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The map label for this gene is csgA [H]

Identifier: 118478685

GI number: 118478685

Start: 3255530

End: 3256234

Strand: Reverse

Name: csgA [H]

Synonym: BALH_3071

Alternate gene names: 118478685

Gene position: 3256234-3255530 (Counterclockwise)

Preceding gene: 118478686

Following gene: 118478684

Centisome position: 61.94

GC content: 36.17

Gene sequence:

>705_bases
ATGAGAGTGTTTATTACAGGTGGAAATCGTGGATTAGGGTTACAGTTAGTAAAAGTATTTCATGAAAATGGGCATATTGT
TTACCCGTTAGTTAGAACTGAGGTTGCGGTAACACAATTGAAGCAAATGTTTAGTTGTAGATGTTTTCCTATATTAGCAG
ACTTATCGGCTGATGAGAGTACAGAGCAAATTAAGAAACAGCTTGAGGAATATACAGAGTATATTGATCTAGTTATAAAT
AACGCTGGAATTACTGGAAAGGAGACTGAGGTTTTACATACGAATTCAGAAGAGTTAACGGACTTATTTAATATTCATTG
CTTAGGTGTAATTCGAGCTGTAAAAGGTACATATGTGGCTTTAGCTAAATCGGATCATCCGAGAATCATAAATGTATCTT
CTCGATTAGGCTCATTGCATAAAATGGCGAACAAAGAGTTTCCACAAGGTCAGTTCTCATATTCATATCGAATTGCTAAA
GCTGCACAAAATATGTTAACGCTCTGCTTACAACAAGAGTTTGAGGATAAAGGAATAAGTGTAACTGCCATTCATCCTGG
AAAATTAAAGACTGACATTGGTGCTTTTGATGCGAATATGACCCCGGCTGAAGGAGCAAAAAATATATATGATTGGGTAA
TAGATTCAAATGAGGATGTTTCAGGGAAGTTTATTGAGCCAGGTGTAGGTGAAATAAAGTGGTGA

Upstream 100 bases:

>100_bases
GAGCAGGTTTTTCTTTTGAATGTAAGAGAGAGGCGTTTTCTTTAGAGAATGGTAAGTGGATGGATTTTCTTATTTATTAT
AAAAATAAGGAGATGGATAT

Downstream 100 bases:

>100_bases
TATACGATCTTGCAATCATTCAGAATTTGTTTGGCCCTTCTAAAAAAGTATTAAATGGCTTACCAAATGCAGTGAGCATT
GAAGAAATAGAAGAAGACGT

Product: short chain dehydrogenase

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: C signal [H]

Number of amino acids: Translated: 234; Mature: 234

Protein sequence:

>234_residues
MRVFITGGNRGLGLQLVKVFHENGHIVYPLVRTEVAVTQLKQMFSCRCFPILADLSADESTEQIKKQLEEYTEYIDLVIN
NAGITGKETEVLHTNSEELTDLFNIHCLGVIRAVKGTYVALAKSDHPRIINVSSRLGSLHKMANKEFPQGQFSYSYRIAK
AAQNMLTLCLQQEFEDKGISVTAIHPGKLKTDIGAFDANMTPAEGAKNIYDWVIDSNEDVSGKFIEPGVGEIKW

Sequences:

>Translated_234_residues
MRVFITGGNRGLGLQLVKVFHENGHIVYPLVRTEVAVTQLKQMFSCRCFPILADLSADESTEQIKKQLEEYTEYIDLVIN
NAGITGKETEVLHTNSEELTDLFNIHCLGVIRAVKGTYVALAKSDHPRIINVSSRLGSLHKMANKEFPQGQFSYSYRIAK
AAQNMLTLCLQQEFEDKGISVTAIHPGKLKTDIGAFDANMTPAEGAKNIYDWVIDSNEDVSGKFIEPGVGEIKW
>Mature_234_residues
MRVFITGGNRGLGLQLVKVFHENGHIVYPLVRTEVAVTQLKQMFSCRCFPILADLSADESTEQIKKQLEEYTEYIDLVIN
NAGITGKETEVLHTNSEELTDLFNIHCLGVIRAVKGTYVALAKSDHPRIINVSSRLGSLHKMANKEFPQGQFSYSYRIAK
AAQNMLTLCLQQEFEDKGISVTAIHPGKLKTDIGAFDANMTPAEGAKNIYDWVIDSNEDVSGKFIEPGVGEIKW

Specific function: Cell-cell signaling protein required for fruiting body morphogenesis. Necessary for cellular aggregation, for spore differentiation, and for gene expression that is initiated after 6 hour of starvation [H]

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: To yeast YKL071W [H]

Homologues:

Organism=Escherichia coli, GI1787335, Length=190, Percent_Identity=24.2105263157895, Blast_Score=71, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI17558006, Length=226, Percent_Identity=29.646017699115, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17558990, Length=214, Percent_Identity=27.5700934579439, Blast_Score=71, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17558994, Length=217, Percent_Identity=28.110599078341, Blast_Score=68, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6322779, Length=243, Percent_Identity=26.3374485596708, Blast_Score=68, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24640547, Length=250, Percent_Identity=24.8, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 26064; Mature: 26064

Theoretical pI: Translated: 6.16; Mature: 6.16

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVFITGGNRGLGLQLVKVFHENGHIVYPLVRTEVAVTQLKQMFSCRCFPILADLSADES
CEEEEECCCCCCHHHHHEEHHCCCCEEEEHHHHHHHHHHHHHHHCCCCEEEEECCCCCCH
TEQIKKQLEEYTEYIDLVINNAGITGKETEVLHTNSEELTDLFNIHCLGVIRAVKGTYVA
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHCCCEEE
LAKSDHPRIINVSSRLGSLHKMANKEFPQGQFSYSYRIAKAAQNMLTLCLQQEFEDKGIS
EEECCCCCEEEHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCE
VTAIHPGKLKTDIGAFDANMTPAEGAKNIYDWVIDSNEDVSGKFIEPGVGEIKW
EEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHEECCCCCCCCEEECCCCCCCCC
>Mature Secondary Structure
MRVFITGGNRGLGLQLVKVFHENGHIVYPLVRTEVAVTQLKQMFSCRCFPILADLSADES
CEEEEECCCCCCHHHHHEEHHCCCCEEEEHHHHHHHHHHHHHHHCCCCEEEEECCCCCCH
TEQIKKQLEEYTEYIDLVINNAGITGKETEVLHTNSEELTDLFNIHCLGVIRAVKGTYVA
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHCCCEEE
LAKSDHPRIINVSSRLGSLHKMANKEFPQGQFSYSYRIAKAAQNMLTLCLQQEFEDKGIS
EEECCCCCEEEHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCE
VTAIHPGKLKTDIGAFDANMTPAEGAKNIYDWVIDSNEDVSGKFIEPGVGEIKW
EEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHEECCCCCCCCEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2152896; 2107980; 2118510; 1372277 [H]