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The map label for this gene is yisQ [H]

Identifier: 118476765

GI number: 118476765

Start: 1198620

End: 1200065

Strand: Reverse

Name: yisQ [H]

Synonym: BALH_1047

Alternate gene names: 118476765

Gene position: 1200065-1198620 (Counterclockwise)

Preceding gene: 118476768

Following gene: 118476759

Centisome position: 22.83

GC content: 39.63

Gene sequence:

>1446_bases
ATGTTACGATACACTTTGCTAAAAATAGATATCGGTAAAGAGGGGACGGACATGACAGCAATTCAGGCAAAAAACGGGCC
TACTGAGAAATTAAGTTTATTCCTATTAACATGGCCTATTTTTCTAGAAGTTTTTCTATTTATGTTAATGGGGATCGCTG
ATACTTTCATGTTAAGTGCATTATCAGACGATGCTGTATCTGGGGTTGGTGCAGCGAATCAATATCTCCATATCGCTATT
TTGGTACTAGAAGTGATCGGGAACGGCGCTGCTATCGTCGTATCTCAATACCTCGGTTCCAAACGTTTTATGGAAGCATC
TAAAATATCAGCTTTAGCCGTCACATTAAATTTAGTGGTCGGACTCGTTATAAGCGCTGGTTTTCTTTTATTCTCAAAAC
ATATGATGATGGCAATGAACTTACAAGGCGATGTACTTATGTATGCACAAAGCTATTTATCTATCGTCGGGGGAGCTATT
TTCCTTCAAGCTATTATTAATTCATTAGCCGCAATTATCCGCGTACATGGCTTCACAAAGCAAGCGATGTTTATTTCACT
TGGAATGAACATTATTCATATCGCTGGAAACTACGTACTCATTTTCGGGAAATTTGGTTTCCCAGAACTCGGTGTACAAG
GGGCTGCTATTTCTTCTGCTGTCAGCAGATTAATCGCACTTATCGTTTTCTTCTGGTTACTGTACCGCGTTATGGAATAC
CGTGTGAAATTACAATATTACTTTACTTTATCAAAAGAATATATCGGAAAAATTTTAAAAATCGGGATTCCATCTGCATT
TGAGCAGGTTATGTATCAAGCTTGCCAAATTGTCTTCTTATACTATGCAACATATTTAGGAACGGAATCGTTAGCGGCTA
GACAATACGCTACGAACATTTCTATGTTTACTTATTTATTCGCTATTGCAATCGGTATGGGAACTGCAATTATTATCGGA
CGCCTCGTTGGTGGTGGTGAAAAAGATGAAGCGTATGAACGCGTATGGAAAAGTGTAAAGTGGGCGATTGGTGTCACTTT
ATGTATGGTTGCTCTCGTTATTACATTCCGCACACAATTAATGGGACTATTTACAGATAATCCGCACATTATTGCGTTAG
GTGCAAGCGTCCTTTTACTAAGTGTACTACTTGAAACAGGGCGTACGATGAACATCGTCATCATCAATTCACTTCGCGCA
GCTGGTGATGCAAAGTACCCCGTTTTAATCGGCGCATTCTCTATGGTGTTAATGAGTTTACCACTCGGTTACTTTTTCGC
ATTCCATTTAGATATGGGACTCGTTGGTATTTGGTTAGCGATTGCTATTGATGAATGGACACGTGCGATTATTATGTTCT
TCCGCTGGAAAAGTAGAGCGTGGGAGCGTTATGCACTTGTTAAACCTGAAGAACAAGAGGAGATTGTTTCTGTTCAGGCG
CAATAA

Upstream 100 bases:

>100_bases
AATACTTTATGCATAATTATCCTTCTCTTTTTATCATAAAATAGCACTCCCTTCATAATAAAGATATGTAGGTTAAAATG
AGTGCAAAGGTTAAGAAAGT

Downstream 100 bases:

>100_bases
TACTCGTTTAATTAAGGTGTAGTCATTCGTATAGGAAACTTATATTTACGATTCTTTAAATATATCGACTTACGGAGAAA
TATTGACAACTCTTTTATAT

Product: efflux protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 481; Mature: 481

Protein sequence:

>481_residues
MLRYTLLKIDIGKEGTDMTAIQAKNGPTEKLSLFLLTWPIFLEVFLFMLMGIADTFMLSALSDDAVSGVGAANQYLHIAI
LVLEVIGNGAAIVVSQYLGSKRFMEASKISALAVTLNLVVGLVISAGFLLFSKHMMMAMNLQGDVLMYAQSYLSIVGGAI
FLQAIINSLAAIIRVHGFTKQAMFISLGMNIIHIAGNYVLIFGKFGFPELGVQGAAISSAVSRLIALIVFFWLLYRVMEY
RVKLQYYFTLSKEYIGKILKIGIPSAFEQVMYQACQIVFLYYATYLGTESLAARQYATNISMFTYLFAIAIGMGTAIIIG
RLVGGGEKDEAYERVWKSVKWAIGVTLCMVALVITFRTQLMGLFTDNPHIIALGASVLLLSVLLETGRTMNIVIINSLRA
AGDAKYPVLIGAFSMVLMSLPLGYFFAFHLDMGLVGIWLAIAIDEWTRAIIMFFRWKSRAWERYALVKPEEQEEIVSVQA
Q

Sequences:

>Translated_481_residues
MLRYTLLKIDIGKEGTDMTAIQAKNGPTEKLSLFLLTWPIFLEVFLFMLMGIADTFMLSALSDDAVSGVGAANQYLHIAI
LVLEVIGNGAAIVVSQYLGSKRFMEASKISALAVTLNLVVGLVISAGFLLFSKHMMMAMNLQGDVLMYAQSYLSIVGGAI
FLQAIINSLAAIIRVHGFTKQAMFISLGMNIIHIAGNYVLIFGKFGFPELGVQGAAISSAVSRLIALIVFFWLLYRVMEY
RVKLQYYFTLSKEYIGKILKIGIPSAFEQVMYQACQIVFLYYATYLGTESLAARQYATNISMFTYLFAIAIGMGTAIIIG
RLVGGGEKDEAYERVWKSVKWAIGVTLCMVALVITFRTQLMGLFTDNPHIIALGASVLLLSVLLETGRTMNIVIINSLRA
AGDAKYPVLIGAFSMVLMSLPLGYFFAFHLDMGLVGIWLAIAIDEWTRAIIMFFRWKSRAWERYALVKPEEQEEIVSVQA
Q
>Mature_481_residues
MLRYTLLKIDIGKEGTDMTAIQAKNGPTEKLSLFLLTWPIFLEVFLFMLMGIADTFMLSALSDDAVSGVGAANQYLHIAI
LVLEVIGNGAAIVVSQYLGSKRFMEASKISALAVTLNLVVGLVISAGFLLFSKHMMMAMNLQGDVLMYAQSYLSIVGGAI
FLQAIINSLAAIIRVHGFTKQAMFISLGMNIIHIAGNYVLIFGKFGFPELGVQGAAISSAVSRLIALIVFFWLLYRVMEY
RVKLQYYFTLSKEYIGKILKIGIPSAFEQVMYQACQIVFLYYATYLGTESLAARQYATNISMFTYLFAIAIGMGTAIIIG
RLVGGGEKDEAYERVWKSVKWAIGVTLCMVALVITFRTQLMGLFTDNPHIIALGASVLLLSVLLETGRTMNIVIINSLRA
AGDAKYPVLIGAFSMVLMSLPLGYFFAFHLDMGLVGIWLAIAIDEWTRAIIMFFRWKSRAWERYALVKPEEQEEIVSVQA
Q

Specific function: Unknown

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family [H]

Homologues:

Organism=Homo sapiens, GI153792564, Length=438, Percent_Identity=21.689497716895, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI38261960, Length=470, Percent_Identity=21.063829787234, Blast_Score=74, Evalue=3e-13,
Organism=Escherichia coli, GI226510954, Length=443, Percent_Identity=25.5079006772009, Blast_Score=135, Evalue=8e-33,
Organism=Escherichia coli, GI48994890, Length=449, Percent_Identity=22.9398663697105, Blast_Score=75, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 53215; Mature: 53215

Theoretical pI: Translated: 8.99; Mature: 8.99

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
5.0 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRYTLLKIDIGKEGTDMTAIQAKNGPTEKLSLFLLTWPIFLEVFLFMLMGIADTFMLSA
CCEEEEEEEEECCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LSDDAVSGVGAANQYLHIAILVLEVIGNGAAIVVSQYLGSKRFMEASKISALAVTLNLVV
HCCHHHCCCCCCHHHHHHHHHHHHHHCCCHHEEHHHHHCCHHHHHHHHHHHHHHHHHHHH
GLVISAGFLLFSKHMMMAMNLQGDVLMYAQSYLSIVGGAIFLQAIINSLAAIIRVHGFTK
HHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
QAMFISLGMNIIHIAGNYVLIFGKFGFPELGVQGAAISSAVSRLIALIVFFWLLYRVMEY
HHHHHHHCCEEEEEECCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
RVKLQYYFTLSKEYIGKILKIGIPSAFEQVMYQACQIVFLYYATYLGTESLAARQYATNI
HHEEEEEEEECHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
SMFTYLFAIAIGMGTAIIIGRLVGGGEKDEAYERVWKSVKWAIGVTLCMVALVITFRTQL
HHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MGLFTDNPHIIALGASVLLLSVLLETGRTMNIVIINSLRAAGDAKYPVLIGAFSMVLMSL
HHHCCCCCEEEEECHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHH
PLGYFFAFHLDMGLVGIWLAIAIDEWTRAIIMFFRWKSRAWERYALVKPEEQEEIVSVQA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHEECCCCCCCHHHHEECC
Q
C
>Mature Secondary Structure
MLRYTLLKIDIGKEGTDMTAIQAKNGPTEKLSLFLLTWPIFLEVFLFMLMGIADTFMLSA
CCEEEEEEEEECCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LSDDAVSGVGAANQYLHIAILVLEVIGNGAAIVVSQYLGSKRFMEASKISALAVTLNLVV
HCCHHHCCCCCCHHHHHHHHHHHHHHCCCHHEEHHHHHCCHHHHHHHHHHHHHHHHHHHH
GLVISAGFLLFSKHMMMAMNLQGDVLMYAQSYLSIVGGAIFLQAIINSLAAIIRVHGFTK
HHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
QAMFISLGMNIIHIAGNYVLIFGKFGFPELGVQGAAISSAVSRLIALIVFFWLLYRVMEY
HHHHHHHCCEEEEEECCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
RVKLQYYFTLSKEYIGKILKIGIPSAFEQVMYQACQIVFLYYATYLGTESLAARQYATNI
HHEEEEEEEECHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
SMFTYLFAIAIGMGTAIIIGRLVGGGEKDEAYERVWKSVKWAIGVTLCMVALVITFRTQL
HHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MGLFTDNPHIIALGASVLLLSVLLETGRTMNIVIINSLRAAGDAKYPVLIGAFSMVLMSL
HHHCCCCCEEEEECHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHH
PLGYFFAFHLDMGLVGIWLAIAIDEWTRAIIMFFRWKSRAWERYALVKPEEQEEIVSVQA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHEECCCCCCCHHHHEECC
Q
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9353932; 9384377 [H]