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The map label for this gene is pbp1A [H]

Identifier: 118477750

GI number: 118477750

Start: 2234232

End: 2236736

Strand: Direct

Name: pbp1A [H]

Synonym: BALH_2087

Alternate gene names: 118477750

Gene position: 2234232-2236736 (Clockwise)

Preceding gene: 118477749

Following gene: 118477752

Centisome position: 42.5

GC content: 36.97

Gene sequence:

>2505_bases
ATGTCAGAAAATTATCGTTCTCGAGAGGAGCGACGACAAGTTAAAAAGAAAAAACAGCCAGCTTCTAAAACACAAAAACC
AAAAGGTAAAACATCGTTCTTTCGCAAGTTTTTAATTACTTGTTTATTACTTGGTATTGTTGGTTTAGTGGGGGGAGTTG
CTACCTTTTTCGTAATGATTAAGGATGCACCAAAACTTGAGAAAGCAAAACTTGTTAATCCGTTATCCTCAAAAATTTAT
GATAAAAATGGCGATTTGGTATATGAATACGGGAAAGAAAAACGGACGAATGTTACGTATGATCAAATTCCTAAATTAGT
AGAAAATGCATTTTTAGCAACAGAAGATGCACGTTTTTACGAGCATAGCGGAGTAGACTTTAAAGGTACTGCCCGTGCTG
TTTTGGTGAGTCTTAAAGGCGATTACGGTTCACAAGGTGGAAGTACGATAACACAGCAGGTTATTAAAAATTACTTCTTA
TCGATGGAAAAAACATCAAAACGTAAGATTCAAGAAATATATTTAGCGTATAAGCTAGAACAACAGTATTCAAAACATGA
AATTTTAGAAATGTATTTAAATAAAATTAATTTAGGTAATCGTTCATATGGTATCGCAACAGCAGCACAAAACTACTACG
GTAAAGAATTAAAAGAGTTAACTTTACCAGAAGTTGCGATGCTTGCAGGTTTACCAAAAGCACCGAATAACTATGATCCA
ACGAAGACAGAAAATGTTCAAAGAGCAACAGAAAGAAGAAATGTTGTCCTAAAATTAATGAATCGACATGGTTATATTAC
GAAGGCAGAAATGGAAGAAGCTTCGAAAGTTGAAGTAACAGATGGACTTAAGACTGCAACTGTACAAGCAATGCCATATC
CTGCATTTATGGATGCGGTTGTGAAAGAAGTTGAAAAAGAATTGCCAGATGCTAATATTGGTTCTGACGGTTTAGAAATT
TATACAACATTAGACATAGACGCACAGAAGGCTGCCGACAGGATATTAGATGCTAATATTATTAATTATCCAAATGATAA
ATTCCAAAGTGCTTTCACATTTATGGATACGAAAACAGGAGAAGTTCGTGCTATAGGTAGTGGACGTGGTGAAAATAAAG
CAGTATTTAAAGGGCATAATATGGCAATTGAATTAGATCGTGCAGCTGGTTCAACTATGAAGCCAATCTTTGATTACGGT
CCTGCAATTGAATACTTAAAATGGGCTACGTATCATCAAATTGATGATTCTCCATTTAAATATTCAACTGGACAAGAAGT
TCGAAATGCGGACAGAAGTCATTTAGGATCAATTACGATGCGTGAAGCATTAAAAATGTCGCGTAACGTTCCGGCAGTTA
AAACTGCAAAAGAAGTAGGACTTAATAAAGCGAAGGAATTCTCTGAGAAATTAGGTATTACACTTAAGTCAGCACCAGAA
TCTACAGCGATTGGTACAAACGAAGTATCACCAACTGAAATAGCGGGTGCTTATGCGACATTTGGTAATGGTGGAAAGTA
TGCAAAACCGCATTTTGTTAAGAAAGTAGTTTATCCAGACGGCAAGTCACAAAGTTTTGGACAAAAACCAAAACAAGTTA
TAGCTGACTCTACAGCATATATGATTACTGATATGCTTCGTTCAGTAGTGACATCAGGTACTGGTACAGCAGCAAATATA
AGTTCTTTAGATGTAGCTGGAAAAACAGGTACAACAAACTATGATTCAAAACAATTAGCGAAATTTAATATTCCGGAAAG
TGCAACTCGTGATAGTTGGTTTGCAGGTTATACGCCGCAATATACGATGGCAGTATGGACTGGGTATATGAAAGATGGTA
AGGACGAGTATATTAGTAGTAAAAATACGAAAATTGCACAGTTGATCTTTAAAGAAATGATGAGCGAGATGGCTACAGAT
AAATCAAGATTTAAAATGCCAAGTAGTGTAATTCAAGAAGGTAGTGAGCTGCGTATAAAAGGTGAAAAACGTGATTCTTC
TCCAAATACGAGCGTACCGGATACAACAGAAAAACCAAAACAAGATCAACAGCAAAAAACTGAAGAAGAGAAAAAGCAAG
AAGAATTAAAAAAACAAGAAGAACTTAAAAAACAAGAAGAAGAAAAGAAACAAGAGGAACTGAAGAAGCAGGAAGAACAA
AAGAAACTAGAAGAGCAAAAGAAACAAGAAGAAGAAAAGAAACAAAATGAACAAAATAATGGAAATGGTCAAGGAACGAC
CCCTCCAGCAAATAACGGAGGAGGCCAAGGAAATACAACCCCTCCAGCAAATAACGGAGGAGGTCAAGGAAATACAACCC
CTCCAGCAAATAACGGAGGAGGTCAAGGAAATACGACTCCTCCAGCAAATAACGGAGGAGGTCAAGGAAATACAACCCCT
CCAGCAAATAATGGAGGAGGTCAAGGAAATACAACTCCACCAGCGACCACACAACCGGAGACTGGCGGTAATGCAGGAGA
GGCCCCTGCTAATAATGGGCAATAA

Upstream 100 bases:

>100_bases
CTCCAGGTCGATATACTTTCTTAATTTAATTCATTTTAGAAAGTGACCTCAATATTTTTAAGTAAATCAACGGGAGAATT
GAAAGGCAGGAGAAAGTAAC

Downstream 100 bases:

>100_bases
GAAAATTTTATAAAAAATATTAAAAAGCACTTAAGATTTGTAAAAATTACAATCTTAAGTGCTTTTTTCGTTAAATGTAG
TAGCTATGAGACGATGTATT

Product: penicillin-binding protein 1A

Products: NA

Alternate protein names: PBP1; Penicillin-insensitive transglycosylase; Peptidoglycan TGase; Penicillin-sensitive transpeptidase; DD-transpeptidase [H]

Number of amino acids: Translated: 834; Mature: 833

Protein sequence:

>834_residues
MSENYRSREERRQVKKKKQPASKTQKPKGKTSFFRKFLITCLLLGIVGLVGGVATFFVMIKDAPKLEKAKLVNPLSSKIY
DKNGDLVYEYGKEKRTNVTYDQIPKLVENAFLATEDARFYEHSGVDFKGTARAVLVSLKGDYGSQGGSTITQQVIKNYFL
SMEKTSKRKIQEIYLAYKLEQQYSKHEILEMYLNKINLGNRSYGIATAAQNYYGKELKELTLPEVAMLAGLPKAPNNYDP
TKTENVQRATERRNVVLKLMNRHGYITKAEMEEASKVEVTDGLKTATVQAMPYPAFMDAVVKEVEKELPDANIGSDGLEI
YTTLDIDAQKAADRILDANIINYPNDKFQSAFTFMDTKTGEVRAIGSGRGENKAVFKGHNMAIELDRAAGSTMKPIFDYG
PAIEYLKWATYHQIDDSPFKYSTGQEVRNADRSHLGSITMREALKMSRNVPAVKTAKEVGLNKAKEFSEKLGITLKSAPE
STAIGTNEVSPTEIAGAYATFGNGGKYAKPHFVKKVVYPDGKSQSFGQKPKQVIADSTAYMITDMLRSVVTSGTGTAANI
SSLDVAGKTGTTNYDSKQLAKFNIPESATRDSWFAGYTPQYTMAVWTGYMKDGKDEYISSKNTKIAQLIFKEMMSEMATD
KSRFKMPSSVIQEGSELRIKGEKRDSSPNTSVPDTTEKPKQDQQQKTEEEKKQEELKKQEELKKQEEEKKQEELKKQEEQ
KKLEEQKKQEEEKKQNEQNNGNGQGTTPPANNGGGQGNTTPPANNGGGQGNTTPPANNGGGQGNTTPPANNGGGQGNTTP
PANNGGGQGNTTPPATTQPETGGNAGEAPANNGQ

Sequences:

>Translated_834_residues
MSENYRSREERRQVKKKKQPASKTQKPKGKTSFFRKFLITCLLLGIVGLVGGVATFFVMIKDAPKLEKAKLVNPLSSKIY
DKNGDLVYEYGKEKRTNVTYDQIPKLVENAFLATEDARFYEHSGVDFKGTARAVLVSLKGDYGSQGGSTITQQVIKNYFL
SMEKTSKRKIQEIYLAYKLEQQYSKHEILEMYLNKINLGNRSYGIATAAQNYYGKELKELTLPEVAMLAGLPKAPNNYDP
TKTENVQRATERRNVVLKLMNRHGYITKAEMEEASKVEVTDGLKTATVQAMPYPAFMDAVVKEVEKELPDANIGSDGLEI
YTTLDIDAQKAADRILDANIINYPNDKFQSAFTFMDTKTGEVRAIGSGRGENKAVFKGHNMAIELDRAAGSTMKPIFDYG
PAIEYLKWATYHQIDDSPFKYSTGQEVRNADRSHLGSITMREALKMSRNVPAVKTAKEVGLNKAKEFSEKLGITLKSAPE
STAIGTNEVSPTEIAGAYATFGNGGKYAKPHFVKKVVYPDGKSQSFGQKPKQVIADSTAYMITDMLRSVVTSGTGTAANI
SSLDVAGKTGTTNYDSKQLAKFNIPESATRDSWFAGYTPQYTMAVWTGYMKDGKDEYISSKNTKIAQLIFKEMMSEMATD
KSRFKMPSSVIQEGSELRIKGEKRDSSPNTSVPDTTEKPKQDQQQKTEEEKKQEELKKQEELKKQEEEKKQEELKKQEEQ
KKLEEQKKQEEEKKQNEQNNGNGQGTTPPANNGGGQGNTTPPANNGGGQGNTTPPANNGGGQGNTTPPANNGGGQGNTTP
PANNGGGQGNTTPPATTQPETGGNAGEAPANNGQ
>Mature_833_residues
SENYRSREERRQVKKKKQPASKTQKPKGKTSFFRKFLITCLLLGIVGLVGGVATFFVMIKDAPKLEKAKLVNPLSSKIYD
KNGDLVYEYGKEKRTNVTYDQIPKLVENAFLATEDARFYEHSGVDFKGTARAVLVSLKGDYGSQGGSTITQQVIKNYFLS
MEKTSKRKIQEIYLAYKLEQQYSKHEILEMYLNKINLGNRSYGIATAAQNYYGKELKELTLPEVAMLAGLPKAPNNYDPT
KTENVQRATERRNVVLKLMNRHGYITKAEMEEASKVEVTDGLKTATVQAMPYPAFMDAVVKEVEKELPDANIGSDGLEIY
TTLDIDAQKAADRILDANIINYPNDKFQSAFTFMDTKTGEVRAIGSGRGENKAVFKGHNMAIELDRAAGSTMKPIFDYGP
AIEYLKWATYHQIDDSPFKYSTGQEVRNADRSHLGSITMREALKMSRNVPAVKTAKEVGLNKAKEFSEKLGITLKSAPES
TAIGTNEVSPTEIAGAYATFGNGGKYAKPHFVKKVVYPDGKSQSFGQKPKQVIADSTAYMITDMLRSVVTSGTGTAANIS
SLDVAGKTGTTNYDSKQLAKFNIPESATRDSWFAGYTPQYTMAVWTGYMKDGKDEYISSKNTKIAQLIFKEMMSEMATDK
SRFKMPSSVIQEGSELRIKGEKRDSSPNTSVPDTTEKPKQDQQQKTEEEKKQEELKKQEELKKQEEEKKQEELKKQEEQK
KLEEQKKQEEEKKQNEQNNGNGQGTTPPANNGGGQGNTTPPANNGGGQGNTTPPANNGGGQGNTTPPANNGGGQGNTTPP
ANNGGGQGNTTPPATTQPETGGNAGEAPANNGQ

Specific function: Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal

COG id: COG0744

COG function: function code M; Membrane carboxypeptidase (penicillin-binding protein)

Gene ontology:

Cell location: Cell membrane; Single-pass type II membrane protein. Note=Probably found all over the whole cell at low concentrations. Also localizes to the division site in vegetative cells [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 fibronectin type-III domain [H]

Homologues:

Organism=Escherichia coli, GI87082258, Length=314, Percent_Identity=42.0382165605096, Blast_Score=239, Evalue=7e-64,
Organism=Escherichia coli, GI1786343, Length=541, Percent_Identity=33.826247689464, Blast_Score=224, Evalue=2e-59,
Organism=Escherichia coli, GI1788867, Length=581, Percent_Identity=27.3666092943201, Blast_Score=132, Evalue=1e-31,
Organism=Escherichia coli, GI1789601, Length=233, Percent_Identity=31.3304721030043, Blast_Score=91, Evalue=4e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR008957
- InterPro:   IPR003961
- InterPro:   IPR001264
- InterPro:   IPR013783
- InterPro:   IPR011816
- InterPro:   IPR001460 [H]

Pfam domain/function: PF00041 fn3; PF00912 Transgly; PF00905 Transpeptidase [H]

EC number: 2.4.2.-; 3.4.-.-

Molecular weight: Translated: 91721; Mature: 91590

Theoretical pI: Translated: 9.51; Mature: 9.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSENYRSREERRQVKKKKQPASKTQKPKGKTSFFRKFLITCLLLGIVGLVGGVATFFVMI
CCCCCCCHHHHHHHHHHCCCCHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KDAPKLEKAKLVNPLSSKIYDKNGDLVYEYGKEKRTNVTYDQIPKLVENAFLATEDARFY
CCCCCHHHHHHHCHHHHHHCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHCCCCCHHH
EHSGVDFKGTARAVLVSLKGDYGSQGGSTITQQVIKNYFLSMEKTSKRKIQEIYLAYKLE
HCCCCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QQYSKHEILEMYLNKINLGNRSYGIATAAQNYYGKELKELTLPEVAMLAGLPKAPNNYDP
HHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCCC
TKTENVQRATERRNVVLKLMNRHGYITKAEMEEASKVEVTDGLKTATVQAMPYPAFMDAV
CCHHHHHHHHHHHHHHHHHHHHCCCEEEHHHHCCCCEECCCCCCCEEEECCCCHHHHHHH
VKEVEKELPDANIGSDGLEIYTTLDIDAQKAADRILDANIINYPNDKFQSAFTFMDTKTG
HHHHHHHCCCCCCCCCCEEEEEEECCCHHHHHHHHHHCHHCCCCCHHHHHHHHHHCCCCC
EVRAIGSGRGENKAVFKGHNMAIELDRAAGSTMKPIFDYGPAIEYLKWATYHQIDDSPFK
CEEEECCCCCCCCEEEECCCEEEEEECCCCCCCCHHHHCCCHHHHHHHHHHHCCCCCCCC
YSTGQEVRNADRSHLGSITMREALKMSRNVPAVKTAKEVGLNKAKEFSEKLGITLKSAPE
CCCCHHHHHCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCHHHHHHHHHHCCEEECCCC
STAIGTNEVSPTEIAGAYATFGNGGKYAKPHFVKKVVYPDGKSQSFGQKPKQVIADSTAY
CCCCCCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHEECCCCCCCCCCCCHHHHHHCCHHH
MITDMLRSVVTSGTGTAANISSLDVAGKTGTTNYDSKQLAKFNIPESATRDSWFAGYTPQ
HHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCC
YTMAVWTGYMKDGKDEYISSKNTKIAQLIFKEMMSEMATDKSRFKMPSSVIQEGSELRIK
HHHHHHHHHHHCCHHHHHCCCCCHHHHHHHHHHHHHHHCCHHHHCCCHHHHCCCCCEEEE
GEKRDSSPNTSVPDTTEKPKQDQQQKTEEEKKQEELKKQEELKKQEEEKKQEELKKQEEQ
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KKLEEQKKQEEEKKQNEQNNGNGQGTTPPANNGGGQGNTTPPANNGGGQGNTTPPANNGG
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
GQGNTTPPANNGGGQGNTTPPANNGGGQGNTTPPATTQPETGGNAGEAPANNGQ
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SENYRSREERRQVKKKKQPASKTQKPKGKTSFFRKFLITCLLLGIVGLVGGVATFFVMI
CCCCCCHHHHHHHHHHCCCCHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KDAPKLEKAKLVNPLSSKIYDKNGDLVYEYGKEKRTNVTYDQIPKLVENAFLATEDARFY
CCCCCHHHHHHHCHHHHHHCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHCCCCCHHH
EHSGVDFKGTARAVLVSLKGDYGSQGGSTITQQVIKNYFLSMEKTSKRKIQEIYLAYKLE
HCCCCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QQYSKHEILEMYLNKINLGNRSYGIATAAQNYYGKELKELTLPEVAMLAGLPKAPNNYDP
HHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCCC
TKTENVQRATERRNVVLKLMNRHGYITKAEMEEASKVEVTDGLKTATVQAMPYPAFMDAV
CCHHHHHHHHHHHHHHHHHHHHCCCEEEHHHHCCCCEECCCCCCCEEEECCCCHHHHHHH
VKEVEKELPDANIGSDGLEIYTTLDIDAQKAADRILDANIINYPNDKFQSAFTFMDTKTG
HHHHHHHCCCCCCCCCCEEEEEEECCCHHHHHHHHHHCHHCCCCCHHHHHHHHHHCCCCC
EVRAIGSGRGENKAVFKGHNMAIELDRAAGSTMKPIFDYGPAIEYLKWATYHQIDDSPFK
CEEEECCCCCCCCEEEECCCEEEEEECCCCCCCCHHHHCCCHHHHHHHHHHHCCCCCCCC
YSTGQEVRNADRSHLGSITMREALKMSRNVPAVKTAKEVGLNKAKEFSEKLGITLKSAPE
CCCCHHHHHCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCHHHHHHHHHHCCEEECCCC
STAIGTNEVSPTEIAGAYATFGNGGKYAKPHFVKKVVYPDGKSQSFGQKPKQVIADSTAY
CCCCCCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHEECCCCCCCCCCCCHHHHHHCCHHH
MITDMLRSVVTSGTGTAANISSLDVAGKTGTTNYDSKQLAKFNIPESATRDSWFAGYTPQ
HHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCC
YTMAVWTGYMKDGKDEYISSKNTKIAQLIFKEMMSEMATDKSRFKMPSSVIQEGSELRIK
HHHHHHHHHHHCCHHHHHCCCCCHHHHHHHHHHHHHHHCCHHHHCCCHHHHCCCCCEEEE
GEKRDSSPNTSVPDTTEKPKQDQQQKTEEEKKQEELKKQEELKKQEEEKKQEELKKQEEQ
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KKLEEQKKQEEEKKQNEQNNGNGQGTTPPANNGGGQGNTTPPANNGGGQGNTTPPANNGG
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
GQGNTTPPANNGGGQGNTTPPANNGGGQGNTTPPATTQPETGGNAGEAPANNGQ
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Transferases; Acyltransferases; Aminoacyltransferases [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7814321; 8760912; 9384377; 9721295; 10322023 [H]