of amino acids: Translated: 250; Mature: 250

Protein sequence:

>250_residues
MNALAGKTVLITRAQHQAKQMSVAVKEKSGIPLEIPLLRMEGMSHRQIQHIAGQLHSYDWVIFTSKNGVAFFLDSLRKKL
PVTTKIAAVGVKTKLELEKRGYHVDFVPTSFVAEVFAEEFVKRLSGNERILFPKGNLAREVIPVALREIGVSLDELIVYG
TKVNIEKKQELIAALKLGKVDIITFTSPSTVTSFVRLLDGTNWREWTKKCTIACIGPITEKEASLYFPHVIMPKEYTVEA
LLQCVCESIK

Sequences:

>Translated_250_residues
MNALAGKTVLITRAQHQAKQMSVAVKEKSGIPLEIPLLRMEGMSHRQIQHIAGQLHSYDWVIFTSKNGVAFFLDSLRKKL
PVTTKIAAVGVKTKLELEKRGYHVDFVPTSFVAEVFAEEFVKRLSGNERILFPKGNLAREVIPVALREIGVSLDELIVYG
TKVNIEKKQELIAALKLGKVDIITFTSPSTVTSFVRLLDGTNWREWTKKCTIACIGPITEKEASLYFPHVIMPKEYTVEA
LLQCVCESIK
>Mature_250_residues
MNALAGKTVLITRAQHQAKQMSVAVKEKSGIPLEIPLLRMEGMSHRQIQHIAGQLHSYDWVIFTSKNGVAFFLDSLRKKL
PVTTKIAAVGVKTKLELEKRGYHVDFVPTSFVAEVFAEEFVKRLSGNERILFPKGNLAREVIPVALREIGVSLDELIVYG
TKVNIEKKQELIAALKLGKVDIITFTSPSTVTSFVRLLDGTNWREWTKKCTIACIGPITEKEASLYFPHVIMPKEYTVEA
LLQCVCESIK

Specific function: Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III [H]

COG id: COG1587

COG function: function code H; Uroporphyrinogen-III synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen-III synthase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003754 [H]

Pfam domain/function: PF02602 HEM4 [H]

EC number: =4.2.1.75 [H]

Molecular weight: Translated: 28010; Mature: 28010

Theoretical pI: Translated: 9.73; Mature: 9.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNALAGKTVLITRAQHQAKQMSVAVKEKSGIPLEIPLLRMEGMSHRQIQHIAGQLHSYDW
CCCCCCCEEEEECCHHHHHHHHEEEECCCCCCEEEEHHCCCCCCHHHHHHHHHHHCCCEE
VIFTSKNGVAFFLDSLRKKLPVTTKIAAVGVKTKLELEKRGYHVDFVPTSFVAEVFAEEF
EEEECCCCHHHHHHHHHHHCCCHHHHEEECCCEEEEHHHCCCEEEECCHHHHHHHHHHHH
VKRLSGNERILFPKGNLAREVIPVALREIGVSLDELIVYGTKVNIEKKQELIAALKLGKV
HHHHCCCCEEEECCCCHHHHHHHHHHHHHCCCHHHHEEECCEECHHHHHHHHHHHHCCCE
DIITFTSPSTVTSFVRLLDGTNWREWTKKCTIACIGPITEKEASLYFPHVIMPKEYTVEA
EEEEECCCHHHHHHHHHHCCCCHHHHHHHEEEEEECCCCCCCCCEECCEEECCCCCCHHH
LLQCVCESIK
HHHHHHHHCC
>Mature Secondary Structure
MNALAGKTVLITRAQHQAKQMSVAVKEKSGIPLEIPLLRMEGMSHRQIQHIAGQLHSYDW
CCCCCCCEEEEECCHHHHHHHHEEEECCCCCCEEEEHHCCCCCCHHHHHHHHHHHCCCEE
VIFTSKNGVAFFLDSLRKKLPVTTKIAAVGVKTKLELEKRGYHVDFVPTSFVAEVFAEEF
EEEECCCCHHHHHHHHHHHCCCHHHHEEECCCEEEEHHHCCCEEEECCHHHHHHHHHHHH
VKRLSGNERILFPKGNLAREVIPVALREIGVSLDELIVYGTKVNIEKKQELIAALKLGKV
HHHHCCCCEEEECCCCHHHHHHHHHHHHHCCCHHHHEEECCEECHHHHHHHHHHHHCCCE
DIITFTSPSTVTSFVRLLDGTNWREWTKKCTIACIGPITEKEASLYFPHVIMPKEYTVEA
EEEEECCCHHHHHHHHHHCCCCHHHHHHHEEEEEECCCCCCCCCEECCEEECCCCCCHHH
LLQCVCESIK
HHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1672867; 9384377; 2110138 [H]