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The map label for this gene is groEL [H]

Identifier: 118476013

GI number: 118476013

Start: 270801

End: 272435

Strand: Direct

Name: groEL [H]

Synonym: BALH_0251

Alternate gene names: 118476013

Gene position: 270801-272435 (Clockwise)

Preceding gene: 162382787

Following gene: 118476014

Centisome position: 5.15

GC content: 41.77

Gene sequence:

>1635_bases
ATGGCAAAAGATATTAAATTTAGTGAAGAAGCACGTCGTTCGATGCTTCGCGGTGTCGACACTCTTGCAAATGCAGTAAA
AGTAACGCTTGGACCAAAAGGTCGTAACGTTGTACTTGAGAAAAAATTTGGTTCACCACTTATTACAAATGATGGTGTAA
CAATCGCAAAAGAAATCGAATTAGAAGATGCATTCGAAAACATGGGTGCGAAATTAGTAGCAGAAGTTGCTAGCAAAACA
AATGATGTAGCTGGTGACGGAACAACAACTGCAACTGTATTAGCACAAGCTATGATTCGTGAAGGTCTTAAAAACGTAAC
AGCTGGTGCGAACCCAATGGGTCTTCGTAAAGGTATCGAAAAAGCTGTAGTTGCTGCAGTAGAAGAATTAAAAACGATTT
CTAAACCAATCGAAGGTAAATCTTCAATCGCACAAGTAGCTGCTATTTCTGCGGCTGACGAAGAAGTAGGTCAATTAATC
GCTGAAGCAATGGAGCGCGTTGGTAACGACGGCGTTATTACTTTAGAAGAATCTAAAGGATTCACAACAGAATTAGATGT
AGTAGAAGGTATGCAATTTGATCGTGGATATGCATCTCCTTACATGATTACTGATTCTGACAAAATGGAAGCAGTTCTTG
ATAACCCATACATCTTAATCACTGACAAAAAGATTTCTAACATTCAAGAAATCTTACCAGTATTAGAGCAAGTGGTACAA
CAAGGTAAACCGCTTCTTATCATTGCTGAAGATGTAGAAGGCGAAGCATTAGCTACATTAGTAGTGAACAAACTTCGTGG
TACATTCAATGTAGTAGCTGTTAAAGCTCCTGGATTTGGTGACCGTCGTAAAGCAATGCTAGAAGATATCGCAATCTTAA
CTGGTGGCGAAGTAATCACTGAAGAATTAGGCCGTGACTTAAAATCTGCTACAGTTGAATCTTTAGGACGCGCTGGTAAG
GTTGTTGTAACGAAAGAAAACACAACTGTAGTTGAAGGTGTAGGAAGCACAGAACAAATCGAAGCTCGCATCGGTCAAAT
CCGTGCGCAATTAGAAGAAACAACTTCTGAATTCGATCGTGAAAAATTACAAGAGCGTCTTGCAAAACTTGCAGGTGGCG
TAGCAGTAATTAAAGTAGGTGCAGCAACTGAAACTGAGTTGAAAGAGCGCAAACTTCGCATTGAAGATGCACTTAACTCA
ACTCGTGCAGCAGTAGAAGAAGGTATCGTTGCAGGTGGTGGTACTTCACTTATGAACGTATACACAAAAGTAGCTTCTAT
CGTAGCTGAAGGCGACGAAGCAACAGGTATCAACATCGTACTTCGAGCACTAGAAGAGCCAGTTCGTCAAATCGCAATCA
ACGCTGGTCTAGAAGGATCTGTAGTTGTAGAGCGTCTAAAAGGCGAAAAAGTAGGCGTTGGTTTCAACGCAGCAACTGGC
GAGTGGGTTAACATGCTTGAAACTGGTATTGTAGATCCAGCTAAAGTAACTCGCTCTGCACTTCAAAACGCAGCATCTGT
TGCAGCTATGTTCTTAACAACTGAAGCTGTAGTAGCTGACAAACCAGAACCAAATGCACCAGCAATGCCTGACATGGGCG
GCATGGGCATGGGCGGTATGGGCGGAATGATGTAA

Upstream 100 bases:

>100_bases
AATATGAAGGTACAGACTACTTGATTTTACGTGAAAGTGACATTTTAGCAGTTATCGGTTAATTATATAAATCTTAAAAA
ATCCAAGGGGGTCAATTATT

Downstream 100 bases:

>100_bases
TAAGCATCACTCTGTGAAGCTGTGCAATGTATAAATAGTTAATTAGAAGAAGGCTACTTCCTTGATGAGAGGAGGTAGTC
TTTTTTGTGTTATTAAAGTT

Product: chaperonin GroEL

Products: NA

Alternate protein names: GroEL protein; Protein Cpn60 [H]

Number of amino acids: Translated: 544; Mature: 543

Protein sequence:

>544_residues
MAKDIKFSEEARRSMLRGVDTLANAVKVTLGPKGRNVVLEKKFGSPLITNDGVTIAKEIELEDAFENMGAKLVAEVASKT
NDVAGDGTTTATVLAQAMIREGLKNVTAGANPMGLRKGIEKAVVAAVEELKTISKPIEGKSSIAQVAAISAADEEVGQLI
AEAMERVGNDGVITLEESKGFTTELDVVEGMQFDRGYASPYMITDSDKMEAVLDNPYILITDKKISNIQEILPVLEQVVQ
QGKPLLIIAEDVEGEALATLVVNKLRGTFNVVAVKAPGFGDRRKAMLEDIAILTGGEVITEELGRDLKSATVESLGRAGK
VVVTKENTTVVEGVGSTEQIEARIGQIRAQLEETTSEFDREKLQERLAKLAGGVAVIKVGAATETELKERKLRIEDALNS
TRAAVEEGIVAGGGTSLMNVYTKVASIVAEGDEATGINIVLRALEEPVRQIAINAGLEGSVVVERLKGEKVGVGFNAATG
EWVNMLETGIVDPAKVTRSALQNAASVAAMFLTTEAVVADKPEPNAPAMPDMGGMGMGGMGGMM

Sequences:

>Translated_544_residues
MAKDIKFSEEARRSMLRGVDTLANAVKVTLGPKGRNVVLEKKFGSPLITNDGVTIAKEIELEDAFENMGAKLVAEVASKT
NDVAGDGTTTATVLAQAMIREGLKNVTAGANPMGLRKGIEKAVVAAVEELKTISKPIEGKSSIAQVAAISAADEEVGQLI
AEAMERVGNDGVITLEESKGFTTELDVVEGMQFDRGYASPYMITDSDKMEAVLDNPYILITDKKISNIQEILPVLEQVVQ
QGKPLLIIAEDVEGEALATLVVNKLRGTFNVVAVKAPGFGDRRKAMLEDIAILTGGEVITEELGRDLKSATVESLGRAGK
VVVTKENTTVVEGVGSTEQIEARIGQIRAQLEETTSEFDREKLQERLAKLAGGVAVIKVGAATETELKERKLRIEDALNS
TRAAVEEGIVAGGGTSLMNVYTKVASIVAEGDEATGINIVLRALEEPVRQIAINAGLEGSVVVERLKGEKVGVGFNAATG
EWVNMLETGIVDPAKVTRSALQNAASVAAMFLTTEAVVADKPEPNAPAMPDMGGMGMGGMGGMM
>Mature_543_residues
AKDIKFSEEARRSMLRGVDTLANAVKVTLGPKGRNVVLEKKFGSPLITNDGVTIAKEIELEDAFENMGAKLVAEVASKTN
DVAGDGTTTATVLAQAMIREGLKNVTAGANPMGLRKGIEKAVVAAVEELKTISKPIEGKSSIAQVAAISAADEEVGQLIA
EAMERVGNDGVITLEESKGFTTELDVVEGMQFDRGYASPYMITDSDKMEAVLDNPYILITDKKISNIQEILPVLEQVVQQ
GKPLLIIAEDVEGEALATLVVNKLRGTFNVVAVKAPGFGDRRKAMLEDIAILTGGEVITEELGRDLKSATVESLGRAGKV
VVTKENTTVVEGVGSTEQIEARIGQIRAQLEETTSEFDREKLQERLAKLAGGVAVIKVGAATETELKERKLRIEDALNST
RAAVEEGIVAGGGTSLMNVYTKVASIVAEGDEATGINIVLRALEEPVRQIAINAGLEGSVVVERLKGEKVGVGFNAATGE
WVNMLETGIVDPAKVTRSALQNAASVAAMFLTTEAVVADKPEPNAPAMPDMGGMGMGGMGGMM

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions [H]

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family [H]

Homologues:

Organism=Homo sapiens, GI41399285, Length=526, Percent_Identity=51.7110266159696, Blast_Score=521, Evalue=1e-148,
Organism=Homo sapiens, GI31542947, Length=526, Percent_Identity=51.7110266159696, Blast_Score=521, Evalue=1e-148,
Organism=Homo sapiens, GI24307939, Length=500, Percent_Identity=24.6, Blast_Score=76, Evalue=9e-14,
Organism=Homo sapiens, GI5453603, Length=567, Percent_Identity=23.4567901234568, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI38455427, Length=130, Percent_Identity=30.7692307692308, Blast_Score=67, Evalue=6e-11,
Organism=Escherichia coli, GI1790586, Length=527, Percent_Identity=64.326375711575, Blast_Score=663, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17555558, Length=530, Percent_Identity=47.9245283018868, Blast_Score=484, Evalue=1e-137,
Organism=Caenorhabditis elegans, GI193210679, Length=209, Percent_Identity=45.933014354067, Blast_Score=182, Evalue=3e-46,
Organism=Caenorhabditis elegans, GI25147750, Length=560, Percent_Identity=25.1785714285714, Blast_Score=78, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17564182, Length=556, Percent_Identity=24.1007194244604, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI25144674, Length=185, Percent_Identity=30.2702702702703, Blast_Score=75, Evalue=9e-14,
Organism=Saccharomyces cerevisiae, GI6323288, Length=524, Percent_Identity=53.0534351145038, Blast_Score=526, Evalue=1e-150,
Organism=Saccharomyces cerevisiae, GI6322350, Length=565, Percent_Identity=23.1858407079646, Blast_Score=76, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6322524, Length=121, Percent_Identity=33.8842975206612, Blast_Score=74, Evalue=9e-14,
Organism=Saccharomyces cerevisiae, GI6322446, Length=555, Percent_Identity=20.7207207207207, Blast_Score=64, Evalue=8e-11,
Organism=Drosophila melanogaster, GI24641193, Length=528, Percent_Identity=50.5681818181818, Blast_Score=520, Evalue=1e-148,
Organism=Drosophila melanogaster, GI24641191, Length=528, Percent_Identity=50.5681818181818, Blast_Score=520, Evalue=1e-148,
Organism=Drosophila melanogaster, GI45550936, Length=525, Percent_Identity=48.5714285714286, Blast_Score=488, Evalue=1e-138,
Organism=Drosophila melanogaster, GI45550132, Length=525, Percent_Identity=48.5714285714286, Blast_Score=488, Evalue=1e-138,
Organism=Drosophila melanogaster, GI45550935, Length=525, Percent_Identity=48.5714285714286, Blast_Score=488, Evalue=1e-138,
Organism=Drosophila melanogaster, GI17864606, Length=543, Percent_Identity=42.7255985267035, Blast_Score=431, Evalue=1e-121,
Organism=Drosophila melanogaster, GI24584129, Length=541, Percent_Identity=37.1534195933457, Blast_Score=308, Evalue=5e-84,
Organism=Drosophila melanogaster, GI19921262, Length=541, Percent_Identity=37.1534195933457, Blast_Score=308, Evalue=5e-84,
Organism=Drosophila melanogaster, GI28571140, Length=567, Percent_Identity=24.6913580246914, Blast_Score=86, Evalue=5e-17,
Organism=Drosophila melanogaster, GI18858175, Length=567, Percent_Identity=24.6913580246914, Blast_Score=86, Evalue=6e-17,
Organism=Drosophila melanogaster, GI24645179, Length=503, Percent_Identity=24.4532803180915, Blast_Score=85, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24583944, Length=542, Percent_Identity=23.9852398523985, Blast_Score=70, Evalue=5e-12,
Organism=Drosophila melanogaster, GI17647245, Length=142, Percent_Identity=29.5774647887324, Blast_Score=68, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24652903, Length=130, Percent_Identity=31.5384615384615, Blast_Score=68, Evalue=2e-11,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018370
- InterPro:   IPR001844
- InterPro:   IPR002423 [H]

Pfam domain/function: PF00118 Cpn60_TCP1 [H]

EC number: NA

Molecular weight: Translated: 57405; Mature: 57273

Theoretical pI: Translated: 4.48; Mature: 4.48

Prosite motif: PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKDIKFSEEARRSMLRGVDTLANAVKVTLGPKGRNVVLEKKFGSPLITNDGVTIAKEIE
CCCCCCCHHHHHHHHHHHHHHHHHHEEEEECCCCCEEEEEECCCCCEEECCCCEEEECCC
LEDAFENMGAKLVAEVASKTNDVAGDGTTTATVLAQAMIREGLKNVTAGANPMGLRKGIE
HHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
KAVVAAVEELKTISKPIEGKSSIAQVAAISAADEEVGQLIAEAMERVGNDGVITLEESKG
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCC
FTTELDVVEGMQFDRGYASPYMITDSDKMEAVLDNPYILITDKKISNIQEILPVLEQVVQ
CEEEHHHHHCCCCCCCCCCCEEEECCCHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHH
QGKPLLIIAEDVEGEALATLVVNKLRGTFNVVAVKAPGFGDRRKAMLEDIAILTGGEVIT
CCCCEEEEEECCCCHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCHHHH
EELGRDLKSATVESLGRAGKVVVTKENTTVVEGVGSTEQIEARIGQIRAQLEETTSEFDR
HHHCCHHHHHHHHHHCCCCEEEEEECCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHH
EKLQERLAKLAGGVAVIKVGAATETELKERKLRIEDALNSTRAAVEEGIVAGGGTSLMNV
HHHHHHHHHHHCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
YTKVASIVAEGDEATGINIVLRALEEPVRQIAINAGLEGSVVVERLKGEKVGVGFNAATG
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCEECCCCCCCCH
EWVNMLETGIVDPAKVTRSALQNAASVAAMFLTTEAVVADKPEPNAPAMPDMGGMGMGGM
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCC
GGMM
CCCC
>Mature Secondary Structure 
AKDIKFSEEARRSMLRGVDTLANAVKVTLGPKGRNVVLEKKFGSPLITNDGVTIAKEIE
CCCCCCHHHHHHHHHHHHHHHHHHEEEEECCCCCEEEEEECCCCCEEECCCCEEEECCC
LEDAFENMGAKLVAEVASKTNDVAGDGTTTATVLAQAMIREGLKNVTAGANPMGLRKGIE
HHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
KAVVAAVEELKTISKPIEGKSSIAQVAAISAADEEVGQLIAEAMERVGNDGVITLEESKG
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCC
FTTELDVVEGMQFDRGYASPYMITDSDKMEAVLDNPYILITDKKISNIQEILPVLEQVVQ
CEEEHHHHHCCCCCCCCCCCEEEECCCHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHH
QGKPLLIIAEDVEGEALATLVVNKLRGTFNVVAVKAPGFGDRRKAMLEDIAILTGGEVIT
CCCCEEEEEECCCCHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCHHHH
EELGRDLKSATVESLGRAGKVVVTKENTTVVEGVGSTEQIEARIGQIRAQLEETTSEFDR
HHHCCHHHHHHHHHHCCCCEEEEEECCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHH
EKLQERLAKLAGGVAVIKVGAATETELKERKLRIEDALNSTRAAVEEGIVAGGGTSLMNV
HHHHHHHHHHHCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
YTKVASIVAEGDEATGINIVLRALEEPVRQIAINAGLEGSVVVERLKGEKVGVGFNAATG
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCEECCCCCCCCH
EWVNMLETGIVDPAKVTRSALQNAASVAAMFLTTEAVVADKPEPNAPAMPDMGGMGMGGM
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCC
GGMM
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA