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The map label for this gene is thrC [H]

Identifier: 118477422

GI number: 118477422

Start: 1897886

End: 1898962

Strand: Direct

Name: thrC [H]

Synonym: BALH_1742

Alternate gene names: 118477422

Gene position: 1897886-1898962 (Clockwise)

Preceding gene: 118477421

Following gene: 118477423

Centisome position: 36.1

GC content: 39.55

Gene sequence:

>1077_bases
TTGAGGAGGAAAAACAATATGTATAAAGGATTATTAAAACAGTATGCTTCTTATTTACCGGTGAATGAAAACACACCAGA
TGTGAGCTTAATGGAAGGAAATACACCTCTTATTCCGTTGTTAAATATATCAAACCAATTAGGGATTCAGTTATACGGGA
AGTATGAAGGAGCGAATCCGACAGGTTCTTTTAAAGATCGAGGCATGGTAATGGCTGTTGCGAAGGCGAAAGAAGAAGGT
TCGGAGGCAATCATTTGTGCGTCAACAGGTAATACATCAGCATCGGCCGCAGCATACGCGGCACGTCTTGGAATGAAATG
TATTATCGTAATCCCAGAAGGGAAAATTGCACATGGAAAATTAGCGCAAGCAGTTGCGTATGGTGCTGAAATCATTTCAA
TAGAAGGAAATTTTGATGATGCATTAAAAGCTGTAAGAAATATTGCTGCGGAAGAGCCGATTACGTTAGTAAACTCAGTG
AATCCTTATCGAATTGAAGGGCAAAAAACAGCAGCGTTTGAAATTTGTGATCAGCTGCAAAGTGCACCAGATGTTCTAGC
GATTCCTGTTGGGAATGCGGGAAATATTACAGCGTATTGGAAAGGTTTCTGTGAATATGAGAAAGAAAAAGGCTATAAGA
AACCAAGAATTCACGGATTTGAAGCGGAAGGAGCAGCTGCTATTGTAAAAGGGCAGGTTATTGAAGAACCTGAAACAATT
GCAACTGCGATTCGCATCGGTAACCCAGCAAGTTGGTCATATGCGGTAGAGGCTGCTCAGCAATCTCACGGCGAAATAGA
TATGGTATCAGATGAGGAGATTTTACATGCGTATAGATTATTAGCAAAATCGGAAGGGGTTTTCGCTGAGCCAGGATCAA
ATGCTTCATTAGCTGGCGTAATGAAACATGTTCAATCTGGAAAAATCAAAAAGGGAGAAACAGTTGTTGCAGTTTTAACT
GGAAATGGCTTGAAAGATCCTGATATCGCAATTTCTTCTAATACATTAGATATTGCAAGTGTCTCAAATAATATAGAACA
AATTAAAGAGCATATTAAAGGGGTGATTATGTCGTGA

Upstream 100 bases:

>100_bases
GAAGTCGTTGTTGTGACACATCAAACTTCAAAGTATCAATTCGAACGAGTTTTAGGAGCGATAGAAGATGTTGCAAGTGA
AATAAACAGTTACTACATTA

Downstream 100 bases:

>100_bases
TACCACTAAGTATTCGTGTTCCTGCTAGTACAGCGAATGTTGGACCTGGATTTGATTCAGTAGGAATAGCTTTGTCATTG
TATTTACATGTAGTAGTAAA

Product: threonine synthase

Products: NA

Alternate protein names: TS [H]

Number of amino acids: Translated: 358; Mature: 358

Protein sequence:

>358_residues
MRRKNNMYKGLLKQYASYLPVNENTPDVSLMEGNTPLIPLLNISNQLGIQLYGKYEGANPTGSFKDRGMVMAVAKAKEEG
SEAIICASTGNTSASAAAYAARLGMKCIIVIPEGKIAHGKLAQAVAYGAEIISIEGNFDDALKAVRNIAAEEPITLVNSV
NPYRIEGQKTAAFEICDQLQSAPDVLAIPVGNAGNITAYWKGFCEYEKEKGYKKPRIHGFEAEGAAAIVKGQVIEEPETI
ATAIRIGNPASWSYAVEAAQQSHGEIDMVSDEEILHAYRLLAKSEGVFAEPGSNASLAGVMKHVQSGKIKKGETVVAVLT
GNGLKDPDIAISSNTLDIASVSNNIEQIKEHIKGVIMS

Sequences:

>Translated_358_residues
MRRKNNMYKGLLKQYASYLPVNENTPDVSLMEGNTPLIPLLNISNQLGIQLYGKYEGANPTGSFKDRGMVMAVAKAKEEG
SEAIICASTGNTSASAAAYAARLGMKCIIVIPEGKIAHGKLAQAVAYGAEIISIEGNFDDALKAVRNIAAEEPITLVNSV
NPYRIEGQKTAAFEICDQLQSAPDVLAIPVGNAGNITAYWKGFCEYEKEKGYKKPRIHGFEAEGAAAIVKGQVIEEPETI
ATAIRIGNPASWSYAVEAAQQSHGEIDMVSDEEILHAYRLLAKSEGVFAEPGSNASLAGVMKHVQSGKIKKGETVVAVLT
GNGLKDPDIAISSNTLDIASVSNNIEQIKEHIKGVIMS
>Mature_358_residues
MRRKNNMYKGLLKQYASYLPVNENTPDVSLMEGNTPLIPLLNISNQLGIQLYGKYEGANPTGSFKDRGMVMAVAKAKEEG
SEAIICASTGNTSASAAAYAARLGMKCIIVIPEGKIAHGKLAQAVAYGAEIISIEGNFDDALKAVRNIAAEEPITLVNSV
NPYRIEGQKTAAFEICDQLQSAPDVLAIPVGNAGNITAYWKGFCEYEKEKGYKKPRIHGFEAEGAAAIVKGQVIEEPETI
ATAIRIGNPASWSYAVEAAQQSHGEIDMVSDEEILHAYRLLAKSEGVFAEPGSNASLAGVMKHVQSGKIKKGETVVAVLT
GNGLKDPDIAISSNTLDIASVSNNIEQIKEHIKGVIMS

Specific function: Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine [H]

COG id: COG0498

COG function: function code E; Threonine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=322, Percent_Identity=28.2608695652174, Blast_Score=72, Evalue=6e-13,
Organism=Homo sapiens, GI295821200, Length=322, Percent_Identity=28.2608695652174, Blast_Score=72, Evalue=6e-13,
Organism=Homo sapiens, GI4557415, Length=322, Percent_Identity=28.2608695652174, Blast_Score=72, Evalue=6e-13,
Organism=Homo sapiens, GI11345492, Length=291, Percent_Identity=30.9278350515464, Blast_Score=70, Evalue=4e-12,
Organism=Homo sapiens, GI33469958, Length=277, Percent_Identity=25.6317689530686, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1790207, Length=295, Percent_Identity=26.4406779661017, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI2367138, Length=223, Percent_Identity=27.8026905829596, Blast_Score=66, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI71991565, Length=306, Percent_Identity=26.797385620915, Blast_Score=66, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6322631, Length=275, Percent_Identity=29.4545454545455, Blast_Score=79, Evalue=8e-16,
Organism=Drosophila melanogaster, GI24643623, Length=189, Percent_Identity=33.8624338624339, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI20129101, Length=189, Percent_Identity=33.8624338624339, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: 1344 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 800 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR004450 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.2.3.1 [H]

Molecular weight: Translated: 38196; Mature: 38196

Theoretical pI: Translated: 5.72; Mature: 5.72

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRKNNMYKGLLKQYASYLPVNENTPDVSLMEGNTPLIPLLNISNQLGIQLYGKYEGANP
CCCCCHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCEEEEECCCCCCCEEEEEEECCCCC
TGSFKDRGMVMAVAKAKEEGSEAIICASTGNTSASAAAYAARLGMKCIIVIPEGKIAHGK
CCCCCCCCEEEEEEEHHCCCCCEEEEEECCCCCHHHHHHHHHCCCEEEEEECCCCCCCHH
LAQAVAYGAEIISIEGNFDDALKAVRNIAAEEPITLVNSVNPYRIEGQKTAAFEICDQLQ
HHHHHHCCEEEEEEECCHHHHHHHHHHHHCCCCEEEECCCCCEEECCCCHHHHHHHHHHH
SAPDVLAIPVGNAGNITAYWKGFCEYEKEKGYKKPRIHGFEAEGAAAIVKGQVIEEPETI
CCCCEEEEECCCCCCEEHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEECCCCCCCHHH
ATAIRIGNPASWSYAVEAAQQSHGEIDMVSDEEILHAYRLLAKSEGVFAEPGSNASLAGV
EEEEECCCCCCHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHCCCCEECCCCCCHHHHH
MKHVQSGKIKKGETVVAVLTGNGLKDPDIAISSNTLDIASVSNNIEQIKEHIKGVIMS
HHHHHCCCCCCCCEEEEEEECCCCCCCCEEEECCCEEEHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MRRKNNMYKGLLKQYASYLPVNENTPDVSLMEGNTPLIPLLNISNQLGIQLYGKYEGANP
CCCCCHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCEEEEECCCCCCCEEEEEEECCCCC
TGSFKDRGMVMAVAKAKEEGSEAIICASTGNTSASAAAYAARLGMKCIIVIPEGKIAHGK
CCCCCCCCEEEEEEEHHCCCCCEEEEEECCCCCHHHHHHHHHCCCEEEEEECCCCCCCHH
LAQAVAYGAEIISIEGNFDDALKAVRNIAAEEPITLVNSVNPYRIEGQKTAAFEICDQLQ
HHHHHHCCEEEEEEECCHHHHHHHHHHHHCCCCEEEECCCCCEEECCCCHHHHHHHHHHH
SAPDVLAIPVGNAGNITAYWKGFCEYEKEKGYKKPRIHGFEAEGAAAIVKGQVIEEPETI
CCCCEEEEECCCCCCEEHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEECCCCCCCHHH
ATAIRIGNPASWSYAVEAAQQSHGEIDMVSDEEILHAYRLLAKSEGVFAEPGSNASLAGV
EEEEECCCCCCHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHCCCCEECCCCCCHHHHH
MKHVQSGKIKKGETVVAVLTGNGLKDPDIAISSNTLDIASVSNNIEQIKEHIKGVIMS
HHHHHCCCCCCCCEEEEEEECCCCCCCCEEEECCCEEEHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3186450; 8768250 [H]