Click here to switch to the map view.

The map label for this gene is lcfB [H]

Identifier: 118477435

GI number: 118477435

Start: 1914338

End: 1915648

Strand: Direct

Name: lcfB [H]

Synonym: BALH_1755

Alternate gene names: 118477435

Gene position: 1914338-1915648 (Clockwise)

Preceding gene: 118477434

Following gene: 118477436

Centisome position: 36.41

GC content: 35.09

Gene sequence:

>1311_bases
ATGAAGTTCCAAATCCATTGTATAGAGCAAGACAACTTAACATACAAAAATCAGTTGCTACAGGGGGAAATTATGCTAAT
TGTTAATAGAGAAGAGTATAGCAAAAGTGATTTTGATTTGAGATTACAAGCTTATGAGGAAATGGAACAATTTCAAGAAG
CAGCAGGAAATAGATTTGCACTTTGTCTGAAAGATCCATTCGATATTATTACGCTTGTGTTTTTCTTAAAAGAAAAGAAA
TCATCCGTGTTACTTATACATGAAGATACGCCAAAAGAAACGGCTATTGAAATGGCGAAGCGTGCAAATTGTATCGGAAT
TTTATATGGAGAAAATAGCGATTTTACGAAATTAGAAGTAGTGAATTATTTAGCAGAAGAGCCTTCTTTATTGCAATATA
GTTCTGGAACTACAGGAGAACCGAAACTGATTCGTAGAGCATGGACGGAAGTTGATATAGAAATTAAGGCTTATAATGAA
GCTTTAAACTGTGAAATAGATGAAGTACCGATTGTTATGGCTCCTGTTTCACATTCATACGGACTAATATGTGGTACGTT
ATCTGCAATTACGAGGGGAAGCAAACCTATCATCATTACGAATAAAAACCCTAAATTCGCATTAAATATAGTTCGCAATA
CAGAAAGACATATTATATATGCAGTACCACTTATGCTACATATTATGGGGAGTTTTCCGCAAGGAACGTTTCAGTTTCAT
AAAATTATGACATCCGGAGCACCTTTGCCAGAAGCATTATTTTGTAAACTAAAAGAAACGACAACATATATGATGCAACA
ATACGGTTGTTCTGAAGCAGGTTGTATTAGTATATGTCATGATATGAAAAGCCATTTAGATTTAGGAAACCCGCTACCTC
ATGCAAGTATAAGTATAGGTTCAGATGAAAATGCACCGGAAGAAATCGTAGTGAAAATGAATGATAAGGAAATTTTCACG
AAAGATTTAGGGTATAAATCTGAACGTGGCCTTCATTTTATGGGACGTATGGACGATGTGATTAACGTTTCAGGATTAAA
AGTGTTTCCTATAGAGGTAGAAGAAACGATGCTTCGATTGGAAGGTGTGCAAGAGGCGATTGTATATCGAGGGAAACATC
CTGTCATGGGGGAAATTGTTAAAGCGAAAGTAATCTCTCATATTGATCCAGTTCAAATAAGAGAATGGTGTATGCAACAT
TTACCATCTTATAAAGTTCCGCATGAGATTGAAAGTGTAACTGAAATTCCGAAAAATAAAACTGGAAAAGTAAGTAGAAA
GTTACTAGAGATGGGAGAGGTTACAATATGA

Upstream 100 bases:

>100_bases
TTGAAAGATAGATTTGAAAGTATTCAGCTATACACTCCTACATTCTATGCGGAGCAATTAACGAAGCGTCGATTATATAT
GGATGTGGAATCGCTAGTTC

Downstream 100 bases:

>100_bases
GACGGGAAGCGTTAAAGAATGCTGTATTAAAAATTATGACAGAAAAAATGGAACTGAAAAATGTAACGCATTTAGAAGAA
ACGATGCGTTTAAATCAAGA

Product: acyl-CoA synthetase

Products: NA

Alternate protein names: Long-chain acyl-CoA synthetase [H]

Number of amino acids: Translated: 436; Mature: 436

Protein sequence:

>436_residues
MKFQIHCIEQDNLTYKNQLLQGEIMLIVNREEYSKSDFDLRLQAYEEMEQFQEAAGNRFALCLKDPFDIITLVFFLKEKK
SSVLLIHEDTPKETAIEMAKRANCIGILYGENSDFTKLEVVNYLAEEPSLLQYSSGTTGEPKLIRRAWTEVDIEIKAYNE
ALNCEIDEVPIVMAPVSHSYGLICGTLSAITRGSKPIIITNKNPKFALNIVRNTERHIIYAVPLMLHIMGSFPQGTFQFH
KIMTSGAPLPEALFCKLKETTTYMMQQYGCSEAGCISICHDMKSHLDLGNPLPHASISIGSDENAPEEIVVKMNDKEIFT
KDLGYKSERGLHFMGRMDDVINVSGLKVFPIEVEETMLRLEGVQEAIVYRGKHPVMGEIVKAKVISHIDPVQIREWCMQH
LPSYKVPHEIESVTEIPKNKTGKVSRKLLEMGEVTI

Sequences:

>Translated_436_residues
MKFQIHCIEQDNLTYKNQLLQGEIMLIVNREEYSKSDFDLRLQAYEEMEQFQEAAGNRFALCLKDPFDIITLVFFLKEKK
SSVLLIHEDTPKETAIEMAKRANCIGILYGENSDFTKLEVVNYLAEEPSLLQYSSGTTGEPKLIRRAWTEVDIEIKAYNE
ALNCEIDEVPIVMAPVSHSYGLICGTLSAITRGSKPIIITNKNPKFALNIVRNTERHIIYAVPLMLHIMGSFPQGTFQFH
KIMTSGAPLPEALFCKLKETTTYMMQQYGCSEAGCISICHDMKSHLDLGNPLPHASISIGSDENAPEEIVVKMNDKEIFT
KDLGYKSERGLHFMGRMDDVINVSGLKVFPIEVEETMLRLEGVQEAIVYRGKHPVMGEIVKAKVISHIDPVQIREWCMQH
LPSYKVPHEIESVTEIPKNKTGKVSRKLLEMGEVTI
>Mature_436_residues
MKFQIHCIEQDNLTYKNQLLQGEIMLIVNREEYSKSDFDLRLQAYEEMEQFQEAAGNRFALCLKDPFDIITLVFFLKEKK
SSVLLIHEDTPKETAIEMAKRANCIGILYGENSDFTKLEVVNYLAEEPSLLQYSSGTTGEPKLIRRAWTEVDIEIKAYNE
ALNCEIDEVPIVMAPVSHSYGLICGTLSAITRGSKPIIITNKNPKFALNIVRNTERHIIYAVPLMLHIMGSFPQGTFQFH
KIMTSGAPLPEALFCKLKETTTYMMQQYGCSEAGCISICHDMKSHLDLGNPLPHASISIGSDENAPEEIVVKMNDKEIFT
KDLGYKSERGLHFMGRMDDVINVSGLKVFPIEVEETMLRLEGVQEAIVYRGKHPVMGEIVKAKVISHIDPVQIREWCMQH
LPSYKVPHEIESVTEIPKNKTGKVSRKLLEMGEVTI

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG0318

COG function: function code IQ; Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II

Gene ontology:

Cell location: Partially Membrane-Associated [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI157311624, Length=355, Percent_Identity=25.6338028169014, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI157311622, Length=355, Percent_Identity=25.6338028169014, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI58082049, Length=355, Percent_Identity=25.0704225352113, Blast_Score=96, Evalue=6e-20,
Organism=Homo sapiens, GI115511026, Length=126, Percent_Identity=38.8888888888889, Blast_Score=77, Evalue=4e-14,
Organism=Homo sapiens, GI38505220, Length=361, Percent_Identity=24.0997229916898, Blast_Score=76, Evalue=5e-14,
Organism=Homo sapiens, GI28416953, Length=167, Percent_Identity=28.1437125748503, Blast_Score=66, Evalue=6e-11,
Organism=Escherichia coli, GI1788107, Length=364, Percent_Identity=26.0989010989011, Blast_Score=83, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI25141359, Length=321, Percent_Identity=28.9719626168224, Blast_Score=88, Evalue=8e-18,
Organism=Caenorhabditis elegans, GI17557194, Length=353, Percent_Identity=23.7960339943343, Blast_Score=68, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI17558820, Length=366, Percent_Identity=24.3169398907104, Blast_Score=68, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71994690, Length=362, Percent_Identity=23.2044198895028, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71994694, Length=362, Percent_Identity=23.2044198895028, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71994703, Length=362, Percent_Identity=23.2044198895028, Blast_Score=67, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6319699, Length=438, Percent_Identity=22.8310502283105, Blast_Score=70, Evalue=8e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020459
- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.3 [H]

Molecular weight: Translated: 49406; Mature: 49406

Theoretical pI: Translated: 5.76; Mature: 5.76

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
6.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFQIHCIEQDNLTYKNQLLQGEIMLIVNREEYSKSDFDLRLQAYEEMEQFQEAAGNRFA
CCEEEEEECCCCCCHHHHCCCCEEEEEEECHHCCCCCCEEEHHHHHHHHHHHHHCCCEEE
LCLKDPFDIITLVFFLKEKKSSVLLIHEDTPKETAIEMAKRANCIGILYGENSDFTKLEV
EEECCCHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHCCCEEEEEECCCCCCHHHHH
VNYLAEEPSLLQYSSGTTGEPKLIRRAWTEVDIEIKAYNEALNCEIDEVPIVMAPVSHSY
HHHHHCCCCEEEECCCCCCCHHHHHHHHHHEEEEEEEECCCCCCEECCCCEEEEECCCCC
GLICGTLSAITRGSKPIIITNKNPKFALNIVRNTERHIIYAVPLMLHIMGSFPQGTFQFH
CHHHHHHHHHHCCCCCEEEECCCCCEEEEEEECCCCEEEEEHHHHHHHHCCCCCCHHHHH
KIMTSGAPLPEALFCKLKETTTYMMQQYGCSEAGCISICHDMKSHLDLGNPLPHASISIG
HHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCEEECC
SDENAPEEIVVKMNDKEIFTKDLGYKSERGLHFMGRMDDVINVSGLKVFPIEVEETMLRL
CCCCCCCEEEEEECCCHHHHHHCCCCCCCCEEEECCCCCCEECCCEEEEEEEHHHHHHHH
EGVQEAIVYRGKHPVMGEIVKAKVISHIDPVQIREWCMQHLPSYKVPHEIESVTEIPKNK
HHHHHHHHCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCC
TGKVSRKLLEMGEVTI
CCHHHHHHHHHCCCCC
>Mature Secondary Structure
MKFQIHCIEQDNLTYKNQLLQGEIMLIVNREEYSKSDFDLRLQAYEEMEQFQEAAGNRFA
CCEEEEEECCCCCCHHHHCCCCEEEEEEECHHCCCCCCEEEHHHHHHHHHHHHHCCCEEE
LCLKDPFDIITLVFFLKEKKSSVLLIHEDTPKETAIEMAKRANCIGILYGENSDFTKLEV
EEECCCHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHCCCEEEEEECCCCCCHHHHH
VNYLAEEPSLLQYSSGTTGEPKLIRRAWTEVDIEIKAYNEALNCEIDEVPIVMAPVSHSY
HHHHHCCCCEEEECCCCCCCHHHHHHHHHHEEEEEEEECCCCCCEECCCCEEEEECCCCC
GLICGTLSAITRGSKPIIITNKNPKFALNIVRNTERHIIYAVPLMLHIMGSFPQGTFQFH
CHHHHHHHHHHCCCCCEEEECCCCCEEEEEEECCCCEEEEEHHHHHHHHCCCCCCHHHHH
KIMTSGAPLPEALFCKLKETTTYMMQQYGCSEAGCISICHDMKSHLDLGNPLPHASISIG
HHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCEEECC
SDENAPEEIVVKMNDKEIFTKDLGYKSERGLHFMGRMDDVINVSGLKVFPIEVEETMLRL
CCCCCCCEEEEEECCCHHHHHHCCCCCCCCEEEECCCCCCEECCCEEEEEEEHHHHHHHH
EGVQEAIVYRGKHPVMGEIVKAKVISHIDPVQIREWCMQHLPSYKVPHEIESVTEIPKNK
HHHHHHHHCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCC
TGKVSRKLLEMGEVTI
CCHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377 [H]