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The map label for this gene is mhpE [C]

Identifier: 118477519

GI number: 118477519

Start: 1996006

End: 1997031

Strand: Direct

Name: mhpE [C]

Synonym: BALH_1844

Alternate gene names: 118477519

Gene position: 1996006-1997031 (Clockwise)

Preceding gene: 118477518

Following gene: 118477520

Centisome position: 37.97

GC content: 39.38

Gene sequence:

>1026_bases
ATGAGGCGAAATAGTGAAAGACCAGTGAGAATAACGGAAGTTTGTTTACGTGATGGAAGTCATGTAATGAAACATCAATT
TACAGAAGAGCAAGTTCGATTTGTAACAAGGGCATTAGATGAGGCAGGTATGCATTATATCGAAGTGAGCCATGGAGATG
GTTTAGGTGGTTCTACTTTACAATATGGGAAGTCATTAGTGAATGAAATGAAGCTCATTGAAGCTGCGGTAGATGAGTGT
AAGCAAGCTCAAATAGCTGTCTTGTTAATTCCTGGTATTGGAACGATTCATGAATTAAAGCAAGCTGCAAATATTGGTGC
GAAACTAGTTCGTGTAGCAACACATGTAACAGAAGCGGATGTTTCCGCTCAGCATATTCAATTTGCGCGTGAGTTAGGTA
TGGAAGTGTGCGGTTTTTTAATGATGGCACATTCTGCATCGGTTGAAAAGTTAGTAGAACAAGCAAAGCTTATGGAAAGT
TATGGTGCAGAAGCAGTTTATGTAACAGATTCTGCAGGAGCTTTATTGCCTCATGAAGTACGTGAACGTATCCGTGCTTT
GCGTCAATCTTTAAATATTGAAATTGGTTTCCATGGTCATAATAATCTTTCGGTTGCAGTAGCAAATACAATTACTGCAA
TTGAAGAAGGAGCGACACGTATTGATGGAAGTGTACGATGTCTTGGCGCAGGAGCTGGAAATGCCCAAACAGAAGTATTG
CTCGCTGTTTTGGATCGTATGGGATATAAGCTAGATATAGATTTATATAAGATGATGGATGTCGCAGAGGAGGTTGTTGC
CCCTTTATTACCAGTACCACAAGAAATTCAAAAAGGTAGTCTAGTAATGGGATATGCAGGGGTATACTCTAGCTTTTTAT
TACATGCTGAAAGGGCGGCACAACGCTTTAATGTAGACGCACGTGATATTTTAATAGAACTTGGGAAAAGAAAAGTAGTT
GGAGGACAAGAGGATATGATTTTAGATGTAGCTGCAGAATTAGCAAAGATAAAAATGGAGGTGTAA

Upstream 100 bases:

>100_bases
CCTTATGCCGGTAATTTAGATATTATGACAGCTGCAGCATTAAAAGTAGGTGAAGAATTTGCAACGCAAATCATCTCAGA
GAAGAAAAGAGGTGTAATGA

Downstream 100 bases:

>100_bases
CATATGGCTTTAGTGAAAGGGGCAGATTTAGAAATTATTGATTATTTACTTCAAGCTGAAAAGGAAAGAAAAGAAGTAGT
AAAAGTAACGGATAAGCATC

Product: 4-hydroxy-2-ketovalerate aldolase

Products: NA

Alternate protein names: HOA; 4-hydroxy-2-keto-pentanoic acid aldolase; 4-hydroxy-2-oxopentanoate aldolase

Number of amino acids: Translated: 341; Mature: 341

Protein sequence:

>341_residues
MRRNSERPVRITEVCLRDGSHVMKHQFTEEQVRFVTRALDEAGMHYIEVSHGDGLGGSTLQYGKSLVNEMKLIEAAVDEC
KQAQIAVLLIPGIGTIHELKQAANIGAKLVRVATHVTEADVSAQHIQFARELGMEVCGFLMMAHSASVEKLVEQAKLMES
YGAEAVYVTDSAGALLPHEVRERIRALRQSLNIEIGFHGHNNLSVAVANTITAIEEGATRIDGSVRCLGAGAGNAQTEVL
LAVLDRMGYKLDIDLYKMMDVAEEVVAPLLPVPQEIQKGSLVMGYAGVYSSFLLHAERAAQRFNVDARDILIELGKRKVV
GGQEDMILDVAAELAKIKMEV

Sequences:

>Translated_341_residues
MRRNSERPVRITEVCLRDGSHVMKHQFTEEQVRFVTRALDEAGMHYIEVSHGDGLGGSTLQYGKSLVNEMKLIEAAVDEC
KQAQIAVLLIPGIGTIHELKQAANIGAKLVRVATHVTEADVSAQHIQFARELGMEVCGFLMMAHSASVEKLVEQAKLMES
YGAEAVYVTDSAGALLPHEVRERIRALRQSLNIEIGFHGHNNLSVAVANTITAIEEGATRIDGSVRCLGAGAGNAQTEVL
LAVLDRMGYKLDIDLYKMMDVAEEVVAPLLPVPQEIQKGSLVMGYAGVYSSFLLHAERAAQRFNVDARDILIELGKRKVV
GGQEDMILDVAAELAKIKMEV
>Mature_341_residues
MRRNSERPVRITEVCLRDGSHVMKHQFTEEQVRFVTRALDEAGMHYIEVSHGDGLGGSTLQYGKSLVNEMKLIEAAVDEC
KQAQIAVLLIPGIGTIHELKQAANIGAKLVRVATHVTEADVSAQHIQFARELGMEVCGFLMMAHSASVEKLVEQAKLMES
YGAEAVYVTDSAGALLPHEVRERIRALRQSLNIEIGFHGHNNLSVAVANTITAIEEGATRIDGSVRCLGAGAGNAQTEVL
LAVLDRMGYKLDIDLYKMMDVAEEVVAPLLPVPQEIQKGSLVMGYAGVYSSFLLHAERAAQRFNVDARDILIELGKRKVV
GGQEDMILDVAAELAKIKMEV

Specific function: Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta-cleavage pathway for the degradation of aromatic compounds

COG id: COG0119

COG function: function code E; Isopropylmalate/homocitrate/citramalate synthases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 4-hydroxy-2-oxovalerate aldolase family

Homologues:

Organism=Escherichia coli, GI1786548, Length=334, Percent_Identity=54.4910179640719, Blast_Score=353, Evalue=6e-99,
Organism=Saccharomyces cerevisiae, GI6320019, Length=311, Percent_Identity=26.3665594855305, Blast_Score=68, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6320071, Length=316, Percent_Identity=26.2658227848101, Blast_Score=67, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HOA_BACAH (A0RD70)

Other databases:

- EMBL:   CP000485
- RefSeq:   YP_894670.1
- ProteinModelPortal:   A0RD70
- SMR:   A0RD70
- STRING:   A0RD70
- EnsemblBacteria:   EBBACT00000069960
- GeneID:   4545494
- GenomeReviews:   CP000485_GR
- KEGG:   btl:BALH_1844
- NMPDR:   fig|412694.5.peg.1830
- eggNOG:   COG0119
- GeneTree:   EBGT00050000000891
- HOGENOM:   HBG300122
- OMA:   MMAHMAS
- ProtClustDB:   PRK08195
- BioCyc:   BTHU412694:BALH_1844-MONOMER
- HAMAP:   MF_01656
- InterPro:   IPR017629
- InterPro:   IPR013785
- InterPro:   IPR012425
- InterPro:   IPR000891
- Gene3D:   G3DSA:3.20.20.70
- ProDom:   PD005364
- TIGRFAMs:   TIGR03217

Pfam domain/function: PF07836 DmpG_comm; PF00682 HMGL-like

EC number: =4.1.3.39

Molecular weight: Translated: 37226; Mature: 37226

Theoretical pI: Translated: 5.76; Mature: 5.76

Prosite motif: PS50991 PYR_CT

Important sites: BINDING 171-171 BINDING 198-198 BINDING 289-289

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRNSERPVRITEVCLRDGSHVMKHQFTEEQVRFVTRALDEAGMHYIEVSHGDGLGGSTL
CCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCHHH
QYGKSLVNEMKLIEAAVDECKQAQIAVLLIPGIGTIHELKQAANIGAKLVRVATHVTEAD
HHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHC
VSAQHIQFARELGMEVCGFLMMAHSASVEKLVEQAKLMESYGAEAVYVTDSAGALLPHEV
CHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCHHH
RERIRALRQSLNIEIGFHGHNNLSVAVANTITAIEEGATRIDGSVRCLGAGAGNAQTEVL
HHHHHHHHHHCCEEEEEECCCCEEEEHHHHHHHHHHCCHHCCCCEEEEECCCCCHHHHHH
LAVLDRMGYKLDIDLYKMMDVAEEVVAPLLPVPQEIQKGSLVMGYAGVYSSFLLHAERAA
HHHHHHCCCEEEHHHHHHHHHHHHHHHHCCCCCHHHCCCCEEEEHHHHHHHHHHHHHHHH
QRFNVDARDILIELGKRKVVGGQEDMILDVAAELAKIKMEV
HHCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MRRNSERPVRITEVCLRDGSHVMKHQFTEEQVRFVTRALDEAGMHYIEVSHGDGLGGSTL
CCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCHHH
QYGKSLVNEMKLIEAAVDECKQAQIAVLLIPGIGTIHELKQAANIGAKLVRVATHVTEAD
HHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHC
VSAQHIQFARELGMEVCGFLMMAHSASVEKLVEQAKLMESYGAEAVYVTDSAGALLPHEV
CHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCHHH
RERIRALRQSLNIEIGFHGHNNLSVAVANTITAIEEGATRIDGSVRCLGAGAGNAQTEVL
HHHHHHHHHHCCEEEEEECCCCEEEEHHHHHHHHHHCCHHCCCCEEEEECCCCCHHHHHH
LAVLDRMGYKLDIDLYKMMDVAEEVVAPLLPVPQEIQKGSLVMGYAGVYSSFLLHAERAA
HHHHHHCCCEEEHHHHHHHHHHHHHHHHCCCCCHHHCCCCEEEEHHHHHHHHHHHHHHHH
QRFNVDARDILIELGKRKVVGGQEDMILDVAAELAKIKMEV
HHCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA