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The map label for this gene is mmgD [H]

Identifier: 118477755

GI number: 118477755

Start: 2239169

End: 2240323

Strand: Direct

Name: mmgD [H]

Synonym: BALH_2093

Alternate gene names: 118477755

Gene position: 2239169-2240323 (Clockwise)

Preceding gene: 118477754

Following gene: 118477756

Centisome position: 42.59

GC content: 36.45

Gene sequence:

>1155_bases
GTGCACGAAGATCTATTAGGATTGGAGGAAATAATGATGAAAGCTGAAGAAAAATTTTCCCCGGGATTAGATGGTATAGT
GGCAGCGGAGACGAAGATCTCGTTTCTTGACACAGTGAAAGGTGAAATTGTAATTCAAGGGTATGATTTAATCGAACTCT
CAAAAACAAAAGAGTATTTAGACATTGTGCACCTTTTATTGGAAGAACATCTACCGAATGAGGATGAAAAAGCAACACTT
GAAAAGAAATTAAAAGAAGAATACGCGGTACCAGAAGGTGTATTCAACGTATTAAAGGCATTACCGAAAGAAACGCACCC
TATGGATGGATTGCGTACAGGTGTGTCCGCATTAGCTGGTTACGATAATGATATTGAAAATCGCTCGTTAGAAGTAAACA
AAAGCCGCGGATACAAATTATTGAGTAAAGTACCAAACATTGTAGCGAATAGCTATCATATTTTAAATAATGAAGAGCCA
ATCGAACCACTTAAGGAATTATCATATAGTGCAAATTTCTTCTATATGTTAACAGGTAAAAAACCAACTGAACTTGAGGA
GAAGATCTTTGATCGTTCCCTTGTTTTATATAGTGAACATGAAATGCCAAACTCTACATTTACAGCGCGCGTTATTGCAT
CTACACAATCCGACTTATATGGTGCTTTAACAGGTGCGGTTGCATCTTTAAAAGGTAGCTTACACGGCGGTGCAAACGAA
GCGGTTATGTACATGCTTTTAGAAGCTGGTAATGTTGAGAAATTTGAAGAATTATTACAGAAGAAACTATATAACAAAGA
AAAAATTATGGGCTTTGGACACCGTGTATATATGAAGAAAATGGATCCAAGAGCTTTAATGATGAAGGAAGCTTTAAAAC
AGTTATGTGATGTAAAAGGTGATTATACACTATATGAAATGTGTGAAGCTGGAGAAAAGATTATGGAGAAGGAAAAAGGA
ATTTATCCAAACCTTGATTATTATGCAGCTCCAGTATATTGGATGCTTGGTATTCCAATTCAACTATACACGCCAATCTT
CTTTAGCTCTAGAACAGTAGGACTATGTGCGCACGTTATTGAACAACATACGAACAATCGTTTGTTCCGTCCACGTGTAA
ATTATATTGGCGAGCGACATGTACTTAGTAAGTAA

Upstream 100 bases:

>100_bases
TAGGAAACTTATCATTATAAAATAAATTGAAATCTTCTAAAAACTCTGATACATTGAAATAGAAATGTAGTTTCACAATA
TTGTAAAGGCTTACAGTTAT

Downstream 100 bases:

>100_bases
AAACAACTGGGGAGTTGTTAGCACCGCCCGCCAGATGGGTGTTTGACCGACACCCATCATTAATAATAACGAATTTTCGA
CAGAAAGGGAAGGATAGCAT

Product: citrate synthase 3

Products: NA

Alternate protein names: Citrate synthase 3; Citrate synthase III; Methylcitrate synthase [H]

Number of amino acids: Translated: 384; Mature: 384

Protein sequence:

>384_residues
MHEDLLGLEEIMMKAEEKFSPGLDGIVAAETKISFLDTVKGEIVIQGYDLIELSKTKEYLDIVHLLLEEHLPNEDEKATL
EKKLKEEYAVPEGVFNVLKALPKETHPMDGLRTGVSALAGYDNDIENRSLEVNKSRGYKLLSKVPNIVANSYHILNNEEP
IEPLKELSYSANFFYMLTGKKPTELEEKIFDRSLVLYSEHEMPNSTFTARVIASTQSDLYGALTGAVASLKGSLHGGANE
AVMYMLLEAGNVEKFEELLQKKLYNKEKIMGFGHRVYMKKMDPRALMMKEALKQLCDVKGDYTLYEMCEAGEKIMEKEKG
IYPNLDYYAAPVYWMLGIPIQLYTPIFFSSRTVGLCAHVIEQHTNNRLFRPRVNYIGERHVLSK

Sequences:

>Translated_384_residues
MHEDLLGLEEIMMKAEEKFSPGLDGIVAAETKISFLDTVKGEIVIQGYDLIELSKTKEYLDIVHLLLEEHLPNEDEKATL
EKKLKEEYAVPEGVFNVLKALPKETHPMDGLRTGVSALAGYDNDIENRSLEVNKSRGYKLLSKVPNIVANSYHILNNEEP
IEPLKELSYSANFFYMLTGKKPTELEEKIFDRSLVLYSEHEMPNSTFTARVIASTQSDLYGALTGAVASLKGSLHGGANE
AVMYMLLEAGNVEKFEELLQKKLYNKEKIMGFGHRVYMKKMDPRALMMKEALKQLCDVKGDYTLYEMCEAGEKIMEKEKG
IYPNLDYYAAPVYWMLGIPIQLYTPIFFSSRTVGLCAHVIEQHTNNRLFRPRVNYIGERHVLSK
>Mature_384_residues
MHEDLLGLEEIMMKAEEKFSPGLDGIVAAETKISFLDTVKGEIVIQGYDLIELSKTKEYLDIVHLLLEEHLPNEDEKATL
EKKLKEEYAVPEGVFNVLKALPKETHPMDGLRTGVSALAGYDNDIENRSLEVNKSRGYKLLSKVPNIVANSYHILNNEEP
IEPLKELSYSANFFYMLTGKKPTELEEKIFDRSLVLYSEHEMPNSTFTARVIASTQSDLYGALTGAVASLKGSLHGGANE
AVMYMLLEAGNVEKFEELLQKKLYNKEKIMGFGHRVYMKKMDPRALMMKEALKQLCDVKGDYTLYEMCEAGEKIMEKEKG
IYPNLDYYAAPVYWMLGIPIQLYTPIFFSSRTVGLCAHVIEQHTNNRLFRPRVNYIGERHVLSK

Specific function: Catalyzes the synthesis of citrate from acetyl-CoA and oxaloacetate. The genomic context suggests that this protein probably functions as a 2-methylcitrate synthase, i.e. catalyzes the synthesis of 2-methylcitrate from propionyl-CoA and oxaloacetate [H]

COG id: COG0372

COG function: function code C; Citrate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the citrate synthase family [H]

Homologues:

Organism=Homo sapiens, GI38327625, Length=373, Percent_Identity=28.4182305630027, Blast_Score=100, Evalue=3e-21,
Organism=Escherichia coli, GI1786527, Length=361, Percent_Identity=38.5041551246537, Blast_Score=257, Evalue=1e-69,
Organism=Escherichia coli, GI1786939, Length=397, Percent_Identity=32.2418136020151, Blast_Score=199, Evalue=3e-52,
Organism=Caenorhabditis elegans, GI17555174, Length=373, Percent_Identity=28.9544235924933, Blast_Score=102, Evalue=4e-22,
Organism=Saccharomyces cerevisiae, GI6324328, Length=334, Percent_Identity=25.748502994012, Blast_Score=85, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6319850, Length=334, Percent_Identity=25.1497005988024, Blast_Score=82, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6325257, Length=344, Percent_Identity=24.7093023255814, Blast_Score=69, Evalue=9e-13,
Organism=Drosophila melanogaster, GI24640124, Length=373, Percent_Identity=28.4182305630027, Blast_Score=104, Evalue=8e-23,
Organism=Drosophila melanogaster, GI24640126, Length=373, Percent_Identity=28.4182305630027, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI21356863, Length=323, Percent_Identity=23.5294117647059, Blast_Score=72, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016142
- InterPro:   IPR016143
- InterPro:   IPR002020
- InterPro:   IPR016141
- InterPro:   IPR019810 [H]

Pfam domain/function: PF00285 Citrate_synt [H]

EC number: =2.3.3.5; =2.3.3.1 [H]

Molecular weight: Translated: 43668; Mature: 43668

Theoretical pI: Translated: 5.50; Mature: 5.50

Prosite motif: PS00480 CITRATE_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHEDLLGLEEIMMKAEEKFSPGLDGIVAAETKISFLDTVKGEIVIQGYDLIELSKTKEYL
CCCHHHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHCCCEEEEECCCEEEHHHHHHHH
DIVHLLLEEHLPNEDEKATLEKKLKEEYAVPEGVFNVLKALPKETHPMDGLRTGVSALAG
HHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHC
YDNDIENRSLEVNKSRGYKLLSKVPNIVANSYHILNNEEPIEPLKELSYSANFFYMLTGK
CCCCCCCCCEEECHHCCHHHHHHHHHHHHCCEEECCCCCCHHHHHHCCCCCCEEEEEECC
KPTELEEKIFDRSLVLYSEHEMPNSTFTARVIASTQSDLYGALTGAVASLKGSLHGGANE
CCCHHHHHHHCCCEEEEECCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCHH
AVMYMLLEAGNVEKFEELLQKKLYNKEKIMGFGHRVYMKKMDPRALMMKEALKQLCDVKG
HHHHHHHHCCCHHHHHHHHHHHHCCHHHHHCCCHHEEHHHCCHHHHHHHHHHHHHHCCCC
DYTLYEMCEAGEKIMEKEKGIYPNLDYYAAPVYWMLGIPIQLYTPIFFSSRTVGLCAHVI
CCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCHHHHCHHHCCCCHHHHHHHHH
EQHTNNRLFRPRVNYIGERHVLSK
HHHCCCCEECCHHHHCCCHHCCCC
>Mature Secondary Structure
MHEDLLGLEEIMMKAEEKFSPGLDGIVAAETKISFLDTVKGEIVIQGYDLIELSKTKEYL
CCCHHHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHCCCEEEEECCCEEEHHHHHHHH
DIVHLLLEEHLPNEDEKATLEKKLKEEYAVPEGVFNVLKALPKETHPMDGLRTGVSALAG
HHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHC
YDNDIENRSLEVNKSRGYKLLSKVPNIVANSYHILNNEEPIEPLKELSYSANFFYMLTGK
CCCCCCCCCEEECHHCCHHHHHHHHHHHHCCEEECCCCCCHHHHHHCCCCCCEEEEEECC
KPTELEEKIFDRSLVLYSEHEMPNSTFTARVIASTQSDLYGALTGAVASLKGSLHGGANE
CCCHHHHHHHCCCEEEEECCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCHH
AVMYMLLEAGNVEKFEELLQKKLYNKEKIMGFGHRVYMKKMDPRALMMKEALKQLCDVKG
HHHHHHHHCCCHHHHHHHHHHHHCCHHHHHCCCHHEEHHHCCHHHHHHHHHHHHHHCCCC
DYTLYEMCEAGEKIMEKEKGIYPNLDYYAAPVYWMLGIPIQLYTPIFFSSRTVGLCAHVI
CCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCHHHHCHHHCCCCHHHHHHHHH
EQHTNNRLFRPRVNYIGERHVLSK
HHHCCCCEECCHHHHCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8759838; 8969508; 9384377 [H]