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The map label for this gene is hemL [H]

Identifier: 118479627

GI number: 118479627

Start: 4275064

End: 4276353

Strand: Reverse

Name: hemL [H]

Synonym: BALH_4054

Alternate gene names: 118479627

Gene position: 4276353-4275064 (Counterclockwise)

Preceding gene: 118479628

Following gene: 118479626

Centisome position: 81.34

GC content: 41.16

Gene sequence:

>1290_bases
ATGAAAAAGTTTGATAAGTCGATTGCAGCGTTTGAAGAGGCTCAAGATTTAATGCCTGGTGGCGTAAATAGCCCGGTTCG
TGCATTTAAGTCTGTCGGTATGAATCCGTTGTTTATGGAGCGTGGAAAAGGCTCTAAAGTATATGATATCGATGGGAATG
AATACATCGATTACGTATTATCATGGGGTCCTTTAATTCATGGGCATGCAAATGATCGTGTTGTTGAGGCCTTAAAAGCT
GTTGCGGAAAGAGGTACAAGCTTCGGTGCTCCAACGGAAATTGAAAATAAATTAGCGAAACTTGTTATTGAGCGTGTACC
GTCAATTGAAATTGTGCGTATGGTTAACTCTGGAACAGAAGCAACAATGAGTGCGCTACGTTTAGCTCGTGGTTATACAG
GCCGTAACAAAATTTTGAAATTTATCGGTTGTTATCACGGTCATGGTGACTCGTTATTAATTAAAGCGGGTTCCGGTGTA
GCAACGCTAGGTTTACCAGATAGCCCTGGTGTACCAGAAGGTGTAGCGAAAAATACGATTACAGTAGCGTATAACGATTT
AGAAAGTGTGAAATACGCTTTCGAACAATTCGGTGATGATATTGCTTGTGTCATTGTAGAACCAGTAGCAGGGAACATGG
GTGTTGTTCCTCCGCAGCCAGGATTTTTAGAAGGTCTTCGTGAAGTAACAGAGCAAAATGGTGCATTGCTTATTTTTGAT
GAAGTAATGACAGGATTCCGAGTTGCTTATAATTGTGGACAAGGTTATTACGGTGTAACACCTGATTTAACTTGTTTAGG
TAAAGTAATTGGTGGTGGATTACCGGTAGGAGCATACGGTGGTAAAGCAGAAATTATGCGCCAAGTTGCACCGAGCGGAC
CGATTTACCAAGCAGGTACTTTATCAGGTAACCCACTTGCAATGGCAGCAGGTTATGAAACGTTAGTACAGTTAACGCCA
GAATCATATGTAGAATTCGAGCGTAAAGCTGAAATGTTAGAAGCTGGCTTACGTAAAGCGGCTGAAAAACATGGTATTCC
GCATCATATTAACCGTGCTGGTTCTATGATTGGTATCTTCTTTACAGATGAACCAGTTATTAATTACGATGCAGCAAAAT
CTTCAAACTTACAATTCTTTGCGGCTTACTATCGTGAAATGGTAGAACAAGGGGTATTTTTACCGCCATCTCAATTCGAA
GGTCTATTCTTATCGACAGCACATAGTGATGCAGATATTGAGGCGACGATTGCAGCGGCTGAAATTGCCATGTCAAAGTT
AAAAGCTTAA

Upstream 100 bases:

>100_bases
TTGAAAAATTAATTAGTATGAAACGTGCAGGAGCAGATTTAATTATTACGTATCATGCAAAAGATGCAGCAAGATGGTTA
CAAGAAGGAGGCGCTAAATA

Downstream 100 bases:

>100_bases
TTGAATAAAAAAAAATCGCTCTCCAAAAGGGGAGCGATTTTTTTTATTCATAAAGTCAGCTTTCCGTACATAAATCTGTA
ATGACATATAGTTTGGGAGG

Product: glutamate-1-semialdehyde aminotransferase

Products: NA

Alternate protein names: GSA 2; Glutamate-1-semialdehyde aminotransferase 2; GSA-AT 2 [H]

Number of amino acids: Translated: 429; Mature: 429

Protein sequence:

>429_residues
MKKFDKSIAAFEEAQDLMPGGVNSPVRAFKSVGMNPLFMERGKGSKVYDIDGNEYIDYVLSWGPLIHGHANDRVVEALKA
VAERGTSFGAPTEIENKLAKLVIERVPSIEIVRMVNSGTEATMSALRLARGYTGRNKILKFIGCYHGHGDSLLIKAGSGV
ATLGLPDSPGVPEGVAKNTITVAYNDLESVKYAFEQFGDDIACVIVEPVAGNMGVVPPQPGFLEGLREVTEQNGALLIFD
EVMTGFRVAYNCGQGYYGVTPDLTCLGKVIGGGLPVGAYGGKAEIMRQVAPSGPIYQAGTLSGNPLAMAAGYETLVQLTP
ESYVEFERKAEMLEAGLRKAAEKHGIPHHINRAGSMIGIFFTDEPVINYDAAKSSNLQFFAAYYREMVEQGVFLPPSQFE
GLFLSTAHSDADIEATIAAAEIAMSKLKA

Sequences:

>Translated_429_residues
MKKFDKSIAAFEEAQDLMPGGVNSPVRAFKSVGMNPLFMERGKGSKVYDIDGNEYIDYVLSWGPLIHGHANDRVVEALKA
VAERGTSFGAPTEIENKLAKLVIERVPSIEIVRMVNSGTEATMSALRLARGYTGRNKILKFIGCYHGHGDSLLIKAGSGV
ATLGLPDSPGVPEGVAKNTITVAYNDLESVKYAFEQFGDDIACVIVEPVAGNMGVVPPQPGFLEGLREVTEQNGALLIFD
EVMTGFRVAYNCGQGYYGVTPDLTCLGKVIGGGLPVGAYGGKAEIMRQVAPSGPIYQAGTLSGNPLAMAAGYETLVQLTP
ESYVEFERKAEMLEAGLRKAAEKHGIPHHINRAGSMIGIFFTDEPVINYDAAKSSNLQFFAAYYREMVEQGVFLPPSQFE
GLFLSTAHSDADIEATIAAAEIAMSKLKA
>Mature_429_residues
MKKFDKSIAAFEEAQDLMPGGVNSPVRAFKSVGMNPLFMERGKGSKVYDIDGNEYIDYVLSWGPLIHGHANDRVVEALKA
VAERGTSFGAPTEIENKLAKLVIERVPSIEIVRMVNSGTEATMSALRLARGYTGRNKILKFIGCYHGHGDSLLIKAGSGV
ATLGLPDSPGVPEGVAKNTITVAYNDLESVKYAFEQFGDDIACVIVEPVAGNMGVVPPQPGFLEGLREVTEQNGALLIFD
EVMTGFRVAYNCGQGYYGVTPDLTCLGKVIGGGLPVGAYGGKAEIMRQVAPSGPIYQAGTLSGNPLAMAAGYETLVQLTP
ESYVEFERKAEMLEAGLRKAAEKHGIPHHINRAGSMIGIFFTDEPVINYDAAKSSNLQFFAAYYREMVEQGVFLPPSQFE
GLFLSTAHSDADIEATIAAAEIAMSKLKA

Specific function: Porphyrin biosynthesis by the C5 pathway; second step. [C]

COG id: COG0001

COG function: function code H; Glutamate-1-semialdehyde aminotransferase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=303, Percent_Identity=31.023102310231, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI13994255, Length=327, Percent_Identity=27.82874617737, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI24119277, Length=349, Percent_Identity=26.647564469914, Blast_Score=90, Evalue=5e-18,
Organism=Homo sapiens, GI284507298, Length=222, Percent_Identity=32.4324324324324, Blast_Score=86, Evalue=5e-17,
Organism=Homo sapiens, GI37574042, Length=348, Percent_Identity=25.8620689655172, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI226442705, Length=343, Percent_Identity=26.2390670553936, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI226442709, Length=268, Percent_Identity=27.6119402985075, Blast_Score=76, Evalue=7e-14,
Organism=Escherichia coli, GI1786349, Length=424, Percent_Identity=57.5471698113208, Blast_Score=493, Evalue=1e-140,
Organism=Escherichia coli, GI1789759, Length=331, Percent_Identity=33.2326283987915, Blast_Score=139, Evalue=4e-34,
Organism=Escherichia coli, GI1789016, Length=350, Percent_Identity=30.5714285714286, Blast_Score=137, Evalue=2e-33,
Organism=Escherichia coli, GI1788044, Length=350, Percent_Identity=33.7142857142857, Blast_Score=135, Evalue=5e-33,
Organism=Escherichia coli, GI145693181, Length=340, Percent_Identity=30.8823529411765, Blast_Score=131, Evalue=9e-32,
Organism=Escherichia coli, GI1787560, Length=376, Percent_Identity=27.6595744680851, Blast_Score=99, Evalue=6e-22,
Organism=Escherichia coli, GI1786991, Length=377, Percent_Identity=26.2599469496021, Blast_Score=79, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI71992977, Length=392, Percent_Identity=27.2959183673469, Blast_Score=107, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI25144271, Length=309, Percent_Identity=28.4789644012945, Blast_Score=104, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI25144274, Length=147, Percent_Identity=34.6938775510204, Blast_Score=78, Evalue=9e-15,
Organism=Saccharomyces cerevisiae, GI6324432, Length=354, Percent_Identity=27.4011299435028, Blast_Score=97, Evalue=7e-21,
Organism=Saccharomyces cerevisiae, GI6323470, Length=288, Percent_Identity=28.8194444444444, Blast_Score=96, Evalue=1e-20,
Organism=Drosophila melanogaster, GI21357415, Length=300, Percent_Identity=27, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI21356575, Length=302, Percent_Identity=26.158940397351, Blast_Score=87, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004639
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =5.4.3.8 [H]

Molecular weight: Translated: 46004; Mature: 46004

Theoretical pI: Translated: 5.07; Mature: 5.07

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKFDKSIAAFEEAQDLMPGGVNSPVRAFKSVGMNPLFMERGKGSKVYDIDGNEYIDYVL
CCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCEEEECCCCCEEEECCCCHHHHHHH
SWGPLIHGHANDRVVEALKAVAERGTSFGAPTEIENKLAKLVIERVPSIEIVRMVNSGTE
HCCCEEECCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCHH
ATMSALRLARGYTGRNKILKFIGCYHGHGDSLLIKAGSGVATLGLPDSPGVPEGVAKNTI
HHHHHHHHHHCCCCHHHHHHHHHHHCCCCCEEEEECCCCEEEECCCCCCCCCCCCCCCEE
TVAYNDLESVKYAFEQFGDDIACVIVEPVAGNMGVVPPQPGFLEGLREVTEQNGALLIFD
EEEECHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEH
EVMTGFRVAYNCGQGYYGVTPDLTCLGKVIGGGLPVGAYGGKAEIMRQVAPSGPIYQAGT
HHHHHHHEEEECCCCCCCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCCEECCC
LSGNPLAMAAGYETLVQLTPESYVEFERKAEMLEAGLRKAAEKHGIPHHINRAGSMIGIF
CCCCCEEEECCHHHHHEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCEEEEE
FTDEPVINYDAAKSSNLQFFAAYYREMVEQGVFLPPSQFEGLFLSTAHSDADIEATIAAA
EECCCEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCCHHHHHHH
EIAMSKLKA
HHHHHHHCC
>Mature Secondary Structure
MKKFDKSIAAFEEAQDLMPGGVNSPVRAFKSVGMNPLFMERGKGSKVYDIDGNEYIDYVL
CCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCEEEECCCCCEEEECCCCHHHHHHH
SWGPLIHGHANDRVVEALKAVAERGTSFGAPTEIENKLAKLVIERVPSIEIVRMVNSGTE
HCCCEEECCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCHH
ATMSALRLARGYTGRNKILKFIGCYHGHGDSLLIKAGSGVATLGLPDSPGVPEGVAKNTI
HHHHHHHHHHCCCCHHHHHHHHHHHCCCCCEEEEECCCCEEEECCCCCCCCCCCCCCCEE
TVAYNDLESVKYAFEQFGDDIACVIVEPVAGNMGVVPPQPGFLEGLREVTEQNGALLIFD
EEEECHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEH
EVMTGFRVAYNCGQGYYGVTPDLTCLGKVIGGGLPVGAYGGKAEIMRQVAPSGPIYQAGT
HHHHHHHEEEECCCCCCCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCCEECCC
LSGNPLAMAAGYETLVQLTPESYVEFERKAEMLEAGLRKAAEKHGIPHHINRAGSMIGIF
CCCCCEEEECCHHHHHEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCEEEEE
FTDEPVINYDAAKSSNLQFFAAYYREMVEQGVFLPPSQFEGLFLSTAHSDADIEATIAAA
EECCCEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCCHHHHHHH
EIAMSKLKA
HHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA