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The map label for this gene is fumA [H]

Identifier: 118476175

GI number: 118476175

Start: 481675

End: 483252

Strand: Direct

Name: fumA [H]

Synonym: BALH_0422

Alternate gene names: 118476175

Gene position: 481675-483252 (Clockwise)

Preceding gene: 118476174

Following gene: 118476176

Centisome position: 9.16

GC content: 39.73

Gene sequence:

>1578_bases
ATGGAATTTTCAGCTCATAACGTTTTGGTAGCGTTCACAATTGAGGGGGAAGTAACAATGGAAAAGCTTCAAGAAAGCAT
GTATCAACTAATTGTTGAAACGTCAACGAACTTACCGAAAGATGTTCGTCGTGCGATTCAACAAGCGAAAGAGCGAGAAA
ATGCAGGGACTCGCTCTGCAATGGCACTTGGCACAATTACGAATAATATTAAAATGGCTGATGATAACATCTCACCAATT
TGCCAAGATACAGGGATGCCAACGTTTAAAATTTATACACCAGTTGGTGTGAATCAATTAAAGTTGAAGAAAGCTATCTA
TAATGCGCTTGAGCGGGCGACAAAAGATGGTAAACTTCGTCCAAATTCTGTTGATTCTCTTTTTGGAGACAATAGTGGAA
ATAATTTAGGACCAGGTACACCGGTTATTAAGTTTGAACAATGGGAAAAAGATTATATTGATGCACGTTTAATTCTAAAG
GGTGGTGGCTGTGAGAATAAAAATATTCAGTATAGCTTACCATGTGAATTAGAAGGACTTGGACGCGCAGGCCGTGATTT
AGAAGGGATTCGTAAATGCCTTCTTCATGCAGTGTATCAAGCGCAAGGTCAAGGATGTAGTGCAGGTGTAATTGGTGTTG
GTATCGGGGGAGACCGCACATCAGGTTATGAATTAGCAAAAAATCAATTATTCCGTACATTAGATGATGTTAATCCAATC
CCAGAATTACAACAACTTGAAGAGTACGTATTAGAAAATGCGAATAAGCTTGGCATTGGTACGATGGGATTTGGCGGAGA
AACAACTTTACTTGGCTGTAAAATTGGCGTGTATAACCGTCTACCAGCTAGCTTCTATGTATCTGTGGCGTATAATTGCT
GGGCATATCGCCGCCTTGGTGTAACGATCCATCCTGAAACAGGAGAAATTATGGAGTGGCTATATCAAGAAGGTGACGAT
ACACTTCAGCAAGAGGCGCAAGAAAAGACAGAGCAACGTGAGATTGTATTACAAGCACCAATTACAGAAGAGCAAATTCG
TGAACTTCGCGTTGGTGATGTTGTAACAATTAATGGCATGATGTATACAGGTCGTGACGCAATCCATAAGCATTTAATGG
ATAATGATTGTCCAGTAGATTTAAATGGACAAGTTATTTATCACTGTGGTCCAGTTGTCGTGAAAGATGAAAATGACAAT
TGGCAAATTAAAGCGGCAGGTCCAACGACAAGTATTCGTGAAGAACCGTACCAAGGTGATATTATGAAGAAATTCGGTAT
TCGCGCTGTCATTGGAAAAGGCGGTATGGGTGCGAAAACATTAGCGGCTTTAGAAGAACACGGCGGTGTATATTTAAACG
CAATCGGTGGTGCAGCGCAGTATTATGCTGAATGTATTAAAGAAGTGAAAGATGTTGATTTCTTACAATTTGGTATTCCA
GAGGCAATGTGGCATTTACGTATTGAAGGGTTTAAAGCAGTTGTAACGATGGATTCTCATGGTAATAGCTTACATGCAGA
TGTTGATAAAACATCACTTGAAAAATTAGCGAGCTTTAAAGAGCCAGTATTTAAGTAA

Upstream 100 bases:

>100_bases
GATAATAGAAGGACGATAGAAAAAGAGGTATAATCAAGTTGTGAAAAATTTCATTTATGCTTTAATAGTGTGAAATAAAT
AAAAGCTAAAGAGCATAACA

Downstream 100 bases:

>100_bases
ACAAAAATGCATCTCGAATGATTCGAGATGCATTTTTTTGGTATATATAGAAAAACATGTTCAGCATGAAAGAATGCACG
GCAACAGAAACTACAAGTAC

Product: fumarase

Products: NA

Alternate protein names: Fumarase [H]

Number of amino acids: Translated: 525; Mature: 525

Protein sequence:

>525_residues
MEFSAHNVLVAFTIEGEVTMEKLQESMYQLIVETSTNLPKDVRRAIQQAKERENAGTRSAMALGTITNNIKMADDNISPI
CQDTGMPTFKIYTPVGVNQLKLKKAIYNALERATKDGKLRPNSVDSLFGDNSGNNLGPGTPVIKFEQWEKDYIDARLILK
GGGCENKNIQYSLPCELEGLGRAGRDLEGIRKCLLHAVYQAQGQGCSAGVIGVGIGGDRTSGYELAKNQLFRTLDDVNPI
PELQQLEEYVLENANKLGIGTMGFGGETTLLGCKIGVYNRLPASFYVSVAYNCWAYRRLGVTIHPETGEIMEWLYQEGDD
TLQQEAQEKTEQREIVLQAPITEEQIRELRVGDVVTINGMMYTGRDAIHKHLMDNDCPVDLNGQVIYHCGPVVVKDENDN
WQIKAAGPTTSIREEPYQGDIMKKFGIRAVIGKGGMGAKTLAALEEHGGVYLNAIGGAAQYYAECIKEVKDVDFLQFGIP
EAMWHLRIEGFKAVVTMDSHGNSLHADVDKTSLEKLASFKEPVFK

Sequences:

>Translated_525_residues
MEFSAHNVLVAFTIEGEVTMEKLQESMYQLIVETSTNLPKDVRRAIQQAKERENAGTRSAMALGTITNNIKMADDNISPI
CQDTGMPTFKIYTPVGVNQLKLKKAIYNALERATKDGKLRPNSVDSLFGDNSGNNLGPGTPVIKFEQWEKDYIDARLILK
GGGCENKNIQYSLPCELEGLGRAGRDLEGIRKCLLHAVYQAQGQGCSAGVIGVGIGGDRTSGYELAKNQLFRTLDDVNPI
PELQQLEEYVLENANKLGIGTMGFGGETTLLGCKIGVYNRLPASFYVSVAYNCWAYRRLGVTIHPETGEIMEWLYQEGDD
TLQQEAQEKTEQREIVLQAPITEEQIRELRVGDVVTINGMMYTGRDAIHKHLMDNDCPVDLNGQVIYHCGPVVVKDENDN
WQIKAAGPTTSIREEPYQGDIMKKFGIRAVIGKGGMGAKTLAALEEHGGVYLNAIGGAAQYYAECIKEVKDVDFLQFGIP
EAMWHLRIEGFKAVVTMDSHGNSLHADVDKTSLEKLASFKEPVFK
>Mature_525_residues
MEFSAHNVLVAFTIEGEVTMEKLQESMYQLIVETSTNLPKDVRRAIQQAKERENAGTRSAMALGTITNNIKMADDNISPI
CQDTGMPTFKIYTPVGVNQLKLKKAIYNALERATKDGKLRPNSVDSLFGDNSGNNLGPGTPVIKFEQWEKDYIDARLILK
GGGCENKNIQYSLPCELEGLGRAGRDLEGIRKCLLHAVYQAQGQGCSAGVIGVGIGGDRTSGYELAKNQLFRTLDDVNPI
PELQQLEEYVLENANKLGIGTMGFGGETTLLGCKIGVYNRLPASFYVSVAYNCWAYRRLGVTIHPETGEIMEWLYQEGDD
TLQQEAQEKTEQREIVLQAPITEEQIRELRVGDVVTINGMMYTGRDAIHKHLMDNDCPVDLNGQVIYHCGPVVVKDENDN
WQIKAAGPTTSIREEPYQGDIMKKFGIRAVIGKGGMGAKTLAALEEHGGVYLNAIGGAAQYYAECIKEVKDVDFLQFGIP
EAMWHLRIEGFKAVVTMDSHGNSLHADVDKTSLEKLASFKEPVFK

Specific function: Unknown

COG id: COG1951

COG function: function code C; Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I fumarase family [H]

Homologues:

Organism=Escherichia coli, GI1789443, Length=183, Percent_Identity=34.9726775956284, Blast_Score=134, Evalue=1e-32,
Organism=Escherichia coli, GI1789442, Length=289, Percent_Identity=27.681660899654, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI1790564, Length=467, Percent_Identity=25.4817987152034, Blast_Score=101, Evalue=1e-22,
Organism=Escherichia coli, GI1787897, Length=475, Percent_Identity=25.4736842105263, Blast_Score=99, Evalue=7e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004646
- InterPro:   IPR004647
- InterPro:   IPR011167 [H]

Pfam domain/function: PF05681 Fumerase; PF05683 Fumerase_C [H]

EC number: =4.2.1.2 [H]

Molecular weight: Translated: 57983; Mature: 57983

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEFSAHNVLVAFTIEGEVTMEKLQESMYQLIVETSTNLPKDVRRAIQQAKERENAGTRSA
CCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCHHH
MALGTITNNIKMADDNISPICQDTGMPTFKIYTPVGVNQLKLKKAIYNALERATKDGKLR
EEEEEEECCEEECCCCCCCHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCC
PNSVDSLFGDNSGNNLGPGTPVIKFEQWEKDYIDARLILKGGGCENKNIQYSLPCELEGL
CCCHHHHCCCCCCCCCCCCCCEEEEECCCCCCCCEEEEEECCCCCCCCEEEECCCCCCCC
GRAGRDLEGIRKCLLHAVYQAQGQGCSAGVIGVGIGGDRTSGYELAKNQLFRTLDDVNPI
CCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHCCCCC
PELQQLEEYVLENANKLGIGTMGFGGETTLLGCKIGVYNRLPASFYVSVAYNCWAYRRLG
HHHHHHHHHHHCCCCCCCEEEECCCCCEEEEEEEECCCCCCCHHEEEEEHHCCEEEEEEC
VTIHPETGEIMEWLYQEGDDTLQQEAQEKTEQREIVLQAPITEEQIRELRVGDVVTINGM
EEECCCCHHHHHHHHHCCCHHHHHHHHHHHHHHEEEEECCCCHHHHHHHCCCCEEEECCE
MYTGRDAIHKHLMDNDCPVDLNGQVIYHCGPVVVKDENDNWQIKAAGPTTSIREEPYQGD
EECCHHHHHHHHCCCCCCCCCCCEEEEEECCEEEECCCCCEEEEECCCCCCCCCCCCCCC
IMKKFGIRAVIGKGGMGAKTLAALEEHGGVYLNAIGGAAQYYAECIKEVKDVDFLQFGIP
HHHHCCCEEEECCCCCCHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHCCHHHHHCCH
EAMWHLRIEGFKAVVTMDSHGNSLHADVDKTSLEKLASFKEPVFK
HHHHHEEEECEEEEEEECCCCCEEECCCCHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MEFSAHNVLVAFTIEGEVTMEKLQESMYQLIVETSTNLPKDVRRAIQQAKERENAGTRSA
CCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCHHH
MALGTITNNIKMADDNISPICQDTGMPTFKIYTPVGVNQLKLKKAIYNALERATKDGKLR
EEEEEEECCEEECCCCCCCHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCC
PNSVDSLFGDNSGNNLGPGTPVIKFEQWEKDYIDARLILKGGGCENKNIQYSLPCELEGL
CCCHHHHCCCCCCCCCCCCCCEEEEECCCCCCCCEEEEEECCCCCCCCEEEECCCCCCCC
GRAGRDLEGIRKCLLHAVYQAQGQGCSAGVIGVGIGGDRTSGYELAKNQLFRTLDDVNPI
CCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHCCCCC
PELQQLEEYVLENANKLGIGTMGFGGETTLLGCKIGVYNRLPASFYVSVAYNCWAYRRLG
HHHHHHHHHHHCCCCCCCEEEECCCCCEEEEEEEECCCCCCCHHEEEEEHHCCEEEEEEC
VTIHPETGEIMEWLYQEGDDTLQQEAQEKTEQREIVLQAPITEEQIRELRVGDVVTINGM
EEECCCCHHHHHHHHHCCCHHHHHHHHHHHHHHEEEEECCCCHHHHHHHCCCCEEEECCE
MYTGRDAIHKHLMDNDCPVDLNGQVIYHCGPVVVKDENDNWQIKAAGPTTSIREEPYQGD
EECCHHHHHHHHCCCCCCCCCCCEEEEEECCEEEECCCCCEEEEECCCCCCCCCCCCCCC
IMKKFGIRAVIGKGGMGAKTLAALEEHGGVYLNAIGGAAQYYAECIKEVKDVDFLQFGIP
HHHHCCCEEEECCCCCCHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHCCHHHHHCCH
EAMWHLRIEGFKAVVTMDSHGNSLHADVDKTSLEKLASFKEPVFK
HHHHHEEEECEEEEEEECCCCCEEECCCCHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8473853 [H]