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The map label for this gene is drrA [H]

Identifier: 118477352

GI number: 118477352

Start: 1821123

End: 1821836

Strand: Direct

Name: drrA [H]

Synonym: BALH_1670

Alternate gene names: 118477352

Gene position: 1821123-1821836 (Clockwise)

Preceding gene: 118477351

Following gene: 118477353

Centisome position: 34.64

GC content: 41.18

Gene sequence:

>714_bases
ATGGAAAATCTAAAAAACAAAAAAATATTAATTGTGGACGATGAACAAGAAATCAGAATAATGATTGAAAGATTTTTAAG
AAAAGAGGGATTTTTTCGCATTTATACTGCTGTTGACTGCGCTTCTGCTCTGTCATTTTGCCAGGTAGACAATCCAGATA
TCGTAATTCTGGATGTTATGTTACCGGATGGTGACGGATTTTCTTTACTGTCTTCCATTAGGAAGTTTTCGAGCACACCG
GTTCTTTTTCTCTCTGCGCGGGGAGAGGATGAAGATCGATTGCTTGGATTGGGCTTGGGGGCAGATGATTACATGGTGAA
GCCATTTCTGCCACGTGAGCTGGTATTACGGCTCATGGCGATTTTGAAACGTGTATATTCTTCCTCGGTCACAGAGCGTC
TATCTATCTTTAGATTAGGAGAACAAATCGTTGATCTTGAAAGCGCTGTTGTACACAGAGGGCAGAAAGAGATGCCATTG
ACGGCAAAGGAGCATGCCATTCTTGTAAAGCTTTATGAAAATCAAGGACGTATCATTACAAATGATGCCTTATGTCAGGC
TGTTTGGGGAGATGACAGCTACGGTCTTGAGAATACTTTGATGGTTCATATCAGGCGGATACGTGAAAAGATTGAGCTGG
ATCCTTCCAAACCAATCTATCTTCTCACCTTCAGGGGATTGGGATATAAATTGCTAGTAAAGGAGACGTATTGA

Upstream 100 bases:

>100_bases
ATTATTTGTTTGAATTTTAAAAAGGTATTAAGAAGTAAAGTTGAATTAAAACACCAAAAAATCCCTTTTTTTTGTGTATA
ATCAAATGAGGTGATGTAAA

Downstream 100 bases:

>100_bases
GTGGAAGGAATTACTCGTATATTACAGCGATTTGTCACCACGACCATCCTTATTTCAATATTTGTGCTTATTTTTAATTT
CGTGCTACTAGGTACCTTGG

Product: response regulator DrrA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 237; Mature: 237

Protein sequence:

>237_residues
MENLKNKKILIVDDEQEIRIMIERFLRKEGFFRIYTAVDCASALSFCQVDNPDIVILDVMLPDGDGFSLLSSIRKFSSTP
VLFLSARGEDEDRLLGLGLGADDYMVKPFLPRELVLRLMAILKRVYSSSVTERLSIFRLGEQIVDLESAVVHRGQKEMPL
TAKEHAILVKLYENQGRIITNDALCQAVWGDDSYGLENTLMVHIRRIREKIELDPSKPIYLLTFRGLGYKLLVKETY

Sequences:

>Translated_237_residues
MENLKNKKILIVDDEQEIRIMIERFLRKEGFFRIYTAVDCASALSFCQVDNPDIVILDVMLPDGDGFSLLSSIRKFSSTP
VLFLSARGEDEDRLLGLGLGADDYMVKPFLPRELVLRLMAILKRVYSSSVTERLSIFRLGEQIVDLESAVVHRGQKEMPL
TAKEHAILVKLYENQGRIITNDALCQAVWGDDSYGLENTLMVHIRRIREKIELDPSKPIYLLTFRGLGYKLLVKETY
>Mature_237_residues
MENLKNKKILIVDDEQEIRIMIERFLRKEGFFRIYTAVDCASALSFCQVDNPDIVILDVMLPDGDGFSLLSSIRKFSSTP
VLFLSARGEDEDRLLGLGLGADDYMVKPFLPRELVLRLMAILKRVYSSSVTERLSIFRLGEQIVDLESAVVHRGQKEMPL
TAKEHAILVKLYENQGRIITNDALCQAVWGDDSYGLENTLMVHIRRIREKIELDPSKPIYLLTFRGLGYKLLVKETY

Specific function: Member of the two-component regulatory system YvrG/YvrH that positively regulates 7 transcriptional units (wprA, wapA- yxxG, dltABCDE, sunA, sunT-bdbA-yolJ-bdbB, sigO-rsoA, and sigX- rsiX), and negatively regulates the lytABC operon [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786911, Length=226, Percent_Identity=36.283185840708, Blast_Score=156, Evalue=1e-39,
Organism=Escherichia coli, GI1789809, Length=229, Percent_Identity=33.1877729257642, Blast_Score=139, Evalue=2e-34,
Organism=Escherichia coli, GI1786599, Length=231, Percent_Identity=35.0649350649351, Blast_Score=133, Evalue=8e-33,
Organism=Escherichia coli, GI1790860, Length=235, Percent_Identity=34.8936170212766, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI87082012, Length=226, Percent_Identity=34.070796460177, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI1786784, Length=229, Percent_Identity=33.6244541484716, Blast_Score=113, Evalue=1e-26,
Organism=Escherichia coli, GI2367329, Length=230, Percent_Identity=34.3478260869565, Blast_Score=113, Evalue=1e-26,
Organism=Escherichia coli, GI1788394, Length=235, Percent_Identity=30.6382978723404, Blast_Score=109, Evalue=2e-25,
Organism=Escherichia coli, GI1790863, Length=233, Percent_Identity=29.6137339055794, Blast_Score=106, Evalue=1e-24,
Organism=Escherichia coli, GI1790552, Length=233, Percent_Identity=32.618025751073, Blast_Score=102, Evalue=2e-23,
Organism=Escherichia coli, GI1787375, Length=223, Percent_Identity=30.4932735426009, Blast_Score=94, Evalue=8e-21,
Organism=Escherichia coli, GI1787229, Length=232, Percent_Identity=28.8793103448276, Blast_Score=92, Evalue=3e-20,
Organism=Escherichia coli, GI1789402, Length=225, Percent_Identity=30.6666666666667, Blast_Score=88, Evalue=5e-19,
Organism=Escherichia coli, GI145693140, Length=229, Percent_Identity=27.9475982532751, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1788550, Length=104, Percent_Identity=35.5769230769231, Blast_Score=68, Evalue=5e-13,
Organism=Escherichia coli, GI1788191, Length=124, Percent_Identity=33.0645161290323, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI1787487, Length=159, Percent_Identity=31.4465408805031, Blast_Score=64, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 27116; Mature: 27116

Theoretical pI: Translated: 5.83; Mature: 5.83

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MENLKNKKILIVDDEQEIRIMIERFLRKEGFFRIYTAVDCASALSFCQVDNPDIVILDVM
CCCCCCCEEEEEECCHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHCCCCCCEEEEEEE
LPDGDGFSLLSSIRKFSSTPVLFLSARGEDEDRLLGLGLGADDYMVKPFLPRELVLRLMA
ECCCCCHHHHHHHHHHCCCCEEEEEECCCCCCEEEEEECCCCCCEECCCCCHHHHHHHHH
ILKRVYSSSVTERLSIFRLGEQIVDLESAVVHRGQKEMPLTAKEHAILVKLYENQGRIIT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEEECCCCEEE
NDALCQAVWGDDSYGLENTLMVHIRRIREKIELDPSKPIYLLTFRGLGYKLLVKETY
CHHHEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCEEEEEEECC
>Mature Secondary Structure
MENLKNKKILIVDDEQEIRIMIERFLRKEGFFRIYTAVDCASALSFCQVDNPDIVILDVM
CCCCCCCEEEEEECCHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHCCCCCCEEEEEEE
LPDGDGFSLLSSIRKFSSTPVLFLSARGEDEDRLLGLGLGADDYMVKPFLPRELVLRLMA
ECCCCCHHHHHHHHHHCCCCEEEEEECCCCCCEEEEEECCCCCCEECCCCCHHHHHHHHH
ILKRVYSSSVTERLSIFRLGEQIVDLESAVVHRGQKEMPLTAKEHAILVKLYENQGRIIT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEEECCCCEEE
NDALCQAVWGDDSYGLENTLMVHIRRIREKIELDPSKPIYLLTFRGLGYKLLVKETY
CHHHEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9639930; 9384377 [H]