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The map label for this gene is tdcB [H]

Identifier: 118477856

GI number: 118477856

Start: 2353696

End: 2354697

Strand: Direct

Name: tdcB [H]

Synonym: BALH_2199

Alternate gene names: 118477856

Gene position: 2353696-2354697 (Clockwise)

Preceding gene: 118477855

Following gene: 118477860

Centisome position: 44.77

GC content: 36.53

Gene sequence:

>1002_bases
ATGATAACTAAAAAACTACCATTGCATATAGACGATATTAAAAAAGCTCAAAGCATTCTGGATAGAAATGCTCGTAAAAC
TCCATTAGTAAAATCATTTTATTTGACTAGTAAAACGGGTGGAGAAATTCACTTGAAATTAGAAAATATGCAATTAACAG
GTTCGTTTAAATTCCGTGGTGCGTTTAATAAAATGTCACAGCTGACAGATCAAGAAAAAGAGAGAGGAGTAATTGCTTGT
TCTGCTGGTAATCACGCGCAAGGAATTGCTTTATCTGCTCATTTACTCGGTATTAAAAGTAAAATTGTAATGCCGATTTC
TGCACCTCAGGCGAAAGTTGATGCAACGAAAGGATATGGATCTGAAGTGGTTTTACATGGTGAAACCTTTGATGATGCGA
AGGCAAAATGTGAGGAGATTATTAGAGAAACAGGTGAAACATACTTACATCCATATGACGATGTAGAAGTAATGGCTGGT
CAAGGTACAATAGGATTAGATATTCTTGATGATATGTGGGATGTTGATACGATCATTGTACCAATTGGTGGAGGAGGAAT
TATTTCTGGAATTGCTGTTGCATTAAAATCTTTTAATCCATCGATTCATATAATTGGTGTGCAAGCAGAAAATGTTCATG
GGATGAAGGCATCTTATGACAAAGGCAAAATTATAGAACATTATGAGGCACCTACGATAGCAGATGGTTGCGCGGTAAAA
ATACCAGGCAATTTAACTTTTGAAGTTGTAAAAGAACTAGTAGATGATATTGTAACAGTATCAGAAAAAGAGCTGGAAGT
AGCGATGAAAGACTTATTACAACGCGGGAAAGCTGTTGTAGAAGGTGCAGGCGCATTAGCTACTGCTGCTCTACTTGCAG
GGAAAGTGGATACATATATTAAAGAGAAAAAAGTAGTAGCAGTTATATCTGGTGGGAACGTAGACTTACAGCGTATATCG
AGTGTTTGTGAACAATTTTTTGTGGCGAATGAAGTGAAATAG

Upstream 100 bases:

>100_bases
AGGTTCATATATAAAGAATGGTCTTTAACATAGATGGTTTCGTATAAAGGAGCTGCGACTTACGAAAACTTAGGAAGAGA
ACATTGGAAGAGGTGTTAGT

Downstream 100 bases:

>100_bases
TTTTATGAAAAAGGAGCTAAGTGAAGTTATATTAGCTCCTTTTTCATTATGTTTGTGCGGGAGTAAATAATGACTCCATT
TTTACTTTGCTCTTTTCTCG

Product: threonine dehydratase

Products: NA

Alternate protein names: Threonine deaminase [H]

Number of amino acids: Translated: 333; Mature: 333

Protein sequence:

>333_residues
MITKKLPLHIDDIKKAQSILDRNARKTPLVKSFYLTSKTGGEIHLKLENMQLTGSFKFRGAFNKMSQLTDQEKERGVIAC
SAGNHAQGIALSAHLLGIKSKIVMPISAPQAKVDATKGYGSEVVLHGETFDDAKAKCEEIIRETGETYLHPYDDVEVMAG
QGTIGLDILDDMWDVDTIIVPIGGGGIISGIAVALKSFNPSIHIIGVQAENVHGMKASYDKGKIIEHYEAPTIADGCAVK
IPGNLTFEVVKELVDDIVTVSEKELEVAMKDLLQRGKAVVEGAGALATAALLAGKVDTYIKEKKVVAVISGGNVDLQRIS
SVCEQFFVANEVK

Sequences:

>Translated_333_residues
MITKKLPLHIDDIKKAQSILDRNARKTPLVKSFYLTSKTGGEIHLKLENMQLTGSFKFRGAFNKMSQLTDQEKERGVIAC
SAGNHAQGIALSAHLLGIKSKIVMPISAPQAKVDATKGYGSEVVLHGETFDDAKAKCEEIIRETGETYLHPYDDVEVMAG
QGTIGLDILDDMWDVDTIIVPIGGGGIISGIAVALKSFNPSIHIIGVQAENVHGMKASYDKGKIIEHYEAPTIADGCAVK
IPGNLTFEVVKELVDDIVTVSEKELEVAMKDLLQRGKAVVEGAGALATAALLAGKVDTYIKEKKVVAVISGGNVDLQRIS
SVCEQFFVANEVK
>Mature_333_residues
MITKKLPLHIDDIKKAQSILDRNARKTPLVKSFYLTSKTGGEIHLKLENMQLTGSFKFRGAFNKMSQLTDQEKERGVIAC
SAGNHAQGIALSAHLLGIKSKIVMPISAPQAKVDATKGYGSEVVLHGETFDDAKAKCEEIIRETGETYLHPYDDVEVMAG
QGTIGLDILDDMWDVDTIIVPIGGGGIISGIAVALKSFNPSIHIIGVQAENVHGMKASYDKGKIIEHYEAPTIADGCAVK
IPGNLTFEVVKELVDDIVTVSEKELEVAMKDLLQRGKAVVEGAGALATAALLAGKVDTYIKEKKVVAVISGGNVDLQRIS
SVCEQFFVANEVK

Specific function: Acts on both serine and threonine, and properly considered as a hydroxy amino acid deaminase [H]

COG id: COG1171

COG function: function code E; Threonine dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the serine/threonine dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI11345492, Length=311, Percent_Identity=36.3344051446945, Blast_Score=191, Evalue=7e-49,
Organism=Homo sapiens, GI33469958, Length=319, Percent_Identity=25.705329153605, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI19923959, Length=302, Percent_Identity=26.8211920529801, Blast_Score=74, Evalue=2e-13,
Organism=Escherichia coli, GI1789505, Length=321, Percent_Identity=59.190031152648, Blast_Score=347, Evalue=9e-97,
Organism=Escherichia coli, GI1790207, Length=304, Percent_Identity=42.1052631578947, Blast_Score=213, Evalue=1e-56,
Organism=Escherichia coli, GI2367138, Length=269, Percent_Identity=24.5353159851301, Blast_Score=63, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI71991565, Length=308, Percent_Identity=42.5324675324675, Blast_Score=221, Evalue=4e-58,
Organism=Caenorhabditis elegans, GI17537387, Length=318, Percent_Identity=34.9056603773585, Blast_Score=156, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI17508781, Length=305, Percent_Identity=29.5081967213115, Blast_Score=130, Evalue=9e-31,
Organism=Saccharomyces cerevisiae, GI6322631, Length=311, Percent_Identity=40.5144694533762, Blast_Score=209, Evalue=4e-55,
Organism=Saccharomyces cerevisiae, GI6320930, Length=307, Percent_Identity=37.4592833876222, Blast_Score=191, Evalue=2e-49,
Organism=Saccharomyces cerevisiae, GI6319788, Length=281, Percent_Identity=24.5551601423488, Blast_Score=92, Evalue=1e-19,
Organism=Drosophila melanogaster, GI21355833, Length=318, Percent_Identity=37.7358490566038, Blast_Score=154, Evalue=8e-38,
Organism=Drosophila melanogaster, GI24645328, Length=226, Percent_Identity=38.0530973451327, Blast_Score=100, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR005789 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.3.1.19 [H]

Molecular weight: Translated: 35814; Mature: 35814

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITKKLPLHIDDIKKAQSILDRNARKTPLVKSFYLTSKTGGEIHLKLENMQLTGSFKFRG
CCCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCEEEEEEEEEEEEEEEEECC
AFNKMSQLTDQEKERGVIACSAGNHAQGIALSAHLLGIKSKIVMPISAPQAKVDATKGYG
HHHHHHHHHHHHHHCCEEEEECCCCCCCEEEEEEEEECCCEEEEEECCCCCCCCCCCCCC
SEVVLHGETFDDAKAKCEEIIRETGETYLHPYDDVEVMAGQGTIGLDILDDMWDVDTIIV
CEEEEECCCCCHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCCHHHHHCCCCCCEEEE
PIGGGGIISGIAVALKSFNPSIHIIGVQAENVHGMKASYDKGKIIEHYEAPTIADGCAVK
EECCCHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCCCEEEECCCCCCCCCCEEE
IPGNLTFEVVKELVDDIVTVSEKELEVAMKDLLQRGKAVVEGAGALATAALLAGKVDTYI
ECCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCHHHECCCCHHHHHHHHHHHHHHHH
KEKKVVAVISGGNVDLQRISSVCEQFFVANEVK
CCCEEEEEEECCCCCHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MITKKLPLHIDDIKKAQSILDRNARKTPLVKSFYLTSKTGGEIHLKLENMQLTGSFKFRG
CCCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCEEEEEEEEEEEEEEEEECC
AFNKMSQLTDQEKERGVIACSAGNHAQGIALSAHLLGIKSKIVMPISAPQAKVDATKGYG
HHHHHHHHHHHHHHCCEEEEECCCCCCCEEEEEEEEECCCEEEEEECCCCCCCCCCCCCC
SEVVLHGETFDDAKAKCEEIIRETGETYLHPYDDVEVMAGQGTIGLDILDDMWDVDTIIV
CEEEEECCCCCHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCCHHHHHCCCCCCEEEE
PIGGGGIISGIAVALKSFNPSIHIIGVQAENVHGMKASYDKGKIIEHYEAPTIADGCAVK
EECCCHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCCCEEEECCCCCCCCCCEEE
IPGNLTFEVVKELVDDIVTVSEKELEVAMKDLLQRGKAVVEGAGALATAALLAGKVDTYI
ECCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCHHHECCCCHHHHHHHHHHHHHHHH
KEKKVVAVISGGNVDLQRISSVCEQFFVANEVK
CCCEEEEEEECCCCCHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA