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The map label for this gene is copA [H]

Identifier: 118477364

GI number: 118477364

Start: 1832788

End: 1834443

Strand: Direct

Name: copA [H]

Synonym: BALH_1683

Alternate gene names: 118477364

Gene position: 1832788-1834443 (Clockwise)

Preceding gene: 118477363

Following gene: 118477365

Centisome position: 34.86

GC content: 35.02

Gene sequence:

>1656_bases
ATGAAGCGATATATATTAACAGCGGTTACAGTCTCAGTAATATTTTTAATTGCTGCATGTTCTGTGACGACAAATACAAC
AAATGACCATAAAAATAGGAATGATAAAAAAACTAAACAAACTGAAACGGCTACAAAACCATTGGAAATTGTAAAGGGAC
CAGAAGTTACTTTAATAGCGAAAGAAAAAAAGCAAAAATTAAGTAACGGTGTTATTGTTCCGGTCTGGACATTTAATGGC
TCATCTCCTGGTCCGGAAATTCGGGTAAAAAAAGGTGAAAAGGTGAAAGTGACATTAAAAAATGAACTATCTGCACCAGT
ATCTATTCACTGGCATGGGTATCCTGTCCCAAATGATATGGATGGAATTCCAGGTGTGACGCAAGATGCAGTCGAACCAG
GAAAAAGTTTCACTTACGAATTTGAAGCGAACGTACTAGGAACGTACTGGTATCATTCACATCAAGATTCTGTAAATCAA
TTAGATAGAGGATTATATGGTGCTTTCGTTGTAGAAGATACAAATGAAAAGTATGATAAAGATTACACATTAATGTTAGA
TGAATGGATAACGGATAAAGAAGAGATGAATAAACAGTTAAAAGAAATGACAAAAGGAAAAACAGAAAAAGCAGACGGTA
ATAAATCTAGTAAGGGTAATGAAAATACGAAAAAGAATGATGATAAGAACAGCATGGATCATTCTGGTATGGACATGGAC
AGTGATAAAAAAGACTCTGGCAATATGGCAGGAATGGACCATGGAAATATGAAGATGGAAGGTCATGATATGAGTATGTA
TGATTTATTCACACTCAACGGAAAAAGTGGTGATTTAGTAGAGCCATTGAAAGTGAATAAGGGAGATAAAGTTCGTCTTC
GACTCGTTAATGCCGGTTATCTATCACATAATATACATGTTCACGGTCATGACATTAAAGTGATTGCAACAGATGGTCAA
CCAATAAACGACCCAAAAGTTATAAAGGATAAAGTAATTTCAATCGCACCGGGTGAACGTTATGATGTTGAGTTTACTGC
TAATAATCCTGGAAAATGGTATGTTGAAGACCATTCAGAAAATAAAGGTGCAAAAGGAATGAAGGCTATTATTGAATATG
ATGGTAGCAAAGAGATGAAAGATATAGCAGATGAAAAAGAAAAATTATCGAAATTAGATATGACGAAATATGGTGCTAAA
AAATTAGGTGGTTTCACGTTAAATCAGCAGTATACTGCCACATATAATATGGACTTAAATACGCAAATGAATGGAAATGA
AATGGTATATACAATTAACGGGAAGGTGTTTCCGGATATTGACCCAGTTCAAGTGAAAAAGGATGATTTAGTAAAAGTGA
AATTGGTAAATCGTTCTAAAATGGATGATCATCCAATGCATTTACATGGTCACTTCTTCCAGGTGTTGAGTAAAGATGGA
AAACCGGTAGAAGGTTCTCCAATTGTAAAAGATACATTGAACTTAAAACCGGGAGAAGAATATGAAGTAGCCTTTGTAGC
AGACAATCCGGGTGAGTGGATGTTTCATTGTCATGATTTACATCATGCTTCAGCGGGGATGGTAACGGAAGTGAAATATA
AAGATTATAAATCTGACTATGTTCCAAACCCAAACATTCCTAATAAGCCAGAATAA

Upstream 100 bases:

>100_bases
CAATTTTGGGCGTCCTTTTATTTTGCCCATTTTAAATCTCCTTATTTTCTTGAAAATCATCTTCTAGAATGATTTTGAAA
AAGAAAAGGAGGGATTTTCC

Downstream 100 bases:

>100_bases
TATGAAAAACATGTAGTTTATTAATGATGTAAAGCAGTTATCTTTAATAGGTGGCTGCTTTTATATGTCATGTTGTGAAT
TAGGAATATTATTTTTGTGA

Product: multicopper oxidase family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 551; Mature: 551

Protein sequence:

>551_residues
MKRYILTAVTVSVIFLIAACSVTTNTTNDHKNRNDKKTKQTETATKPLEIVKGPEVTLIAKEKKQKLSNGVIVPVWTFNG
SSPGPEIRVKKGEKVKVTLKNELSAPVSIHWHGYPVPNDMDGIPGVTQDAVEPGKSFTYEFEANVLGTYWYHSHQDSVNQ
LDRGLYGAFVVEDTNEKYDKDYTLMLDEWITDKEEMNKQLKEMTKGKTEKADGNKSSKGNENTKKNDDKNSMDHSGMDMD
SDKKDSGNMAGMDHGNMKMEGHDMSMYDLFTLNGKSGDLVEPLKVNKGDKVRLRLVNAGYLSHNIHVHGHDIKVIATDGQ
PINDPKVIKDKVISIAPGERYDVEFTANNPGKWYVEDHSENKGAKGMKAIIEYDGSKEMKDIADEKEKLSKLDMTKYGAK
KLGGFTLNQQYTATYNMDLNTQMNGNEMVYTINGKVFPDIDPVQVKKDDLVKVKLVNRSKMDDHPMHLHGHFFQVLSKDG
KPVEGSPIVKDTLNLKPGEEYEVAFVADNPGEWMFHCHDLHHASAGMVTEVKYKDYKSDYVPNPNIPNKPE

Sequences:

>Translated_551_residues
MKRYILTAVTVSVIFLIAACSVTTNTTNDHKNRNDKKTKQTETATKPLEIVKGPEVTLIAKEKKQKLSNGVIVPVWTFNG
SSPGPEIRVKKGEKVKVTLKNELSAPVSIHWHGYPVPNDMDGIPGVTQDAVEPGKSFTYEFEANVLGTYWYHSHQDSVNQ
LDRGLYGAFVVEDTNEKYDKDYTLMLDEWITDKEEMNKQLKEMTKGKTEKADGNKSSKGNENTKKNDDKNSMDHSGMDMD
SDKKDSGNMAGMDHGNMKMEGHDMSMYDLFTLNGKSGDLVEPLKVNKGDKVRLRLVNAGYLSHNIHVHGHDIKVIATDGQ
PINDPKVIKDKVISIAPGERYDVEFTANNPGKWYVEDHSENKGAKGMKAIIEYDGSKEMKDIADEKEKLSKLDMTKYGAK
KLGGFTLNQQYTATYNMDLNTQMNGNEMVYTINGKVFPDIDPVQVKKDDLVKVKLVNRSKMDDHPMHLHGHFFQVLSKDG
KPVEGSPIVKDTLNLKPGEEYEVAFVADNPGEWMFHCHDLHHASAGMVTEVKYKDYKSDYVPNPNIPNKPE
>Mature_551_residues
MKRYILTAVTVSVIFLIAACSVTTNTTNDHKNRNDKKTKQTETATKPLEIVKGPEVTLIAKEKKQKLSNGVIVPVWTFNG
SSPGPEIRVKKGEKVKVTLKNELSAPVSIHWHGYPVPNDMDGIPGVTQDAVEPGKSFTYEFEANVLGTYWYHSHQDSVNQ
LDRGLYGAFVVEDTNEKYDKDYTLMLDEWITDKEEMNKQLKEMTKGKTEKADGNKSSKGNENTKKNDDKNSMDHSGMDMD
SDKKDSGNMAGMDHGNMKMEGHDMSMYDLFTLNGKSGDLVEPLKVNKGDKVRLRLVNAGYLSHNIHVHGHDIKVIATDGQ
PINDPKVIKDKVISIAPGERYDVEFTANNPGKWYVEDHSENKGAKGMKAIIEYDGSKEMKDIADEKEKLSKLDMTKYGAK
KLGGFTLNQQYTATYNMDLNTQMNGNEMVYTINGKVFPDIDPVQVKKDDLVKVKLVNRSKMDDHPMHLHGHFFQVLSKDG
KPVEGSPIVKDTLNLKPGEEYEVAFVADNPGEWMFHCHDLHHASAGMVTEVKYKDYKSDYVPNPNIPNKPE

Specific function: Mediates copper resistance by sequestration of copper in the periplasm along with the copper-binding protein CopC. May have oxidase activity [H]

COG id: COG2132

COG function: function code Q; Putative multicopper oxidases

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multicopper oxidase family. CopA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786314, Length=133, Percent_Identity=33.0827067669173, Blast_Score=71, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6320714, Length=528, Percent_Identity=24.8106060606061, Blast_Score=114, Evalue=4e-26,
Organism=Saccharomyces cerevisiae, GI6323703, Length=125, Percent_Identity=40, Blast_Score=88, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6321067, Length=162, Percent_Identity=30.2469135802469, Blast_Score=73, Evalue=1e-13,
Organism=Drosophila melanogaster, GI221330000, Length=305, Percent_Identity=27.5409836065574, Blast_Score=93, Evalue=4e-19,
Organism=Drosophila melanogaster, GI28574104, Length=354, Percent_Identity=25.7062146892655, Blast_Score=93, Evalue=5e-19,
Organism=Drosophila melanogaster, GI24585842, Length=327, Percent_Identity=27.217125382263, Blast_Score=93, Evalue=5e-19,
Organism=Drosophila melanogaster, GI281360167, Length=327, Percent_Identity=27.217125382263, Blast_Score=92, Evalue=7e-19,
Organism=Drosophila melanogaster, GI221329998, Length=327, Percent_Identity=27.217125382263, Blast_Score=92, Evalue=7e-19,
Organism=Drosophila melanogaster, GI24650186, Length=154, Percent_Identity=35.0649350649351, Blast_Score=82, Evalue=1e-15,
Organism=Drosophila melanogaster, GI18859919, Length=145, Percent_Identity=33.7931034482759, Blast_Score=77, Evalue=4e-14,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001117
- InterPro:   IPR011706
- InterPro:   IPR011707
- InterPro:   IPR006376
- InterPro:   IPR002355
- InterPro:   IPR008972
- InterPro:   IPR006311 [H]

Pfam domain/function: PF00394 Cu-oxidase; PF07731 Cu-oxidase_2; PF07732 Cu-oxidase_3 [H]

EC number: NA

Molecular weight: Translated: 61908; Mature: 61908

Theoretical pI: Translated: 6.64; Mature: 6.64

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS00079 MULTICOPPER_OXIDASE1 ; PS00080 MULTICOPPER_OXIDASE2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRYILTAVTVSVIFLIAACSVTTNTTNDHKNRNDKKTKQTETATKPLEIVKGPEVTLIA
CCCEEHHHHHHHHHHHHHHHEEECCCCCCCCCCCCCHHHHHHHCCCCCEEECCCCEEEEE
KEKKQKLSNGVIVPVWTFNGSSPGPEIRVKKGEKVKVTLKNELSAPVSIHWHGYPVPNDM
CHHHHHHHCCEEEEEEEECCCCCCCEEEEECCCEEEEEECCCCCCCEEEEECCCCCCCCC
DGIPGVTQDAVEPGKSFTYEFEANVLGTYWYHSHQDSVNQLDRGLYGAFVVEDTNEKYDK
CCCCCCCHHHHCCCCCEEEEEECCEEEEEEEECCCCHHHHHHCCCEEEEEEECCCCCCCC
DYTLMLDEWITDKEEMNKQLKEMTKGKTEKADGNKSSKGNENTKKNDDKNSMDHSGMDMD
CEEEEEEHHCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
SDKKDSGNMAGMDHGNMKMEGHDMSMYDLFTLNGKSGDLVEPLKVNKGDKVRLRLVNAGY
CCCCCCCCCCCCCCCCEEECCCCCEEEEEEEEECCCCCCCCCEECCCCCEEEEEEEECCE
LSHNIHVHGHDIKVIATDGQPINDPKVIKDKVISIAPGERYDVEFTANNPGKWYVEDHSE
EEEEEEEECCEEEEEECCCCCCCCCHHHHEEEEEECCCCEEEEEEEECCCCEEEEECCCC
NKGAKGMKAIIEYDGSKEMKDIADEKEKLSKLDMTKYGAKKLGGFTLNQQYTATYNMDLN
CCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHCHHHHCHHHHCCEEECCEEEEEEEEEEC
TQMNGNEMVYTINGKVFPDIDPVQVKKDDLVKVKLVNRSKMDDHPMHLHGHFFQVLSKDG
CEECCCEEEEEECCEECCCCCCEEECCCCEEEEEEECCCCCCCCCEEEHHHHHHHHCCCC
KPVEGSPIVKDTLNLKPGEEYEVAFVADNPGEWMFHCHDLHHASAGMVTEVKYKDYKSDY
CCCCCCCCEEECCCCCCCCCEEEEEEECCCCCEEEEEEECCCCCCCCEEEEEECCCCCCC
VPNPNIPNKPE
CCCCCCCCCCC
>Mature Secondary Structure
MKRYILTAVTVSVIFLIAACSVTTNTTNDHKNRNDKKTKQTETATKPLEIVKGPEVTLIA
CCCEEHHHHHHHHHHHHHHHEEECCCCCCCCCCCCCHHHHHHHCCCCCEEECCCCEEEEE
KEKKQKLSNGVIVPVWTFNGSSPGPEIRVKKGEKVKVTLKNELSAPVSIHWHGYPVPNDM
CHHHHHHHCCEEEEEEEECCCCCCCEEEEECCCEEEEEECCCCCCCEEEEECCCCCCCCC
DGIPGVTQDAVEPGKSFTYEFEANVLGTYWYHSHQDSVNQLDRGLYGAFVVEDTNEKYDK
CCCCCCCHHHHCCCCCEEEEEECCEEEEEEEECCCCHHHHHHCCCEEEEEEECCCCCCCC
DYTLMLDEWITDKEEMNKQLKEMTKGKTEKADGNKSSKGNENTKKNDDKNSMDHSGMDMD
CEEEEEEHHCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
SDKKDSGNMAGMDHGNMKMEGHDMSMYDLFTLNGKSGDLVEPLKVNKGDKVRLRLVNAGY
CCCCCCCCCCCCCCCCEEECCCCCEEEEEEEEECCCCCCCCCEECCCCCEEEEEEEECCE
LSHNIHVHGHDIKVIATDGQPINDPKVIKDKVISIAPGERYDVEFTANNPGKWYVEDHSE
EEEEEEEECCEEEEEECCCCCCCCCHHHHEEEEEECCCCEEEEEEEECCCCEEEEECCCC
NKGAKGMKAIIEYDGSKEMKDIADEKEKLSKLDMTKYGAKKLGGFTLNQQYTATYNMDLN
CCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHCHHHHCHHHHCCEEECCEEEEEEEEEEC
TQMNGNEMVYTINGKVFPDIDPVQVKKDDLVKVKLVNRSKMDDHPMHLHGHFFQVLSKDG
CEECCCEEEEEECCEECCCCCCEEECCCCEEEEEEECCCCCCCCCEEEHHHHHHHHCCCC
KPVEGSPIVKDTLNLKPGEEYEVAFVADNPGEWMFHCHDLHHASAGMVTEVKYKDYKSDY
CCCCCCCCEEECCCCCCCCCEEEEEEECCCCCEEEEEEECCCCCCCCEEEEEECCCCCCC
VPNPNIPNKPE
CCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3372485; 1924351 [H]