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The map label for this gene is prsA [H]

Identifier: 118477742

GI number: 118477742

Start: 2227624

End: 2228520

Strand: Direct

Name: prsA [H]

Synonym: BALH_2079

Alternate gene names: 118477742

Gene position: 2227624-2228520 (Clockwise)

Preceding gene: 118477740

Following gene: 118477743

Centisome position: 42.37

GC content: 31.55

Gene sequence:

>897_bases
TTGTATAGTCATTCTTGTATAATAATAAAAGTGAGGTATTTTGAATTGAAAAAGAAAAAGCTATTTTTAGGAACAATTAT
TTCATGCGTAGTACTGGCATTATCTGCATGTGGTTCCTCAGACAACGTAGTAACATCAAAAGTAGGAAATATTACAGAGA
AAGAATTAAGTAAAGAATTAAGACAAAAATATGGGGAAAGTACTTTATACCAAATGGTGTTAAGTAAGGCGTTGCTAGAT
AAATATAAAGTTTCAGATGAGGAAGCAAAAAAACAAGTAGAAGAAGCAAAAGATAAAATGGGTGACAACTTCAAATCGAC
TTTAGAGCAAGTTGGATTGAAAAACGAAGATGAATTAAAAGAAAAAATGAAGCCAGAAATTGCATTTGAGAAGGCGATTA
CAGCAACTGTCACAGAAAAGGATGTAAAAGATAACTATAAACCAGAAATGAAGGTAAGTCACATTTTAGTAAAAGATGAA
AAGACTGCTAAAGAAGTGAAAGAGAAAGTGAATAATGGAGAAGATTTTGCAGCTTTAGCGAAGCAATACTCAGAGGATAC
TGGTTCAAAAGAACAGGGCGGAGAAATAACTGGTTTTGCTCCAGGACAAACGGTAAAAGAATTTGAGGAAGCTGCATATA
AATTAGATGCAGGACAAGTAAGTGAGCCAGTAAAAACAACTTATGGTTACCATATTATAAAAGTGACAAATAAAAAAGAA
TTGAAGCCATTTGATGAAGTAAAAGATTCAATTCGTAAAGATATAGAACAGCAAAGACTACAAGATACGACAGGTAAATG
GAAACAGCAAGTAGTCAATGAATTATTAAAAGATGCCGATATTAAGGTGAATGATAAAGAGTTTAAAAATACATTTGAAT
TTCTAGAAAAGAAATAA

Upstream 100 bases:

>100_bases
AGTAAGATGACCTTTCATATTTGAACAAAAAGAACTTCATACATAGTTTTTTCAAATGAAATGAATTACATGTAGAAAAC
ACATTGTTTACACAAGAACA

Downstream 100 bases:

>100_bases
TGACTGTAACTAGAAAAGGGAACCTTTAAAGGTTCCCTTTTCTAGTTAGTGTGTGAGTTATAAATAGATAGTAAGACAAT
ACAATATTACATATAAATAT

Product: peptidylprolyl isomerase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 298; Mature: 298

Protein sequence:

>298_residues
MYSHSCIIIKVRYFELKKKKLFLGTIISCVVLALSACGSSDNVVTSKVGNITEKELSKELRQKYGESTLYQMVLSKALLD
KYKVSDEEAKKQVEEAKDKMGDNFKSTLEQVGLKNEDELKEKMKPEIAFEKAITATVTEKDVKDNYKPEMKVSHILVKDE
KTAKEVKEKVNNGEDFAALAKQYSEDTGSKEQGGEITGFAPGQTVKEFEEAAYKLDAGQVSEPVKTTYGYHIIKVTNKKE
LKPFDEVKDSIRKDIEQQRLQDTTGKWKQQVVNELLKDADIKVNDKEFKNTFEFLEKK

Sequences:

>Translated_298_residues
MYSHSCIIIKVRYFELKKKKLFLGTIISCVVLALSACGSSDNVVTSKVGNITEKELSKELRQKYGESTLYQMVLSKALLD
KYKVSDEEAKKQVEEAKDKMGDNFKSTLEQVGLKNEDELKEKMKPEIAFEKAITATVTEKDVKDNYKPEMKVSHILVKDE
KTAKEVKEKVNNGEDFAALAKQYSEDTGSKEQGGEITGFAPGQTVKEFEEAAYKLDAGQVSEPVKTTYGYHIIKVTNKKE
LKPFDEVKDSIRKDIEQQRLQDTTGKWKQQVVNELLKDADIKVNDKEFKNTFEFLEKK
>Mature_298_residues
MYSHSCIIIKVRYFELKKKKLFLGTIISCVVLALSACGSSDNVVTSKVGNITEKELSKELRQKYGESTLYQMVLSKALLD
KYKVSDEEAKKQVEEAKDKMGDNFKSTLEQVGLKNEDELKEKMKPEIAFEKAITATVTEKDVKDNYKPEMKVSHILVKDE
KTAKEVKEKVNNGEDFAALAKQYSEDTGSKEQGGEITGFAPGQTVKEFEEAAYKLDAGQVSEPVKTTYGYHIIKVTNKKE
LKPFDEVKDSIRKDIEQQRLQDTTGKWKQQVVNELLKDADIKVNDKEFKNTFEFLEKK

Specific function: Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins. Important for the secretion of the protective antigen. The three psrA proteins in this organism show different but overlapping

COG id: COG0760

COG function: function code O; Parvulin-like peptidyl-prolyl isomerase

Gene ontology:

Cell location: Cell membrane; Lipid-anchor (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PpiC domain [H]

Homologues:

Organism=Escherichia coli, GI1790211, Length=82, Percent_Identity=41.4634146341463, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI1786238, Length=133, Percent_Identity=27.8195488721804, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023059
- InterPro:   IPR000297
- InterPro:   IPR008880 [H]

Pfam domain/function: PF00639 Rotamase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 33908; Mature: 33908

Theoretical pI: Translated: 7.43; Mature: 7.43

Prosite motif: PS50198 PPIC_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYSHSCIIIKVRYFELKKKKLFLGTIISCVVLALSACGSSDNVVTSKVGNITEKELSKEL
CCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCHHHHHHHHH
RQKYGESTLYQMVLSKALLDKYKVSDEEAKKQVEEAKDKMGDNFKSTLEQVGLKNEDELK
HHHHCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHH
EKMKPEIAFEKAITATVTEKDVKDNYKPEMKVSHILVKDEKTAKEVKEKVNNGEDFAALA
HHHCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHEEECCHHHHHHHHHHHCCCHHHHHHH
KQYSEDTGSKEQGGEITGFAPGQTVKEFEEAAYKLDAGQVSEPVKTTYGYHIIKVTNKKE
HHHHHCCCCCCCCCCEECCCCCHHHHHHHHHHHHCCCCCCCCCHHHHCCEEEEEECCCCC
LKPFDEVKDSIRKDIEQQRLQDTTGKWKQQVVNELLKDADIKVNDKEFKNTFEFLEKK
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MYSHSCIIIKVRYFELKKKKLFLGTIISCVVLALSACGSSDNVVTSKVGNITEKELSKEL
CCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCHHHHHHHHH
RQKYGESTLYQMVLSKALLDKYKVSDEEAKKQVEEAKDKMGDNFKSTLEQVGLKNEDELK
HHHHCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHH
EKMKPEIAFEKAITATVTEKDVKDNYKPEMKVSHILVKDEKTAKEVKEKVNNGEDFAALA
HHHCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHEEECCHHHHHHHHHHHCCCHHHHHHH
KQYSEDTGSKEQGGEITGFAPGQTVKEFEEAAYKLDAGQVSEPVKTTYGYHIIKVTNKKE
HHHHHCCCCCCCCCCEECCCCCHHHHHHHHHHHHCCCCCCCCCHHHHCCEEEEEECCCCC
LKPFDEVKDSIRKDIEQQRLQDTTGKWKQQVVNELLKDADIKVNDKEFKNTFEFLEKK
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12721629; 12606539 [H]