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The map label for this gene is fadI [H]

Identifier: 117919908

GI number: 117919908

Start: 1693217

End: 1694527

Strand: Direct

Name: fadI [H]

Synonym: Shewana3_1460

Alternate gene names: 117919908

Gene position: 1693217-1694527 (Clockwise)

Preceding gene: 117919890

Following gene: 117919909

Centisome position: 34.05

GC content: 50.95

Gene sequence:

>1311_bases
ATGAGTGATAGACAACAGGTAACTAACGCAAAGGGTGAGCGTATCGCCATTGTGGCTGGCTTAAGAACGCCATTTGCGAA
ACAGGCGACCGCATTCCACGGTGTGTCGGCGCTCGATATGGGCAAAATGGTGGTTAACGAGCTGCTGGCCCGTAGCGAAC
TGGATCCTAAATTGATTGAGCAACTGGTGTATGGTCAGGTGGTACAAATGCCAGCGGCACCCAACATTGCCCGTGAAATC
GTGTTAGGGACCGGCATGGATGTGTCAACCGATGCTTATAGCGTGACCCGCGCCTGTGCGACCAGTTTTCAATCTGCGGT
GAATGTGGCCGAGTCAATCATGACGGGCAATATTGAGATTGGTATTGCCGGCGGCGCCGATTCTTCCTCGGTATTGCCTA
TTGGGGTATCTAAAAAACTTGCCCATGCCTTAGTCGATCTGAATAAAGCCCGCAGCTTTGGCCAAAAACTACAGATTTTC
CGTCGTTTAGGCATCAAAGATTTATTGCCTGTGCCACCTGCCGTTGCTGAGTATTCTACGGGATTGTCCATGGGGCAAAC
CGCTGAACAAATGGCCAAAACGTATAATATCAGCCGTGCTGACCAAGATGCGCTGGCGCACCGCTCCCACACGCTGGCGA
GTGAAACGTGGGCCTCAGGTCACCTACGTGACGAAGTGATGGTGGCCCATGTTCCCCCCTACAAACAGTTTATCGAGCGC
GATAATAACATTCGTGAAAACTCCGATTTAAGCTCTTACGCTAAACTGCGTCCCGCTTTCGATAAAAAGCATGGCAGTGT
CACCGCCGCGAACAGTACACCGCTGACCGATGGCGCCTCGGCGATCATTTTGATGAGTGAAGGCCGTGCTAAAGCCTTGG
GGTATCAACCTATTGGTTACATTAAGAGCTACGCATTTACCGCGATTGATGTCTGGCAAGACATGTTGATGGGACCTTCC
TACGCAACGCCATTGGCATTAAAACGCGCCGGCATGGAATTAGAAGATTTAACCCTCATCGAAATGCACGAAGCCTTTGC
GGCACAAACCTTAGCGAACATGCAGATGTTTGCCTCAAAGAAATTTGCCGAAGAAAAATTAGGGCGCAATCGTGCCATTG
GTGAAATCGATATGAGCAAATTTAACGTGCTCGGCGGCTCTTTAGCTTACGGCCATCCTTTTGCGGCCACAGGTACGCGT
TTAATCACTCAGGTTTGTCGTGAGCTTAAACGTCGTGGTGGCGGAACGGGACTAGCAACGGCCTGTGCTGCGGGTGGTTT
AGGGGCTGCAATGATTGTGGAAGTGGAGTAA

Upstream 100 bases:

>100_bases
TGTTATTGGGCTTTTTTAGTGCCAAACAGCAGGGCAAACATGGAAATCGATAGCGCCGCCTGAAATCTCTCAGCGATAGC
GCACATAAAGAGGGTGACAA

Downstream 100 bases:

>100_bases
TGGCGATGGAAAAGACATTTAATTTAACCCGCCGTGAAGACGGTATCGCCATTCTAATGATGGACGTACCCGGCGAAACC
ATGAATACCCTCAAGGCAGA

Product: 3-ketoacyl-CoA thiolase

Products: NA

Alternate protein names: ACSs; Acetyl-CoA acyltransferase; Acyl-CoA ligase; Beta-ketothiolase; Fatty acid oxidation complex subunit beta [H]

Number of amino acids: Translated: 436; Mature: 435

Protein sequence:

>436_residues
MSDRQQVTNAKGERIAIVAGLRTPFAKQATAFHGVSALDMGKMVVNELLARSELDPKLIEQLVYGQVVQMPAAPNIAREI
VLGTGMDVSTDAYSVTRACATSFQSAVNVAESIMTGNIEIGIAGGADSSSVLPIGVSKKLAHALVDLNKARSFGQKLQIF
RRLGIKDLLPVPPAVAEYSTGLSMGQTAEQMAKTYNISRADQDALAHRSHTLASETWASGHLRDEVMVAHVPPYKQFIER
DNNIRENSDLSSYAKLRPAFDKKHGSVTAANSTPLTDGASAIILMSEGRAKALGYQPIGYIKSYAFTAIDVWQDMLMGPS
YATPLALKRAGMELEDLTLIEMHEAFAAQTLANMQMFASKKFAEEKLGRNRAIGEIDMSKFNVLGGSLAYGHPFAATGTR
LITQVCRELKRRGGGTGLATACAAGGLGAAMIVEVE

Sequences:

>Translated_436_residues
MSDRQQVTNAKGERIAIVAGLRTPFAKQATAFHGVSALDMGKMVVNELLARSELDPKLIEQLVYGQVVQMPAAPNIAREI
VLGTGMDVSTDAYSVTRACATSFQSAVNVAESIMTGNIEIGIAGGADSSSVLPIGVSKKLAHALVDLNKARSFGQKLQIF
RRLGIKDLLPVPPAVAEYSTGLSMGQTAEQMAKTYNISRADQDALAHRSHTLASETWASGHLRDEVMVAHVPPYKQFIER
DNNIRENSDLSSYAKLRPAFDKKHGSVTAANSTPLTDGASAIILMSEGRAKALGYQPIGYIKSYAFTAIDVWQDMLMGPS
YATPLALKRAGMELEDLTLIEMHEAFAAQTLANMQMFASKKFAEEKLGRNRAIGEIDMSKFNVLGGSLAYGHPFAATGTR
LITQVCRELKRRGGGTGLATACAAGGLGAAMIVEVE
>Mature_435_residues
SDRQQVTNAKGERIAIVAGLRTPFAKQATAFHGVSALDMGKMVVNELLARSELDPKLIEQLVYGQVVQMPAAPNIAREIV
LGTGMDVSTDAYSVTRACATSFQSAVNVAESIMTGNIEIGIAGGADSSSVLPIGVSKKLAHALVDLNKARSFGQKLQIFR
RLGIKDLLPVPPAVAEYSTGLSMGQTAEQMAKTYNISRADQDALAHRSHTLASETWASGHLRDEVMVAHVPPYKQFIERD
NNIRENSDLSSYAKLRPAFDKKHGSVTAANSTPLTDGASAIILMSEGRAKALGYQPIGYIKSYAFTAIDVWQDMLMGPSY
ATPLALKRAGMELEDLTLIEMHEAFAAQTLANMQMFASKKFAEEKLGRNRAIGEIDMSKFNVLGGSLAYGHPFAATGTRL
ITQVCRELKRRGGGTGLATACAAGGLGAAMIVEVE

Specific function: Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed [H]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI4504327, Length=420, Percent_Identity=40.7142857142857, Blast_Score=331, Evalue=1e-90,
Organism=Homo sapiens, GI167614485, Length=423, Percent_Identity=31.6784869976359, Blast_Score=190, Evalue=2e-48,
Organism=Homo sapiens, GI4557237, Length=434, Percent_Identity=28.3410138248848, Blast_Score=188, Evalue=9e-48,
Organism=Homo sapiens, GI148539872, Length=438, Percent_Identity=29.6803652968037, Blast_Score=178, Evalue=1e-44,
Organism=Homo sapiens, GI4501853, Length=430, Percent_Identity=29.3023255813954, Blast_Score=171, Evalue=1e-42,
Organism=Escherichia coli, GI1788683, Length=426, Percent_Identity=73.0046948356808, Blast_Score=642, Evalue=0.0,
Organism=Escherichia coli, GI87082165, Length=427, Percent_Identity=32.0843091334895, Blast_Score=196, Evalue=2e-51,
Organism=Escherichia coli, GI1788554, Length=423, Percent_Identity=33.806146572104, Blast_Score=191, Evalue=1e-49,
Organism=Escherichia coli, GI48994986, Length=433, Percent_Identity=33.0254041570439, Blast_Score=182, Evalue=3e-47,
Organism=Escherichia coli, GI1787663, Length=424, Percent_Identity=30.8962264150943, Blast_Score=166, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI17551802, Length=421, Percent_Identity=40.1425178147268, Blast_Score=301, Evalue=6e-82,
Organism=Caenorhabditis elegans, GI133906874, Length=426, Percent_Identity=30.9859154929577, Blast_Score=187, Evalue=9e-48,
Organism=Caenorhabditis elegans, GI25147385, Length=420, Percent_Identity=28.0952380952381, Blast_Score=161, Evalue=7e-40,
Organism=Caenorhabditis elegans, GI17535921, Length=437, Percent_Identity=27.2311212814645, Blast_Score=149, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI17535917, Length=427, Percent_Identity=22.9508196721311, Blast_Score=100, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6325229, Length=430, Percent_Identity=28.3720930232558, Blast_Score=170, Evalue=3e-43,
Organism=Saccharomyces cerevisiae, GI6322031, Length=432, Percent_Identity=29.6296296296296, Blast_Score=162, Evalue=7e-41,
Organism=Drosophila melanogaster, GI17137578, Length=434, Percent_Identity=41.2442396313364, Blast_Score=330, Evalue=1e-90,
Organism=Drosophila melanogaster, GI24655093, Length=424, Percent_Identity=29.2452830188679, Blast_Score=179, Evalue=2e-45,
Organism=Drosophila melanogaster, GI17648125, Length=429, Percent_Identity=28.9044289044289, Blast_Score=160, Evalue=2e-39,
Organism=Drosophila melanogaster, GI24640423, Length=430, Percent_Identity=24.1860465116279, Blast_Score=153, Evalue=2e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012806
- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.16 [H]

Molecular weight: Translated: 46681; Mature: 46550

Theoretical pI: Translated: 8.43; Mature: 8.43

Prosite motif: PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDRQQVTNAKGERIAIVAGLRTPFAKQATAFHGVSALDMGKMVVNELLARSELDPKLIE
CCCHHHHHCCCCCEEEEEEECCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCHHHHH
QLVYGQVVQMPAAPNIAREIVLGTGMDVSTDAYSVTRACATSFQSAVNVAESIMTGNIEI
HHHHHHHHCCCCCCCHHHHHHEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEE
GIAGGADSSSVLPIGVSKKLAHALVDLNKARSFGQKLQIFRRLGIKDLLPVPPAVAEYST
EEECCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCHHHHHHC
GLSMGQTAEQMAKTYNISRADQDALAHRSHTLASETWASGHLRDEVMVAHVPPYKQFIER
CCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCHHHHHHC
DNNIRENSDLSSYAKLRPAFDKKHGSVTAANSTPLTDGASAIILMSEGRAKALGYQPIGY
CCCCCCCCCHHHHHHHCCHHHCCCCCEEECCCCCCCCCCCEEEEEECCCCHHCCCCCHHH
IKSYAFTAIDVWQDMLMGPSYATPLALKRAGMELEDLTLIEMHEAFAAQTLANMQMFASK
HHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
KFAEEKLGRNRAIGEIDMSKFNVLGGSLAYGHPFAATGTRLITQVCRELKRRGGGTGLAT
HHHHHHHCCCCCCCCCCHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHH
ACAAGGLGAAMIVEVE
HHHCCCCCEEEEEEEC
>Mature Secondary Structure 
SDRQQVTNAKGERIAIVAGLRTPFAKQATAFHGVSALDMGKMVVNELLARSELDPKLIE
CCHHHHHCCCCCEEEEEEECCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCHHHHH
QLVYGQVVQMPAAPNIAREIVLGTGMDVSTDAYSVTRACATSFQSAVNVAESIMTGNIEI
HHHHHHHHCCCCCCCHHHHHHEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEE
GIAGGADSSSVLPIGVSKKLAHALVDLNKARSFGQKLQIFRRLGIKDLLPVPPAVAEYST
EEECCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCHHHHHHC
GLSMGQTAEQMAKTYNISRADQDALAHRSHTLASETWASGHLRDEVMVAHVPPYKQFIER
CCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCHHHHHHC
DNNIRENSDLSSYAKLRPAFDKKHGSVTAANSTPLTDGASAIILMSEGRAKALGYQPIGY
CCCCCCCCCHHHHHHHCCHHHCCCCCEEECCCCCCCCCCCEEEEEECCCCHHCCCCCHHH
IKSYAFTAIDVWQDMLMGPSYATPLALKRAGMELEDLTLIEMHEAFAAQTLANMQMFASK
HHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
KFAEEKLGRNRAIGEIDMSKFNVLGGSLAYGHPFAATGTRLITQVCRELKRRGGGTGLAT
HHHHHHHCCCCCCCCCCHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHH
ACAAGGLGAAMIVEVE
HHHCCCCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA