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The map label for this gene is kinD [H]

Identifier: 118476905

GI number: 118476905

Start: 1352469

End: 1353965

Strand: Reverse

Name: kinD [H]

Synonym: BALH_1197

Alternate gene names: 118476905

Gene position: 1353965-1352469 (Counterclockwise)

Preceding gene: 118476909

Following gene: 118476904

Centisome position: 25.76

GC content: 34.34

Gene sequence:

>1497_bases
TTGAAATTCAAATTCCACAACATAGTTTTATATATATTGCTTGTTATCCTACCAACGATCGGTATTGGTGCTACATTTTA
TTCATATCATTCGTATAAAATGAAACAGGAAAACAAACGAATTGCTCATACGGTGCTCTTTTTATATAGAGACTATTTAG
ATCACCATCTTGGCGAAGCAATTTCTGCCTTAGAAATGCTCTCAAAGGTCGTAGGAACCGAGACTGGAAATATTAATGGA
ATGAAAGAAATTGTACATGATACTGATGGAAACGATGCACGTTTTTCTGGTCTATATTACACTACACCAGAAGGTATCAT
TACAATTGCATCAGAAGGCGACCGGCCACCTGTTGATGTCTCAGATCGTAAATATATTCAAAACGCATTACAAACTAAGA
AAACAACTGTATCATCCGTCATTACAGATCGTGTTCTTGGCCATCAAGCTATTATGATTGCTTCTCCCATTTTCAATAAA
CAGAAGGAGCTCTCAGGCTTATTGTTAGCAAGTTTACGCTTTGACTACATTTCATCATCCTTAAATGCCATTAAACCGCA
ATACCATTTTGAAGTAACTGATAAGTATGATGTAGTTTTTCTAACCGATGATAATAATGAAACAAGTGATGCGCATTATA
ATATGCTTACTACTCCACTCCAAAGATTAGATTGGAAGGTCTCTGTTTCTCCTTTACCTATTCATCAAAAAACTTTAAAT
CAGTGGGTTGCCGTAGAATGTATAGCTACTTTATTTTTAATGTCAATTTTATTTTTACTCGCTCAATATATGTTGTTAAA
ACGACAAACAAAACTGGAAAGACAACAAAATGAACTACAAAAAATTGAATTAGTTGGAACTTTTGCAGCTAGTACAGCCC
ACGAAATCCGTAATCCACTTACCGGAATTAAAGGGCTCGTCGCTCTATTAAAAGAGAAATATAAAGATGAACAAGATCAG
TTCTATTTTTCCATCATCGAACAAGAGATAAAACGAATTAATGAAATTGTAAGTGAATTTCTTATTCTTGGAAAGCCAAC
TGCAACCATTGAACAAACATATGATGTGAGAACCATTCTAAATGAGGTAGCATTAATTATTCAATCTGAGGCGAATCTAC
ATAACATTGTATTCCATTTACATTTGCCAGACCACCCTGTTCATATCCGGTGCTCAAAAGACCATATGAAACAAGTGGTT
TTAAACATTACAAAAAATGCAATTGAAGCTATGACTTCTGGTGATACACTAACTATTTCCGTAACAAGCAATGAAACACA
CGCACAATTGCAAATTATAGATACTGGAAAAGGGATTCCAAAACATATTCAAAAACACCTCTTTCATCCGTTCTTTACTA
ATAAAGATACTGGAACAGGTCTTGGACTTGTCATATGTAAACGAATTGTAGAGATGTATAATGGGCACCTTTTTATTGAC
AGTATAGAAAACGAAGGAACGACAGTTCATGTCGAAATTCCATTACACATAGTATAA

Upstream 100 bases:

>100_bases
TACCTCTCCCAAAATATATTATGAATGATTCTTGAATAAAAACATGACAATTTTAACATAGTTTATATATAATGATAATA
AAAAAGAAGGAGTTCCAAAT

Downstream 100 bases:

>100_bases
TTATCCTTATCCCAAAAGGGTAATTATACTTATTTCATAAAACCAGCCACAAGCATTCGCCAAAAATTACTTGATTTCCC
TTCATACCCAATTTGAAAAA

Product: sensor histidine kinase, sporulation kinase

Products: NA

Alternate protein names: Sensor histidine kinase D [H]

Number of amino acids: Translated: 498; Mature: 498

Protein sequence:

>498_residues
MKFKFHNIVLYILLVILPTIGIGATFYSYHSYKMKQENKRIAHTVLFLYRDYLDHHLGEAISALEMLSKVVGTETGNING
MKEIVHDTDGNDARFSGLYYTTPEGIITIASEGDRPPVDVSDRKYIQNALQTKKTTVSSVITDRVLGHQAIMIASPIFNK
QKELSGLLLASLRFDYISSSLNAIKPQYHFEVTDKYDVVFLTDDNNETSDAHYNMLTTPLQRLDWKVSVSPLPIHQKTLN
QWVAVECIATLFLMSILFLLAQYMLLKRQTKLERQQNELQKIELVGTFAASTAHEIRNPLTGIKGLVALLKEKYKDEQDQ
FYFSIIEQEIKRINEIVSEFLILGKPTATIEQTYDVRTILNEVALIIQSEANLHNIVFHLHLPDHPVHIRCSKDHMKQVV
LNITKNAIEAMTSGDTLTISVTSNETHAQLQIIDTGKGIPKHIQKHLFHPFFTNKDTGTGLGLVICKRIVEMYNGHLFID
SIENEGTTVHVEIPLHIV

Sequences:

>Translated_498_residues
MKFKFHNIVLYILLVILPTIGIGATFYSYHSYKMKQENKRIAHTVLFLYRDYLDHHLGEAISALEMLSKVVGTETGNING
MKEIVHDTDGNDARFSGLYYTTPEGIITIASEGDRPPVDVSDRKYIQNALQTKKTTVSSVITDRVLGHQAIMIASPIFNK
QKELSGLLLASLRFDYISSSLNAIKPQYHFEVTDKYDVVFLTDDNNETSDAHYNMLTTPLQRLDWKVSVSPLPIHQKTLN
QWVAVECIATLFLMSILFLLAQYMLLKRQTKLERQQNELQKIELVGTFAASTAHEIRNPLTGIKGLVALLKEKYKDEQDQ
FYFSIIEQEIKRINEIVSEFLILGKPTATIEQTYDVRTILNEVALIIQSEANLHNIVFHLHLPDHPVHIRCSKDHMKQVV
LNITKNAIEAMTSGDTLTISVTSNETHAQLQIIDTGKGIPKHIQKHLFHPFFTNKDTGTGLGLVICKRIVEMYNGHLFID
SIENEGTTVHVEIPLHIV
>Mature_498_residues
MKFKFHNIVLYILLVILPTIGIGATFYSYHSYKMKQENKRIAHTVLFLYRDYLDHHLGEAISALEMLSKVVGTETGNING
MKEIVHDTDGNDARFSGLYYTTPEGIITIASEGDRPPVDVSDRKYIQNALQTKKTTVSSVITDRVLGHQAIMIASPIFNK
QKELSGLLLASLRFDYISSSLNAIKPQYHFEVTDKYDVVFLTDDNNETSDAHYNMLTTPLQRLDWKVSVSPLPIHQKTLN
QWVAVECIATLFLMSILFLLAQYMLLKRQTKLERQQNELQKIELVGTFAASTAHEIRNPLTGIKGLVALLKEKYKDEQDQ
FYFSIIEQEIKRINEIVSEFLILGKPTATIEQTYDVRTILNEVALIIQSEANLHNIVFHLHLPDHPVHIRCSKDHMKQVV
LNITKNAIEAMTSGDTLTISVTSNETHAQLQIIDTGKGIPKHIQKHLFHPFFTNKDTGTGLGLVICKRIVEMYNGHLFID
SIENEGTTVHVEIPLHIV

Specific function: Phosphorylates the sporulation-regulatory protein spo0F and, to a minor extent, is responsible for heterogeneous expression of spo0A during logarithmical growth. Also phosphorylates spo0A under biofilm growth conditions [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790436, Length=254, Percent_Identity=33.8582677165354, Blast_Score=142, Evalue=7e-35,
Organism=Escherichia coli, GI1788549, Length=232, Percent_Identity=29.3103448275862, Blast_Score=132, Evalue=6e-32,
Organism=Escherichia coli, GI145693157, Length=239, Percent_Identity=27.6150627615063, Blast_Score=89, Evalue=6e-19,
Organism=Escherichia coli, GI1790300, Length=233, Percent_Identity=26.1802575107296, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1789808, Length=213, Percent_Identity=27.6995305164319, Blast_Score=83, Evalue=4e-17,
Organism=Escherichia coli, GI1790861, Length=246, Percent_Identity=23.1707317073171, Blast_Score=76, Evalue=6e-15,
Organism=Escherichia coli, GI1789149, Length=225, Percent_Identity=25.7777777777778, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1788713, Length=242, Percent_Identity=26.4462809917355, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI1788393, Length=219, Percent_Identity=25.1141552511416, Blast_Score=69, Evalue=7e-13,
Organism=Escherichia coli, GI87081816, Length=240, Percent_Identity=25, Blast_Score=69, Evalue=7e-13,
Organism=Escherichia coli, GI1786600, Length=224, Percent_Identity=24.5535714285714, Blast_Score=69, Evalue=1e-12,
Organism=Escherichia coli, GI1790346, Length=248, Percent_Identity=20.9677419354839, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI48994928, Length=239, Percent_Identity=23.8493723849372, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 56547; Mature: 56547

Theoretical pI: Translated: 6.88; Mature: 6.88

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFKFHNIVLYILLVILPTIGIGATFYSYHSYKMKQENKRIAHTVLFLYRDYLDHHLGEA
CCEEHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ISALEMLSKVVGTETGNINGMKEIVHDTDGNDARFSGLYYTTPEGIITIASEGDRPPVDV
HHHHHHHHHHHCCCCCCCCHHHHHHCCCCCCCCEECCEEEECCCCEEEEECCCCCCCCCC
SDRKYIQNALQTKKTTVSSVITDRVLGHQAIMIASPIFNKQKELSGLLLASLRFDYISSS
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHH
LNAIKPQYHFEVTDKYDVVFLTDDNNETSDAHYNMLTTPLQRLDWKVSVSPLPIHQKTLN
HHHCCCCEEEEECCCEEEEEEECCCCCCCCCHHHHHHHHHHHCCEEEECCCCCCHHHHHH
QWVAVECIATLFLMSILFLLAQYMLLKRQTKLERQQNELQKIELVGTFAASTAHEIRNPL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TGIKGLVALLKEKYKDEQDQFYFSIIEQEIKRINEIVSEFLILGKPTATIEQTYDVRTIL
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
NEVALIIQSEANLHNIVFHLHLPDHPVHIRCSKDHMKQVVLNITKNAIEAMTSGDTLTIS
HHHHHHHCCCCCEEEEEEEEECCCCCEEEEECHHHHHHHHHHHHHHHHHHHCCCCEEEEE
VTSNETHAQLQIIDTGKGIPKHIQKHLFHPFFTNKDTGTGLGLVICKRIVEMYNGHLFID
EECCCCEEEEEEEECCCCCHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCEEEEE
SIENEGTTVHVEIPLHIV
EECCCCCEEEEEEEEEEC
>Mature Secondary Structure
MKFKFHNIVLYILLVILPTIGIGATFYSYHSYKMKQENKRIAHTVLFLYRDYLDHHLGEA
CCEEHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ISALEMLSKVVGTETGNINGMKEIVHDTDGNDARFSGLYYTTPEGIITIASEGDRPPVDV
HHHHHHHHHHHCCCCCCCCHHHHHHCCCCCCCCEECCEEEECCCCEEEEECCCCCCCCCC
SDRKYIQNALQTKKTTVSSVITDRVLGHQAIMIASPIFNKQKELSGLLLASLRFDYISSS
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHH
LNAIKPQYHFEVTDKYDVVFLTDDNNETSDAHYNMLTTPLQRLDWKVSVSPLPIHQKTLN
HHHCCCCEEEEECCCEEEEEEECCCCCCCCCHHHHHHHHHHHCCEEEECCCCCCHHHHHH
QWVAVECIATLFLMSILFLLAQYMLLKRQTKLERQQNELQKIELVGTFAASTAHEIRNPL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TGIKGLVALLKEKYKDEQDQFYFSIIEQEIKRINEIVSEFLILGKPTATIEQTYDVRTIL
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
NEVALIIQSEANLHNIVFHLHLPDHPVHIRCSKDHMKQVVLNITKNAIEAMTSGDTLTIS
HHHHHHHCCCCCEEEEEEEEECCCCCEEEEECHHHHHHHHHHHHHHHHHHHCCCCEEEEE
VTSNETHAQLQIIDTGKGIPKHIQKHLFHPFFTNKDTGTGLGLVICKRIVEMYNGHLFID
EECCCCEEEEEEEECCCCCHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCEEEEE
SIENEGTTVHVEIPLHIV
EECCCCCEEEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]