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The map label for this gene is sdaC [H]

Identifier: 118478670

GI number: 118478670

Start: 3242513

End: 3243883

Strand: Reverse

Name: sdaC [H]

Synonym: BALH_3056

Alternate gene names: 118478670

Gene position: 3243883-3242513 (Counterclockwise)

Preceding gene: 118478671

Following gene: 118478669

Centisome position: 61.7

GC content: 34.72

Gene sequence:

>1371_bases
TTGTTAGATGCAAAGAGAGATGCAGGAATAGATACAAGGGGGAGTTATTATATGAACGGGAATACTGCAAAGAAAATAGA
AGTTCAAGCTGAAAATAACGCACTAAAAAATGAGCAATATGCAGATCCGAAAAAGTGGCATAAGCAGGATACTACATGGG
CACTCAGTCTATTTGGAACTGCAATTGGAGCAGGGGTGCTCTTTTTACCGATTAATGCAGGTTCAGGTGGTTTATTATCA
TTACTACTAATTACATTGCTTGCATATCCAGTTATGTATTACTCACATAGGGCACTTGCTAAAATGATATACGCTTCTAA
TTCTGCTGATGAGGGGATCACAGGTACAATTAGAGAGTATTTCGGAAATAAAGCGAGTATCATTTTTAACATCGTATATT
TCGGTTCAATTTATACAATCGTACTAATGTATTCGGTTGCGCTTACAAATACTGCAAGTAGTTTTATCGTGCATCAATTG
AACATGCCAGAACCTCCAAGGGCTATTTTATCACTTGTATTAGTACTTGGTCTTATCGCTATACTAAACTTTGGTCAAGA
TATTACTGTAAAGGTAATGAGTATGCTAGTGTATCCTTTCATAGCTTCTCTACTGTTTATCGCAATATCTTTAATTCCAC
AGTGGAATACGTCAATGCTTAATTTTTCAAGTGTTTCAACTGCTTCAACAGGAACAGGATATTTTGGAACGATATTGATG
ATTTTACCAATCATCGTATTCTCATTTAATCATTCACCTATGATTTCATCATTTGTTGTGAAGCAAAGAGCTACGTATGG
AATCGATGCTACTGATGCTAAATGTGCGCAAATACAAAAAGTTTGTTATATTATGACATTTGCTGTTGTTATGTTCTTCG
TTTGGAGTAGCGCGCTAAGCTTGACTCCAGATGATATTAAAATGGCAAAAGAACAAAACCTATCAATTCTTTCTTATCTT
GCTAATGAGCTTAATTCACCTGTAATCACGATTGCAGCTCCAATCATTGCTTTTGTGGCTATTACAAAGTCTTTCCTTGG
CCATTATAGTGGAGCATTTGAAGTAATGCGTGACATGATTATTAAGTTTGGTAAATCACGTGGAAAAGATATTGAAGAAA
AAACAATTAAGACAATAATCCTTACTTTTGTTGTATTATCATGCTGGTTTGTTGCTTATACAAATCCAAGTATTCTTGGA
CTTATTGATTCTCTAAGCGGTCCATTAGTTGCTGCTATCTTATGTTTATTACCGATGTATGCGATTCAAAAAGTACCAGT
ACTAGCTAAATACAAAGGGAAAATGAGTAACGTATTTGTTATTATTGTAGGTGTGCTTACTGTTTTAGCAAGTATTAAGT
CATTATTCTAA

Upstream 100 bases:

>100_bases
AGGACGCTAACTAACGAATGTTTCAATTTGGTTTTATTATGATGAAGAACATACAATGTGGGGCAACTTGTAAGGAATTC
ATTTTCCAGAAAGGGAATAT

Downstream 100 bases:

>100_bases
TTCACGATTGTTAGTTCTAATATAAAATAGAACAATTTTGGGACAGGCTTCTCCGTTTGGAGAGTCTGTCCCTTTTTCAT
GCGTTACAGTTTAATCTTAT

Product: serine transporter

Products: Proton [Cytoplasm]; D-serine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 456; Mature: 456

Protein sequence:

>456_residues
MLDAKRDAGIDTRGSYYMNGNTAKKIEVQAENNALKNEQYADPKKWHKQDTTWALSLFGTAIGAGVLFLPINAGSGGLLS
LLLITLLAYPVMYYSHRALAKMIYASNSADEGITGTIREYFGNKASIIFNIVYFGSIYTIVLMYSVALTNTASSFIVHQL
NMPEPPRAILSLVLVLGLIAILNFGQDITVKVMSMLVYPFIASLLFIAISLIPQWNTSMLNFSSVSTASTGTGYFGTILM
ILPIIVFSFNHSPMISSFVVKQRATYGIDATDAKCAQIQKVCYIMTFAVVMFFVWSSALSLTPDDIKMAKEQNLSILSYL
ANELNSPVITIAAPIIAFVAITKSFLGHYSGAFEVMRDMIIKFGKSRGKDIEEKTIKTIILTFVVLSCWFVAYTNPSILG
LIDSLSGPLVAAILCLLPMYAIQKVPVLAKYKGKMSNVFVIIVGVLTVLASIKSLF

Sequences:

>Translated_456_residues
MLDAKRDAGIDTRGSYYMNGNTAKKIEVQAENNALKNEQYADPKKWHKQDTTWALSLFGTAIGAGVLFLPINAGSGGLLS
LLLITLLAYPVMYYSHRALAKMIYASNSADEGITGTIREYFGNKASIIFNIVYFGSIYTIVLMYSVALTNTASSFIVHQL
NMPEPPRAILSLVLVLGLIAILNFGQDITVKVMSMLVYPFIASLLFIAISLIPQWNTSMLNFSSVSTASTGTGYFGTILM
ILPIIVFSFNHSPMISSFVVKQRATYGIDATDAKCAQIQKVCYIMTFAVVMFFVWSSALSLTPDDIKMAKEQNLSILSYL
ANELNSPVITIAAPIIAFVAITKSFLGHYSGAFEVMRDMIIKFGKSRGKDIEEKTIKTIILTFVVLSCWFVAYTNPSILG
LIDSLSGPLVAAILCLLPMYAIQKVPVLAKYKGKMSNVFVIIVGVLTVLASIKSLF
>Mature_456_residues
MLDAKRDAGIDTRGSYYMNGNTAKKIEVQAENNALKNEQYADPKKWHKQDTTWALSLFGTAIGAGVLFLPINAGSGGLLS
LLLITLLAYPVMYYSHRALAKMIYASNSADEGITGTIREYFGNKASIIFNIVYFGSIYTIVLMYSVALTNTASSFIVHQL
NMPEPPRAILSLVLVLGLIAILNFGQDITVKVMSMLVYPFIASLLFIAISLIPQWNTSMLNFSSVSTASTGTGYFGTILM
ILPIIVFSFNHSPMISSFVVKQRATYGIDATDAKCAQIQKVCYIMTFAVVMFFVWSSALSLTPDDIKMAKEQNLSILSYL
ANELNSPVITIAAPIIAFVAITKSFLGHYSGAFEVMRDMIIKFGKSRGKDIEEKTIKTIILTFVVLSCWFVAYTNPSILG
LIDSLSGPLVAAILCLLPMYAIQKVPVLAKYKGKMSNVFVIIVGVLTVLASIKSLF

Specific function: Involved in the import of serine into the cell. May be required for phage C1 adsorption by interacting with DrcB. May also be involved in ampicillin sensitivity [H]

COG id: COG0814

COG function: function code E; Amino acid permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid/polyamine transporter 2 family. SdaC/TdcC subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789160, Length=429, Percent_Identity=50.8158508158508, Blast_Score=420, Evalue=1e-118,
Organism=Escherichia coli, GI1789504, Length=428, Percent_Identity=44.8598130841121, Blast_Score=351, Evalue=5e-98,
Organism=Escherichia coli, GI1789211, Length=411, Percent_Identity=36.7396593673966, Blast_Score=253, Evalue=1e-68,
Organism=Escherichia coli, GI145693183, Length=429, Percent_Identity=25.1748251748252, Blast_Score=134, Evalue=2e-32,
Organism=Escherichia coli, GI1789961, Length=413, Percent_Identity=23.9709443099274, Blast_Score=117, Evalue=1e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004694
- InterPro:   IPR018227 [H]

Pfam domain/function: PF03222 Trp_Tyr_perm [H]

EC number: NA

Molecular weight: Translated: 49922; Mature: 49922

Theoretical pI: Translated: 9.43; Mature: 9.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDAKRDAGIDTRGSYYMNGNTAKKIEVQAENNALKNEQYADPKKWHKQDTTWALSLFGT
CCCCCCCCCCCCCCCEEECCCCCEEEEEEECCCCCCCCCCCCHHHHCCCCCHHHHHHHHH
AIGAGVLFLPINAGSGGLLSLLLITLLAYPVMYYSHRALAKMIYASNSADEGITGTIREY
HHCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHH
FGNKASIIFNIVYFGSIYTIVLMYSVALTNTASSFIVHQLNMPEPPRAILSLVLVLGLIA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHHH
ILNFGQDITVKVMSMLVYPFIASLLFIAISLIPQWNTSMLNFSSVSTASTGTGYFGTILM
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEECCCCCCCCCCCHHHHHHHH
ILPIIVFSFNHSPMISSFVVKQRATYGIDATDAKCAQIQKVCYIMTFAVVMFFVWSSALS
HHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
LTPDDIKMAKEQNLSILSYLANELNSPVITIAAPIIAFVAITKSFLGHYSGAFEVMRDMI
CCHHHHHHHHHCCHHHHHHHHHHHCCCEEHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
IKFGKSRGKDIEEKTIKTIILTFVVLSCWFVAYTNPSILGLIDSLSGPLVAAILCLLPMY
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHHH
AIQKVPVLAKYKGKMSNVFVIIVGVLTVLASIKSLF
HHHHCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MLDAKRDAGIDTRGSYYMNGNTAKKIEVQAENNALKNEQYADPKKWHKQDTTWALSLFGT
CCCCCCCCCCCCCCCEEECCCCCEEEEEEECCCCCCCCCCCCHHHHCCCCCHHHHHHHHH
AIGAGVLFLPINAGSGGLLSLLLITLLAYPVMYYSHRALAKMIYASNSADEGITGTIREY
HHCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHH
FGNKASIIFNIVYFGSIYTIVLMYSVALTNTASSFIVHQLNMPEPPRAILSLVLVLGLIA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHHH
ILNFGQDITVKVMSMLVYPFIASLLFIAISLIPQWNTSMLNFSSVSTASTGTGYFGTILM
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEECCCCCCCCCCCHHHHHHHH
ILPIIVFSFNHSPMISSFVVKQRATYGIDATDAKCAQIQKVCYIMTFAVVMFFVWSSALS
HHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
LTPDDIKMAKEQNLSILSYLANELNSPVITIAAPIIAFVAITKSFLGHYSGAFEVMRDMI
CCHHHHHHHHHCCHHHHHHHHHHHCCCEEHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
IKFGKSRGKDIEEKTIKTIILTFVVLSCWFVAYTNPSILGLIDSLSGPLVAAILCLLPMY
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHHH
AIQKVPVLAKYKGKMSNVFVIIVGVLTVLASIKSLF
HHHHCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; D-serine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + D-serine [Periplasm] = Proton [Cytoplasm] + D-serine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]