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The map label for this gene is ycgH [H]

Identifier: 118478421

GI number: 118478421

Start: 2947773

End: 2949116

Strand: Reverse

Name: ycgH [H]

Synonym: BALH_2789

Alternate gene names: 118478421

Gene position: 2949116-2947773 (Counterclockwise)

Preceding gene: 118478422

Following gene: 118478418

Centisome position: 56.1

GC content: 33.41

Gene sequence:

>1344_bases
ATGACCTGTCATGATGTTGAGAACGAAACGGAAGAAAAAAAAGATTTAAAATGGTGGCAGCTCTCACTTATTGGGATTGG
TTGTACAATAGGGACCGGCTTCTTTTTAGGATCCAGTATAGGTATTAAAATAGGTGGATCTTCAATTATTCTCATTCTCA
TTTTAACTGGATTTACTACTTATATTGTATTTGAAGCATTGGCAAAAATGGCTGTAGAAGATCCGCAAAAAGGATCTTTT
CGCATGTATTCAAAAAAAGCTTTTGGAAATTGGGCGGGTTTTAGTCATGGATGGACATACTGGTGTTCTGAACTGCTTAT
TATGGGCAGCCAGTTAAGTGCGTTAGGAATCTTTTCACGCTACTGGTTTCCTAAAATACCATTATGGATATTTGCTGCTA
TATACGGAGTAGCAGCTATATTAATTATTTTTATAGGGGTAAAGATATTTGAACGCCTAGAAAAATGGATGGCTATTATA
AAAATTGCGGCTATTATAGGATTCATCGTAATTGCTATTTTAGTTATTTTAGGATTTATAAAGGGTGGTTTATATAAAGC
ACAAATTCCGCGGGATTTTAAAGACTGGTTCCCAAATGGATTAAAAGGCACTTGGTCCTCTCTAATTTATGCATTTTATG
CATTTGGAGGAATCGAAATTATGGGGTTAATGACAATAAGACTGAAAGACCCTAAAGATGCACAAAAATCAGGAAGAGTA
ATGTTAATGATTTTAACGATTATTTACGTAGTTTCTTTAGGGTTGGCAATTATGATGGTTCCATTAAACCAGTTTAATAC
GAAAGAAAGCCCTTTTGTAATAGCATTACAAGACTATAATTTGCCGTATGTGCCATTTATTTTAAATGTAGTGTTAATTT
TAGCGGGTTTTTCAACATTAGTTGGTTCATTATTTGCAGTGACAAGTGTACTCATGAACTTAGCTGAAGAAGGTGATGCA
CCTGCAATGTTTGCTAAAAAAAACAAAAAAAACATCTCTTTTCCAGCTCTAATTCTTATTATAATTGGACTTGGTGCTTC
TATCCTTAGTGCTTTATTACTACCGAAAAATATATATGAATATGTAACAACTGCAGCTGGATTAATGTTGTTATATACAT
GGAGTCTCATCCTTCTTTCATTTTGGAGATTAATGAATCCAAAAGGTTGGATGCAGATAAAAAGCATTATTGGTCTTATA
ATGATTGCATTAGCTGTTAGTGGGACATTATTGCAAAAAACAACGCGTTTTGGTTTCCTAGTGAGCTTGTTGTTTTTAGG
AATAGTTATTATTGTTACTATAATTGTTCATTTTGTCTCAAAGAAAAGGAATACAGCTATATGA

Upstream 100 bases:

>100_bases
TAAAGGCTCATAATGTCACTGATGTTATTGAAAAGCTTGCCGAGAAGTATTCAAGTGATCATGAGGGGCATTCTCAAAAT
GAATAAAGGAGAATAGTAAT

Downstream 100 bases:

>100_bases
AGAATCTATTTTTATACAATATGAGTAGTATGTAACAACTAAATAATAGAAGCTAGTGAAAAATGATTTGGTAAGTTTGA
AAACCAAAATATAATCCATA

Product: amino acid permease

Products: Proton [Cytoplasm]; L-proline [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 447; Mature: 446

Protein sequence:

>447_residues
MTCHDVENETEEKKDLKWWQLSLIGIGCTIGTGFFLGSSIGIKIGGSSIILILILTGFTTYIVFEALAKMAVEDPQKGSF
RMYSKKAFGNWAGFSHGWTYWCSELLIMGSQLSALGIFSRYWFPKIPLWIFAAIYGVAAILIIFIGVKIFERLEKWMAII
KIAAIIGFIVIAILVILGFIKGGLYKAQIPRDFKDWFPNGLKGTWSSLIYAFYAFGGIEIMGLMTIRLKDPKDAQKSGRV
MLMILTIIYVVSLGLAIMMVPLNQFNTKESPFVIALQDYNLPYVPFILNVVLILAGFSTLVGSLFAVTSVLMNLAEEGDA
PAMFAKKNKKNISFPALILIIIGLGASILSALLLPKNIYEYVTTAAGLMLLYTWSLILLSFWRLMNPKGWMQIKSIIGLI
MIALAVSGTLLQKTTRFGFLVSLLFLGIVIIVTIIVHFVSKKRNTAI

Sequences:

>Translated_447_residues
MTCHDVENETEEKKDLKWWQLSLIGIGCTIGTGFFLGSSIGIKIGGSSIILILILTGFTTYIVFEALAKMAVEDPQKGSF
RMYSKKAFGNWAGFSHGWTYWCSELLIMGSQLSALGIFSRYWFPKIPLWIFAAIYGVAAILIIFIGVKIFERLEKWMAII
KIAAIIGFIVIAILVILGFIKGGLYKAQIPRDFKDWFPNGLKGTWSSLIYAFYAFGGIEIMGLMTIRLKDPKDAQKSGRV
MLMILTIIYVVSLGLAIMMVPLNQFNTKESPFVIALQDYNLPYVPFILNVVLILAGFSTLVGSLFAVTSVLMNLAEEGDA
PAMFAKKNKKNISFPALILIIIGLGASILSALLLPKNIYEYVTTAAGLMLLYTWSLILLSFWRLMNPKGWMQIKSIIGLI
MIALAVSGTLLQKTTRFGFLVSLLFLGIVIIVTIIVHFVSKKRNTAI
>Mature_446_residues
TCHDVENETEEKKDLKWWQLSLIGIGCTIGTGFFLGSSIGIKIGGSSIILILILTGFTTYIVFEALAKMAVEDPQKGSFR
MYSKKAFGNWAGFSHGWTYWCSELLIMGSQLSALGIFSRYWFPKIPLWIFAAIYGVAAILIIFIGVKIFERLEKWMAIIK
IAAIIGFIVIAILVILGFIKGGLYKAQIPRDFKDWFPNGLKGTWSSLIYAFYAFGGIEIMGLMTIRLKDPKDAQKSGRVM
LMILTIIYVVSLGLAIMMVPLNQFNTKESPFVIALQDYNLPYVPFILNVVLILAGFSTLVGSLFAVTSVLMNLAEEGDAP
AMFAKKNKKNISFPALILIIIGLGASILSALLLPKNIYEYVTTAAGLMLLYTWSLILLSFWRLMNPKGWMQIKSIIGLIM
IALAVSGTLLQKTTRFGFLVSLLFLGIVIIVTIIVHFVSKKRNTAI

Specific function: Permease That Is Involved In The Transport Across The Cytoplasmic Membrane Of Proline. [C]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily [H]

Homologues:

Organism=Escherichia coli, GI1786302, Length=386, Percent_Identity=28.2383419689119, Blast_Score=183, Evalue=2e-47,
Organism=Escherichia coli, GI1786602, Length=459, Percent_Identity=30.2832244008715, Blast_Score=183, Evalue=2e-47,
Organism=Escherichia coli, GI1790653, Length=394, Percent_Identity=28.4263959390863, Blast_Score=174, Evalue=1e-44,
Organism=Escherichia coli, GI87081915, Length=408, Percent_Identity=26.7156862745098, Blast_Score=171, Evalue=7e-44,
Organism=Escherichia coli, GI1786789, Length=380, Percent_Identity=28.4210526315789, Blast_Score=170, Evalue=2e-43,
Organism=Escherichia coli, GI87081708, Length=460, Percent_Identity=23.4782608695652, Blast_Score=167, Evalue=1e-42,
Organism=Escherichia coli, GI1789017, Length=385, Percent_Identity=26.7532467532467, Blast_Score=157, Evalue=1e-39,
Organism=Escherichia coli, GI48994972, Length=384, Percent_Identity=27.34375, Blast_Score=152, Evalue=6e-38,
Organism=Escherichia coli, GI1788480, Length=398, Percent_Identity=27.1356783919598, Blast_Score=146, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI17532491, Length=392, Percent_Identity=22.9591836734694, Blast_Score=71, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6324061, Length=415, Percent_Identity=27.2289156626506, Blast_Score=129, Evalue=1e-30,
Organism=Saccharomyces cerevisiae, GI6320772, Length=402, Percent_Identity=26.3681592039801, Blast_Score=124, Evalue=4e-29,
Organism=Saccharomyces cerevisiae, GI6320251, Length=407, Percent_Identity=25.0614250614251, Blast_Score=118, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6319542, Length=397, Percent_Identity=25.6926952141058, Blast_Score=117, Evalue=3e-27,
Organism=Saccharomyces cerevisiae, GI6324990, Length=401, Percent_Identity=25.9351620947631, Blast_Score=114, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6320717, Length=408, Percent_Identity=24.7549019607843, Blast_Score=108, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6322892, Length=339, Percent_Identity=27.7286135693215, Blast_Score=108, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6321053, Length=414, Percent_Identity=24.6376811594203, Blast_Score=106, Evalue=7e-24,
Organism=Saccharomyces cerevisiae, GI6319824, Length=400, Percent_Identity=25.25, Blast_Score=106, Evalue=8e-24,
Organism=Saccharomyces cerevisiae, GI6321629, Length=397, Percent_Identity=23.4256926952141, Blast_Score=105, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6324924, Length=382, Percent_Identity=24.0837696335079, Blast_Score=99, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6324553, Length=394, Percent_Identity=25.3807106598985, Blast_Score=96, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6322967, Length=343, Percent_Identity=25.3644314868805, Blast_Score=92, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6324059, Length=357, Percent_Identity=22.96918767507, Blast_Score=84, Evalue=5e-17,
Organism=Saccharomyces cerevisiae, GI6319608, Length=349, Percent_Identity=23.2091690544413, Blast_Score=82, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6319543, Length=406, Percent_Identity=23.6453201970443, Blast_Score=77, Evalue=5e-15,
Organism=Saccharomyces cerevisiae, GI6324981, Length=354, Percent_Identity=24.0112994350282, Blast_Score=68, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24667468, Length=417, Percent_Identity=23.021582733813, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24668806, Length=399, Percent_Identity=22.3057644110276, Blast_Score=66, Evalue=5e-11,
Organism=Drosophila melanogaster, GI21356285, Length=399, Percent_Identity=22.3057644110276, Blast_Score=66, Evalue=5e-11,
Organism=Drosophila melanogaster, GI24668802, Length=399, Percent_Identity=22.3057644110276, Blast_Score=66, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 49630; Mature: 49498

Theoretical pI: Translated: 10.10; Mature: 10.10

Prosite motif: PS00012 PHOSPHOPANTETHEINE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTCHDVENETEEKKDLKWWQLSLIGIGCTIGTGFFLGSSIGIKIGGSSIILILILTGFTT
CCCCCCCCCHHHHHCCHHHHHHHEEEHHHHHHHHHHCCCCCEEECCCHHHHHHHHHHHHH
YIVFEALAKMAVEDPQKGSFRMYSKKAFGNWAGFSHGWTYWCSELLIMGSQLSALGIFSR
HHHHHHHHHHHHCCCCCCCEEEHHHHHCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHH
YWFPKIPLWIFAAIYGVAAILIIFIGVKIFERLEKWMAIIKIAAIIGFIVIAILVILGFI
HCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KGGLYKAQIPRDFKDWFPNGLKGTWSSLIYAFYAFGGIEIMGLMTIRLKDPKDAQKSGRV
HCCCEEECCCCHHHHHCCCCCCHHHHHHHHHHHHHCCCEEEEEEEEEECCCCCHHHCCCC
MLMILTIIYVVSLGLAIMMVPLNQFNTKESPFVIALQDYNLPYVPFILNVVLILAGFSTL
HHHHHHHHHHHHHHHHHHHHCCHHCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHH
VGSLFAVTSVLMNLAEEGDAPAMFAKKNKKNISFPALILIIIGLGASILSALLLPKNIYE
HHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
YVTTAAGLMLLYTWSLILLSFWRLMNPKGWMQIKSIIGLIMIALAVSGTLLQKTTRFGFL
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VSLLFLGIVIIVTIIVHFVSKKRNTAI
HHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
TCHDVENETEEKKDLKWWQLSLIGIGCTIGTGFFLGSSIGIKIGGSSIILILILTGFTT
CCCCCCCCHHHHHCCHHHHHHHEEEHHHHHHHHHHCCCCCEEECCCHHHHHHHHHHHHH
YIVFEALAKMAVEDPQKGSFRMYSKKAFGNWAGFSHGWTYWCSELLIMGSQLSALGIFSR
HHHHHHHHHHHHCCCCCCCEEEHHHHHCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHH
YWFPKIPLWIFAAIYGVAAILIIFIGVKIFERLEKWMAIIKIAAIIGFIVIAILVILGFI
HCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KGGLYKAQIPRDFKDWFPNGLKGTWSSLIYAFYAFGGIEIMGLMTIRLKDPKDAQKSGRV
HCCCEEECCCCHHHHHCCCCCCHHHHHHHHHHHHHCCCEEEEEEEEEECCCCCHHHCCCC
MLMILTIIYVVSLGLAIMMVPLNQFNTKESPFVIALQDYNLPYVPFILNVVLILAGFSTL
HHHHHHHHHHHHHHHHHHHHCCHHCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHH
VGSLFAVTSVLMNLAEEGDAPAMFAKKNKKNISFPALILIIIGLGASILSALLLPKNIYE
HHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
YVTTAAGLMLLYTWSLILLSFWRLMNPKGWMQIKSIIGLIMIALAVSGTLLQKTTRFGFL
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VSLLFLGIVIIVTIIVHFVSKKRNTAI
HHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-proline [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-proline [Periplasm] = Proton [Cytoplasm] + L-proline [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8969502; 9384377 [H]