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The map label for this gene is flp [H]

Identifier: 118477970

GI number: 118477970

Start: 2485945

End: 2487390

Strand: Direct

Name: flp [H]

Synonym: BALH_2316

Alternate gene names: 118477970

Gene position: 2485945-2487390 (Clockwise)

Preceding gene: 118477969

Following gene: 118477971

Centisome position: 47.29

GC content: 30.64

Gene sequence:

>1446_bases
ATGAAGAATGCGATCTATAAAGTCTTTCTAATTTGTATTCTTTGTAATGTATTTATGCTATGTATCACACATCCAAAAGT
TTACGCTCAGCAAAATGTTAAAGTTACATTAGATAAGTATATTGAAAAATTTATAAAGGAACAGAATATTCCAGGAGCTG
CTGTTGCAATTGTACATAATAAAGAAGTATTCTTCACAAAAACGATGGGGGTTACTGGAGAATCTGAAAAAAAGGTAACT
AGTAAAACGCCATTTGCAATCGGCTCAATAAGTAAATCTTTAACAGCTTTAGCTATAGTGAAATTAATAGAAGATAAAAA
AATAAAATTAGAGGATCCAGTTCAACGATATCTCCCCTGTTTTAAACTAAAAAACCCTCAAATATCCTCAACTATAACAA
TCCAACATCTACTAACTCATACAAGCGGAATCAACACATATGAGGGCTTAGCATTATCAGATAAGCAATCCAAAAGTTCT
ACAGCATTAAAAGAAAATGTAATGAAGCTTTCAAATGTAAAAGTAACTGCTCCACCAGGTGAGAAATATCAATATAGTAA
TGCAAATTATATTGTTTTAGGTGCACTGATTGAAGAAGTTACAAATGAAACATATTCATCATATATGGAAAAGTATATTT
TTCAGCCGTTAAATATGAATGGCGCGGCAGCAAGTAAAGAAAATGCATATGAAAAAGGTTATTTAACAGGTTATCAGTCT
TGGTTTGGCATTCCAAGAAAAAGTGTAGTGTCCTATGATAATGCCGGGGCACCGTATGGCTATATTACTGCAAATTTAGA
AGATATGATTCAATATATTATGTTTTTGAATCGTCCAGAGGGTGCTCAATTATTAAAGCAAGAAAATATGCATCTTTATC
TATCACCACTTTATAAAATAAATTCAGAAAAAAGTTATGGTTTTGGATTAAGAACAACAAATATAAATGAAAGTGAAACG
ATGATTTGGCATTCAGGATCAACGCCCGATGCTCGTGCAGAAATATTTACTTTAAATAAAAGTGGATGGAGTGGAGTAAT
TTTAACAAATAAAAATCATGTATTAGAAGAAACAGCACTATCAGTATTGAAAAAGGGTATTATTAGTATTTTGAATGGAG
AAGAACCGGTTGATATCCCTAAAAAAATACCATTAACACAAATTATTTTGTTGGTAGTTACACTCATACTTTTCATAATA
TCAATTATGTTAATTAAAAAGTATAAACATATGAAAACTGTAAAAAAGGTAATTTGGTTATTCATAGGGAGTCTATCCCT
ACTATTATCTATTATTTTTATCCCACTGCTTACTTATAGTACGAGTTCACCTTGGCGTACGATTAAAATATTTGCGCCAG
ACGTAGCTTTATTTACAAGTATTAGTGTAACTTTATTAGCTGTTAACGGACTAATATCAATTTTTATAGCTTTAAGAAGG
AGGTAA

Upstream 100 bases:

>100_bases
CAATGGTGGAACGCATTATTAATAATGACTAGTTTGACACTCTCTGTAGTAGTATATATTAGTTTAGTAAGTTATAAAAA
AAGAAAGCATCTAAAGTATA

Downstream 100 bases:

>100_bases
GTAGAAGGGGAAAGAATGAAAGAAATATAAGTTAAGTGTTAGAAACAGTTGACTCTCACACAATGTCATTGTTTAAGATG
AAGTTGAACTTCGAAGTAGA

Product: penicillin-binding protein

Products: A Substituted Beta- Amino Acid. [C]

Alternate protein names: FmtA-like protein [H]

Number of amino acids: Translated: 481; Mature: 481

Protein sequence:

>481_residues
MKNAIYKVFLICILCNVFMLCITHPKVYAQQNVKVTLDKYIEKFIKEQNIPGAAVAIVHNKEVFFTKTMGVTGESEKKVT
SKTPFAIGSISKSLTALAIVKLIEDKKIKLEDPVQRYLPCFKLKNPQISSTITIQHLLTHTSGINTYEGLALSDKQSKSS
TALKENVMKLSNVKVTAPPGEKYQYSNANYIVLGALIEEVTNETYSSYMEKYIFQPLNMNGAAASKENAYEKGYLTGYQS
WFGIPRKSVVSYDNAGAPYGYITANLEDMIQYIMFLNRPEGAQLLKQENMHLYLSPLYKINSEKSYGFGLRTTNINESET
MIWHSGSTPDARAEIFTLNKSGWSGVILTNKNHVLEETALSVLKKGIISILNGEEPVDIPKKIPLTQIILLVVTLILFII
SIMLIKKYKHMKTVKKVIWLFIGSLSLLLSIIFIPLLTYSTSSPWRTIKIFAPDVALFTSISVTLLAVNGLISIFIALRR
R

Sequences:

>Translated_481_residues
MKNAIYKVFLICILCNVFMLCITHPKVYAQQNVKVTLDKYIEKFIKEQNIPGAAVAIVHNKEVFFTKTMGVTGESEKKVT
SKTPFAIGSISKSLTALAIVKLIEDKKIKLEDPVQRYLPCFKLKNPQISSTITIQHLLTHTSGINTYEGLALSDKQSKSS
TALKENVMKLSNVKVTAPPGEKYQYSNANYIVLGALIEEVTNETYSSYMEKYIFQPLNMNGAAASKENAYEKGYLTGYQS
WFGIPRKSVVSYDNAGAPYGYITANLEDMIQYIMFLNRPEGAQLLKQENMHLYLSPLYKINSEKSYGFGLRTTNINESET
MIWHSGSTPDARAEIFTLNKSGWSGVILTNKNHVLEETALSVLKKGIISILNGEEPVDIPKKIPLTQIILLVVTLILFII
SIMLIKKYKHMKTVKKVIWLFIGSLSLLLSIIFIPLLTYSTSSPWRTIKIFAPDVALFTSISVTLLAVNGLISIFIALRR
R
>Mature_481_residues
MKNAIYKVFLICILCNVFMLCITHPKVYAQQNVKVTLDKYIEKFIKEQNIPGAAVAIVHNKEVFFTKTMGVTGESEKKVT
SKTPFAIGSISKSLTALAIVKLIEDKKIKLEDPVQRYLPCFKLKNPQISSTITIQHLLTHTSGINTYEGLALSDKQSKSS
TALKENVMKLSNVKVTAPPGEKYQYSNANYIVLGALIEEVTNETYSSYMEKYIFQPLNMNGAAASKENAYEKGYLTGYQS
WFGIPRKSVVSYDNAGAPYGYITANLEDMIQYIMFLNRPEGAQLLKQENMHLYLSPLYKINSEKSYGFGLRTTNINESET
MIWHSGSTPDARAEIFTLNKSGWSGVILTNKNHVLEETALSVLKKGIISILNGEEPVDIPKKIPLTQIILLVVTLILFII
SIMLIKKYKHMKTVKKVIWLFIGSLSLLLSIIFIPLLTYSTSSPWRTIKIFAPDVALFTSISVTLLAVNGLISIFIALRR
R

Specific function: Its precise function is unknown. Has no penicillin- binding activity and is not involved in methicillin resistance [H]

COG id: COG1680

COG function: function code V; Beta-lactamase class C and other penicillin binding proteins

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1790593, Length=272, Percent_Identity=28.6764705882353, Blast_Score=92, Evalue=9e-20,
Organism=Caenorhabditis elegans, GI17550934, Length=326, Percent_Identity=26.6871165644172, Blast_Score=96, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI115533026, Length=376, Percent_Identity=23.6702127659574, Blast_Score=76, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17565630, Length=251, Percent_Identity=25.8964143426295, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR001466 [H]

Pfam domain/function: PF00144 Beta-lactamase [H]

EC number: 3.5.2.6 [C]

Molecular weight: Translated: 53971; Mature: 53971

Theoretical pI: Translated: 9.87; Mature: 9.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNAIYKVFLICILCNVFMLCITHPKVYAQQNVKVTLDKYIEKFIKEQNIPGAAVAIVHN
CCCHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCEEEHHHHHHHHHHHCCCCCEEEEEEEC
KEVFFTKTMGVTGESEKKVTSKTPFAIGSISKSLTALAIVKLIEDKKIKLEDPVQRYLPC
CEEEEEEECCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCH
FKLKNPQISSTITIQHLLTHTSGINTYEGLALSDKQSKSSTALKENVMKLSNVKVTAPPG
HCCCCCCCCHHEEHHHHHHHCCCCCCCCCCEECCCCCCHHHHHHHHHHHHHCEEEECCCC
EKYQYSNANYIVLGALIEEVTNETYSSYMEKYIFQPLNMNGAAASKENAYEKGYLTGYQS
CCEEECCCCEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHCCCCCCHHH
WFGIPRKSVVSYDNAGAPYGYITANLEDMIQYIMFLNRPEGAQLLKQENMHLYLSPLYKI
HHCCCCHHHCCCCCCCCCCEEEECCHHHHHHHHHHHCCCCHHHHHHHCCCEEEEEEHEEE
NSEKSYGFGLRTTNINESETMIWHSGSTPDARAEIFTLNKSGWSGVILTNKNHVLEETAL
CCCCCCCCEEEECCCCCCCEEEEECCCCCCCCEEEEEEECCCCCEEEEECCCHHHHHHHH
SVLKKGIISILNGEEPVDIPKKIPLTQIILLVVTLILFIISIMLIKKYKHMKTVKKVIWL
HHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FIGSLSLLLSIIFIPLLTYSTSSPWRTIKIFAPDVALFTSISVTLLAVNGLISIFIALRR
HHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHC
R
C
>Mature Secondary Structure
MKNAIYKVFLICILCNVFMLCITHPKVYAQQNVKVTLDKYIEKFIKEQNIPGAAVAIVHN
CCCHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCEEEHHHHHHHHHHHCCCCCEEEEEEEC
KEVFFTKTMGVTGESEKKVTSKTPFAIGSISKSLTALAIVKLIEDKKIKLEDPVQRYLPC
CEEEEEEECCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCH
FKLKNPQISSTITIQHLLTHTSGINTYEGLALSDKQSKSSTALKENVMKLSNVKVTAPPG
HCCCCCCCCHHEEHHHHHHHCCCCCCCCCCEECCCCCCHHHHHHHHHHHHHCEEEECCCC
EKYQYSNANYIVLGALIEEVTNETYSSYMEKYIFQPLNMNGAAASKENAYEKGYLTGYQS
CCEEECCCCEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHCCCCCCHHH
WFGIPRKSVVSYDNAGAPYGYITANLEDMIQYIMFLNRPEGAQLLKQENMHLYLSPLYKI
HHCCCCHHHCCCCCCCCCCEEEECCHHHHHHHHHHHCCCCHHHHHHHCCCEEEEEEHEEE
NSEKSYGFGLRTTNINESETMIWHSGSTPDARAEIFTLNKSGWSGVILTNKNHVLEETAL
CCCCCCCCEEEECCCCCCCEEEEECCCCCCCCEEEEEEECCCCCEEEEECCCHHHHHHHH
SVLKKGIISILNGEEPVDIPKKIPLTQIILLVVTLILFIISIMLIKKYKHMKTVKKVIWL
HHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FIGSLSLLLSIIFIPLLTYSTSSPWRTIKIFAPDVALFTSISVTLLAVNGLISIFIALRR
HHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHC
R
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: A Beta-Lactam; H2O [C]

Specific reaction: A Beta-Lactam + H2O = A Substituted Beta- Amino Acid. [C]

General reaction: Carboxylic acid amide hydrolysis [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA