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The map label for this gene is phoR [H]

Identifier: 118477413

GI number: 118477413

Start: 1888489

End: 1889562

Strand: Direct

Name: phoR [H]

Synonym: BALH_1733

Alternate gene names: 118477413

Gene position: 1888489-1889562 (Clockwise)

Preceding gene: 118477412

Following gene: 118477415

Centisome position: 35.92

GC content: 34.26

Gene sequence:

>1074_bases
ATGAGAAAAAGAGAACGAATGAGTAAATTCAAGATGCTGAAAGTAACAGGAGTGATAATAGCACTCTTTTCTTTTCTTAC
TATTATTTGGTCTACAGCATTTTATGTATCATCTAGTATATTGGATGCCCTTGCAATACATTTATCTCCTTTTGTTACTT
ACCTCATTAGTGACATACTCAGTTTTATATTTATGATTCTTCTTTGGATATTCATTGCAGTATTAATGAGACCGAAGCGA
GAGGCGATGATTTGGACTATTATTGAACCGATACAAAAAATTGCAAAAGGGGACTTTTCGGTAAAAATACGAAATGAAGA
GAAATATGATGGGGAAATTGGTGTGCTCGTAAAAAGTATAAATGATATGACAGATGAACTGAATGCGATGGAGAAGATGC
GTCAGGAATTTGTTTCGAATGTTTCTCATGAAATACAGTCACCATTAACTTCTATAAAAGGGTTTGCTAGAGCACTACAA
GATACTAATCTTCCTGAGGAAAAAAGAAAGCATTATCTTACCATTATTGAAACAGAAACGACGAGATTATCTAAACTAAG
TCAAAATTTACTGAAACTCACCCTATTAGAGTCGGAAGAATATACACCAGAAAGAGTTACTTATCGATTAGATCAACAGT
TAAAGCAAATTGTGTTAAATAGTGAACCGCTTTGGGCTGAGAAAGAAATTGAATTAGACCTTGATTTAGAAAAAGTGCAT
ATAACTGCTGACCAAGAAAGTATGAGTCAAGTTTGGATTAATTTAATTCATAATAGTATTAAATTTACTCCAAGTAGCGG
TACGATTTCAATCAAGCTAAAAGAATATGAGACATTAGTAGAAGTACGTATACGTGATACGGGAATTGGTATATCCGAAG
AACAAAAGCAACATATTTTTGAGCGTTTTTATAAAGCGGACTCTTCACGAAATCGTGCTTATGGAGGAAGTGGCTTAGGA
TTGGCCATCGTACAAAAAGTACTCGACCTTCATCGAGGAGAAATAAAAGTCGAGAGTGAGGAAGGGAATGGGACTGAATT
TATTGTTTGTATTCCGAAGTATGAAGAGAAATAG

Upstream 100 bases:

>100_bases
ACGTTCATATAAATCGGTTACGTGAGAAGTTTCAAGAAGAGAAGTCGAAATTTAGTATTAAAACAATAAGGGGTTTAGGA
TATCGCTTAGAGGTAAGTAA

Downstream 100 bases:

>100_bases
TGTTAGGAGGAAACCCTTCTAACACTATTTCTCTTTAAAGACACATTTCCCGTTACTGCAACTATATTGATAAGCATTTC
CTTCGTTATTCATACGGTAT

Product: sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 357; Mature: 357

Protein sequence:

>357_residues
MRKRERMSKFKMLKVTGVIIALFSFLTIIWSTAFYVSSSILDALAIHLSPFVTYLISDILSFIFMILLWIFIAVLMRPKR
EAMIWTIIEPIQKIAKGDFSVKIRNEEKYDGEIGVLVKSINDMTDELNAMEKMRQEFVSNVSHEIQSPLTSIKGFARALQ
DTNLPEEKRKHYLTIIETETTRLSKLSQNLLKLTLLESEEYTPERVTYRLDQQLKQIVLNSEPLWAEKEIELDLDLEKVH
ITADQESMSQVWINLIHNSIKFTPSSGTISIKLKEYETLVEVRIRDTGIGISEEQKQHIFERFYKADSSRNRAYGGSGLG
LAIVQKVLDLHRGEIKVESEEGNGTEFIVCIPKYEEK

Sequences:

>Translated_357_residues
MRKRERMSKFKMLKVTGVIIALFSFLTIIWSTAFYVSSSILDALAIHLSPFVTYLISDILSFIFMILLWIFIAVLMRPKR
EAMIWTIIEPIQKIAKGDFSVKIRNEEKYDGEIGVLVKSINDMTDELNAMEKMRQEFVSNVSHEIQSPLTSIKGFARALQ
DTNLPEEKRKHYLTIIETETTRLSKLSQNLLKLTLLESEEYTPERVTYRLDQQLKQIVLNSEPLWAEKEIELDLDLEKVH
ITADQESMSQVWINLIHNSIKFTPSSGTISIKLKEYETLVEVRIRDTGIGISEEQKQHIFERFYKADSSRNRAYGGSGLG
LAIVQKVLDLHRGEIKVESEEGNGTEFIVCIPKYEEK
>Mature_357_residues
MRKRERMSKFKMLKVTGVIIALFSFLTIIWSTAFYVSSSILDALAIHLSPFVTYLISDILSFIFMILLWIFIAVLMRPKR
EAMIWTIIEPIQKIAKGDFSVKIRNEEKYDGEIGVLVKSINDMTDELNAMEKMRQEFVSNVSHEIQSPLTSIKGFARALQ
DTNLPEEKRKHYLTIIETETTRLSKLSQNLLKLTLLESEEYTPERVTYRLDQQLKQIVLNSEPLWAEKEIELDLDLEKVH
ITADQESMSQVWINLIHNSIKFTPSSGTISIKLKEYETLVEVRIRDTGIGISEEQKQHIFERFYKADSSRNRAYGGSGLG
LAIVQKVLDLHRGEIKVESEEGNGTEFIVCIPKYEEK

Specific function: Member of the two-component regulatory system phoP/phoR involved in the alkaline phosphatase genes regulation. PhoR may function as a membrane-associated protein kinase that phosphorylates phoP in response to environmental signals [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1788393, Length=275, Percent_Identity=28, Blast_Score=134, Evalue=1e-32,
Organism=Escherichia coli, GI1786783, Length=308, Percent_Identity=27.5974025974026, Blast_Score=131, Evalue=6e-32,
Organism=Escherichia coli, GI1789149, Length=224, Percent_Identity=33.0357142857143, Blast_Score=122, Evalue=5e-29,
Organism=Escherichia coli, GI145693157, Length=240, Percent_Identity=30.4166666666667, Blast_Score=121, Evalue=6e-29,
Organism=Escherichia coli, GI1786600, Length=235, Percent_Identity=28.936170212766, Blast_Score=116, Evalue=2e-27,
Organism=Escherichia coli, GI1788549, Length=250, Percent_Identity=28, Blast_Score=101, Evalue=9e-23,
Organism=Escherichia coli, GI1790436, Length=235, Percent_Identity=28.0851063829787, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1788713, Length=253, Percent_Identity=26.4822134387352, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1787894, Length=383, Percent_Identity=25.065274151436, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1790861, Length=229, Percent_Identity=31.8777292576419, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI48994928, Length=239, Percent_Identity=28.4518828451883, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1790346, Length=241, Percent_Identity=27.8008298755187, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1789403, Length=316, Percent_Identity=26.5822784810127, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI87082128, Length=309, Percent_Identity=24.2718446601942, Blast_Score=89, Evalue=6e-19,
Organism=Escherichia coli, GI1786912, Length=226, Percent_Identity=26.5486725663717, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI1789808, Length=305, Percent_Identity=22.6229508196721, Blast_Score=79, Evalue=6e-16,
Organism=Escherichia coli, GI1788279, Length=315, Percent_Identity=25.7142857142857, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI1790551, Length=249, Percent_Identity=25.3012048192771, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1790300, Length=237, Percent_Identity=27.0042194092827, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI87081816, Length=230, Percent_Identity=25.2173913043478, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 41214; Mature: 41214

Theoretical pI: Translated: 6.20; Mature: 6.20

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKRERMSKFKMLKVTGVIIALFSFLTIIWSTAFYVSSSILDALAIHLSPFVTYLISDIL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SFIFMILLWIFIAVLMRPKREAMIWTIIEPIQKIAKGDFSVKIRNEEKYDGEIGVLVKSI
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHH
NDMTDELNAMEKMRQEFVSNVSHEIQSPLTSIKGFARALQDTNLPEEKRKHYLTIIETET
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCEEEEEECCH
TRLSKLSQNLLKLTLLESEEYTPERVTYRLDQQLKQIVLNSEPLWAEKEIELDLDLEKVH
HHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECEEEEE
ITADQESMSQVWINLIHNSIKFTPSSGTISIKLKEYETLVEVRIRDTGIGISEEQKQHIF
EECCHHHHHHHHHHHHHCCCEEECCCCEEEEEEHHHHHHHHEEEECCCCCCCHHHHHHHH
ERFYKADSSRNRAYGGSGLGLAIVQKVLDLHRGEIKVESEEGNGTEFIVCIPKYEEK
HHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEECCCCCCCEEEEEECCCCCC
>Mature Secondary Structure
MRKRERMSKFKMLKVTGVIIALFSFLTIIWSTAFYVSSSILDALAIHLSPFVTYLISDIL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SFIFMILLWIFIAVLMRPKREAMIWTIIEPIQKIAKGDFSVKIRNEEKYDGEIGVLVKSI
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHH
NDMTDELNAMEKMRQEFVSNVSHEIQSPLTSIKGFARALQDTNLPEEKRKHYLTIIETET
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCEEEEEECCH
TRLSKLSQNLLKLTLLESEEYTPERVTYRLDQQLKQIVLNSEPLWAEKEIELDLDLEKVH
HHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECEEEEE
ITADQESMSQVWINLIHNSIKFTPSSGTISIKLKEYETLVEVRIRDTGIGISEEQKQHIF
EECCHHHHHHHHHHHHHCCCEEECCCCEEEEEEHHHHHHHHEEEECCCCCCCHHHHHHHH
ERFYKADSSRNRAYGGSGLGLAIVQKVLDLHRGEIKVESEEGNGTEFIVCIPKYEEK
HHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEECCCCCCCEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3142862; 9387221; 9384377 [H]