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The map label for this gene is sqhC [H]

Identifier: 118478804

GI number: 118478804

Start: 3388452

End: 3390347

Strand: Reverse

Name: sqhC [H]

Synonym: BALH_3198

Alternate gene names: 118478804

Gene position: 3390347-3388452 (Counterclockwise)

Preceding gene: 118478805

Following gene: 118478803

Centisome position: 64.49

GC content: 37.34

Gene sequence:

>1896_bases
TTGAATATCGTTATACGGATTTCGAAAGGGTGGGTGAGTAACTTGTTATTAGACGAAAAAGCGCATGAAGAAATAGTGAG
AAGAGCAACTGCACTTCAAACAATGCAATGGCAAGATGGTACGTGGCGATTTTGTTTTGAAGGAGCTCCATTAACAGATT
GCCATACGATTTTTTTATTAAAATTATTAGGTAGAGATAAAGAGATAGAACCGTTCGTAGAAAGAGTGGCATCACTCCAA
ACAAATGAAGGAACATGGAAATTGTATGAAGATGAAGTAGGAGGTAATTTATCAGCTACAATTCAATCTTATGCCGCCTT
ACTTGCATCGAAAAAATATACAAAAGAAGATGCGAATATGAAACGAGCAGAAAATTTTATTCAGGAACGCGGTGGTGTGG
CGCGTGCTCATTTTATGACGAAGTTTTTATTAGCAATTCATGGAGAATATGAATATCCTTCACTCTTTCATGTACCAACA
CCAATCATGTTTCTACAGAATGATTCCCCCTTTAGTATATTTGAATTAAGTAGCTCAGCACGTATTCATTTAATTCCGAT
GATGCTATGTTTAAATAAAAGATTTCGAGTAGGGAAAAAGTTATTACCAAATTTAAATCACATTGCGGGCGGAGGCGGAG
AATGGTTTCGGGAGGATCGGTCTCCAGTTTTTCAAACGTTATTAAGTGATGTAAAACAAATTATATCGTATCCACTTTCG
TTACATCATAAAGGATATAAGGAAATAGAACGTTTTATGAAAGAGCGTATTGATGAAAATGGAACGTTATATAGTTACGC
AACTGCCTCGTTTTATATGATTTATGCTTTACTTGCGTTAGGGCATTCTCTTCAATCATCAATGATTCAAAAGGCTATAG
CTGGGATAACATCTTATATATGGAAGATGGAAAGAGGGAATCATTTGCAAAACTCTCCTTCAACCGTGTGGGATACAGCT
TTATTAAGCTATGCGTTACAAGAGGCTCAAGTTTCAAAGGATAATAAGATGATTCAAAATGCAACAGCGTATTTATTAAA
AAAACAGCATACAAAAAAAGCTGATTGGAGCGTACATGCTCAGGCACTTACTCCTGGCGGTTGGGGTTTTTCGGATGTGA
ATACGACAATTCCAGATATAGATGATACAACAGCTGTGCTAAGGGCATTGGCACGAAGTAGAGGAAACAAAAATATAGAT
AATGCTTGGAAGAAAGGGGTCAATTGGATTAAAGGATTACAAAACAATGATGGTGGCTGGGGAGCATTTGAAAAAGGTGT
GACGAGCAAATTATTAGCAAAATTACCAATCGAAAACGCAAGTGATATGATTACAGATCCTTCTACGCCAGATATTACGG
GGAGAGTGTTAGAGTTTTTCGGGACGTATGCACAAAACGAATTGCCTGAGAAACAGATACAAAGGGCAATAAATTGGTTA
ATGAATGTACAAGAGGAAAATGGATCATGGTATGGGAAATGGGGGATTTGTTATATATATGGTACGTGGGCTGTTATGAC
TGGTTTACGGTCACTCGGAATTCCGTCTAGCAATCCTTCATTGACACGAGCAGCTTCATGGCTTGAACATATACAGCATG
AAGATGGTGGTTGGGGAGAATCATGCCACAGTAGTGTGGAGAAAAGGTTCGTTACTTTACCATTTAGTACACCATCCCAA
ACTGCATGGGCGTTAGATGCTCTCATTTCTTACTATGATACAGAAACGCCAGCTATTCGAAAAGGTGTTTCATATTTGCT
TTCGAATCCTTATGTGAATGAAAGATATCCTACTGGAACAGGTTTACCAGGTGCGTTTTATATTAGATATCATAGCTATG
CCCATATATATCCACTACTTACTTTGGCACATTATATAAAAAAATATAGAAAATAA

Upstream 100 bases:

>100_bases
TGCTTTATTAGGGATTATTGTCGGAGTAGGATATTGTTTATGAGCAGAACATTTTATATGTTCTGCTTTTCTTTGTATTC
ATACATATTCAGCTACCTTC

Downstream 100 bases:

>100_bases
ACCGAGAGATATCTCTCGGTTTATTTTGTTGGGTAGTAGGTCCCTGTTGAAAAGAATAAGGTTGTGCTTCCTTATTTTTC
TGTTGACTGGCGTTTTTGAC

Product: squalene-hopene cyclase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 631; Mature: 631

Protein sequence:

>631_residues
MNIVIRISKGWVSNLLLDEKAHEEIVRRATALQTMQWQDGTWRFCFEGAPLTDCHTIFLLKLLGRDKEIEPFVERVASLQ
TNEGTWKLYEDEVGGNLSATIQSYAALLASKKYTKEDANMKRAENFIQERGGVARAHFMTKFLLAIHGEYEYPSLFHVPT
PIMFLQNDSPFSIFELSSSARIHLIPMMLCLNKRFRVGKKLLPNLNHIAGGGGEWFREDRSPVFQTLLSDVKQIISYPLS
LHHKGYKEIERFMKERIDENGTLYSYATASFYMIYALLALGHSLQSSMIQKAIAGITSYIWKMERGNHLQNSPSTVWDTA
LLSYALQEAQVSKDNKMIQNATAYLLKKQHTKKADWSVHAQALTPGGWGFSDVNTTIPDIDDTTAVLRALARSRGNKNID
NAWKKGVNWIKGLQNNDGGWGAFEKGVTSKLLAKLPIENASDMITDPSTPDITGRVLEFFGTYAQNELPEKQIQRAINWL
MNVQEENGSWYGKWGICYIYGTWAVMTGLRSLGIPSSNPSLTRAASWLEHIQHEDGGWGESCHSSVEKRFVTLPFSTPSQ
TAWALDALISYYDTETPAIRKGVSYLLSNPYVNERYPTGTGLPGAFYIRYHSYAHIYPLLTLAHYIKKYRK

Sequences:

>Translated_631_residues
MNIVIRISKGWVSNLLLDEKAHEEIVRRATALQTMQWQDGTWRFCFEGAPLTDCHTIFLLKLLGRDKEIEPFVERVASLQ
TNEGTWKLYEDEVGGNLSATIQSYAALLASKKYTKEDANMKRAENFIQERGGVARAHFMTKFLLAIHGEYEYPSLFHVPT
PIMFLQNDSPFSIFELSSSARIHLIPMMLCLNKRFRVGKKLLPNLNHIAGGGGEWFREDRSPVFQTLLSDVKQIISYPLS
LHHKGYKEIERFMKERIDENGTLYSYATASFYMIYALLALGHSLQSSMIQKAIAGITSYIWKMERGNHLQNSPSTVWDTA
LLSYALQEAQVSKDNKMIQNATAYLLKKQHTKKADWSVHAQALTPGGWGFSDVNTTIPDIDDTTAVLRALARSRGNKNID
NAWKKGVNWIKGLQNNDGGWGAFEKGVTSKLLAKLPIENASDMITDPSTPDITGRVLEFFGTYAQNELPEKQIQRAINWL
MNVQEENGSWYGKWGICYIYGTWAVMTGLRSLGIPSSNPSLTRAASWLEHIQHEDGGWGESCHSSVEKRFVTLPFSTPSQ
TAWALDALISYYDTETPAIRKGVSYLLSNPYVNERYPTGTGLPGAFYIRYHSYAHIYPLLTLAHYIKKYRK
>Mature_631_residues
MNIVIRISKGWVSNLLLDEKAHEEIVRRATALQTMQWQDGTWRFCFEGAPLTDCHTIFLLKLLGRDKEIEPFVERVASLQ
TNEGTWKLYEDEVGGNLSATIQSYAALLASKKYTKEDANMKRAENFIQERGGVARAHFMTKFLLAIHGEYEYPSLFHVPT
PIMFLQNDSPFSIFELSSSARIHLIPMMLCLNKRFRVGKKLLPNLNHIAGGGGEWFREDRSPVFQTLLSDVKQIISYPLS
LHHKGYKEIERFMKERIDENGTLYSYATASFYMIYALLALGHSLQSSMIQKAIAGITSYIWKMERGNHLQNSPSTVWDTA
LLSYALQEAQVSKDNKMIQNATAYLLKKQHTKKADWSVHAQALTPGGWGFSDVNTTIPDIDDTTAVLRALARSRGNKNID
NAWKKGVNWIKGLQNNDGGWGAFEKGVTSKLLAKLPIENASDMITDPSTPDITGRVLEFFGTYAQNELPEKQIQRAINWL
MNVQEENGSWYGKWGICYIYGTWAVMTGLRSLGIPSSNPSLTRAASWLEHIQHEDGGWGESCHSSVEKRFVTLPFSTPSQ
TAWALDALISYYDTETPAIRKGVSYLLSNPYVNERYPTGTGLPGAFYIRYHSYAHIYPLLTLAHYIKKYRK

Specific function: Catalyzes the cyclization of squalene into hopene [H]

COG id: COG1657

COG function: function code I; Squalene cyclase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 3 PFTB repeats [H]

Homologues:

Organism=Homo sapiens, GI47933395, Length=627, Percent_Identity=23.6044657097289, Blast_Score=125, Evalue=2e-28,
Organism=Homo sapiens, GI47933397, Length=627, Percent_Identity=23.6044657097289, Blast_Score=125, Evalue=2e-28,
Organism=Homo sapiens, GI224177558, Length=627, Percent_Identity=23.6044657097289, Blast_Score=125, Evalue=2e-28,
Organism=Homo sapiens, GI224177556, Length=564, Percent_Identity=23.4042553191489, Blast_Score=120, Evalue=4e-27,
Organism=Saccharomyces cerevisiae, GI6321863, Length=292, Percent_Identity=28.0821917808219, Blast_Score=82, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001330
- InterPro:   IPR018333
- InterPro:   IPR008930 [H]

Pfam domain/function: PF00432 Prenyltrans [H]

EC number: =5.4.99.17 [H]

Molecular weight: Translated: 71516; Mature: 71516

Theoretical pI: Translated: 8.85; Mature: 8.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIVIRISKGWVSNLLLDEKAHEEIVRRATALQTMQWQDGTWRFCFEGAPLTDCHTIFLL
CCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHH
KLLGRDKEIEPFVERVASLQTNEGTWKLYEDEVGGNLSATIQSYAALLASKKYTKEDANM
HHHCCCCCCHHHHHHHHHCCCCCCCEEEEHHCCCCCHHHHHHHHHHHHHHHHHCHHHHHH
KRAENFIQERGGVARAHFMTKFLLAIHGEYEYPSLFHVPTPIMFLQNDSPFSIFELSSSA
HHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCEEECCCCEEEEECCCCCEEEEECCCC
RIHLIPMMLCLNKRFRVGKKLLPNLNHIAGGGGEWFREDRSPVFQTLLSDVKQIISYPLS
EEHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCHHHHHHCCCHHHHHHHHHHHHHHHCCHH
LHHKGYKEIERFMKERIDENGTLYSYATASFYMIYALLALGHSLQSSMIQKAIAGITSYI
HCCCCHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
WKMERGNHLQNSPSTVWDTALLSYALQEAQVSKDNKMIQNATAYLLKKQHTKKADWSVHA
HHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEE
QALTPGGWGFSDVNTTIPDIDDTTAVLRALARSRGNKNIDNAWKKGVNWIKGLQNNDGGW
EEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCC
GAFEKGVTSKLLAKLPIENASDMITDPSTPDITGRVLEFFGTYAQNELPEKQIQRAINWL
CHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
MNVQEENGSWYGKWGICYIYGTWAVMTGLRSLGIPSSNPSLTRAASWLEHIQHEDGGWGE
HCCHHCCCCEEECCEEEEEEHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCH
SCHSSVEKRFVTLPFSTPSQTAWALDALISYYDTETPAIRKGVSYLLSNPYVNERYPTGT
HHHHHHHHCEEECCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCC
GLPGAFYIRYHSYAHIYPLLTLAHYIKKYRK
CCCCEEEEEECCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNIVIRISKGWVSNLLLDEKAHEEIVRRATALQTMQWQDGTWRFCFEGAPLTDCHTIFLL
CCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHH
KLLGRDKEIEPFVERVASLQTNEGTWKLYEDEVGGNLSATIQSYAALLASKKYTKEDANM
HHHCCCCCCHHHHHHHHHCCCCCCCEEEEHHCCCCCHHHHHHHHHHHHHHHHHCHHHHHH
KRAENFIQERGGVARAHFMTKFLLAIHGEYEYPSLFHVPTPIMFLQNDSPFSIFELSSSA
HHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCEEECCCCEEEEECCCCCEEEEECCCC
RIHLIPMMLCLNKRFRVGKKLLPNLNHIAGGGGEWFREDRSPVFQTLLSDVKQIISYPLS
EEHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCHHHHHHCCCHHHHHHHHHHHHHHHCCHH
LHHKGYKEIERFMKERIDENGTLYSYATASFYMIYALLALGHSLQSSMIQKAIAGITSYI
HCCCCHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
WKMERGNHLQNSPSTVWDTALLSYALQEAQVSKDNKMIQNATAYLLKKQHTKKADWSVHA
HHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEE
QALTPGGWGFSDVNTTIPDIDDTTAVLRALARSRGNKNIDNAWKKGVNWIKGLQNNDGGW
EEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCC
GAFEKGVTSKLLAKLPIENASDMITDPSTPDITGRVLEFFGTYAQNELPEKQIQRAINWL
CHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
MNVQEENGSWYGKWGICYIYGTWAVMTGLRSLGIPSSNPSLTRAASWLEHIQHEDGGWGE
HCCHHCCCCEEECCEEEEEEHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCH
SCHSSVEKRFVTLPFSTPSQTAWALDALISYYDTETPAIRKGVSYLLSNPYVNERYPTGT
HHHHHHHHCEEECCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCC
GLPGAFYIRYHSYAHIYPLLTLAHYIKKYRK
CCCCEEEEEECCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]