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The map label for this gene is fes [H]

Identifier: 118478071

GI number: 118478071

Start: 2594806

End: 2596113

Strand: Reverse

Name: fes [H]

Synonym: BALH_2426

Alternate gene names: 118478071

Gene position: 2596113-2594806 (Counterclockwise)

Preceding gene: 118478072

Following gene: 118478070

Centisome position: 49.38

GC content: 34.1

Gene sequence:

>1308_bases
TTGATCATTTTTCTAATCAATAACTTCTCTAAACACATAACTTACGACTACTTTTATATGGGGATTCTAATGAAAACACT
ACATATAGAATACTACCAAGGCGGAAGAGGGGTGACTACAATAATCAGTCCTAAGTTAGAGAAGCTTAAAAATCACTTAA
AGAATGGAAATGAAAAAGCTCTTTATACTTTTTTGCATGAGATCAAGTCAAATCATACACCACTAGTAGAACAGTGTCCT
ATAGATAATCAGTATAAGCTTATAACGTATATATGGTTAGGGGACCGAGAAACTGAAAACGTTTATGTATTCGGTAGTTT
TCCTGGTTGGGATCTGTCTGTAAATCAATTACAACGATTGCTACAGACAGATATTTGGCATGTTACGTTTAGGACGAATA
AGAGGTTTATTTCAACTTATTATTTTACAGTAAATGATTTTTTCAAAAATGATTGGATAAAGCGTAGTGAACAGTACCGA
CTAGACCCATTCAATGAAAATGTATTTGGAGAAGGTGCCAATAAAGCGTCTGTGTTAAAAATAGGTATGGACGTGCAGTA
TAGCAGTCGTTTTCCTTCAAATCATTATCCATCCGGAAAGATTGAAACATATTCTTTTTATAGTTCGATTTTAAATAACA
CACGTAAAATTCATATTTATACGCCTCATGATTATTCTCACAATTCATATCTTCAAGAACTTCTCATTGTATTTGATGGG
AATTCATTCATTAATGACCTTTCAACCACAAAAACACTTAATTATTTAATTTACGAAAAAGAAATCCCATCGTGTATTGC
TGTTGCTATAGATCCTGTTGATCGATTAGAAGAGCTAACTTATAACGATAAAATGAATACATTTTTAACGAAGGAATTAC
TTCCATGGATTCAGGCGAAGTATCGTGTGCATCAAGAAGCGAACCATACAACAATTGCCGGTTTCAGTCTGGGTGGCTTA
GCAGCTTGTTATGCAGCGCTTCAAAATCCACACATTTTCGGGAACGTGTTGTCAATGTCTGGATCCGTACATTGGAAAAA
GGATGGGTATGAAAATAAAATTCCTTGGATTGAAAATCAAATTTCATCTATAGATTCAAATGCGACGCAACCTCATTTTT
ATATAGCAGCAGGAGAACTTGAAAACAAACCTCTTTTAACGGCTAATAGACGTCTGTATAAAGCTTTAAAAGAAAAGGAA
TACCAAATTACTTATGAAGAGTTTCAAGGCGGCCATGACGGTGTTTGGTGGCGAGAAAAGTTATTTGATGGGTTGAAAGC
TTTAAAACTTACAAAAAACACACTATAA

Upstream 100 bases:

>100_bases
CCATCAATTGAAAAGATTTATGTTAAGTCAAAGCTCGGGAGTCCTCAAAGAACTCTTTTAGAAAGAAGAATAAAATCATT
GGAACTTTCTATTCAAGCAA

Downstream 100 bases:

>100_bases
AATAAAAAGGAGAGAGAATCTATGAATCAAGAAGAACTAGATAAAAAACTAAAAAAGCAAGAGATTTTAGTAAAAGATGA
GAAAGTTTGGACCTTTACGT

Product: esterase

Products: Fe [C]

Alternate protein names: Ferric enterobactin esterase [H]

Number of amino acids: Translated: 435; Mature: 435

Protein sequence:

>435_residues
MIIFLINNFSKHITYDYFYMGILMKTLHIEYYQGGRGVTTIISPKLEKLKNHLKNGNEKALYTFLHEIKSNHTPLVEQCP
IDNQYKLITYIWLGDRETENVYVFGSFPGWDLSVNQLQRLLQTDIWHVTFRTNKRFISTYYFTVNDFFKNDWIKRSEQYR
LDPFNENVFGEGANKASVLKIGMDVQYSSRFPSNHYPSGKIETYSFYSSILNNTRKIHIYTPHDYSHNSYLQELLIVFDG
NSFINDLSTTKTLNYLIYEKEIPSCIAVAIDPVDRLEELTYNDKMNTFLTKELLPWIQAKYRVHQEANHTTIAGFSLGGL
AACYAALQNPHIFGNVLSMSGSVHWKKDGYENKIPWIENQISSIDSNATQPHFYIAAGELENKPLLTANRRLYKALKEKE
YQITYEEFQGGHDGVWWREKLFDGLKALKLTKNTL

Sequences:

>Translated_435_residues
MIIFLINNFSKHITYDYFYMGILMKTLHIEYYQGGRGVTTIISPKLEKLKNHLKNGNEKALYTFLHEIKSNHTPLVEQCP
IDNQYKLITYIWLGDRETENVYVFGSFPGWDLSVNQLQRLLQTDIWHVTFRTNKRFISTYYFTVNDFFKNDWIKRSEQYR
LDPFNENVFGEGANKASVLKIGMDVQYSSRFPSNHYPSGKIETYSFYSSILNNTRKIHIYTPHDYSHNSYLQELLIVFDG
NSFINDLSTTKTLNYLIYEKEIPSCIAVAIDPVDRLEELTYNDKMNTFLTKELLPWIQAKYRVHQEANHTTIAGFSLGGL
AACYAALQNPHIFGNVLSMSGSVHWKKDGYENKIPWIENQISSIDSNATQPHFYIAAGELENKPLLTANRRLYKALKEKE
YQITYEEFQGGHDGVWWREKLFDGLKALKLTKNTL
>Mature_435_residues
MIIFLINNFSKHITYDYFYMGILMKTLHIEYYQGGRGVTTIISPKLEKLKNHLKNGNEKALYTFLHEIKSNHTPLVEQCP
IDNQYKLITYIWLGDRETENVYVFGSFPGWDLSVNQLQRLLQTDIWHVTFRTNKRFISTYYFTVNDFFKNDWIKRSEQYR
LDPFNENVFGEGANKASVLKIGMDVQYSSRFPSNHYPSGKIETYSFYSSILNNTRKIHIYTPHDYSHNSYLQELLIVFDG
NSFINDLSTTKTLNYLIYEKEIPSCIAVAIDPVDRLEELTYNDKMNTFLTKELLPWIQAKYRVHQEANHTTIAGFSLGGL
AACYAALQNPHIFGNVLSMSGSVHWKKDGYENKIPWIENQISSIDSNATQPHFYIAAGELENKPLLTANRRLYKALKEKE
YQITYEEFQGGHDGVWWREKLFDGLKALKLTKNTL

Specific function: Upon internalization, ferric enterobactin is processed via an exquisitely specific pathway that is dependent on FES activity, making iron available for metabolic use [H]

COG id: COG2382

COG function: function code P; Enterochelin esterase and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fes family [H]

Homologues:

Organism=Escherichia coli, GI1786799, Length=333, Percent_Identity=26.7267267267267, Blast_Score=117, Evalue=2e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR021764
- InterPro:   IPR000801
- InterPro:   IPR014756 [H]

Pfam domain/function: PF11806 DUF3327; PF00756 Esterase [H]

EC number: NA

Molecular weight: Translated: 50779; Mature: 50779

Theoretical pI: Translated: 7.79; Mature: 7.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIIFLINNFSKHITYDYFYMGILMKTLHIEYYQGGRGVTTIISPKLEKLKNHLKNGNEKA
CEEEEEECCCHHHHHHHHHHHHHHHHHEEEEEECCCCEEEEECHHHHHHHHHHCCCCCHH
LYTFLHEIKSNHTPLVEQCPIDNQYKLITYIWLGDRETENVYVFGSFPGWDLSVNQLQRL
HHHHHHHHHCCCCCCHHHCCCCCCEEEEEEEEECCCCCCCEEEEECCCCCCCCHHHHHHH
LQTDIWHVTFRTNKRFISTYYFTVNDFFKNDWIKRSEQYRLDPFNENVFGEGANKASVLK
HHCCEEEEEEECCCEEEEEEEEEEHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEE
IGMDVQYSSRFPSNHYPSGKIETYSFYSSILNNTRKIHIYTPHDYSHNSYLQELLIVFDG
EECCEEECCCCCCCCCCCCCEEHHHHHHHHHCCCEEEEEECCCCCCCHHHHHEEEEEECC
NSFINDLSTTKTLNYLIYEKEIPSCIAVAIDPVDRLEELTYNDKMNTFLTKELLPWIQAK
CHHHHHHHHHHEEEEEEEECCCCCEEEEEECCHHHHHHHCCCCCHHHHHHHHHHHHHHHH
YRVHQEANHTTIAGFSLGGLAACYAALQNPHIFGNVLSMSGSVHWKKDGYENKIPWIENQ
HHHHHCCCCEEEEEECHHHHHHHHHHHCCCCEEEEEEECCCCEEECCCCCCCCCCCHHHH
ISSIDSNATQPHFYIAAGELENKPLLTANRRLYKALKEKEYQITYEEFQGGHDGVWWREK
HHHCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHCCCEEEEHHHHCCCCCCCHHHHH
LFDGLKALKLTKNTL
HHHHHHHHHHHCCCC
>Mature Secondary Structure
MIIFLINNFSKHITYDYFYMGILMKTLHIEYYQGGRGVTTIISPKLEKLKNHLKNGNEKA
CEEEEEECCCHHHHHHHHHHHHHHHHHEEEEEECCCCEEEEECHHHHHHHHHHCCCCCHH
LYTFLHEIKSNHTPLVEQCPIDNQYKLITYIWLGDRETENVYVFGSFPGWDLSVNQLQRL
HHHHHHHHHCCCCCCHHHCCCCCCEEEEEEEEECCCCCCCEEEEECCCCCCCCHHHHHHH
LQTDIWHVTFRTNKRFISTYYFTVNDFFKNDWIKRSEQYRLDPFNENVFGEGANKASVLK
HHCCEEEEEEECCCEEEEEEEEEEHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEE
IGMDVQYSSRFPSNHYPSGKIETYSFYSSILNNTRKIHIYTPHDYSHNSYLQELLIVFDG
EECCEEECCCCCCCCCCCCCEEHHHHHHHHHCCCEEEEEECCCCCCCHHHHHEEEEEECC
NSFINDLSTTKTLNYLIYEKEIPSCIAVAIDPVDRLEELTYNDKMNTFLTKELLPWIQAK
CHHHHHHHHHHEEEEEEEECCCCCEEEEEECCHHHHHHHCCCCCHHHHHHHHHHHHHHHH
YRVHQEANHTTIAGFSLGGLAACYAALQNPHIFGNVLSMSGSVHWKKDGYENKIPWIENQ
HHHHHCCCCEEEEEECHHHHHHHHHHHCCCCEEEEEEECCCCEEECCCCCCCCCCCHHHH
ISSIDSNATQPHFYIAAGELENKPLLTANRRLYKALKEKEYQITYEEFQGGHDGVWWREK
HHHCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHCCCEEEEHHHHCCCCCCCHHHHH
LFDGLKALKLTKNTL
HHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ferrienterobactin [C]

Specific reaction: ferrienterobactin = Fe [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2974033; 9278503; 8905232 [H]