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The map label for this gene is mutX [H]

Identifier: 118478387

GI number: 118478387

Start: 2914849

End: 2915397

Strand: Reverse

Name: mutX [H]

Synonym: BALH_2752

Alternate gene names: 118478387

Gene position: 2915397-2914849 (Counterclockwise)

Preceding gene: 118478389

Following gene: 118478385

Centisome position: 55.46

GC content: 32.79

Gene sequence:

>549_bases
GTGAAAATGAAAGGAAATGATTGTATGTACAAGTACACAATTTGTTTTATTAGAAAAAGCGATAAAATACTGCTATTAAA
TAGAAATAAAAAGCCAAATATGGGAATGTGGAATGGTGTTGGTGGAAAAATTGAAGATAATGAAACGCCATATGAAGGAA
TAATTAGAGAAACGCTTGAAGAAACAGGCATAGATCTTCCAAGTGTAACGTATAAAGGGAATGTGGTTTTTAAAAGTAAG
GACGAGTCTCGAGGTAGTGAAGGAATGTATGTATTCCTTGCTGACCTGCCAGATGGAGTACATATGGACACGCCATTAAG
TACGGCGGAAGGATTATTAGAATGGAAAGAAATTGATTGGATATTAAATAAGGATAATAGAGGTGTAGTTAGCAATTTAC
CAAAATACTTACCAATAGTATTAACAGAAGAAAATAAGTTAGAGCATATATTCACATATGATAACGGGAATATTATTCAT
TACACAACTTCATATTTGACAGATGATAATGCGAACAAACGGTATGAAAAACAACTCGTTTCTCAATAG

Upstream 100 bases:

>100_bases
TTTGACGTAAAGTGTTTACGCATGAAAGTTGTACTATATACTATGTGGTAAGGAATTGTAAGGCGAGTGTTTTTACTTAA
AAATAAGCCAAATAACTCAT

Downstream 100 bases:

>100_bases
AAAAAATATGACAACAATCACTCTTATAATCTAGTAGATTGCAATTAGATAAGAAGTGGGATGATATAACTTTTCTTATT
ATGAAAGAGTAGAGAACATA

Product: MutT/NUDIX family phosphohydrolase

Products: NA

Alternate protein names: 7,8-dihydro-8-oxoguanine-triphosphatase; 8-oxo-dGTPase; dGTP pyrophosphohydrolase [H]

Number of amino acids: Translated: 182; Mature: 182

Protein sequence:

>182_residues
MKMKGNDCMYKYTICFIRKSDKILLLNRNKKPNMGMWNGVGGKIEDNETPYEGIIRETLEETGIDLPSVTYKGNVVFKSK
DESRGSEGMYVFLADLPDGVHMDTPLSTAEGLLEWKEIDWILNKDNRGVVSNLPKYLPIVLTEENKLEHIFTYDNGNIIH
YTTSYLTDDNANKRYEKQLVSQ

Sequences:

>Translated_182_residues
MKMKGNDCMYKYTICFIRKSDKILLLNRNKKPNMGMWNGVGGKIEDNETPYEGIIRETLEETGIDLPSVTYKGNVVFKSK
DESRGSEGMYVFLADLPDGVHMDTPLSTAEGLLEWKEIDWILNKDNRGVVSNLPKYLPIVLTEENKLEHIFTYDNGNIIH
YTTSYLTDDNANKRYEKQLVSQ
>Mature_182_residues
MKMKGNDCMYKYTICFIRKSDKILLLNRNKKPNMGMWNGVGGKIEDNETPYEGIIRETLEETGIDLPSVTYKGNVVFKSK
DESRGSEGMYVFLADLPDGVHMDTPLSTAEGLLEWKEIDWILNKDNRGVVSNLPKYLPIVLTEENKLEHIFTYDNGNIIH
YTTSYLTDDNANKRYEKQLVSQ

Specific function: Involved in the DNA repair system to avoid A.T to G.C transversions. Degrades 8-oxo-dGTP to the monophosphate, but is also active on all of the nucleoside triphosphates [H]

COG id: COG0494

COG function: function code LR; NTP pyrophosphohydrolases including oxidative damage repair enzymes

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 nudix hydrolase domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003562
- InterPro:   IPR020476
- InterPro:   IPR020084
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF00293 NUDIX [H]

EC number: NA

Molecular weight: Translated: 20925; Mature: 20925

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: PS00893 NUDIX

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKMKGNDCMYKYTICFIRKSDKILLLNRNKKPNMGMWNGVGGKIEDNETPYEGIIRETLE
CCCCCCCEEEEEEEEEEECCCEEEEEECCCCCCCCCCCCCCCEECCCCCCHHHHHHHHHH
ETGIDLPSVTYKGNVVFKSKDESRGSEGMYVFLADLPDGVHMDTPLSTAEGLLEWKEIDW
HHCCCCCCEEEECCEEEECCCCCCCCCCEEEEEEECCCCCCCCCCCCHHHHHHEEEEEEE
ILNKDNRGVVSNLPKYLPIVLTEENKLEHIFTYDNGNIIHYTTSYLTDDNANKRYEKQLV
EEECCCCCHHHCCCCCEEEEEECCCCEEEEEEECCCCEEEEEEEEEECCCCCHHHHHHHH
SQ
CC
>Mature Secondary Structure
MKMKGNDCMYKYTICFIRKSDKILLLNRNKKPNMGMWNGVGGKIEDNETPYEGIIRETLE
CCCCCCCEEEEEEEEEEECCCEEEEEECCCCCCCCCCCCCCCEECCCCCCHHHHHHHHHH
ETGIDLPSVTYKGNVVFKSKDESRGSEGMYVFLADLPDGVHMDTPLSTAEGLLEWKEIDW
HHCCCCCCEEEECCEEEECCCCCCCCCCEEEEEEECCCCCCCCCCCCHHHHHHEEEEEEE
ILNKDNRGVVSNLPKYLPIVLTEENKLEHIFTYDNGNIIHYTTSYLTDDNANKRYEKQLV
EEECCCCCHHHCCCCCEEEEEECCCCEEEEEEECCCCEEEEEEEEEECCCCCHHHHHHHH
SQ
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8170394; 11463916; 8163538 [H]