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The map label for this gene is yclK [H]

Identifier: 118477428

GI number: 118477428

Start: 1905971

End: 1907368

Strand: Direct

Name: yclK [H]

Synonym: BALH_1748

Alternate gene names: 118477428

Gene position: 1905971-1907368 (Clockwise)

Preceding gene: 118477427

Following gene: 118477429

Centisome position: 36.26

GC content: 32.33

Gene sequence:

>1398_bases
GTGGGGAAAAGGATATGTGTGGAAGGAAAGTATAAGATGAAAAGAAAAGTGACTTTATATTTTATGACGGTCATTATACT
TATGCTTGTATTATTTGAAGTCGTATTTTCAGTCTCCGTTTATCGATATTATTATAACGGTATTGTGCAATATGTAGAAT
CTCATGCGAGGACAAGTACACGATTTTTCTCTGAATACAATTCATTATACTTTATTCGTTTGCAAGAATATAGCGGGGAT
ATAATTGAGAGTTTTCAGTTAGAAGGAACCGAATTACAATTAATTGATCGACATGGTACGATTATACAATCGTCAAGTGG
AGAAAAGACAGAGGGTAAAGTAGTTATTCCGTATTCGTTACTAGAAGGAGAAATGTACCACCAAGTGACTACTACGAAGG
ACAAAGTGAAACAATTAGAAGTGATTAGTCCGCTGATTCATCAAGGACAAACGATCGGTGTTTTAAAATATACGACTGTA
TTAACACATGTAAATGCCAAGATTATTGAAATTATTATGTTTACGATTTCTGTAGGTATTGTTATTTCAGGAATTGTATT
CTTAATCAGTAGACGGTTAGCGAATTCGTTTGTTAAACCGATCGAATCTATAATTCATGCTTCTTCTCAAATTGCAGAAG
GTACATTAAAGAAGAAAATTAAAGAAGATTATCCTGGTGAATTAGGTGAGTTAGCACATAGTTTAAATCATATGTCTGAT
AAAATAGAAAAAGCGGAACAGATGAAAAATGAATTTATTGCTTCTATTTCTCATGAAATACGAACCCCTTTAACTGGAAT
TAAAGGTTGGAGTGAAACGTTAAAAACGGTAGATCATTTAACGGAAGAAGAAATAAAGCAAGGCATGGGGATTATTTCAG
GTGAGACAGACCGATTAATTCACTTAGTAGAAGAATTGTTGGATTTTTCAAGATTGCAATCAAATCATTTTAATTTATAT
AAACAAAAGGTGCAATTATACGATATACTAGAGGAGACGATTTGGCAATTAACTCCTAATGCTGAAGAGAAGAAAATGCA
ATTCATCAAAACTATAGAACGAATTGAATTGATAGGAGATCGAAATAGGCTAAAGCAAATTTTCTTGAATATTGTTCAAA
ATGCCATTAAATATTCACATAAAAATGGTAAAGTATATATTGAAGCGACTAAAAATGAAGGACAAGCAGTCATAAAGGTG
AAAGACGATGGGATTGGAATTGCTAAAGAGCATTTACCGTATATAGAACAGTCATTTTACCAGATTAATAATCATACTAC
AGGTGCTGGTCTTGGTTTAGCTATCGTTAAAAAAATGGTGGAGCTTCATGGAGGTACAATAAATATTATAAGTAAAGAAG
GAATAGGAACGACCATTTTGATAAAACTCCCATTATAA

Upstream 100 bases:

>100_bases
CGAATTATGTAGGAGAGACGAAAGTAGTAGATGTAAATATGAGGCGGTTACGTCAAAAGATAGAGTGTAATCCATCAGAA
CCTGAATTTATTCTTACTGT

Downstream 100 bases:

>100_bases
TACATATAAAGTCTGTTTATATAGTGTAATAAAATAAATAGATGTATAATTATATTGGGTGATTTATATATAAGATTAAT
AGGGAGAGGAATTCGATAGA

Product: sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 465; Mature: 464

Protein sequence:

>465_residues
MGKRICVEGKYKMKRKVTLYFMTVIILMLVLFEVVFSVSVYRYYYNGIVQYVESHARTSTRFFSEYNSLYFIRLQEYSGD
IIESFQLEGTELQLIDRHGTIIQSSSGEKTEGKVVIPYSLLEGEMYHQVTTTKDKVKQLEVISPLIHQGQTIGVLKYTTV
LTHVNAKIIEIIMFTISVGIVISGIVFLISRRLANSFVKPIESIIHASSQIAEGTLKKKIKEDYPGELGELAHSLNHMSD
KIEKAEQMKNEFIASISHEIRTPLTGIKGWSETLKTVDHLTEEEIKQGMGIISGETDRLIHLVEELLDFSRLQSNHFNLY
KQKVQLYDILEETIWQLTPNAEEKKMQFIKTIERIELIGDRNRLKQIFLNIVQNAIKYSHKNGKVYIEATKNEGQAVIKV
KDDGIGIAKEHLPYIEQSFYQINNHTTGAGLGLAIVKKMVELHGGTINIISKEGIGTTILIKLPL

Sequences:

>Translated_465_residues
MGKRICVEGKYKMKRKVTLYFMTVIILMLVLFEVVFSVSVYRYYYNGIVQYVESHARTSTRFFSEYNSLYFIRLQEYSGD
IIESFQLEGTELQLIDRHGTIIQSSSGEKTEGKVVIPYSLLEGEMYHQVTTTKDKVKQLEVISPLIHQGQTIGVLKYTTV
LTHVNAKIIEIIMFTISVGIVISGIVFLISRRLANSFVKPIESIIHASSQIAEGTLKKKIKEDYPGELGELAHSLNHMSD
KIEKAEQMKNEFIASISHEIRTPLTGIKGWSETLKTVDHLTEEEIKQGMGIISGETDRLIHLVEELLDFSRLQSNHFNLY
KQKVQLYDILEETIWQLTPNAEEKKMQFIKTIERIELIGDRNRLKQIFLNIVQNAIKYSHKNGKVYIEATKNEGQAVIKV
KDDGIGIAKEHLPYIEQSFYQINNHTTGAGLGLAIVKKMVELHGGTINIISKEGIGTTILIKLPL
>Mature_464_residues
GKRICVEGKYKMKRKVTLYFMTVIILMLVLFEVVFSVSVYRYYYNGIVQYVESHARTSTRFFSEYNSLYFIRLQEYSGDI
IESFQLEGTELQLIDRHGTIIQSSSGEKTEGKVVIPYSLLEGEMYHQVTTTKDKVKQLEVISPLIHQGQTIGVLKYTTVL
THVNAKIIEIIMFTISVGIVISGIVFLISRRLANSFVKPIESIIHASSQIAEGTLKKKIKEDYPGELGELAHSLNHMSDK
IEKAEQMKNEFIASISHEIRTPLTGIKGWSETLKTVDHLTEEEIKQGMGIISGETDRLIHLVEELLDFSRLQSNHFNLYK
QKVQLYDILEETIWQLTPNAEEKKMQFIKTIERIELIGDRNRLKQIFLNIVQNAIKYSHKNGKVYIEATKNEGQAVIKVK
DDGIGIAKEHLPYIEQSFYQINNHTTGAGLGLAIVKKMVELHGGTINIISKEGIGTTILIKLPL

Specific function: Could be member of the two-component regulatory system yclK/yclJ. Potentially phosphorylates yclJ [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1788393, Length=276, Percent_Identity=28.6231884057971, Blast_Score=126, Evalue=3e-30,
Organism=Escherichia coli, GI145693157, Length=247, Percent_Identity=27.5303643724696, Blast_Score=115, Evalue=6e-27,
Organism=Escherichia coli, GI1789149, Length=327, Percent_Identity=29.3577981651376, Blast_Score=114, Evalue=2e-26,
Organism=Escherichia coli, GI87081816, Length=279, Percent_Identity=26.1648745519713, Blast_Score=111, Evalue=1e-25,
Organism=Escherichia coli, GI1790436, Length=232, Percent_Identity=31.0344827586207, Blast_Score=105, Evalue=4e-24,
Organism=Escherichia coli, GI1788549, Length=231, Percent_Identity=29.4372294372294, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1786783, Length=431, Percent_Identity=24.3619489559165, Blast_Score=103, Evalue=3e-23,
Organism=Escherichia coli, GI48994928, Length=233, Percent_Identity=30.0429184549356, Blast_Score=103, Evalue=3e-23,
Organism=Escherichia coli, GI1786600, Length=230, Percent_Identity=28.695652173913, Blast_Score=99, Evalue=6e-22,
Organism=Escherichia coli, GI1787894, Length=348, Percent_Identity=26.1494252873563, Blast_Score=98, Evalue=9e-22,
Organism=Escherichia coli, GI1789808, Length=322, Percent_Identity=25.4658385093168, Blast_Score=98, Evalue=1e-21,
Organism=Escherichia coli, GI1786912, Length=230, Percent_Identity=29.5652173913043, Blast_Score=96, Evalue=7e-21,
Organism=Escherichia coli, GI1790346, Length=274, Percent_Identity=27.7372262773723, Blast_Score=92, Evalue=7e-20,
Organism=Escherichia coli, GI1788713, Length=249, Percent_Identity=28.9156626506024, Blast_Score=92, Evalue=8e-20,
Organism=Escherichia coli, GI87082128, Length=294, Percent_Identity=24.4897959183673, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1789403, Length=291, Percent_Identity=27.8350515463918, Blast_Score=90, Evalue=4e-19,
Organism=Escherichia coli, GI1790551, Length=305, Percent_Identity=22.2950819672131, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1790861, Length=327, Percent_Identity=24.7706422018349, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI1788279, Length=225, Percent_Identity=26.2222222222222, Blast_Score=72, Evalue=7e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 52957; Mature: 52826

Theoretical pI: Translated: 8.33; Mature: 8.33

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGKRICVEGKYKMKRKVTLYFMTVIILMLVLFEVVFSVSVYRYYYNGIVQYVESHARTST
CCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RFFSEYNSLYFIRLQEYSGDIIESFQLEGTELQLIDRHGTIIQSSSGEKTEGKVVIPYSL
HHHHHCCCEEEEEEECCCCCHHHHHCCCCCEEEEEECCCCEEECCCCCCCCCEEEEEHHH
LEGEMYHQVTTTKDKVKQLEVISPLIHQGQTIGVLKYTTVLTHVNAKIIEIIMFTISVGI
HCCHHHHHHHCCHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHCCHHHHHHHHHHHHHHH
VISGIVFLISRRLANSFVKPIESIIHASSQIAEGTLKKKIKEDYPGELGELAHSLNHMSD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
KIEKAEQMKNEFIASISHEIRTPLTGIKGWSETLKTVDHLTEEEIKQGMGIISGETDRLI
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEECCCHHHHH
HLVEELLDFSRLQSNHFNLYKQKVQLYDILEETIWQLTPNAEEKKMQFIKTIERIELIGD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCC
RNRLKQIFLNIVQNAIKYSHKNGKVYIEATKNEGQAVIKVKDDGIGIAKEHLPYIEQSFY
HHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCEEEEEEECCCCCCHHHHCCHHHHHHH
QINNHTTGAGLGLAIVKKMVELHGGTINIISKEGIGTTILIKLPL
HHCCCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCEEEEEEECC
>Mature Secondary Structure 
GKRICVEGKYKMKRKVTLYFMTVIILMLVLFEVVFSVSVYRYYYNGIVQYVESHARTST
CCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RFFSEYNSLYFIRLQEYSGDIIESFQLEGTELQLIDRHGTIIQSSSGEKTEGKVVIPYSL
HHHHHCCCEEEEEEECCCCCHHHHHCCCCCEEEEEECCCCEEECCCCCCCCCEEEEEHHH
LEGEMYHQVTTTKDKVKQLEVISPLIHQGQTIGVLKYTTVLTHVNAKIIEIIMFTISVGI
HCCHHHHHHHCCHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHCCHHHHHHHHHHHHHHH
VISGIVFLISRRLANSFVKPIESIIHASSQIAEGTLKKKIKEDYPGELGELAHSLNHMSD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
KIEKAEQMKNEFIASISHEIRTPLTGIKGWSETLKTVDHLTEEEIKQGMGIISGETDRLI
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEECCCHHHHH
HLVEELLDFSRLQSNHFNLYKQKVQLYDILEETIWQLTPNAEEKKMQFIKTIERIELIGD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCC
RNRLKQIFLNIVQNAIKYSHKNGKVYIEATKNEGQAVIKVKDDGIGIAKEHLPYIEQSFY
HHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCEEEEEEECCCCCCHHHHCCHHHHHHH
QINNHTTGAGLGLAIVKKMVELHGGTINIISKEGIGTTILIKLPL
HHCCCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8969502; 9384377 [H]